Nucleic acid aptamers and their complimentary antidotes. Entering an era of antithrombotic pharmacobiologic therapy.

Abstract:

:The translation of fundamental science-based constructs to the preemptive identification and optimal management of individuals with or those at risk for thrombotic disorders of the cardiovascular system has taken a step closer to being realized with the development of molecular technologies that include nucleic acid aptamers and their complimentary oligonucleotide antidotes. Herein, we summarize our experience with factor IX and von Willebrand factor aptamers, and introduce the era of antithrombotic pharmacobiologic therapy.

journal_name

Hamostaseologie

journal_title

Hamostaseologie

authors

Becker RC,Oney S,Becker KC,Rusconi CP,Sullenger B

subject

Has Abstract

pub_date

2007-12-01 00:00:00

pages

378-82

issue

5

eissn

0720-9355

issn

2567-5761

pii

07050378

journal_volume

27

pub_type

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