Abstract:
:The translation of fundamental science-based constructs to the preemptive identification and optimal management of individuals with or those at risk for thrombotic disorders of the cardiovascular system has taken a step closer to being realized with the development of molecular technologies that include nucleic acid aptamers and their complimentary oligonucleotide antidotes. Herein, we summarize our experience with factor IX and von Willebrand factor aptamers, and introduce the era of antithrombotic pharmacobiologic therapy.
journal_name
Hamostaseologiejournal_title
Hamostaseologieauthors
Becker RC,Oney S,Becker KC,Rusconi CP,Sullenger Bsubject
Has Abstractpub_date
2007-12-01 00:00:00pages
378-82issue
5eissn
0720-9355issn
2567-5761pii
07050378journal_volume
27pub_type
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