Abstract:
:Von Willebrand factor (VWF) structure-function relationship has been studied only through in vitro approaches. The VWF-deficient mouse model has been extremely useful to examine the in vivo function of VWF but does not allow a more subtle analysis of the relative importance of its different domains. However, considering the large size of VWF and its capacity to interact with various ligands in order to support platelet adhesion and aggregation, the necessity to evaluate independently these interactions appeared increasingly crucial. A recently developed technique, known as hydrodynamic injection, which allows transient expression of a transgene by mouse hepatocytes, proved very useful in this regard. Indeed, transient expression of various VWF mutants in VWF-deficient mice contributed to improve our knowledge about the role of VWF interaction with subendothelial collagens and with platelets receptors in VWF roles in haemostasis and thrombosis. These findings can provide new leads in the development of anti-thrombotic therapies.
journal_name
Hamostaseologiejournal_title
Hamostaseologieauthors
Denis CV,Marx I,Badirou I,Pendu R,Christophe Osubject
Has Abstractpub_date
2009-01-01 00:00:00pages
17-8, 20issue
1eissn
0720-9355issn
2567-5761pii
09010017journal_volume
29pub_type
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