Non-polymyxin-based combinations as potential alternatives in treatment against carbapenem-resistant Acinetobacter baumannii infections.

Abstract:

:Due to limited therapeutic options, combination therapy has been used empirically to treat carbapenem-resistant Acinetobacter baumannii (CRAB). Polymyxin-based combinations have been widely studied and used in the clinical setting. However, the use of polymyxins is often limited due to nephrotoxicity and neurotoxicity. This study aimed to evaluate the activity of non-polymyxin-based combinations relative to polymyxin-based combinations and to identify potential synergistic and bactericidal two-drug non-polymyxin-based combinations against CRAB. In vitro activity of 14 two-drug combinations against 50 A. baumannii isolates was evaluated using the checkerboard method. Subsequently, the two best-performing non-polymyxin-based combinations from the checkerboard assay were explored in static time-kill experiments. Concentrations of antibiotics corresponding to the fractional inhibitory concentrations (FIC) and the highest serum concentration achievable clinically were tested. The most synergistic combinations were fosfomycin/sulbactam (synergistic against 37/50 isolates; 74%), followed by meropenem/sulbactam (synergistic against 28/50 isolates; 56%). No antagonism was observed for any combination. Both fosfomycin/sulbactam and meropenem/sulbactam combinations exhibited bactericidal and synergistic activity against both isolates at the highest clinically achievable concentrations in the time-kill experiments. The meropenem/sulbactam combination displayed synergistic and bactericidal activity against one of two strains at concentrations equal to the FIC. Non-polymyxin-based combinations such as fosfomycin/sulbactam and meropenem/sulbactam may have a role in the treatment of CRAB. Further in vivo and clinical studies are required to scrutinise these activities further.

authors

Mohd Sazlly Lim S,Naicker S,Ayfan AK,Zowawi H,Roberts JA,Sime FB

doi

10.1016/j.ijantimicag.2020.106115

subject

Has Abstract

pub_date

2020-10-01 00:00:00

pages

106115

issue

4

eissn

0924-8579

issn

1872-7913

pii

S0924-8579(20)30298-3

journal_volume

56

pub_type

杂志文章
  • A broad-spectrum antifungal from the marine sponge Hyrtios erecta.

    abstract::Spongistatin 1, a macrocyclic lactone polyether from the marine sponge Hyrtios erecta, was fungicidal for a variety of opportunistic yeasts and filamentous fungi, including strains resistant to amphotericin B, ketoconazole and flucytosine. In broth macrodilution assays, MICs ranged from 0.195 to 12.5 microg/ml, and mi...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章

    doi:10.1016/s0924-8579(97)00044-7

    authors: Pettit RK,McAllister SC,Pettit GR,Herald CL,Johnson JM,Cichacz ZA

    更新日期:1997-01-01 00:00:00

  • Drivers and impact of antifungal therapy in critically ill patients with Aspergillus-positive respiratory tract cultures.

    abstract::Invasive pulmonary aspergillosis (IPA) is an increasingly recognised problem in critically ill patients. Little is known about how intensivists react to an Aspergillus-positive respiratory sample or the efficacy of antifungal therapy (AFT). This study aimed to identify drivers of AFT prescription and diagnostic workup...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章

    doi:10.1016/j.ijantimicag.2017.05.017

    authors: Paiva JA,Mergulhão P,Gomes A,Taccone FS,Van den Abeele AM,Bulpa P,Misset B,Meersseman W,Dimopoulos G,Rello J,Vogelaers D,Blot S

    更新日期:2017-10-01 00:00:00

  • Impact of vancomycin minimum inhibitory concentration on clinical outcomes of patients with vancomycin-susceptible Staphylococcus aureus infections: a meta-analysis and meta-regression.

    abstract::Although the vancomycin minimum inhibitory concentration (VMIC) susceptibility breakpoint for Staphylococcus aureus was recently lowered to ≤2 mg/L, it is argued that isolates in the higher levels of the susceptible range may bear adverse clinical outcomes. Clinical outcomes (all-cause mortality and treatment failure)...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章,meta分析,评审

    doi:10.1016/j.ijantimicag.2012.07.023

    authors: Mavros MN,Tansarli GS,Vardakas KZ,Rafailidis PI,Karageorgopoulos DE,Falagas ME

    更新日期:2012-12-01 00:00:00

  • Sulbactam in combination with mezlocillin, piperacillin or cefotaxime: clinical and bacteriological findings in the treatment of serious bacterial infections.

    abstract::An open, multicentre study was performed in hospital in-patients at a total of 12 German hospitals to investigate the efficacy and tolerability of sulbactam combined with mezlocillin, piperacillin or cefotaxime in severe bacterial infections. A total of 155 patients were recruited into the study, of whom 48 were suffe...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章

    doi:

    authors: Manncke K,Springsklee M,Heizmann WR,Sonntag HG

    更新日期:1996-04-01 00:00:00

  • In vitro prevention of Pseudomonas aeruginosa early biofilm formation with antibiotics used in cystic fibrosis patients.

    abstract::The ability of antibiotics used in bronchopulmonary infections in cystic fibrosis (CF) patients to prevent Pseudomonas aeruginosa early biofilm formation was studied using a biofilm microtitre assay with 57 non-mucoid P. aeruginosa isolates (44 first colonisers and 13 recovered during the initial intermittent colonisa...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章

    doi:10.1016/j.ijantimicag.2012.04.006

    authors: Fernández-Olmos A,García-Castillo M,Maiz L,Lamas A,Baquero F,Cantón R

    更新日期:2012-08-01 00:00:00

  • Efficacy of clarithromycin against Streptococcus pneumoniae expressing mef(A)-mediated resistance.

    abstract::As a result of macrolide resistance rates of 25% for pneumococci in the US, the clinical use of this class as empirical therapy has been questioned. However, macrolides continue to be used with clinical success. Using an immunocompromised murine pneumonia model, this study evaluated in vivo efficacy of human simulated...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章

    doi:10.1016/j.ijantimicag.2003.09.028

    authors: Maglio D,Capitano B,Banevicius MA,Tessier PR,Nightingale CH,Nicolau DP

    更新日期:2004-05-01 00:00:00

  • Mechanisms of antibiotic neurotoxicity in renal failure.

    abstract::Neurological complications of antibiotics are relatively common in renal failure. Central nervous system neurotoxicity due to penicillin and beta-lactam antibiotics is best documented with fewer accounts of ototoxicity, peripheral nerve toxicity and neuromuscular blockade. In the context of risk stratification, the go...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章,评审

    doi:10.1016/j.ijantimicag.2003.11.004

    authors: Chow KM,Szeto CC,Hui AC,Li PK

    更新日期:2004-03-01 00:00:00

  • Increasing burden of urinary tract infections due to intrinsic colistin-resistant bacteria in hospitals in Marseille, France.

    abstract::The emergence of multidrug-resistant (MDR) Gram-negative bacteria has become a major public health problem, eliciting renewed interest in colistin, an old antibiotic that is now routinely used to treat MDR bacterial infections. Here we investigated whether colistin use has affected the prevalence of infections due to ...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章

    doi:10.1016/j.ijantimicag.2014.10.010

    authors: Abat C,Desboves G,Olaitan AO,Chaudet H,Roattino N,Fournier PE,Colson P,Raoult D,Rolain JM

    更新日期:2015-02-01 00:00:00

  • Antibiotic resistance in nosocomial isolates in Scotland.

    abstract::In this first multi-centre study in Scotland, 1028 consecutive Gram-negative and staphylococci strains were obtained from four major teaching hospitals. E. coli was the most common organism among both intensive care units (ICUs) (39%) and non-ICU strains (46.6%). The prevalence of antibiotic resistance among E. coli w...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章

    doi:10.1016/0924-8579(96)00310-x

    authors: Shanahan PM,Thomson CJ,Miles RS,Old D,Hood J,Gould IM,Amyes SG

    更新日期:1996-07-01 00:00:00

  • Phenothiazinium-fluoroquinolone drug conjugates.

    abstract::Synthesis and antibacterial screening of a homologous series of 3-dialkylaminophenothiazinium-7-norfloxacin conjugates was carried out alongside a corresponding series of symmetrical methylene blue derivatives. The norfloxacin conjugates maintained typical methylene blue derivative photoproperties, such as long wavele...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章

    doi:10.1016/j.ijantimicag.2009.11.022

    authors: Wainwright M,Shah A,Meegan K,Loughran C,Smith A,Valli N,Dempster N

    更新日期:2010-04-01 00:00:00

  • Changes before and after a policy to restrict antimicrobial usage in upper respiratory infections in Taiwan.

    abstract::The Bureau of National Health Insurance (BNHI) of Taiwan issued a new reimbursement regulation effective from 1 February 2001 forbidding the use of antimicrobials in ambulatory patients with upper respiratory infections (URI) without evidence of bacterial infection. We evaluated the effect of this regulation by analys...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章

    doi:10.1016/j.ijantimicag.2003.10.013

    authors: Ho M,Hsiung CA,Yu HT,Chi CL,Chang HJ

    更新日期:2004-05-01 00:00:00

  • Trends in linezolid susceptibility patterns: report from the 2002-2003 worldwide Zyvox Annual Appraisal of Potency and Spectrum (ZAAPS) Program.

    abstract::Linezolid is an important oxazolidinone antimicrobial for the treatment of infections caused by Gram-positive cocci, especially vancomycin-resistant enterococci and oxacillin-resistant Staphylococcus aureus (ORSA). Since its introduction, however, ribosomal mutations have been detected that produce resistance; thus, l...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章

    doi:10.1016/j.ijantimicag.2005.02.019

    authors: Anderegg TR,Sader HS,Fritsche TR,Ross JE,Jones RN

    更新日期:2005-07-01 00:00:00

  • Ventilator-associated pneumonia.

    abstract::Mechanically ventilated patients are at a substantially higher risk for developing nosocomial pneumonia. Overall, there is a relatively constant 1&!TN!150;3% risk per day of developing pneumonia while receiving mechanical ventilation. The sensitivity and specificity of clinical criteria alone for diagnosis of ventilat...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章

    doi:10.1016/s0924-8579(98)00037-5

    authors: Visnegarwala F,Iyer NG,Hamill RJ

    更新日期:1998-08-01 00:00:00

  • Update on the global spread of dengue.

    abstract::The global spread of dengue fever within and beyond the usual tropical boundaries threatens a large percentage of the world's population, as human and environmental conditions for persistence and even spread are present in all continents. The disease causes great human suffering, a sizable mortality from dengue haemor...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章,评审

    doi:10.1016/j.ijantimicag.2010.06.018

    authors: Guzman A,Istúriz RE

    更新日期:2010-11-01 00:00:00

  • Role of piperacillin/tazobactam as a carbapenem-sparing antibiotic for treatment of acute pyelonephritis due to extended-spectrum β-lactamase-producing Escherichia coli.

    abstract::Extended-spectrum β-lactamase-producing Escherichia coli (ESBL-Ec) is a frequent cause of acute pyelonephritis (APN), requiring carbapenem therapy. However, alternatives to carbapenems are needed due to the emergence of carbapenemase-producing micro-organisms. The purpose of this study was to compare the clinical effi...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章

    doi:10.1016/j.ijantimicag.2016.12.017

    authors: Yoon YK,Kim JH,Sohn JW,Yang KS,Kim MJ

    更新日期:2017-04-01 00:00:00

  • Colistin use and colistin resistance in bacteria from animals.

    abstract::Colistin has been used in veterinary medicine for decades, mainly for the prevention and treatment of Enterobacteriaceae infections. However, data regarding colistin resistance in bacteria from animals and food of animal origin are relatively scarce, partly because there are methodological difficulties hampering the a...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章,评审

    doi:10.1016/j.ijantimicag.2016.09.016

    authors: Kempf I,Jouy E,Chauvin C

    更新日期:2016-12-01 00:00:00

  • Earlier switching from intravenous to oral antibiotics owing to electronic reminders.

    abstract:UNLABELLED:Paper-based interventions have been shown to stimulate switching from intravenous (i.v.) to oral (p.o.) antibiotic therapies. Shorter i.v. durations are associated with a lower risk of iatrogenic infections as well as reduced workload and costs. The purpose of this study was to determine whether automated el...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章

    doi:10.1016/j.ijantimicag.2015.06.013

    authors: Beeler PE,Kuster SP,Eschmann E,Weber R,Blaser J

    更新日期:2015-10-01 00:00:00

  • Strategies for the control of catheter encrustation.

    abstract::Two general strategies have been adopted to develop catheter materials that resist encrustaion by bacterial biofilms: (a) the incorporation of antimicrobial agents into the polymers and (b) the production of materials with surface properties which prevent the adherence of bacterial cells. Our experience to develop non...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章

    doi:10.1016/s0924-8579(02)00091-2

    authors: Stickler DJ,Evans A,Morris N,Hughes G

    更新日期:2002-06-01 00:00:00

  • Scottish Antimicrobial Prescribing Group (SAPG): development and impact of the Scottish National Antimicrobial Stewardship Programme.

    abstract::In 2008, the Scottish Management of Antimicrobial Resistance Action Plan (ScotMARAP) was published by the Scottish Government. One of the key actions was initiation of the Scottish Antimicrobial Prescribing Group (SAPG), hosted within the Scottish Medicines Consortium, to take forward national implementation of the ke...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章,评审

    doi:10.1016/j.ijantimicag.2011.02.005

    authors: Nathwani D,Sneddon J,Malcolm W,Wiuff C,Patton A,Hurding S,Eastaway A,Seaton RA,Watson E,Gillies E,Davey P,Bennie M,Scottish Antimicrobial Prescribing Group.

    更新日期:2011-07-01 00:00:00

  • In vitro activity of KRM-1648, either singly or in combination with ofloxacin, against Mycobacterium ulcerans.

    abstract::The antimicrobial effect of a benzoxazinorifamycin, KRM-1648, either alone or in combination with ofloxacin, was evaluated in vitro against two type strains and six clinical isolates of Mycobacterium ulcerans. Growth of M. ulcerans was measured by plate counts and the BACTEC radiometric method. The minimal inhibitory ...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章

    doi:10.1016/s0924-8579(00)00306-x

    authors: Dhople AM

    更新日期:2001-01-01 00:00:00

  • Caspofungin: an advanced treatment approach for suspected or confirmed invasive aspergillosis.

    abstract::Invasive aspergillosis occurs in a wide range of immunocompromised patients and is typically associated with an extremely poor prognosis. Caspofungin represents an additional therapeutic alternative to standard antifungal therapies in patients with suspected or confirmed invasive aspergillosis, as evidenced by a growi...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章,评审

    doi:10.1016/j.ijantimicag.2006.03.019

    authors: Maertens J

    更新日期:2006-06-01 00:00:00

  • Targeting antimicrobial drug resistance with marine natural products.

    abstract::The rise and spread of antimicrobial resistance represents one of the most pressing health issues of today. Antimicrobial resistance in micro-organisms can arise due to a multiplicity of factors, including permeability changes in the cell membrane, increase of drug efflux pumps, enzymatic modification or inactivation ...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章,评审

    doi:10.1016/j.ijantimicag.2020.106005

    authors: Barbosa F,Pinto E,Kijjoa A,Pinto M,Sousa E

    更新日期:2020-07-01 00:00:00

  • Norfloxacin, the first of a new class of fluoroquinolone antimicrobials, revisited.

    abstract::Norfloxacin is the first in a series of new 4-quinolones that have been introduced into medical practice for the treatment of bacterial infections. This totally synthetic compound is a broad spectrum, bactericidal agent that is much more potent than the earlier analogs, i.e. nalixidic acid, pipemidic acid, cinoxacin, ...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章

    doi:10.1016/0924-8579(91)90019-a

    authors: Gadebusch HH,Shungu DL

    更新日期:1991-01-01 00:00:00

  • Antiparasitic activity of risedronate in a murine model of acute Chagas' disease.

    abstract::We report the results of a study on the activity of the farnesyl-pyrophosphate synthase inhibitor risedronate (Ris) in a murine model of acute Chagas' disease. This compound displays rapid, cytocidal activity in vitro against Trypanosoma cruzi, but its in vivo activity had not been investigated previously. A murine mo...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章

    doi:10.1016/j.ijantimicag.2003.07.019

    authors: Garzoni LR,Waghabi MC,Baptista MM,de Castro SL,Meirelles Mde N,Britto CC,Docampo R,Oldfield E,Urbina JA

    更新日期:2004-03-01 00:00:00

  • Acquired sulphonamide resistance genes in faecal Escherichia coli from healthy children in Bolivia and Peru.

    abstract::Antimicrobial resistance and sulphonamide resistance determinants were studied in 20 co-trimoxazole resistant Escherichia coli in faecal samples from healthy children in Bolivia and Peru. Methods used were disc diffusion susceptibility tests, PCR, sequence analysis and plasmid conjugation assays. All isolates but one ...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章

    doi:10.1016/j.ijantimicag.2004.12.004

    authors: Infante B,Grape M,Larsson M,Kristiansson C,Pallecchi L,Rossolini GM,Kronvall G

    更新日期:2005-04-01 00:00:00

  • Antimicrobial growth promoter use in livestock: a requirement to understand their modes of action to develop effective alternatives.

    abstract::Antimicrobial agents (AMAs) have been used in agriculture since the 1950s as growth-promoting agents [antimicrobial growth promoters (AGPs)]. They have provided benefits to the agricultural industry by increasing production efficiencies and maximising livestock health, yet the potential risks surrounding resistance to...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章,评审

    doi:10.1016/j.ijantimicag.2016.08.006

    authors: Brown K,Uwiera RRE,Kalmokoff ML,Brooks SPJ,Inglis GD

    更新日期:2017-01-01 00:00:00

  • Fluid shifts have no influence on ciprofloxacin pharmacokinetics in intensive care patients with intra-abdominal sepsis.

    abstract::This study aimed to investigate whether fluid shifts alter ciprofloxacin pharmacokinetics in critically ill patients over time. Patients > or = 18 years, with normal renal function, requiring intensive care treatment and parenteral antibiotics were enrolled. Group A (22 patients) included patients with documented intr...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章

    doi:10.1016/j.ijantimicag.2005.04.005

    authors: Gous A,Lipman J,Scribante J,Tshukutsoane S,Hon H,Pinder M,Mathivha R,Verhoef L,Stass H

    更新日期:2005-07-01 00:00:00

  • 'To bead or not to bead?' Treatment of osteomyelitis and prosthetic joint-associated infections with gentamicin bead chains.

    abstract::Gentamicin-containing polymethylmethacrylate (PMMA) beads are frequently used to prevent and treat orthopaedic infections. The beads are typically inserted to fill anatomical defects secondary to surgical debridement. Local gentamicin use results in low serum levels whilst achieving high concentrations at the site of ...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章,评审

    doi:10.1016/j.ijantimicag.2011.03.008

    authors: Barth RE,Vogely HC,Hoepelman AI,Peters EJ

    更新日期:2011-11-01 00:00:00

  • Meropenem: effects on human leukocyte functions and interleukin release.

    abstract::Modifications of the immune response have been reported for a number of antimicrobial agents following both in vivo and in vitro experiments. Present results were obtained from in vitro incubated human polymorphonuclear cells (PMN) and monocytes treated with meropenem, a novel carbapenem antibiotic. Only the highest c...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章

    doi:10.1016/0924-8579(94)00042-s

    authors: Matera G,Berlinghieri MC,Focà A

    更新日期:1995-04-01 00:00:00

  • Approaching zero: temporal effects of a restrictive antibiotic policy on hospital-acquired Clostridium difficile, extended-spectrum β-lactamase-producing coliforms and meticillin-resistant Staphylococcus aureus.

    abstract::A restrictive antibiotic policy banning routine use of ceftriaxone and ciprofloxacin was implemented in a 450-bed district general hospital following an educational campaign. Monthly consumption of nine antibiotics was monitored in defined daily doses (DDDs) per 1000 patient-occupied bed-days (1000 pt-bds) 9 months be...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章

    doi:10.1016/j.ijantimicag.2012.10.013

    authors: Dancer SJ,Kirkpatrick P,Corcoran DS,Christison F,Farmer D,Robertson C

    更新日期:2013-02-01 00:00:00