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Resistance to third-generation cephalosporins in Escherichia coli in the French community: The times they are a-changin'?

Abstract：

OBJECTIVES:Since the early 2000s, Escherichia coli resistance to third-generation cephalosporins (3GCs) has been increasing in all European countries, mainly due to the spread of extended spectrum β-lactamases (ESBLs). Here we present a retrospective study that combines resistance of E. coli to 3GCs and quinolones with data on antibiotic use in the community in a region of Northeastern France. METHODS:Since 2012, an observational surveillance of antimicrobial resistance and antibiotic use in the community was conducted: data on antimicrobial resistance in E. coli isolates were collected from 11 private laboratories, and consumption data were collected from the three main healthcare insurances. RESULTS:A significant decrease in the prevalence of resistance to 3GCs (from 5.6% to 4.2%; P < 0.001), nalidixic acid (from 16.7% to 14.8%; P = 0.004) and ciprofloxacin (from 10.9% to 8.1%; P < 0.001) was reported between 2015 and 2017. Although total antibiotic consumption did not vary significantly between 2012 and 2017, a decrease in the consumption of 3GCs (-32.%; P < 0.001) and quinolones (-25.5%; P < 0.001) was observed. CONCLUSION:Here we report a decrease in the prevalence of E. coli isolates resistant to 3GCs and quinolones in outpatients in the context of significant decreasing consumption of these two antibiotic classes.

journal_name

Int J Antimicrob Agents

journal_title

International journal of antimicrobial agents

authors

Jeanvoine A,Bouxom H,Leroy J,Gbaguidi-Haore H,Bertrand X,Slekovec C

doi

10.1016/j.ijantimicag.2020.105909

subject

Has Abstract

pub_date

2020-05-01 00:00:00

pages

105909

issue

5

eissn

0924-8579

issn

1872-7913

pii

S0924-8579(20)30048-0

journal_volume

55

pub_type

杂志文章

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