当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS期刊下所有文献 > Clonal outbreak caused by VIM-4-producing Proteus mirabilis in a Greek tertiary-care hospital.

Clonal outbreak caused by VIM-4-producing Proteus mirabilis in a Greek tertiary-care hospital.

Abstract：

:Carbapenem-resistant Enterobacterales have become a major public-health issue worldwide. Here we report an outbreak caused by a clonal multidrug-resistant Proteus mirabilis strain producing VIM-4 metallo-β-lactamase (MBL) and TEM-2 β-lactamase in a Greek tertiary-care hospital. From July 2015 to February 2016, 27 imipenem-resistant P. mirabilis isolates were recovered from 14 patients hospitalised in two intensive care units (ICUs) and the internal medicine department in AHEPA University Hospital, Thessaloniki. The isolates were either susceptible or resistant to meropenem and were resistant to all remaining β-lactams except aztreonam. Phenotypic and molecular analysis revealed that all of the isolates harboured a blaVIM-4 MBL gene. Resistome analysis of a representative isolate showed the presence of an IncQ1 plasmid harbouring the blaVIM-4 carbapenemase and blaTEM-2 β-lactamase genes among resistance genes coding for resistance to β-lactams, aminoglycosides, trimethoprim, sulfonamides and lincosamides. Genotyping by pulsed-field electrophoresis (PFGE) revealed that the isolates were epidemiologically related. After recovery of the index carbapenemase-producing P. mirabilis clinical isolate, infection control measures were intensified in the affected departments. Rectal sampling for carbapenem-resistant bacteria was initiated on a weekly basis among patients admitted to the general ICU. The outbreak was finally interrupted 6 months later in February 2016. This is the first documentation of the blaVIM-4 MBL gene in P. mirabilis as well as the first hospital outbreak caused by a MBL-producing P. mirabilis strain.

journal_name

Int J Antimicrob Agents

journal_title

International journal of antimicrobial agents

authors

Protonotariou E,Poulou A,Politi L,Meletis G,Chatzopoulou F,Malousi A,Metallidis S,Tsakris A,Skoura L

doi

10.1016/j.ijantimicag.2020.106060

subject

Has Abstract

pub_date

2020-08-01 00:00:00

pages

106060

issue

2

eissn

0924-8579

issn

1872-7913

pii

S0924-8579(20)30230-2

journal_volume

56

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS文献大全
  • Open-label, multicentre, emergency-use study of clinafloxacin (CI-960) in the treatment of patients with serious life-threatening infections.

    abstract：:In an open-label emergency-use study, 23 patients with bacterial infections caused by multiply drug resistant pathogens were treated with clinafloxacin. Efficacy and safety were evaluated by tabulating investigators' assessments at the end of treatment, treatment discontinuations and adverse event data. Most of the pa...

    journal_title：International journal of antimicrobial agents

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1016/s0924-8579(02)00006-7

    authors： Shah P,Trostmann U,Tack K

    更新日期：2002-03-01 00:00:00

  • Old antimicrobials and Gram-positive cocci through the example of infective endocarditis and bone and joint infections.

    abstract：:The management of some serious infections such as infective endocarditis (IE) and bone and joint infections (BJIs) caused by Gram-positive cocci (GPC) is complex and requires great responsiveness and effective antimicrobials with high bioavailability in heart valves or bone tissues. Treatment of these infections requi...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijantimicag.2017.03.004

    authors： Seng P,Amrane S,Million M,Stein A

    更新日期：2017-05-01 00:00:00

  • Safety and efficacy of lomefloxacin and cefaclor in the treatment of skin and skin structure infections.

    abstract：:The purpose of this study was to compare the safety and efficacy of lomefloxacin with that of cefaclor in the treatment of adult secondary bacterial skin and skin structure infections. The study was conducted as a randomized, single-blind comparison. Eighty patients enrolled in the study, of which 74 were evaluable: 3...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/0924-8579(92)90028-p

    authors： Amaya-Tapia G,Andrade-Villanueva J,Flores-Gaxiola A,Aguirre-Avalos G,Morfin-Otero R,Esparza-Ahumada S,Rodriguez-Noriega E

    更新日期：1992-12-01 00:00:00

  • What is the relevance of fosfomycin pharmacokinetics in the treatment of serious infections in critically ill patients? A systematic review.

    abstract：:As treatment options for critically ill patients with multidrug-resistant bacteria diminish, older antibiotics such as fosfomycin are being investigated for use as last-resort drugs. Fosfomycin is a broad-spectrum antibiotic with activity both against Gram-positive and Gram-negative bacteria. The aim of this review wa...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijantimicag.2013.05.018

    authors： Parker S,Lipman J,Koulenti D,Dimopoulos G,Roberts JA

    更新日期：2013-10-01 00:00:00

  • Oxazolidinone susceptibility patterns for 2005: International Report from the Zyvox Annual Appraisal of Potency and Spectrum Study.

    abstract：:The international (non-USA) ZAAPS Program has accumulated 4 years of linezolid resistance surveillance results tracking infections caused by organisms with evolving resistance profiles. The major organism groups monitored were: Staphylococcus aureus and coagulase-negative staphylococci (including methicillin [oxacilli...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2006.09.025

    authors： Ross JE,Fritsche TR,Sader HS,Jones RN

    更新日期：2007-03-01 00:00:00

  • Detection of amp C in Enterobacter cloacae in China.

    abstract：:PCR amplification of 55 strains of Enterobacter cloacae indicated 51 of them had amp C structural gene verified by DNA sequence and Southern blotting. All PCR products were cleaved into 666- and 328-bp fragments by Kpn1 restriction enzyme. Imipenem was the most potent inducer for mRNA expression of amp C gene and beta...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/s0924-8579(01)00414-9

    authors： Zhang YL,Li JT,Zhao MW

    更新日期：2001-10-01 00:00:00

  • Recent advances and challenges in the treatment of invasive fungal infections.

    abstract：:The frequency of invasive fungal infections (IFIs) has increased over the last decade with the rise in at-risk populations of patients. The morbidity and mortality of IFIs are high and management of these conditions is a great challenge. With the widespread adoption of antifungal prophylaxis, the epidemiology of invas...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijantimicag.2007.07.019

    authors： Shao PL,Huang LM,Hsueh PR

    更新日期：2007-12-01 00:00:00

  • Legal framework of antimicrobial stewardship in hospitals (LEASH): a European Society of Clinical Microbiology and Infectious Diseases (ESCMID) cross-sectional international survey.

    abstract：:Antimicrobial stewardship (AMS) is the cornerstone activity in the combat against antimicrobial resistance. In order to ensure sustainable deployment and development of AMS, a strategic and regulatory framework needs to be provided by national healthcare authorities. Experts from 32 European countries, Israel and Turk...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2018.07.019

    authors： Beović B,Pulcini C,Dumartin C,Béraud G,Nerat B,Maurel C,Doušak M,Čižman M,LEASH Study Group on behalf of ESCMID Study Group for Antimicrobial StewardshiP (ESGAP).

    更新日期：2018-11-01 00:00:00

  • Emergence of extended-spectrum β-lactam resistance among Escherichia coli at a US academic children's hospital is clonal at the sequence type level for CTX-M-15, but not for CMY-2.

    abstract：:Resistance to extended-spectrum β-lactams is increasing worldwide among Escherichia coli and has been linked to a small number of emergent clones (e.g. ST38, ST131 and ST405) recovered from extraintestinal infections in community and hospital settings. There are, however, limited data about the relative contributions ...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2013.01.006

    authors： Weissman SJ,Adler A,Qin X,Zerr DM

    更新日期：2013-05-01 00:00:00

  • Clinical efficacy, cost analysis and patient acceptability of outpatient parenteral antibiotic therapy (OPAT): a decade of Sheffield (UK) OPAT service.

    abstract：:Outpatient parenteral antimicrobial therapy (OPAT) has evolved relatively slowly in the UK. This study describes the OPAT service based in a large UK teaching hospital in Sheffield, and examines the clinical efficacy, patient acceptability and costs saved over a 10-year period. Data on 3812 episodes of OPAT administer...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2017.03.016

    authors： Durojaiye OC,Bell H,Andrews D,Ntziora F,Cartwright K

    更新日期：2018-01-01 00:00:00

  • The role of the hospital pharmacist in cost control and antibiotic policy.

    abstract：:The pharmacist provides a vital role in the management of antibiotic policy. Consumers and payers demand quality care at a significantly reduced price. It is imperative that health care adapt to the times. Physicians must be involved in all phases of programmes that are viewed as cost saving. These programmes should i...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/s0924-8579(00)00250-8

    authors： Milkovich G

    更新日期：2000-11-01 00:00:00

  • Fosfomycin trometamol and N-acetyl-L-cysteine as combined oral therapy of difficult-to-treat chronic bacterial prostatitis: Results of a pilot study.

    abstract：:This paper presents the results of a pilot study of difficult-to-treat patients (exhibiting several previous treatment failures or detection of extended-spectrum beta-lactamase [ESBL] strains) with chronic bacterial prostatitis (CBP) who underwent treatment with fosfomycin trometamol (FT) and N-acetyl-L-cysteine (NAC)...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2020.105935

    authors： Cai T,Tamanini I,Mattevi D,Verze P,Palmieri A,Malossini G,Mirone V,Novelli A,Tascini C,Johansen TEB

    更新日期：2020-07-01 00:00:00

  • Levofloxacin versus ceftriaxone plus clarithromycin in the treatment of adults with community-acquired pneumonia requiring hospitalization.

    abstract：:Consecutive adult patients admitted to the hospital with community-acquired pneumonia from January 2000 to September 2003 were included in this prospective observational cohort study. A total of 459 patients, 259 treated with levofloxacin in single drug therapy at a dose of 500 mg once a day and 209 with the combinati...

    journal_title：International journal of antimicrobial agents

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.ijantimicag.2004.07.013

    authors： Querol-Ribelles JM,Tenías JM,Querol-Borrás JM,Labrador T,Nieto A,González-Granda D,Martínez I

    更新日期：2005-01-01 00:00:00

  • Clonal expansion accounts for an excess of antimicrobial resistance in Staphylococcus aureus colonising HIV-positive individuals in Lagos, Nigeria.

    abstract：:Nasal colonisation with Staphylococcus aureus is a risk factor for invasive infection in human immunodeficiency virus (HIV)-positive individuals. This study aimed to characterise colonising S. aureus from regions with a high HIV prevalence. Single nasal swabs were taken from a total of 374 HIV-positive and 370 healthy...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2012.05.016

    authors： Olalekan AO,Schaumburg F,Nurjadi D,Dike AE,Ojurongbe O,Kolawole DO,Kun JF,Zanger P

    更新日期：2012-09-01 00:00:00

  • Antimicrobial drug resistance mechanisms among Mollicutes.

    abstract：:Representatives of the Mollicutes class are the smallest, wall-less bacteria capable of independent reproduction. They are widespread in nature, most are commensals, and some are pathogens of humans, animals and plants. They are also the main contaminants of cell cultures and vaccine preparations. Despite limited bios...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijantimicag.2020.106253

    authors： Chernova OA,Chernov VM,Mouzykantov AA,Baranova NB,Edelstein IA,Aminov RI

    更新日期：2020-11-29 00:00:00

  • SILA 421, an inhibitor of efflux pumps of cancer cells, enhances the killing of intracellular extensively drug-resistant tuberculosis (XDR-TB).

    abstract：:Multidrug-resistant and extensively drug-resistant tuberculosis (MDR/XDR-TB) are problematic to manage, especially in patients with acquired immune deficiency syndrome (AIDS). There is therefore a dire need for effective anti-MDR/XDR-TB agents. We have previously shown that agents that inhibit the efflux pumps of MDR ...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2008.10.028

    authors： Martins M,Viveiros M,Ramos J,Couto I,Molnar J,Boeree M,Amaral L

    更新日期：2009-05-01 00:00:00

  • Ofloxacin and fleroxacin enhance superoxide production in human polymorphonuclear leukocytes by increasing phosphorylation in the signal transduction pathway.

    abstract：:Many antimicrobial agents including new quinolones (NQs) influence the cellular defense mechanisms such as polymorphonuclear leukocytes (PMNs), macrophages and lymphocytes. We examined the effects of NQs on superoxide (SO) production of PMNs following stimulation of phorbol myristate acetate (PMA). Ofloxacin (OFLX) an...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/0924-8579(95)00024-0

    authors： Matsumoto T,Nagafuji T,Takahashi K,Kubo S,Sakumoto M,Mizunoe Y,Kumazawa J

    更新日期：1995-12-01 00:00:00

  • Repurposing azithromycin and rifampicin against Gram-negative pathogens by combination with peptide potentiators.

    abstract：:Gram-negative bacterial pathogens are intrinsically resistant to several antibiotics that are not able to penetrate the cell envelope barrier. The aim of this study was to identify peptides that at low concentrations induce susceptibility to these antibiotics in multidrug-resistant (MDR) Gram-negative bacterial strain...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2018.10.025

    authors： Baker KR,Jana B,Hansen AM,Vissing KJ,Nielsen HM,Franzyk H,Guardabassi L

    更新日期：2019-06-01 00:00:00

  • Outpatient parenteral antibiotic therapy (OPAT) in different countries: a comparison.

    abstract：:In order to assess how outpatient parenteral antibiotic therapy (OPAT) is managed in different countries, we analyzed the data collected in the USA, UK and Italy by the International OPAT Registry using an ad hoc Access/Excel Microsoft program. The analysis of data concerned 9826 patients in the USA, 981 in the UK and...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2004.06.004

    authors： Esposito S,Noviello S,Leone S,Tice A,Seibold G,Nathwani D,Scaglione F,International OPAT Registry.

    更新日期：2004-11-01 00:00:00

  • In vivo activity of amoxicillin/clavulanic acid and erythromycin in experimental otitis media caused by Streptococcus pneumoniae plus Haemophilus influenzae.

    abstract：:A gerbil model of acute otitis media induced by Streptococcus pneumoniae plus Haemophilus influenzae was used to assess the efficacy of amoxicillin/clavulanic acid (A/C) (1.5/0.3, 2.5/0.5 and 10/2 mg/kg) and erythromycin (2.5, 10, 20 and 50 mg/kg) with or without acetaminophen. The amoxicillin/clavulanic acid MIC was ...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2003.05.016

    authors： Parra A,Ponte C,Cenjor C,García-Olmos M,Giménez MJ,Aguilar L,Soriano F

    更新日期：2004-01-01 00:00:00

  • Sequential emergence of colistin and rifampicin resistance in an OXA-72- producing outbreak strain of Acinetobacter baumannii.

    abstract：OBJECTIVES:This study reported a hospital outbreak due to an extensively drug-resistant (XDR) OXA-72-producing strain of Acinetobacter baumannii (A. baumannii). METHODS AND RESULTS:The isolates were found to be genotypically indistinguishable by whole-genome multiple locus sequence typing, and to belong to the interna...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2019.01.012

    authors： Potron A,Bour M,Triponney P,Muller J,Koebel C,A Bonnin R,Plésiat P

    更新日期：2019-05-01 00:00:00

  • Population pharmacokinetics of tobramycin in hospitalized patients receiving once-daily dosing regimen.

    abstract：:The population pharmacokinetics of tobramycin was investigated in a group of 327 adult hospitalized patients receiving once-daily administration of tobramycin at a dose of 7 mg kg(-1). The patients had an average age of 57+/-18 y and an average weight of 65+/-14 kg; 153 of the patients were female. Data, comprised of ...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/s0924-8579(00)00172-2

    authors： Xuan D,Lu JF,Nicolau DP,Nightingale CH

    更新日期：2000-08-01 00:00:00

  • Appropriate use of antimicrobials: the peculiarity of septic patients.

    abstract：:The treatment of bloodstream infections remains a significant challenge, with persisting high mortality and morbidity. To optimize antimicrobial therapy, the clinician must possess knowledge of the pharmacokinetic and pharmacodynamic properties of commonly used antimicrobials, and how these parameters may be affected ...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章,评审

    doi：10.1016/S0924-8579(09)70568-0

    authors： Scaglione F

    更新日期：2009-01-01 00:00:00

  • Bactericidal oncocin derivatives with superior serum stabilities.

    abstract：:The proline-rich antimicrobial peptide oncocin is remarkably active in vitro against a number of important Gram-negative bacteria of concern to humans owing to their increasing resistance to antibiotics, i.e. Enterobacteriaceae (Escherichia coli, Klebsiella pneumoniae and Enterobacter cloacae) and non-fermenting speci...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2010.10.028

    authors： Knappe D,Kabankov N,Hoffmann R

    更新日期：2011-02-01 00:00:00

  • Upregulation of icaA, atlE and aap genes by linezolid but not vancomycin in Staphylococcus epidermidis RP62A biofilms.

    abstract：:Biofilms are complex bacterial structures protected by a self-produced polymer matrix that enables survival in hostile environments. Biofilms are more resistant to antibiotics than their planktonic counterparts and are therefore more difficult to eradicate. The aim of this study was to investigate the influence of van...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2013.12.003

    authors： Reiter KC,Sant'Anna FH,d'Azevedo PA

    更新日期：2014-03-01 00:00:00

  • Antistaphylococcal penicillins versus cephalosporins for definitive treatment of meticillin-susceptible Staphylococcus aureus bacteraemia: a systematic review and meta-analysis.

    abstract：:The objective of this study was to assess the comparative effectiveness and safety of antistaphylococcal penicillins (ASPs) and cephalosporins for the definitive treatment of patients with meticillin-susceptible Staphylococcus aureus (MSSA) bacteraemia. PubMed and Scopus electronic databases were searched up to Decemb...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.ijantimicag.2014.09.002

    authors： Vardakas KZ,Apiranthiti KN,Falagas ME

    更新日期：2014-12-01 00:00:00

  • Outpatient treatment in the University Hospital Utrecht: organization and infrastructure.

    abstract：:Interest in home care for patients with serious infections is increasing. Home care technology needs reliable equipment that can be operated by the patient without constant supervision. To achieve long-term home treatment requires the establishment of protocols, education programmes, patient support and easy hospital ...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/0924-8579(94)00059-4

    authors： Witteveen PO

    更新日期：1995-01-01 00:00:00

  • A cohort study of treatment-experienced HIV-1-infected patients treated with raltegravir: factors associated with virological response and mutations selected at failure.

    abstract：:This study aimed to identify factors associated with virological response (VR) to raltegravir (RAL)-containing regimens in 468 treatment-experienced but integrase inhibitor-naive HIV-1 patients receiving a RAL-containing regimen. VR was defined at Month 6 (M6) as HIV-1 RNA viral load (VL) <50 copies/mL. The impacts on...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2013.02.016

    authors： Marcelin AG,Delaugerre C,Beaudoux C,Descamps D,Morand-Joubert L,Amiel C,Schneider V,Ferre V,Izopet J,Si-Mohamed A,Maillard A,Henquell C,Desbois D,Lazrek M,Signori-Schmuck A,Rogez S,Yerly S,Trabaud MA,Plantier JC,Fou

    更新日期：2013-07-01 00:00:00

  • The intrinsic resistome of Klebsiella pneumoniae.

    abstract：:Molecular epidemiology studies aiming at understanding the acquisition of antimicrobial resistance by clinical isolates of Klebsiella pneumoniae are regularly published; however, information on the genes that contribute to its characteristic phenotype of resistance to antibiotics (intrinsic resistome) is scarce. To fi...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2018.09.012

    authors： Bernardini A,Cuesta T,Tomás A,Bengoechea JA,Martínez JL,Sánchez MB

    更新日期：2019-01-01 00:00:00

  • Prevalence of streptogramin resistance in enterococci from animals: identification of vatD from animal sources in the USA.

    abstract：:There is considerable debate over the contribution of virginiamycin use in animals to quinupristin/dalfopristin (Q/D) resistance in humans. In this study, the prevalence and mechanisms of streptogramin resistance in enterococci from animals and the environment were investigated. From 2000-2004, enterococci from sample...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2007.03.010

    authors： Jackson CR,Fedorka-Cray PJ,Barrett JB,Hiott LM,Woodley TA

    更新日期：2007-07-01 00:00:00