Abstract:
:Representatives of the Mollicutes class are the smallest, wall-less bacteria capable of independent reproduction. They are widespread in nature, most are commensals, and some are pathogens of humans, animals and plants. They are also the main contaminants of cell cultures and vaccine preparations. Despite limited biosynthetic capabilities, they are highly adaptable and capable of surviving under various stress and extreme conditions, including antimicrobial selective pressure. This review describes current understanding of antibiotic resistance (ABR) mechanisms in Mollicutes. Protective mechanisms in these bacteria include point mutations, which may include non-target genes, and unique gene exchange mechanisms, contributing to transfer of ABR genes. Better understanding of the mechanisms of emergence and dissemination of ABR in Mollicutes is crucial to control these hypermutable bacteria and prevent the occurrence of highly ABR strains.
journal_name
Int J Antimicrob Agentsjournal_title
International journal of antimicrobial agentsauthors
Chernova OA,Chernov VM,Mouzykantov AA,Baranova NB,Edelstein IA,Aminov RIdoi
10.1016/j.ijantimicag.2020.106253subject
Has Abstractpub_date
2020-11-29 00:00:00pages
106253eissn
0924-8579issn
1872-7913pii
S0924-8579(20)30473-8pub_type
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