Abstract：
:Viral respiratory infections (VRI) can act as triggers for acute asthma exacerbations and contribute significantly to asthma-related healthcare costs. Knowing the patterns of viruses amongst asthmatics can be useful in treating and preventing these exacerbations and help decrease the burden they impose on patients and healthcare systems. We aimed to quantify the viral prevalence in asthmatics presenting with exacerbations and identify influencing factors. A meta-analysis with a systematic search was conducted. Random-effect analysis was performed to quantify prevalence of viruses. A meta-regression was conducted to explain sources of heterogeneity and identify confounding factors. A VRI was detected in 52%-65% of the cases, and the detection rate was higher in children compared to adults. Rhinovirus was most often detected [51-71%], followed by respiratory syncytial virus [8-18%], influenza virus [7-15%], human parainfluenza virus [4-11%] and metapneumovirus virus [3-9%]. Meta-regression showed that the variables age and hemisphere contributed to the heterogeneity observed and were significantly associated with the detection of viruses in asthmatics. The climate variable reached significance for RSV and indicated a higher detection rate of viruses in asthmatics living in temperate compared to tropical regions. Besides age, geographic location and related variables significantly influence to what extent respiratory viruses are detected amongst asthmatics with exacerbations. Our results indicate that health authorities should adopt region- and population specific prevention and treatment strategies. Prevention and detection of viral respiratory infections in asthmatics could reduce asthma related disease burden and decrease antibiotic misuse.
journal_name
Respir Medjournal_title
Respiratory medicineauthors
Feddema JJ,Claassen Edoi
10.1016/j.rmed.2020.106020subject
Has Abstractpub_date
2020-11-01 00:00:00pages
106020eissn
0954-6111issn
1532-3064pii
S0954-6111(20)30160-8journal_volume
173pub_type
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pub_type： 临床试验,杂志文章,随机对照试验
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pub_type： 杂志文章
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pub_type： 杂志文章,多中心研究,随机对照试验
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更新日期：2010-10-01 00:00:00
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pub_type： 杂志文章,多中心研究
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更新日期：1997-09-01 00:00:00
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pub_type： 临床试验,杂志文章,随机对照试验
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pub_type： 临床试验,杂志文章
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更新日期：2014-08-01 00:00:00
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journal_title：Respiratory medicine
pub_type： 杂志文章,多中心研究
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更新日期：2006-08-01 00:00:00
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更新日期：2006-09-01 00:00:00
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pub_type： 杂志文章,随机对照试验
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更新日期：2015-02-01 00:00:00
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