Abstract:
BACKGROUND:Pulmonary rehabilitation is very effective in improving exercise capacity, dyspnea and quality of life in the small group of patients with moderate to severe COPD. Given that little is known about exercise training in the large group of patients with mild to moderate COPD, we assessed the effectiveness of an exercise training programme in primary care. METHODS:In this RCT, 90 patients with mild to moderate COPD (FEV1 74.2 ± 13.5%pred) participated in a 4-month exercise training programme or control treatment. Primary outcome was improvement in functional exercise capacity, assessed by the 6-min walking distance (6MWD). Secondary outcomes were breathlessness (MRC dyspnoea score), disease-specific quality of life (CCQ, CRQ), muscle strength and objective daily physical activity. There was a follow-up measurement at 6 months. RESULTS:At 4 months, we found a statistically and clinically relevant between-group difference in 6MWD of +26.6 m (95% CI: 4,3-49.0, p = 0.020). Shoulder strength significantly improved with a between-group difference of 23.9 Nm (p = 0.0350). At 6 months, there was a significant improvement in handgrip force and CRQ sub score mastery of respectively 1.9 KgF (p = 0.028) and 0.5 (p = 0.035). There were no significant between-group differences in breathlessness, quality of life, knee strength and daily physical activity. CONCLUSION:The results indicate that exercise training in primary care is particularly effective in improving physical fitness (exercise capacity and strength), but not in breathlessness, health-related quality of life and daily physical activity. A broader assessment for COPD patients in primary care might be a necessary condition to offer the most effective intervention.
journal_name
Respir Medjournal_title
Respiratory medicineauthors
Fastenau A,van Schayck OC,Winkens B,Aretz K,Gosselink R,Muris JWdoi
10.1016/j.rmed.2020.105943subject
Has Abstractpub_date
2020-01-01 00:00:00pages
105943eissn
0954-6111issn
1532-3064pii
S0954-6111(20)30083-4journal_volume
165pub_type
杂志文章,随机对照试验abstract:INTRODUCTION:Subjective fatigue has been recognised as an important, multi-component symptom in COPD. Pulmonary Rehabilitation (PR) improves fatigue component of the Chronic Respiratory Questionnaire, a quality of life (QoL) measure. However, it is not clear if all fatigue dimensions are affected equally. This study ai...
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abstract:INTRODUCTION:The duration of bronchodilator action of the long-acting beta agonist salmeterol when administered in the evening has not been investigated. In this study we have investigated whether a single evening dose of salmeterol, administered from the combination salmeterol/fluticasone (SFC) Accuhaler significantly...
journal_title:Respiratory medicine
pub_type: 临床试验,杂志文章,随机对照试验
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abstract:OBJECTIVES:To identify factors associated with late recovery (≥ 8 days from exacerbation start) in patients with acute exacerbations of chronic bronchitis/COPD (AECB/AECOPD). METHODS:An international, observational, non-interventional study in outpatients with AECB/AECOPD who received treatment for their exacerbation ...
journal_title:Respiratory medicine
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1016/j.rmed.2012.06.002
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abstract:BACKGROUND:Interleukin-32(IL-32)γ is a pro-inflammatory cytokine involved in the development and severity of chronic inflammatory diseases, but its role in asthma is unclear. OBJECTIVE:This study was conducted to evaluate the relationship of IL-32γ levels in sputum with the severity of asthma. METHODS:IL-32γ levels i...
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更新日期:2008-12-01 00:00:00
abstract::The effect of patient education on morbidity in asthmatics and COPD patients has not previously been investigated in a single study. We randomized 78 asthmatics and 62 COPD patients after ordinary outpatient management. Intervention consisted of educational group sessions and individual sessions administered by a trai...
journal_title:Respiratory medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1053/rmed.1999.0749
更新日期:2000-03-01 00:00:00
abstract::Diffuse panbronchiolitis (DPB) is a distinctive form of small airway disease, which is characterized by chronic inflammation with lymphocyte infiltration around bronchioles. The aim of this study was to evaluate the importance of factors related to apoptosis in peribronchiolar lymphocytes of DPB. We employed immunohis...
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pub_type: 杂志文章
doi:10.1016/j.rmed.2006.02.011
更新日期:2006-11-01 00:00:00
abstract::Chronic obstructive pulmonary disease (COPD) is a condition characterized by progressive airflow limitation, with symptoms of dyspnoea, cough, and sputum production. Aside from information on prevalence, mortality and hospital resource utilization arising from COPD in Canada, there is a lack of data on the impact of t...
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1016/j.rmed.2016.02.004
更新日期:2016-04-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1993-08-01 00:00:00
abstract::Lung cancer remains the most common cause of cancer-related mortality in Scotland, accounting for 28.9% of all cancer deaths in 2007. (1) Current guidelines recommend assessment of patient fitness and operability by a multi-disciplinary team when selecting management options. (2-6) Two of the most important prognostic...
journal_title:Respiratory medicine
pub_type: 杂志文章,评审
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更新日期:2010-12-01 00:00:00
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journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1016/j.rmed.2016.12.014
更新日期:2017-02-01 00:00:00
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journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1016/j.rmed.2011.07.021
更新日期:2012-02-01 00:00:00
abstract::The value of continuous positive airway pressure (CPAP) ventilation via a tight fitting face mask was assessed in eight HIV-1 antibody-positive patients with Pneumocystis carinii pneumonia who were in hypoxaemic respiratory failure. All patients were conscious, able to protect their airway and not hypercapnic. Treatme...
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pub_type: 杂志文章
doi:10.1016/s0954-6111(06)80291-x
更新日期:1991-03-01 00:00:00
abstract:OBJECTIVES:To determine the efficacy of oral theophylline compared with placebo in people with stable chronic obstructive pulmonary disease (COPD). METHODS:Systematic review of randomized-controlled trials comparing oral theophylline with placebo for a minimum of 7 days in people with stable COPD. RESULTS:Twenty rand...
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pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.rmed.2004.10.009
更新日期:2005-02-01 00:00:00
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journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1016/j.rmed.2014.01.014
更新日期:2014-04-01 00:00:00
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pub_type: 临床试验,杂志文章,多中心研究
doi:10.1016/j.rmed.2012.09.008
更新日期:2013-01-01 00:00:00
abstract::During an epidemiological investigation of asthma in an occupational setting, 1126 subjects completed a modified Medical Research Council respiratory questionnaire, then underwent airway responsiveness measurements as PD20FEV1 to methacholine. Previous experience of bronchoconstriction was assessed in the 481 subjects...
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pub_type: 杂志文章
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更新日期:1995-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:2007-10-01 00:00:00
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pub_type: 杂志文章
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更新日期:2011-06-01 00:00:00
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更新日期:2010-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:2020-11-26 00:00:00
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journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1016/j.rmed.2006.06.004
更新日期:2007-03-01 00:00:00
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journal_title:Respiratory medicine
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.rmed.2006.12.002
更新日期:2007-07-01 00:00:00
abstract::Viozan (sibenadet HCl, AR-C68397AA) is a novel dual D2 dopamine receptor, beta2-adrenoceptor agonist that has been investigated for efficacy in alleviating the symptoms of chronic obstructive pulmonary disease (COPD). The slowly progressive nature of this disease means that patients will require ongoing therapeutic ma...
journal_title:Respiratory medicine
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:
更新日期:2003-01-01 00:00:00
abstract::Samples of lung tissue, taken at time of lung transplant, from 13 Dutch Caucasian patients with idiopathic pulmonary arterial hypertension (iPAH) and 14 patients with non-idiopathic PAH were studied for the presence of human herpes virus-8 (HHV-8). By immunohistochemical staining, in none of patients expression of HHV...
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pub_type: 杂志文章
doi:10.1016/j.rmed.2006.08.015
更新日期:2007-04-01 00:00:00
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journal_title:Respiratory medicine
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1999-07-01 00:00:00
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pub_type: 杂志文章
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更新日期:2020-01-01 00:00:00
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journal_title:Respiratory medicine
pub_type: 杂志文章
doi:10.1016/j.rmed.2007.02.002
更新日期:2007-07-01 00:00:00