Abstract：
OBJECTIVE:To describe the differences in clinical characteristics and outcome between adult- and childhood-onset biopsy-proven IgA vasculitis (IgAV) in North America. PATIENTS AND METHODS:Patients with IgAV diagnosed from January 1, 1997, through December 31, 2016, were retrospectively identified. Data were abstracted from direct medical record review. Kaplan-Meier methods were used to estimate survival rates. RESULTS:A total of 243 patients with IgAV were included (227 [93.4%] white, 141 [58.0%] male); 174 patients were adults (≥21 years), and 69 were younger than 21 years. Compared with patients younger than 21 years, adults at baseline more frequently had ulcerative skin lesions (19 [10.9%] vs 1 [1.4%]; P=.02) and nephrotic-range proteinuria (21 of 96 [21.9%] vs 1 of 38 [2.6%]; P=.007) but less commonly had abdominal pain (59 [33.9%] vs 42 [60.9%]; P<.001), ischemic gastrointestinal tract involvement (18 [10.3%] vs 14 [20.3%]; P=.04), and arthralgias (66 [37.9%] vs 42 [60.8%]; P<.001). During 389 person-years of follow-up, 29 deaths were observed. Five-year survival rates for patients aged younger than 21, 21 to 50, and 51 years or older were 100%, 94%, and 40%, respectively. In comparison to data from the United States life tables for whites, patients 51 years or older at diagnosis had a greater than 7-fold increased risk of mortality (standardized mortality, 7.60 [95% CI, 5.01-11.06]; P<.001). CONCLUSION:IgA vasculitis in adults is associated with more severe skin/kidney involvement and poorer renal outcome. Among adults with IgAV, patients aged 51 years or older at diagnosis have significantly higher mortality (P<.001).
journal_name
Mayo Clin Procjournal_title
Mayo Clinic proceedingsauthors
Villatoro-Villar M,Crowson CS,Warrington KJ,Makol A,Ytterberg SR,Koster MJdoi
10.1016/j.mayocp.2019.04.034subject
Has Abstractpub_date
2019-09-01 00:00:00pages
1769-1780issue
9eissn
0025-6196issn
1942-5546pii
S0025-6196(19)30424-0journal_volume
94pub_type
杂志文章abstract：:We describe three critically ill patients who displayed indirect evidence of transient corticotropin deficiency. All these patients were elderly, were poorly nourished, and had unexplained hypotension intraoperatively or immediately postoperatively. During the hypotensive episodes, they had inappropriately low plasma ...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
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abstract：:Hip arthroplasty using the Thompson femoral prosthesis with methyl methacrylate fixation was performed on 109 hips in 106 patients. During an average follow-up period of 36 months, 26 patients died. Fifty-one procedures were performed for fresh fractures of the femoral neck and results were satisfactory in this group ...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：
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journal_title：Mayo Clinic proceedings
pub_type： 临床试验,杂志文章
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journal_title：Mayo Clinic proceedings
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doi：10.1016/s0025-6196(12)65734-6
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abstract：OBJECTIVE:To determine the effect of epinephrine on the QT interval in patients with genotyped long QT syndrome (LQTS). PATIENTS AND METHODS:Between May 1999 and April 2001, 37 patients (24 females) with genotyped LQTS (19 LQT1, 15 LQT2, 3 LQT3, mean age, 27 years; range, 10-53 years) from 21 different kindreds and 27...
journal_title：Mayo Clinic proceedings
pub_type： 临床试验,杂志文章
doi：10.4065/77.5.413
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abstract：:Total respiratory resistance (Rrs) was studied by the forced oscillation technique at a frequency of 3 cps in 76 normal subjects (36 men, 40 women), ages 21 to 64 years. Slopes (equivalent to specific conductance) assuming a linear relationship with zero intercept between 1/Rrs and thoracic gas volume (TGV) were compu...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：
更新日期：1976-09-01 00:00:00
abstract：OBJECTIVE:To assess the efficacy and safety of hyperbaric oxygenation (HBO) therapy as adjunctive treatment for diabetic foot ulcers with a systematic review and meta-analysis of the literature. METHODS:MEDLINE, EMBASE, and the Cochrane Library were searched to find relevant articles published up to April 20, 2012, wi...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章,评审
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abstract：OBJECTIVE:To estimate cancer risks for patients with myotonic dystrophy, given that increased risks for neoplasms in association with myotonic dystrophy type 1 and type 2 have been suggested in several studies but the risks of cancers have not been quantified. PATIENTS AND METHODS:A cohort of 307 patients with myotoni...
journal_title：Mayo Clinic proceedings
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journal_title：Mayo Clinic proceedings
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doi：10.1016/s0025-6196(12)61255-5
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journal_title：Mayo Clinic proceedings
pub_type： 杂志文章,评审
doi：10.4065/71.4.369
更新日期：1996-04-01 00:00:00
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journal_title：Mayo Clinic proceedings
pub_type： 杂志文章,评审
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journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
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更新日期：2016-08-01 00:00:00
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journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：10.1016/j.mayocp.2020.09.019
更新日期：2020-11-01 00:00:00
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journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：10.1016/s0025-6196(12)60217-1
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journal_title：Mayo Clinic proceedings
pub_type： 杂志文章,评审
doi：10.1016/s0025-6196(12)61175-6
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journal_title：Mayo Clinic proceedings
pub_type： 杂志文章,评审
doi：10.1016/S0025-6196(11)62969-8
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pub_type： 杂志文章
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journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：
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journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：10.1016/s0025-6196(12)65623-7
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journal_title：Mayo Clinic proceedings
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doi：
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doi：10.4065/77.6.587
更新日期：2002-06-01 00:00:00
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doi：10.1016/j.mayocp.2016.12.023
更新日期：2017-04-01 00:00:00
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journal_title：Mayo Clinic proceedings
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doi：10.1016/j.mayocp.2019.04.035
更新日期：2019-10-01 00:00:00
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journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：10.1016/s0025-6196(12)61933-8
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journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：10.4065/77.10.1060
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journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：10.1016/j.mayocp.2013.07.012
更新日期：2013-10-01 00:00:00
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journal_title：Mayo Clinic proceedings
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doi：10.1016/S0025-6196(11)63722-1
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journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
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