Abstract:
OBJECTIVE:To characterize the clinicopathologic findings, comorbidities, and treatment outcomes of women with lichen planopilaris (LPP). METHOD:In this retrospective review of women with LPP at Mayo Clinic from 1992 to 2016, we searched for scarring alopecia in all female patients aged 1 to 100 years from January 1, 1992, through December 31, 2016. Men were excluded from this study to more accurately determine the association of hormonal factors in LPP pathogenesis. Two hundred thirty-two patients were included as they met diagnostic criteria for LPP based on clinicopathologic correlation, with 217 having confirmatory biopsies. RESULTS:We identified 232 women with LPP (mean age, 59.8 years). Of those, 92.7% (215) presented with hair loss; 23.7% (55) had preceding inflammation; 30.6% (71) had thyroid disease, including hypothyroidism (23.2%; 54); and 9.4% (22) had vitamin D deficiency. Incidence of depression and anxiety was 45.7% (106) and 41.8% (97), respectively. History of total abdominal hysterectomy/bilateral salpingo-oophorectomies and hormone replacement therapy was found in 16.8% (39) and 16.4% (38), respectively. Lichen planus at other body sites occurred in 16.4% (38) of patients; and 53.2% (123) had slowing of disease progression or disease stabilization, often requiring combination therapies. In those who achieved slowing or stabilization of disease, mean time to recurrence was 1.8 year. The mean time to remission was 1.1 year. CONCLUSION:The typical LPP patient is a 60-year-old female with vertex scarring alopecia who presents with burning, erythema, inflammation, and scale. Almost half of patients will have comorbid autoimmunity. As previously reported, LPP is associated with thyroid disease. We also found higher rates of depression, anxiety, nutritional deficiencies, and skin cancer than reported in the general population.
journal_name
Mayo Clin Procjournal_title
Mayo Clinic proceedingsauthors
Larkin SC,Cantwell HM,Imhof RL,Torgerson RR,Tolkachjov SNdoi
10.1016/j.mayocp.2020.02.028subject
Has Abstractpub_date
2020-08-01 00:00:00pages
1684-1695issue
8eissn
0025-6196issn
1942-5546pii
S0025-6196(20)30212-3journal_volume
95pub_type
杂志文章abstract:OBJECTIVE:To define mortality associated with isolated tricuspid regurgitation (TR) and identify risk factors associated with decreased survival. PATIENTS AND METHODS:We conducted a retrospective cohort study of residents of southeastern Minnesota with moderate-severe or more severe isolated TR diagnosed between Janua...
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pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Mayo Clinic proceedings
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pub_type: 杂志文章,多中心研究
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journal_title:Mayo Clinic proceedings
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doi:10.4065/80.8.1016
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doi:
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doi:
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pub_type: 杂志文章
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更新日期:2000-10-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2014-05-01 00:00:00
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pub_type: 杂志文章
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更新日期:2000-08-01 00:00:00