Abstract：
OBJECTIVE:To assess the effects of body mass index (BMI) variability on the incidence of new-onset atrial fibrillation (AF), stroke, cardiovascular (CV) risk factors, and CV outcomes in a general Asian population. PATIENTS AND METHODS:Data from the National Health Insurance Service-Health Screening cohort in Korea were used: 171,324 patients without AF were included, and BMI measurements occurred biennially from January 1, 2002, through December 31, 2009. Patient outcomes were followed through 2013. The BMI intraindividual variability between visits was measured. RESULTS:During mean ± SD follow-up of 47.4±3.9 months, 1959 patients (1.1%) developed new-onset AF. Overweight or obesity (BMI ≥25) had a greater risk of new-onset AF compared with BMI of 20 to 22.5, with a hazard ratio (HR) of 1.24 (95% CI, 1.10-1.41; P<.001). In underweight or normal-weight participants (initial BMI <25), a 1-kg/m2 increase of BMI variability increased the risk of new-onset AF, with an adjusted HR (aHR) of 1.13 (95% CI, 1.01-1.25; P=.02). Weight gain increased the risk of new-onset AF (aHR, 1.32; 95% CI, 1.01-1.71; P=.04) and myocardial infarction (aHR, 1.52; 95% CI, 1.06-2.18; P=.02) but not stroke. In this group, blood pressure, glucose level, and total cholesterol level were higher in individuals with the greatest BMI variability compared with those with stable BMI. CONCLUSION:In the underweight and normal-weight Asian population, BMI variability, especially weight gain, was related to increased risk of new-onset AF and myocardial infarction. Avoiding weight gain is important to improve CV outcomes.
journal_name
Mayo Clin Procjournal_title
Mayo Clinic proceedingsauthors
Lim YM,Yang PS,Jang E,Yu HT,Kim TH,Uhm JS,Kim JY,Pak HN,Lee MH,Joung B,Lip GYHdoi
10.1016/j.mayocp.2018.10.019subject
Has Abstractpub_date
2019-02-01 00:00:00pages
225-235issue
2eissn
0025-6196issn
1942-5546pii
S0025-6196(18)30855-3journal_volume
94pub_type
杂志文章,多中心研究abstract：:The patient with a hypersensitive carotid sinus reflex and syncope may pose special challenges in evaluation and treatment. Specifically, although the finding of carotid sinus hypersensitivity may indeed indicate an exaggerated vagal tone that causes syncope, it may also be a chance association in a patient with synco...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：10.1016/s0025-6196(12)62417-3
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abstract：:Neuroepidemiology has been important in providing clues about the cause and pathogenesis of multiple sclerosis. In this review, we update the incidence and prevalence rates of multiple sclerosis in Olmsted County, Minnesota, and examine the potential role of viruses, exposure to animals, toxins, trauma, and diet in th...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章,评审
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abstract：OBJECTIVE:To analyze the relationship of ideal cardiovascular health to disease-specific death. PATIENTS AND METHODS:We used data from the Aerobics Center Longitudinal Study from October 9, 1987, to March 3, 1999, to estimate the prevalence of ideal cardiovascular health in 11,993 individuals (24.3% women) and to exam...
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pub_type： 杂志文章
doi：10.1016/j.mayocp.2012.07.015
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abstract：:Vancomycin is a glycopeptide antibiotic that is active against staphylococci, streptococci, and other gram-positive bacteria. It is the drug of choice for the treatment of infections due to methicillin-resistant staphylococci, Corynebacterium jeikeium, and multiply resistant strains of Streptococcus pneumoniae. Vancom...
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pub_type： 杂志文章,评审
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pub_type： 杂志文章,评审
doi：10.4065/78.12.1507
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journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：10.1016/s0025-6196(12)64916-7
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journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：10.1016/s0025-6196(12)65437-8
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journal_title：Mayo Clinic proceedings
pub_type： 杂志文章,评审
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journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：
更新日期：1981-03-01 00:00:00
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journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：
更新日期：1982-01-01 00:00:00
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journal_title：Mayo Clinic proceedings
pub_type： 杂志文章,评审
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journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
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journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：10.1016/s0025-6196(12)60721-6
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journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
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更新日期：1999-09-01 00:00:00
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journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
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journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：10.4065/mcp.2010.0745
更新日期：2011-03-01 00:00:00
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journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：
更新日期：1980-01-01 00:00:00
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journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：10.1016/s0025-6196(12)62192-2
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journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：
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journal_title：Mayo Clinic proceedings
pub_type： 杂志文章,评审
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journal_title：Mayo Clinic proceedings
pub_type： 临床试验,杂志文章,评审
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journal_title：Mayo Clinic proceedings
pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：
更新日期：1979-01-01 00:00:00
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journal_title：Mayo Clinic proceedings
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journal_title：Mayo Clinic proceedings
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更新日期：2012-03-01 00:00:00
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journal_title：Mayo Clinic proceedings
pub_type： 杂志文章,多中心研究
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journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2014-01-01 00:00:00
