Vancomycin.

Abstract:

:Vancomycin is a glycopeptide antibiotic that is active against staphylococci, streptococci, and other gram-positive bacteria. It is the drug of choice for the treatment of infections due to methicillin-resistant staphylococci, Corynebacterium jeikeium, and multiply resistant strains of Streptococcus pneumoniae. Vancomycin is an alternative treatment for serious staphylococcal and streptococcal infections, including endocarditis, when allergy precludes the use of penicillins and cephalosporins. Vancomycin is bactericidal against most strains of staphylococci and nonenterococcal streptococci. Although rare strains of staphylococci and enterococci that are resistant to vancomycin have been reported, bacterial resistance has thus far not emerged as a major clinical problem despite widespread use of vancomycin. When therapy is monitored by periodic determinations of serum concentrations of the drug and rapid infusion rates are avoided, vancomycin is rarely associated with serious toxicity.

journal_name

Mayo Clin Proc

journal_title

Mayo Clinic proceedings

authors

Wilhelm MP

doi

10.1016/s0025-6196(12)65799-1

subject

Has Abstract

pub_date

1991-11-01 00:00:00

pages

1165-70

issue

11

eissn

0025-6196

issn

1942-5546

pii

S0025-6196(12)65799-1

journal_volume

66

pub_type

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