Abstract:
:The sympathetic nervous system plays a key role in regulating arterial blood pressure in humans. This review provides an overview of sympathetic neural control of the circulation and discusses the changes that occur in various disease states, including hypertension, heart failure, and obstructive sleep apnea. It focuses on measurements of sympathetic neural activity (SNA) obtained by microneurography, a technique that allows direct assessment of the electrical activity of sympathetic nerves in conscious human beings. Sympathetic neural activity is tightly linked to blood pressure via the baroreflex for each individual person. However, SNA can vary greatly among individuals and that variability is not related to resting blood pressure; that is, the blood pressure of a person with high SNA can be similar to that of a person with much lower SNA. In healthy normotensive persons, this finding appears to be related to a set of factors that balance the variability in SNA, including cardiac output and vascular adrenergic responsiveness. Measurements of SNA are very reproducible in a given person over a period of several months to a few years, but SNA increases progressively with healthy aging. Cardiovascular disease can be associated with substantial increases in SNA, as seen for example in patients with hypertension, obstructive sleep apnea, or heart failure. Obesity is also associated with an increase in SNA, but the increase in SNA among patients with obstructive sleep apnea appears to be independent of obesity per se. For several disease states, successful treatment is associated with both a decrease in sympathoexcitation and an improvement in prognosis. This finding points to an important link between altered sympathetic neural mechanisms and the fundamental processes of cardiovascular disease.
journal_name
Mayo Clin Procjournal_title
Mayo Clinic proceedingsauthors
Charkoudian N,Rabbitts JAdoi
10.1016/S0025-6196(11)60492-8subject
Has Abstractpub_date
2009-09-01 00:00:00pages
822-30issue
9eissn
0025-6196issn
1942-5546pii
S0025-6196(11)60492-8journal_volume
84pub_type
杂志文章,评审abstract:OBJECTIVE:To report the clinicopathologic findings in patients with Grover's disease. MATERIAL AND METHODS:We reviewed the medical records and biopsy specimens from 72 patients with transient acantholytic dermatosis (Grover's disease) examined at Mayo Clinic Rochester. Hematoxylin-eosin-stained biopsy specimens (from ...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章
doi:10.4065/74.3.229
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abstract:OBJECTIVE:To Investigate the frequency of valvular heart disease in patients taking pergolide. PATIENTS AND METHODS:The medical records of patients seen at the Mayo Clinic in Jacksonville, Fla, between 1998 and 2003 were searched electronically for the word pergolide and the presence of a 2-dimensional echocardiogram....
journal_title:Mayo Clinic proceedings
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journal_title:Mayo Clinic proceedings
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pub_type: 杂志文章,评审
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更新日期:2019-02-01 00:00:00
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journal_title:Mayo Clinic proceedings
pub_type: 杂志文章,评审
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pub_type: 杂志文章
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更新日期:2013-07-01 00:00:00
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journal_title:Mayo Clinic proceedings
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1990-10-01 00:00:00
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journal_title:Mayo Clinic proceedings
pub_type: 杂志文章,评审
doi:
更新日期:1996-10-01 00:00:00
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journal_title:Mayo Clinic proceedings
pub_type: 杂志文章,评审
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更新日期:2015-10-01 00:00:00
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journal_title:Mayo Clinic proceedings
pub_type: 杂志文章
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更新日期:2018-08-01 00:00:00
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pub_type: 杂志文章
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更新日期:2004-06-01 00:00:00
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更新日期:2019-03-01 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2005-04-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章,随机对照试验
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pub_type: 杂志文章
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