Abstract：
:Cardiorespiratory fitness (CRF) is an established risk factor for cardiovascular disease outcomes. However, the relationship of CRF with risk of ventricular arrhythmias (VAs) is unknown. We aimed to assess the prospective association of CRF with the risk of serious VAs. Cardiorespiratory fitness, as measured by maximal oxygen uptake, was assessed using a respiratory gas exchange analyzer in 2299 middle-aged men in the Kuopio Ischemic Heart Disease prospective cohort. We corrected for within-person variability in CRF levels using data from repeated measurements 11 years apart. During median follow-up of 25.3 years (interquartile range, 18.7-27.2 years), 73 serious VAs were recorded. The age-adjusted regression dilution ratio of CRF was 0.58 (95% CI, 0.53-0.64). In analysis adjusted for age, the hazard ratio (HR) for serious VAs per 1-SD increase in CRF was 0.64 (95% CI, 0.49-0.84). The association persisted on additional adjustment for body mass index, systolic blood pressure, history of hypertension, prevalent coronary heart disease, smoking, history of diabetes, cholesterol level, alcohol consumption, and physical activity (HR, 0.67; 95% CI, 0.51-0.88). The corresponding adjusted HRs (95% CIs) were 0.29 (0.14-0.59) and 0.32 (0.15-0.65), respectively, comparing the top vs bottom tertiles. The associations were stronger on correction for regression dilution bias, remained consistent on exclusion of men with a history of coronary heart disease, and did not vary importantly in several relevant clinical subgroups. Cardiorespiratory fitness is inversely associated with future risk of serious VAs, independently of several cardiovascular disease risk factors. Further research is needed to assess the causal relevance of these findings.
journal_name
Mayo Clin Procjournal_title
Mayo Clinic proceedingsauthors
Laukkanen JA,Lavie CJ,Khan H,Kurl S,Kunutsor SKdoi
10.1016/j.mayocp.2018.11.027subject
Has Abstractpub_date
2019-05-01 00:00:00pages
833-841issue
5eissn
0025-6196issn
1942-5546pii
S0025-6196(18)30983-2journal_volume
94pub_type
杂志文章abstract：OBJECTIVES:To determine the prevalence of intra- and extra-articular sacroiliac joint (SIJ) pain, which injection is more beneficial, and whether fluoroscopy improves outcomes. PATIENTS AND METHODS:This patient- and evaluator-blinded comparative effectiveness study randomized 125 participants with SIJ pain from April ...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.mayocp.2018.08.038
更新日期：2019-04-01 00:00:00
abstract：:Noninvasive ventilation refers to the delivery of assisted ventilatory support without the use of an endotracheal tube. Noninvasive positive pressure ventilation (NPPV) can be delivered by using a volume-controlled ventilator, a pressure-controlled ventilator, a bilevel positive airway pressure ventilator, or a contin...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章,评审
doi：10.4065/74.8.817
更新日期：1999-08-01 00:00:00
abstract：:Emergency teams asked to provide cardiopulmonary resuscitation for pediatric patients often consist of nurses and physicians from various pediatric and nonpediatric specialties. Team members should agree on the timing of termination of unsuccessful resuscitative efforts; however, no firm guidelines about such timing h...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：10.1016/s0025-6196(12)60126-8
更新日期：1993-04-01 00:00:00
abstract：:Two cases of rare, catastrophic calcium emboli to the coronary arteries immediately after percutaneous mitral balloon valvuloplasty are presented. Preoperative echocardiographic findings may identify patients at risk for this complication. These cases should increase the awareness of calcium emboli and lead to conside...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：10.4065/76.7.753
更新日期：2001-07-01 00:00:00
abstract：:Aortic thrombus formation is rare in the patients with essential thrombocytosis (ET); therefore, no guidelines for its management have been established. Embolism from ET-associated large vessel thrombi is potentially lethal and has been managed surgically in a few reported cases. We describe herein a 45-year-old black...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：10.4065/76.4.427
更新日期：2001-04-01 00:00:00
abstract：OBJECTIVE:To investigate whether patients with traumatic brain injury (TBI) have an increased risk of stroke or poststroke mortality. PARTICIPANTS AND METHODS:Using Taiwan's National Health Insurance Research Database, we conducted a retrospective cohort study of 30,165 patients with new TBI and 120,660 persons withou...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：10.1016/j.mayocp.2013.09.019
更新日期：2014-02-01 00:00:00
abstract：OBJECTIVE:To analyze the effect of adjuvant perfusion techniques of the distal aorta on the outcome of traumatic thoracic aortic transections. PATIENTS AND METHODS:From 1973 to 2004, 72 patients (mean age, 39 years) with thoracic aortic transections arrived alive at the emergency department. Nineteen patients arrived ...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：10.4065/81.5.625
更新日期：2006-05-01 00:00:00
abstract：OBJECTIVE:To explore the current epidemiological profile of Marfan syndrome in a general population. PATIENTS AND METHODS:Patients who had received a diagnosis of Marfan syndrome were identified from the Taiwan National Health Insurance database records from January 1, 2000, through December 31, 2012 (average populati...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：10.1016/j.mayocp.2013.08.022
更新日期：2014-01-01 00:00:00
abstract：:Sleep disorders and neurodegenerative diseases are commonly encountered in primary care. A common, but underdiagnosed sleep disorder, rapid eye movement sleep behavior disorder (RBD), is highly associated with Parkinson disease and related disorders. Rapid eye movement sleep behavior disorder is common. It is estimate...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章,评审
doi：10.1016/j.mayocp.2016.07.019
更新日期：2016-10-01 00:00:00
abstract：:Crohn's disease can involve any portion of the digestive tract, but isolated gastric Crohn's disease is a rare entity. In the few previously reported cases, the inflammatory disorder has involved only a portion of the stomach. Herein we describe a patient with diffuse involvement of the entire stomach and an associate...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：10.1016/s0025-6196(12)61750-9
更新日期：1989-07-01 00:00:00
abstract：:Cirrhosis and its disease-related complications are the 12th leading cause of mortality among U.S. adults and are the 5th leading cause of death for individuals aged 45 to 54 years. Hospitalization costs for disease-related complications are estimated at 18,000 dollars per episode of care, and 10% of admitted patients...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章,评审
doi：10.4065/80.11.1501
更新日期：2005-11-01 00:00:00
abstract：OBJECTIVE:To elucidate the long-term clinical behavior, treatment, and outcomes of sporadic facial nerve schwannoma (FNS) in a large cohort of patients managed in the post-magnetic resonance imaging era. PATIENTS AND METHODS:Retrospective review at a single tertiary health care system (January 1, 1990, through Decembe...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：10.1016/j.mayocp.2016.07.007
更新日期：2016-11-01 00:00:00
abstract：:Plasma, blood, and urine volumes, renal kallikrein, and arterial pressure were measured in control and renal hypertensive rats in order to study the role of the renal kallikrein system in regulating arterial pressure and its relation with the alterations in water handling observed in hypertension. A decrease in kallik...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：
更新日期：1977-07-01 00:00:00
abstract：:We treated a patient who developed transient multifocal encephalopathy with extrapyramidal symptoms (oromandibular dystonia, oculogyric crisis, and limb dystonia) in temporal proximity to ondansetron administration on emergence from general anesthesia. No other medications known to cause extrapyramidal reactions were ...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：10.4065/78.9.1150
更新日期：2003-09-01 00:00:00
abstract：:Osteoarthritis (OA) is the most common articular disease, and it continues to be a major public health problem related to pain, disability, loss of time from work, and economics. Most patients with OA seek medical attention because of pain. In the past few years, changes in the treatment of OA have been substantial. M...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章,评审
doi：10.4065/76.5.533
更新日期：2001-05-01 00:00:00
abstract：:Restless legs syndrome (RLS) is a common disorder with a prevalence of 5% to 15%. Primary care physicians must become familiar with management of this disorder. This algorithm for the management of RLS was written by members of the Medical Advisory Board of the Restless Legs Syndrome Foundation and is based on scienti...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：10.4065/79.7.916
更新日期：2004-07-01 00:00:00
abstract：OBJECTIVE:To describe the survival of a large nonobstructive hypertrophic cardiomyopathy (NO-HCM) cohort and to identify risk factors for increased mortality in this population. PATIENTS AND METHODS:Patients were identified from the Mayo Clinic HCM database from January 1, 1975, through November 30, 2006, for this ret...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：10.1016/j.mayocp.2016.01.002
更新日期：2016-03-01 00:00:00
abstract：:Guidelines for the use of antibiotics in infants and children must take into account drug absorption, distribution, metabolism, and excretion. In the developing human being, these factors may differ significantly from those in the adult, and so there are differences in therapeutic efficacy and toxicity. Certain drugs ...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：
更新日期：1977-11-01 00:00:00
abstract：OBJECTIVE:To report the long-term follow-up of a matched comparison of radical nephrectomy (RN) and nephron-sparing surgery (NSS) in patients with single unilateral renal cell carcinoma (RCC) and a normal contralateral kidney. PATIENTS AND METHODS:Between August 1966 and March 1999, 1492 and 189 patients with unilater...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：10.4065/75.12.1236
更新日期：2000-12-01 00:00:00
abstract：OBJECTIVE:To assess the potential electromagnetic interference (EMI) effects that new or current-generation cellular telephones have on medical devices. MATERIAL AND METHODS:For this study, performed at the Mayo Clinic in Rochester, Minn, between March 9, 2004, and April 24, 2004, we tested 16 different medical device...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：10.4065/80.10.1286
更新日期：2005-10-01 00:00:00
abstract：:Although measurements of trunk flexibility are an important part of a clinical examination, subjective methods are usually used to assess spinal mobility. We studied three easily performed objective techniques for determining trunk flexibility (the common "fingertip-to-floor" test, the modified Schober and Moll tests,...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：10.1016/s0025-6196(12)61848-5
更新日期：1986-03-01 00:00:00
abstract：:The sympathetic nervous system plays a key role in regulating arterial blood pressure in humans. This review provides an overview of sympathetic neural control of the circulation and discusses the changes that occur in various disease states, including hypertension, heart failure, and obstructive sleep apnea. It focus...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章,评审
doi：10.1016/S0025-6196(11)60492-8
更新日期：2009-09-01 00:00:00
abstract：:Many types of psychotherapeutic drugs (especially antidepressants) directly and indirectly interact with neurotransmitter receptors, the recognition sites for the chemical messengers released by neurons. These interactions can result in increased or decreased sensitivity of certain receptors. Hypotheses exist to expla...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：
更新日期：1982-09-01 00:00:00
abstract：:During the past 16 years, in which 1,600 patients were surgically treated for primary hyperparathyroidism, 10 of these patients also were operated on for hypernephroma; in another patient a hypernephroma was detected 7 2/3 years after treatment for hyperparathyroidism. Four additional patients have elevated serum calc...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：
更新日期：1982-11-01 00:00:00
abstract：:Reperfusion therapy (by either administration of thrombolytic agents or immediate angioplasty) is the mainstay of treatment of acute myocardial infarction, yet it remains underutilized. Additionally, many patients do not experience optimal reperfusion because of suboptimal flow rate in the infarct-related artery, abno...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章,评审
doi：10.4065/70.12.1185
更新日期：1995-12-01 00:00:00
abstract：OBJECTIVE:To evaluate the effect of aspirin and nonaspirin antiplatelet agents (NAAAs) on the performance of the fecal immunochemical test (FIT). PARTICIPANTS AND METHODS:We performed a post hoc analysis of results from a clinical trial that involved 28,696 asymptomatic average-risk men and women aged 50 to 69 years i...
journal_title：Mayo Clinic proceedings
pub_type： 临床试验,杂志文章
doi：10.1016/j.mayocp.2013.04.016
更新日期：2013-07-01 00:00:00
abstract：OBJECTIVE:To estimate the incidence of selected systemic autoimmune diseases (SAIDs) in approximately 14,000 male rescue/recovery workers enrolled in the Fire Department of the City of New York (FDNY) World Trade Center (WTC) Health Program and to compare FDNY incidence to rates from demographically similar men in the ...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：10.1016/j.mayocp.2015.09.019
更新日期：2016-01-01 00:00:00
abstract：OBJECTIVE:To assess the current spectrum of causes and clinical features associated with hypersensitivity pneumonitis (HP). PATIENTS AND METHODS:We studied consecutive patients with HP diagnosed at the Mayo Clinic in Rochester, Minn, from January 1, 1997, through December 31, 2002. Diagnostic criteria for HP included ...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：10.4065/82.7.812
更新日期：2007-07-01 00:00:00
abstract：:Clinical decisions are increasingly driven by evidence-based recommendations of guideline groups, which aim to be based on the highest quality knowledge-randomized clinical trials (RCTs) and meta-analyses. Although RCTs provide the best assessment of the overall value of a therapy, high-quality evidence from RCTs is o...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：10.1016/j.mayocp.2013.07.012
更新日期：2013-10-01 00:00:00
abstract：:The Mayo Three-Community Hypertension Control Program implemented graduated programs for the control of high blood pressure in three rural southeastern Minnesota communities, beginning in 1974. Prevalence of hypertension (when defined as diastolic blood pressure, at initial screening, of 95 mm Hg or more) was similar ...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：
更新日期：1979-05-01 00:00:00
