Abstract：
OBJECTIVE:To evaluate the prognostic impact of Holter findings in patients with light chain amyloidosis. PATIENTS AND METHODS:We evaluated 239 patients in whom light chain amyloidosis was diagnosed from January 1, 2010, through December 31, 2015, who underwent 24-hour Holter monitoring. RESULTS:Holter testing was done before stem cell transplant evaluation in 183 of the 239 patients (76.6%) and at diagnosis in 50 (20.9%). Holter findings were nonsustained ventricular tachycardia (NSVT) in 60 patients (25.1%), ventricular couplets in 103 (43.1)%, accelerated idioventricular rhythm in 32 (13.4%), and atrial fibrillation (AF) in 18 (7.5%). Overall survival (OS) at 3 and 6 months after Holter monitoring in patients with AF vs without AF was 78% (95% CI, 54%-91%) vs 96% (95% CI, 92%-98%) (P=.002) and 61% (95% CI, 38%-80%) vs 92% (95% CI, 87%-95%), (P<.001), respectively. In patients with and without NSVT, 3- and 6-month OS after Holter testing was 90% (95% CI, 80%-94%) vs 96% (95% CI, 91%-98%) (P=.12) and 77% (95% CI, 64%-85%) vs 94% (95% CI, 89%-97%) (P<.001), respectively. For patients with and without ventricular couplets, 3- and 6-month OS was 94% (95% CI, 88%-97%) vs 94% (95% CI, 89%-97%) (P=.98) and 84% (95% CI, 75%-89%) vs 94% (95% CI, 89%-97%) (P=.01), respectively. Atrial fibrillation (hazard ratio, 2.5; 95% CI, 1.2-5.0; P=.02) and NSVT (hazard ratio, 2.0; 95% CI, 1.1-3.5; P=.02) were independent predictors for OS after accounting for age and Mayo stage. For patients undergoing routine testing before stem cell transplant, AF (P=.002) and NSVT (P=.02) were associated with inferior OS at 6 months but did not retain statistical significance after adjusting for Mayo stage (P=.10 and P=.54, respectively). CONCLUSION:Atrial fibrillation and NSVT on 24-hour Holter monitoring are associated with inferior short-term OS outcomes but do not impact peritransplant mortality.
journal_name
Mayo Clin Procjournal_title
Mayo Clinic proceedingsauthors
Sidana S,Tandon N,Brady PA,Grogan M,Gertz MA,Dispenzieri A,Lin G,Dingli D,Buadi FK,Lacy MQ,Kapoor P,Gonsalves WI,Muchtar E,Warsame R,Kumar SK,Kourelis TVdoi
10.1016/j.mayocp.2018.08.039subject
Has Abstractpub_date
2019-03-01 00:00:00pages
455-464issue
3eissn
0025-6196issn
1942-5546pii
S0025-6196(18)30844-9journal_volume
94pub_type
杂志文章abstract：:Hepatitis C virus infection is common, often silent, and almost always chronic and can lead to cirrhosis and hepatocellular cancer. Deaths related to chronic hepatitis C are expected to increase dramatically in the future. Many cases of infection are asymptomatic and are undiagnosed because of a lack of recognition by...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章,评审
doi：10.1016/S0025-6196(11)63702-6
更新日期：1998-04-01 00:00:00
abstract：:An inexpensive and reproducible model to help in developing the technical skills for, and to investigate experimentally, a microvascular anastomosis resembling the superficial temporal-middle cerebral artery bypass is described. The model is used to illustrate the important principles of microvascular surgery. Using a...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：
更新日期：1976-05-01 00:00:00
abstract：OBJECTIVE:To explore the influence of referral bias on complication rates after vaginal hysterectomy. PATIENTS AND METHODS:Community-based (local) and referral patients had benign indications and underwent vaginal hysterectomy from January 1, 2004, through December 31, 2005. We retrospectively evaluated patient charac...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：10.4065/mcp.2009.0299
更新日期：2010-02-01 00:00:00
abstract：:Forty cases of focal sclerosing glomerulonephropathy with nephrotic syndrome or proteinuria were studied retrospectively in regard to clinical presentation, response to steroid therapy and clinical course, and histopathology of the lesion. Morphologically there was a focal segmental and global sclerosis with subendot...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：
更新日期：1975-03-01 00:00:00
abstract：:Extending a study of the period 1935-1964, we determined the incidence rates of leukemia in Olmsted County during the decade 1965-1974. In this decade, the overall crude annual incidence rate was 9.5 per 100,000. The ratio of males to females was 2.4 to 1; and the incidence rate was significantly higher among males th...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：
更新日期：1978-11-01 00:00:00
abstract：OBJECTIVE:To ascertain the usefulness of bone marrow and cerebrospinal fluid (CSF) examinations in identifying or predicting relapse in children with acute lymphoblastic leukemia (ALL) before discontinuation of chemotherapy. MATERIAL AND METHODS:We retrospectively reviewed the medical records of 113 children with ALL ...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：10.4065/71.9.854
更新日期：1996-09-01 00:00:00
abstract：:Wide-angle two-dimensional echocardiography was used to establish criteria for recognition of ventricular situs and ventricular morphology in 27 patients (ages 2 month to 58 years) with atrioventricular amd ventriculoarterial discordance (corrected transposition of the great arteries). The morphologic left ventricle w...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：
更新日期：1981-10-01 00:00:00
abstract：OBJECTIVE:To evaluate, in this before-and-after study, the results of 5 strategies for improving attendance at medical grand rounds at a tertiary care academic medical center. METHODS:The strategies included (1) using electronic card readers to improve understanding of attendance patterns, (2) conducting yearly needs ...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：10.4065/78.5.549
更新日期：2003-05-01 00:00:00
abstract：:A 54-year-old man with no known cardiac disease collapsed outdoors in a small rural community. The cardiac arrest was witnessed, and immediate cardiopulmonary resuscitation was begun by a bystander and a trained first responder who was nearby. The patient was moved into a building across the street for continued resus...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：10.4065/mcp.2011.0229
更新日期：2011-06-01 00:00:00
abstract：OBJECTIVE:To evaluate the outcomes of robotic mitral valve repair (MVr) by primary indication per American Heart Association guidelines for surgery: class I vs class IIa. PATIENTS AND METHODS:From January 1, 2008, through September 30, 2016, 603 patients underwent robotic MVr for severe primary mitral regurgitation. M...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：10.1016/j.mayocp.2019.05.025
更新日期：2019-11-01 00:00:00
abstract：:Clostridioides difficile infection (CDI) is the leading cause of health care-associated infections in the United States. The increasing incidence and recurrence rates of CDI together with its associated morbidity and mortality are great concerns. Newer treatment methods, such as narrow-spectrum antibiotics, monoclonal...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章,评审
doi：10.1016/j.mayocp.2019.08.006
更新日期：2020-04-01 00:00:00
abstract：:Graves disease is an autoimmune thyroid condition characterized by the production of autoantibodies against the thyrotropin receptor. The autoantibodies mimic the effect of the hormone on thyroid cells, which stimulates autonomous production of thyroxine and triiodothyronine. It has been hypothesized that cross-reacti...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：10.4065/77.5.495
更新日期：2002-05-01 00:00:00
abstract：:The symptoms of progressive dyspnea, hemoptysis, spontaneous pneumothorax, chylous effusions, and cough in conjunction with ventilatory obstruction and abnormal gas exchange in a young woman should prompt the diagnosis of pulmonary lymphangiomyomatosis. Cytosol steroid-receptor assays and postmortem studies were condu...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：10.1016/s0025-6196(12)60333-4
更新日期：1984-01-01 00:00:00
abstract：:The frequently encountered disorder of venous thromboembolism (VTE) can cause serious morbidity and even death. Nevertheless, in more than 70% of patients who die of pulmonary embolism (PE), the diagnosis is not considered before death. Thus, clinicians should have a high index of suspicion for VTE, especially in high...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章,评审
doi：10.1016/S0025-6196(11)64664-8
更新日期：1995-01-01 00:00:00
abstract：:Nonrelaxing pelvic floor dysfunction is not widely recognized. Unlike in pelvic floor disorders caused by relaxed muscles (eg, pelvic organ prolapse or urinary incontinence, both of which often are identified readily), women affected by nonrelaxing pelvic floor dysfunction may present with a broad range of nonspecific...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章,评审
doi：10.1016/j.mayocp.2011.09.004
更新日期：2012-02-01 00:00:00
abstract：:Physicians must be able to recognize stroke caused by a mendelian or mitochondrial disorder. Some genetic disorders such as sickle cell anemia and Fabry disease have proven disease-specific treatments, whereas others have no effective treatment, including cerebral autosomal dominant arteriopathy with subcortical infar...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章,评审
doi：10.1016/S0025-6196(11)62969-8
更新日期：2005-01-01 00:00:00
abstract：:Understanding the sequence of events responsible for pressure-related natriuresis and their pathophysiologic alterations may be useful in distinguishing various types of essential hypertension of renal origin. The perturbation of a distal step in the sequence is likely to be reflected in a simple physiologic defect. F...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章,评审
doi：10.1016/s0025-6196(12)65384-1
更新日期：1989-11-01 00:00:00
abstract：OBJECTIVE:To assess resource utilization and outcome in gravely ill patients admitted to an intensive care unit (ICU) and the potential association with health care workers' and family members' expectations. PATIENTS AND METHODS:We retrospectively evaluated ICU patients with a predicted in-hospital mortality rate of 9...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：10.4065/80.2.166
更新日期：2005-02-01 00:00:00
abstract：:The first generation of multicenter randomized controlled trials of coronary artery bypass surgery vs medical treatment in the 1970s found survival advantage only in patients with left main coronary artery disease or with multiple risk factors. Over time, these results have remained reproducible and biologically plaus...
journal_title：Mayo Clinic proceedings
pub_type：
doi：10.4065/77.1.72
更新日期：2002-01-01 00:00:00
abstract：OBJECTIVE:To review our institution's experience with patients who failed to benefit from septal artery ablation, which necessitated subsequent septal myectomy, and to examine reasons for ablation failure and outcome of myectomy after ablation. PARTICIPANTS AND METHODS:Of 550 patients who underwent septal myectomy at ...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：10.1016/S0025-6196(11)61096-3
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abstract：OBJECTIVE:To determine how all-cause hospitalizations within 12 months preceding an index heart failure (HF) hospitalization affect risk stratification for 30-day all-cause readmission. PATIENTS AND METHODS:Early readmission of inpatients with HF is challenging to predict, yet this outcome is used to compare hospital ...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：10.1016/j.mayocp.2013.12.018
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abstract：OBJECTIVE:To assess whether patients with pancreatic cancer-associated pain living near a pain control center were more likely to undergo neurolytic celiac plexus block (NCPB) than those living at a distance and to determine the rationale of physicians at our institution for referring patients for NCPB. DESIGN:We retr...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：10.4065/72.9.831
更新日期：1997-09-01 00:00:00
abstract：OBJECTIVE:To compare cardiovascular (CV) event rates and risk in patients without previous CV disease in whom atorvastatin or simvastatin was newly initiated in a managed care setting. PATIENTS AND METHODS:Patients aged 18 to 64 years in whom atorvastatin or simvastatin was newly initiated between January 1, 2003, and...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：10.1016/S0025-6196(11)60779-9
更新日期：2008-12-01 00:00:00
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journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：10.1016/j.mayocp.2017.03.010
更新日期：2017-08-01 00:00:00
abstract：:A decrease in blood androgen levels is well documented in women who experience natural or surgical menopause. This change may be associated with various negative effects on bone metabolism in addition to psychosocial and sexuality aspects of life. A review of published information on androgen replacement therapy shows...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章,评审
doi：10.4065/72.11.1051
更新日期：1997-11-01 00:00:00
abstract：OBJECTIVE:To Investigate the frequency of valvular heart disease in patients taking pergolide. PATIENTS AND METHODS:The medical records of patients seen at the Mayo Clinic in Jacksonville, Fla, between 1998 and 2003 were searched electronically for the word pergolide and the presence of a 2-dimensional echocardiogram....
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：10.4065/80.8.1016
更新日期：2005-08-01 00:00:00
abstract：:In a study of 49 consecutive patients for whom a test for platelet antibodies had been ordered, tests were performed for both cell-bound and serum platelet antibodies. In cases of autoimmune thrombocytopenia (ITP), the test result for cell-bound antibody was more likely to be positive than was the test result for seru...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：10.1016/s0025-6196(12)65623-7
更新日期：1984-12-01 00:00:00
abstract：OBJECTIVE:To examine 45-year trends in time use and physical activity energy expenditure (PAEE) in a nationally representative sample of US mothers. PARTICIPANTS AND METHODS:We quantified time allocation to physical activity (PA), sedentary behaviors (SED), and PAEE from 1965 to 2010 in mothers with older children (MO...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：10.1016/j.mayocp.2013.09.009
更新日期：2013-12-01 00:00:00
abstract：:A case of inguinal hernia with massive scrotal enlargement is presented. Walking and voiding had become extremely difficult for the patient; only one testicle could be palpated, and the penis could not be delivered from the scrotal mass. Surgical reduction of the massive hernia was accomplished. The right testis with ...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：
更新日期：1982-06-01 00:00:00
abstract：OBJECTIVE:To assess the impact of direct-to-consumer (DTC) predictive genomic risk information on perceived risk and worry in the context of routine clinical care. PATIENTS AND METHODS:Patients attending a preventive medicine clinic between June 1 and December 18, 2009, were randomly assigned to receive either genomic...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章,随机对照试验
doi：10.4065/mcp.2011.0190
更新日期：2011-10-01 00:00:00
