Abstract:
OBJECTIVE:To examine the effects of interval walking training (IWT) on the estimated peak aerobic capacity (eV˙O2peak) and lifestyle-related disease (LSD) score while focusing on exercise intensity and volume in middle-aged and older people. PARTICIPANTS AND METHODS:Men and women (N=679; mean age, 65±7 SD years) completed 5-month IWT. Participants were instructed to repeat 5 or more sets of fast and slow walking for 3 minutes each at 70% or more and 40% eV˙O2peak for walking, respectively, per day for 4 or more d/wk. This study was conducted from April 1, 2005, through February 29, 2008. RESULTS:Interval walking training increased eV˙O2peak by 14% and decreased LSD score by 17% on average (P<.001). During 5-month IWT, fast and slow walking times were 88±65 SD and 100±86 min/wk, respectively, but varied among participants. We divided participants into approximately 10 bins for 6 minutes each of fast and slow walking times per week up to 60 min/wk, and above this time, approximately 8 bins for 30 or 60 minutes each of fast and slow walking up to the maximal time. We found that both eV˙O2peak and LSD score improved as fast walking time per week increased up to 50 min/wk (R2=0.94; P<.001 for eV˙O2peak; R2=0.51; P=.03 for LSDS) but plateaued above this time. In contrast, improvement in neither eV˙O2peak nor LSDS was positively correlated with slow or total walking time per week. Multiple regression analyses confirmed that fast walking time per week was the major determinant of improvements in eV˙O2peak (P<.001) and LSD score (P=.001). CONCLUSION:High-intensity walking time during IWT is a key factor to increase eV˙O2peak and decrease LSD score in middle-aged and older people.
journal_name
Mayo Clin Procjournal_title
Mayo Clinic proceedingsauthors
Masuki S,Morikawa M,Nose Hdoi
10.1016/j.mayocp.2019.04.039subject
Has Abstractpub_date
2019-12-01 00:00:00pages
2415-2426issue
12eissn
0025-6196issn
1942-5546pii
S0025-6196(19)30473-2journal_volume
94pub_type
杂志文章abstract::Tobacco use is a global pandemic. The most common pharmacological treatments of tobacco use and dependence include nicotine replacement therapy and nonnicotine medications. Bupropion sustained release (SR) is the only first-line nonnicotine medication recommended by the US Public Health Service Clinical Practice Guide...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章,评审
doi:10.4065/78.8.1020
更新日期:2003-08-01 00:00:00
abstract:OBJECTIVE:To understand motivations, educational needs, and concerns of individuals contemplating whole-exome sequencing (WES) and determine what amount of genetic information might be obtained by sequencing a generally healthy cohort so as to more effectively counsel future patients. PATIENTS AND METHODS:From 2012 to...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章
doi:10.1016/j.mayocp.2015.05.021
更新日期:2015-10-01 00:00:00
abstract:OBJECTIVE:To determine the risk of congenital cardiac abnormalities associated with use of selective serotonin reuptake inhibitors (SSRIs) during pregnancy. PATIENTS AND METHODS:We conducted a retrospective review of the medical records of all pregnant women presenting at Mayo Clinic's site in Rochester, MN, from Janu...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章
doi:10.4065/84.1.23
更新日期:2009-01-01 00:00:00
abstract::Prospective data and follow-up information were collected on the initial 200 patients who underwent laparoscopic cholecystectomy at the Mayo Clinic. The operation was completed laparoscopically in all but five patients, who required conversion to laparotomy because of dense scarring or stones in the common bile duct. ...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章
doi:10.1016/s0025-6196(12)60390-5
更新日期:1992-05-01 00:00:00
abstract::The issue of whether patients who have invasive carcinoma in an otherwise benign polyp should undergo surgical resection of that bowel segment is controversial. We examined the records of 83 patients with such polyps that were removed endoscopically between 1978 and 1981. After exclusion of 18 patients from the study ...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章
doi:10.1016/s0025-6196(12)65198-2
更新日期:1986-02-01 00:00:00
abstract:OBJECTIVE:To assess the frequency and clinical implications of positive autoimmune serologies in patients with biopsy-confirmed idiopathic pulmonary fibrosis (IPF). PATIENTS AND METHODS:We reviewed the records of patients at our institution with biopsy-confirmed usual interstitial pneumonia (UIP) from January 1, 1995,...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章
doi:10.1016/j.mayocp.2013.11.018
更新日期:2014-03-01 00:00:00
abstract::Intraoperative (IO) transesophageal echocardiography (TEE) is widely used for assessing the results of valvular heart disease (VHD) surgery. Epiaortic ultrasonography (EAU) has been recommended for prevention of perioperative strokes. To what extent does high-quality evidence justify the widespread use of these imagin...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章,meta分析,评审
doi:10.4065/mcp.2009.0629
更新日期:2010-07-01 00:00:00
abstract::The German Pflegeversicherung, introduced in January 1995, has been very successful. It has been well accepted by persons in need and by their relatives and friends, providing benefits for both parties. The insurance is financially sound and has helped to create new workplaces. ...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章
doi:10.4065/74.2.196
更新日期:1999-02-01 00:00:00
abstract::Evidence that host immunologic function may influence the behavior of lung cancer is accumulating. Non-small-cell lung cancers are heavily infiltrated by host lymphocytes. The fact that monoclonal antibodies have been developed against lung cancer cells implies that such cells express surface antigens and are therefor...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章,评审
doi:10.1016/s0025-6196(12)60137-2
更新日期:1993-04-01 00:00:00
abstract::Understanding the sequence of events responsible for pressure-related natriuresis and their pathophysiologic alterations may be useful in distinguishing various types of essential hypertension of renal origin. The perturbation of a distal step in the sequence is likely to be reflected in a simple physiologic defect. F...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章,评审
doi:10.1016/s0025-6196(12)65384-1
更新日期:1989-11-01 00:00:00
abstract::There are a number of changes underway in modern clinical bacteriology laboratories. Panel-based molecular diagnostics are now available for numerous applications, including, but not limited to, detection of bacteria and select antibacterial resistance markers in positive blood culture bottles, detection of acute gast...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章,评审
doi:10.1016/j.mayocp.2016.06.020
更新日期:2016-10-01 00:00:00
abstract::In August 2015, an expert colloquium commissioned by the Sexual Medicine Society of North America (SMSNA) convened in Washington, DC, to discuss the common clinical scenario of men who present with low testosterone (T) and associated signs and symptoms accompanied by low or normal gonadotropin levels. This syndrome is...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章,评审
doi:10.1016/j.mayocp.2016.04.022
更新日期:2016-07-01 00:00:00
abstract::Recent experience with 40 patients with the Zollinger-Ellison syndrome at all Mayo Clinic suggests that traditional clinical criteria for diagnosis are often absent or invalid. Patients are younger have a shorter duration of symptoms, and often present without prior gastric surgery. Clinical, roentgenographic, and end...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章
doi:
更新日期:1978-01-01 00:00:00
abstract::Dual-chamber pacing improved hemodynamics acutely in a subset of patients with left ventricular (LV) dysfunction but conveyed no long-term symptomatic benefit in most. More recently, LV pacing and biventricular (multisite) pacing have been used to improve systolic contractility by altering the electrical and mechanica...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章,评审
doi:10.1016/S0025-6196(11)63225-4
更新日期:2001-08-01 00:00:00
abstract:OBJECTIVE:To determine how all-cause hospitalizations within 12 months preceding an index heart failure (HF) hospitalization affect risk stratification for 30-day all-cause readmission. PATIENTS AND METHODS:Early readmission of inpatients with HF is challenging to predict, yet this outcome is used to compare hospital ...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章
doi:10.1016/j.mayocp.2013.12.018
更新日期:2014-05-01 00:00:00
abstract:OBJECTIVE:To evaluate the overall risk of breast cancer and breast cancer characteristics in women given supradiaphragmatic radiation therapy for Hodgkin lymphoma. PATIENTS AND METHODS:Medical records of 653 female patients who received supradiaphragmatic radiation therapy for Hodgkin lymphoma at the Mayo Clinic in Ro...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章
doi:10.4065/78.6.708
更新日期:2003-06-01 00:00:00
abstract::Patients with ectatic coronary arteries often have occlusion of the affected arteries. Because ectatic arteries are considered to have medial damage, they are normally assumed to have little capacity to constrict; therefore, spasm has not been considered a factor in the occlusive process. In two patients who had diffu...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章
doi:10.1016/s0025-6196(12)64787-9
更新日期:1985-12-01 00:00:00
abstract::Parasitic diseases affect more than 2 billion people globally and cause substantial morbidity and mortality, particularly among the world's poorest people. This overview focuses on the treatment of the major protozoan and helminth infections in humans. Recent developments in antiparasitic therapy include the expansion...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章,评审
doi:10.4065/mcp.2011.0203
更新日期:2011-06-01 00:00:00
abstract:OBJECTIVE:To measure the effect of duty periods no longer than 16 hours on patient care and resident education. PATIENTS AND METHODS:As part of our Educational Innovations Project, we piloted a novel resident schedule for an inpatient service that eliminated shifts longer than 16 hours without increased staffing or de...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章
doi:10.4065/mcp.2010.0745
更新日期:2011-03-01 00:00:00
abstract:OBJECTIVE:To determine whether the use of a computerized bar code-based blood identification system resulted in a reduction in transfusion errors or near-miss transfusion episodes. PATIENTS AND METHODS:Our institution instituted a computerized bar code-based blood identification system in October 2006. After instituti...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章
doi:10.1016/j.mayocp.2012.12.010
更新日期:2013-04-01 00:00:00
abstract:OBJECTIVE:To derive risk models for percutaneous coronary intervention (PCI) outcomes from clinical and laboratory variables available before the procedure so they can be used for preprocedure risk stratification. PATIENTS AND METHODS:Using the Mayo Clinic registry, we analyzed 9035 PCIs on 7640 unique patients from J...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章
doi:10.4065/82.6.701
更新日期:2007-06-01 00:00:00
abstract::The clinical impact of the association between oral contraceptive (OC) use and breast cancer risk is important given that OCs are the most commonly prescribed contraceptive agent and that more than a quarter of a million women are diagnosed as having breast cancer in the United States annually. Substantial changes to ...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章,评审
doi:10.4065/83.1.86
更新日期:2008-01-01 00:00:00
abstract::Autogenic biofeedback training appears to be a promising technique for the treatment of migraine headaches, as reflected in the literature reviewed herein and in the data from 21 patients who were followed up for an average of 10 months. Autogenic biogeedback training exemplifies an important trend in psychosomatic me...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章,评审
doi:
更新日期:1977-12-01 00:00:00
abstract::In ancient times, the sun was venerated as a source of life in some cultures. Scientifically, the relationship between vitamin D and sunlight and the deficiency of vitamin D in patients with rickets were ultimately discovered. In 1903, Niels Finsen was awarded the Nobel Prize in medicine or physiology for his "Finsen ...
journal_title:Mayo Clinic proceedings
pub_type: 历史文章,杂志文章
doi:10.4065/72.5.461
更新日期:1997-05-01 00:00:00
abstract::The positive relationship between the volume of health services (hospital and physician) and health-related outcomes is established in the complex surgical treatment of cancers and certain nononcologic medical conditions. However, this topic has not been systematically explored in the medical management of cancers. We...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章,评审
doi:10.1016/j.mayocp.2015.07.003
更新日期:2015-10-01 00:00:00
abstract::Total respiratory resistance (Rrs) was studied by the forced oscillation technique at a frequency of 3 cps in 76 normal subjects (36 men, 40 women), ages 21 to 64 years. Slopes (equivalent to specific conductance) assuming a linear relationship with zero intercept between 1/Rrs and thoracic gas volume (TGV) were compu...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章
doi:
更新日期:1976-09-01 00:00:00
abstract::Acute disseminated encephalomyelitis, an inflammatory demyelinating disease of the central nervous system, can occur after viral infections or vaccinations. We report the clinical and neuroimaging findings in a 52-year-old man in whom acute disseminated encephalomyelitis developed after accidental self-injection of an...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章
doi:10.4065/73.12.1193
更新日期:1998-12-01 00:00:00
abstract::In the years 1960 through 1966, vagotomy and pyloroplasty was performed for duodenal ulceration in 182 patients. Elective operation was performed in 84% of cases, and intractability of symptoms was the major indication. For emergency operations, bleeding was the main indication. Eight of 182 patients died in the posto...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章
doi:
更新日期:1980-01-01 00:00:00
abstract::The use of pacemakers and implantable cardioverter-defibrillators continues to increase for the management of cardiac dysrhythmias and, more recently, heart failure. Long-term complications associated with their use include infection, lead failure, and spurious shocks. Although the risk of infection with intracardiac ...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章,评审
doi:10.4065/79.4.549
更新日期:2004-04-01 00:00:00
abstract:OBJECTIVE:To assess long-term secular trends in the utilization of bilateral compared with unilateral orchiectomy in the community. PATIENTS AND METHODS:This population-based descriptive study reviewed medical records of all Olmsted County, Minnesota, men undergoing orchiectomy between 1956 and 2000. RESULTS:Over the...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章
doi:10.4065/76.12.1199
更新日期:2001-12-01 00:00:00