Duvelisib, an oral dual PI3K-δ,γ inhibitor, shows clinical and pharmacodynamic activity in chronic lymphocytic leukemia and small lymphocytic lymphoma in a phase 1 study.

abstract：:Patients with indolent non-Hodgkin lymphoma (NHL) have multiple treatment options yet there is no consensus as to the best initial therapy. Lenalidomide, an immunomodulatory agent, has single agent activity in relapsed lymphoma. This trial was conducted to assess feasibility, efficacy, and safety of adding lenalidomid...

journal_title：American journal of hematology

authors： Rosenthal A,Dueck AC,Ansell S,Gano K,Conley C,Nowakowski GS,Camoriano J,Leis JF,Mikhael JR,Keith Stewart A,Inwards D,Dingli D,Kumar S,Noel P,Gertz M,Porrata L,Russell S,Colgan J,Fonseca R,Habermann TM,Kapoor P,B

更新日期：2017-05-01 00:00:00

abstract：:Transferrin-iron uptake by peripheral blood monocytes was studied in vitro to test the hypothesis that the relative paucity of mononuclear phagocyte iron loading in hereditary hemochromatosis results from a defect in uptake of iron from transferrin. Monocytes from nine control subjects and 17 patients with hemochromat...

journal_title：American journal of hematology

authors： Sizemore DJ,Bassett ML

更新日期：1984-05-01 00:00:00

abstract：:Aberrant promoter DNA methylation is a well-described mechanism of leukemogenesis within hematologic malignancies, including acute lymphoblastic leukemia (ALL). However, the importance of methylation patterns among the adolescent and young adult (AYA) ALL population has not been well established. DNA methylation of 18...

journal_title：American journal of hematology

authors： DiNardo CD,Gharibyan V,Yang H,Wei Y,Pierce S,Kantarjian HM,Garcia-Manero G,Rytting M

更新日期：2013-09-01 00:00:00

abstract：:Cerebrospinal fluid beta-2-microglobulin (CSF-beta 2m) was measured longitudinally in 48 patients affected by acute lymphoblastic leukemia (ALL). Thirteen developed a central nervous system (CNS) involvement during the course of the disease; although moderately higher mean CSF-beta 2m levels were found in these subjec...

journal_title：American journal of hematology

authors： Musto P,Tomasi P,Cascavilla N,Ladogana S,La Sala A,Melillo L,Nobile M,Castoldi G,Carotenuto M

更新日期：1988-08-01 00:00:00

abstract：:Cutaneous lymphoma is a disease characterized with massive skin infiltration of lymphoid malignant cells. They commonly express some T-cell markers, such as CD2, CD3, CD4, and CD7, and thus termed as CTCL (cutaneous T cell lymphoma). Here, we present a case with CD56/N-CAM-positive cutaneous lymphoma, which appears ly...

journal_title：American journal of hematology

authors： Adachi M,Maeda K,Takekawa M,Hinoda Y,Imai K,Sugiyama S,Yachi A

更新日期：1994-12-01 00:00:00

abstract：:The main treatment for many patients with Myelodysplastic Syndromes (MDS) remains red cell transfusion to attenuate the symptoms of chronic anemia. Fatigue can reduce a patient's health related quality of life (HRQoL), but there is little understanding of the optimal use of transfusions to improve this. A systematic r...

journal_title：American journal of hematology

authors： Pinchon DJ,Stanworth SJ,Dorée C,Brunskill S,Norfolk DR

更新日期：2009-10-01 00:00:00

abstract：:AL amyloidosis, a systemic disorder characterized by widespread deposition of amyloid fibrils derived from monoclonal Ig light chains in organs and soft tissues, is typically caused by an underlying plasma cell dyscrasia. However, this disease can also be associated rarely with a B-cell lymphoproliferative disorder. I...

journal_title：American journal of hematology

authors： Sanchorawala V,Blanchard E,Seldin DC,O'Hara C,Skinner M,Wright DG

更新日期：2006-09-01 00:00:00

abstract：:Six patients with thrombotic microangiopathy associated with drug therapy had serial analyses of von Willebrand factor (vWF) multimeric patterns in their EDTA-plasma samples by sodium dodecyl sulfate-1% agarose gel electrophoresis and autoradiography. In the plasma of five patients (one with chronic myelogenous leukem...

journal_title：American journal of hematology

authors： Charba D,Moake JL,Harris MA,Hester JP

更新日期：1993-03-01 00:00:00

abstract：:A 77-year-old caucasian man presented on March 2005 with important epigastric pain without any other significant history of gastritis. Patient refers a history of cutaneous Kaposi's sarcoma (KS) treated since 1974 with surgical excision or oncovorin topical injection. He underwent endoscopic evaluation showing a 1.5-c...

journal_title：American journal of hematology

authors： Mirabile A,Devizzi L,Gianni AM,Cabras A,Carbone A

更新日期：2010-10-01 00:00:00

abstract：:Antithrombin III (AT III) was isolated by two procedures using polyethylene glycol-400 (PEG) precipitation as the first stage. The PEG supernatant (PEG-sup) was applied to a heparin-affinity chromatographic system and AT III-heparin cofactor (AT III-HCF) was isolated. The PEG precipitate (PEG-ppt) was separated by a S...

journal_title：American journal of hematology

authors： Gomperts ED,Izadi P

更新日期：1983-08-01 00:00:00

abstract：:Thromboembolic complications following splenectomy for hematologic diseases occur in up to 10% of patients and may range from portal vein thrombosis (PVT) to pulmonary embolism (PE) and deep vein thrombosis (DVT). Up to now there exist no recommendations for the duration and intensity of prophylactic anticoagulation, ...

journal_title：American journal of hematology

authors： Mohren M,Markmann I,Dworschak U,Franke A,Maas C,Mewes S,Weiss G,Jentsch-Ullrich K

更新日期：2004-06-01 00:00:00

abstract：:Dyskeratosis congenita (DC) is a rare inherited telomeropathy most frequently caused by mutations in a number of genes all thought to be involved in telomere maintenance. The main causes of mortality in DC are bone marrow failure as well as malignancies including leukemias and solid tumors. The clinical picture includ...

journal_title：American journal of hematology

authors： Perdigones N,Perin JC,Schiano I,Nicholas P,Biegel JA,Mason PJ,Babushok DV,Bessler M

更新日期：2016-12-01 00:00:00

abstract：:Most reports of prognosis and therapy in diffuse small non-cleaved cell lymphoma (DSNCL), an aggressive high-grade non-Hodgkin's lymphoma (NHL) which appears to be of two histopathologic subtypes, have included predominantly a pediatric population and very few adults. We studied 20 newly diagnosed, previously untreate...

journal_title：American journal of hematology

authors： Morrison VA,Frizzera G,Arthur DC,Ogle KM,Hurd DD,Bloomfield CD,Peterson BA

更新日期：1994-08-01 00:00:00

abstract：:We have studied telomere length in the bone marrow cells or the granulocyte and lymphocyte cell fractions of 54 patients with myelodysplastic syndromes (MDS) by Southern blot hybridization using the (TTAGGG)4 probe. The average telomere length expressed as the peak telomere repeat array (TRA) in the peripheral blood, ...

journal_title：American journal of hematology

authors： Boultwood J,Fidler C,Kusec R,Rack K,Elliott PJ,Atoyebi O,Chapman R,Oscier DG,Wainscoat JS

更新日期：1997-12-01 00:00:00

abstract：:Morbid obesity is a health problem that has been shown to be refractory to diet, exercise, and medical treatment. Surgeries designed to promote weight loss, termed bariatric surgery and typically involving a gastric bypass procedure, have recently been implemented to treat obesity with high success rates. However, lon...

journal_title：American journal of hematology

authors： Love AL,Billett HH

更新日期：2008-05-01 00:00:00

abstract：:We report a case of refractory anemia with excess blasts (RAEB) developing in a 67-year old man with a history of polycythemia vera; results of cytogenetic and immunophenotyping studies are described. In this report the clinical, cytogenetic and hematologic features of myelodysplasia complicating polycythemia vera are...

journal_title：American journal of hematology

authors： Shamdas GJ,Spier CM,List AF

更新日期：1991-05-01 00:00:00

abstract：:The value of menorrhagia as a predictor for mild bleeding disorders has been very little studied and the results are divergent. In the present study on 30 women with objectively verified menorrhagia, we found a significantly increased prevalence of von Willebrand's disease (20%). By keeping a strict sampling and labor...

journal_title：American journal of hematology

authors： Edlund M,Blombäck M,von Schoultz B,Andersson O

更新日期：1996-12-01 00:00:00

abstract：:Limited data are available regarding optimal treatment with desmopressin (DDAVP) or intermediate-purity FVIII concentrates rich in VWF (CFCs) in patients with von Willebrand disease (VWD) who undergo planned surgery. We undertook a retrospective review over 10 years (1988-1997) and identified 27 patients treated with ...

journal_title：American journal of hematology

authors： Nitu-Whalley IC,Griffioen A,Harrington C,Lee CA

更新日期：2001-04-01 00:00:00

abstract：:A 63-year-old white man with myasthenia gravis and red cell aplasia was found to have hepatic iron overload. The differential diagnosis included hereditary hemochromatosis and secondary iron overload related to red cell aplasia. Family studies of siblings, including HLA typing, initially suggested a diagnosis of secon...

journal_title：American journal of hematology

authors： Adams PC

更新日期：1994-03-01 00:00:00

abstract：:Neutrophils that bear receptors for the Fc portion of immunoglobulin G have been demonstrated to be more active in assays of adherence, aggregation, and chemotaxis compared to Fc receptor-negative cells. We examined the relationship of neutrophil Fc receptor activity and cell-cell adherence or aggregation induced by p...

journal_title：American journal of hematology

authors： Spagnuolo PJ,Fain M,Bass SN

更新日期：1987-11-01 00:00:00

abstract：:Central nervous system (CNS) thrombotic events are a well-known complication of acute lymphoblastic leukemia (ALL) induction therapy, especially with treatments including l-asparaginase (l-ASP). Data on risk factors and clinical evolution is still lacking in adult patients. We report on the clinical evolution of 22 CN...

journal_title：American journal of hematology

authors： Couturier MA,Huguet F,Chevallier P,Suarez F,Thomas X,Escoffre-Barbe M,Cacheux V,Pignon JM,Bonmati C,Sanhes L,Bories P,Daguindau E,Dorvaux V,Reman O,Frayfer J,Orvain C,Lhéritier V,Ifrah N,Dombret H,Hunault-Berger M,

更新日期：2015-11-01 00:00:00

abstract：:Two patients from two separate families were diagnosed as having type IIB von Willebrand disease, because they had lifelong bleeding tendencies, prolonged bleeding times, no large von Willebrand factor multimers, and low levels of ristocetin cofactor in plasma with heightened ristocetin-induced platelet aggregation. T...

journal_title：American journal of hematology

authors： Federici AB,Mannucci PM,Bader R,Lombardi R,Lattuada A

更新日期：1986-12-01 00:00:00

abstract：:A quantitative bioassay for serum erythropoietin in anemic patients was established with erythroid colony-forming technique using methyl cellulose. Fetal mouse liver contains many erythropoietin-dependent erythroid colony-forming cells (CFU-E) with the concentration as well as sensitivity to erythropoietin being the h...

journal_title：American journal of hematology

authors： Okamoto T,Kanamaru A,Hara H,Nagai K

更新日期：1982-04-01 00:00:00

abstract：:Sixty-two previously untreated patients with B-cell chronic lymphocytic leukaemia were analysed to study the prognostic value of both the immunologic phenotype and the clinicobiologic characteristics. Univariate studies showed that none of the immunological markers analysed, sheep-rosette, mouse-rosette, slg, and HLA/...

journal_title：American journal of hematology

authors： Orfao A,Gonzalez M,San Miguel JF,Rios A,Canizo MC,Hernandez J,Maricato ML,Lopez Borrasca A

更新日期：1989-05-01 00:00:00

abstract：:Although karyotypic abnormalities are well documented in B-cell chronic lymphocytic leukemia (B-CLL), few sequential cytogenetic studies have been done. In this study, peripheral blood lymphocytes from fifty-one patients with B-CLL were sequentially karyotyped over a mean interval of 13.8 months (range, one to 51 mont...

journal_title：American journal of hematology

authors： Finn WG,Kay NE,Kroft SH,Church S,Peterson LC

更新日期：1998-11-01 00:00:00

abstract：:Mast cell disease (MCD), a proliferation of mast cells (MC), is occasionally associated with hematologic malignancies. Neoplastic MC have activating c-kit mutations. c-kit is a receptor tyrosine kinase required for the development, proliferation, and survival of MC. Interaction of c-kit with its ligand stem cell facto...

journal_title：American journal of hematology

authors： Pullarkat VA,Pullarkat ST,Calverley DC,Brynes RK

更新日期：2000-12-01 00:00:00

abstract：:We retrospectively measured various hemostatic markers in 240 patients with disseminated intravascular coagulation (DIC) before the onset of DIC and in 110 non-DIC patients, and examined their usefulness for the diagnosis of pre-DIC. Changes in prothrombin time ratio and fibrinogen levels were not significant before t...

journal_title：American journal of hematology

authors： Wada H,Sakuragawa N,Mori Y,Takagi M,Nakasaki T,Shimura M,Hiyoyama K,Nisikawa M,Gabazza EC,Deguchi K,Kazama M,Shiku H

更新日期：1999-04-01 00:00:00

abstract：:We describe a 23-year-old retired military officer who was immunocompetent but diagnosed with hemophagocytic syndrome (HPS) by Plasmodium vivax infection. Initially, the patient was suspected to have toxic hepatitis related to heavy drinking. But abnormal hematologic findings required a further bone marrow examination...

journal_title：American journal of hematology

authors： Park TS,Oh SH,Choi JC,Kim HH,Chang CL,Son HC,Lee EY

更新日期：2003-10-01 00:00:00

abstract：:Intravenous (IV) granulocyte colony stimulating factor (G-CSF) might be safer and more convenient than subcutaneous (SC) administration to hospitalized hemato-oncological patients receiving chemotherapy. To compare IV vs. SC G-CSF administration, we conducted a randomized, open-label trial. We included inpatients rece...

journal_title：American journal of hematology

authors： Paul M,Ram R,Kugler E,Farbman L,Peck A,Leibovici L,Lahav M,Yeshurun M,Shpilberg O,Herscovici C,Wolach O,Itchaki G,Bar-Natan M,Vidal L,Gafter-Gvili A,Raanani P

更新日期：2014-03-01 00:00:00

abstract：:The content of peripheral blood B cells (B1+) was reduced in patients of multiple myeloma (MM) and not in those with benign monoclonal gammopathy (BMG) compared to normal donors (P less than 0.01). This observation correlated with the suppression of synthesis of normal immunoglobulin (Ig) in MM. Thus, cytokine activit...

journal_title：American journal of hematology

authors： Kawano M,Iwato K,Asaoku H,Tanabe O,Tanaka H,Ishikawa H,Kuramoto A

更新日期：1989-02-01 00:00:00