Abstract：
:Erythema migrans (EM) is the most common objective manifestation of Borrelia burgdorferi infection. Systemic symptoms are usually present. Most patients do not recall a preceding tick bite. Despite a characteristic appearance, EM is not pathognomonic for Lyme disease and must be distinguished from other similar appearing skin lesions. EM is a clinical diagnosis; serologic and PCR assays are unnecessary. Leukopenia and thrombocytopenia are indicative of either an alternative diagnosis, or coinfection with another tick-borne pathogen. When EM is promptly treated with appropriate antimicrobial agents, the prognosis is excellent. Persons in endemic areas should take measures to prevent tick bites.
journal_name
Infect Dis Clin North Amjournal_title
Infectious disease clinics of North Americaauthors
Nadelman RBdoi
10.1016/j.idc.2015.02.001subject
Has Abstractpub_date
2015-06-01 00:00:00pages
211-39issue
2eissn
0891-5520issn
1557-9824pii
S0891-5520(15)00015-Xjournal_volume
29pub_type
杂志文章,评审abstract：:This article updates the epidemiologic situation of HIV and AIDS infection and summarizes the most common clinical manifestations in Latin American countries. As of December 1992, a total of 59,723 AIDS cases had been reported to the Pan American Health Organization from Mexico, Central America, South America, and the...
journal_title：Infectious disease clinics of North America
pub_type： 杂志文章,评审
doi：
更新日期：1994-03-01 00:00:00
abstract：:Serum protein binding of antimicrobials can reduce antimicrobial activity, restrict tissue distribution, and delay drug elimination. Binding percentages of 80 per cent or more have the potential to significantly reduce free drug levels and affect therapeutic efficacy in patients. However, binding-induced alterations i...
journal_title：Infectious disease clinics of North America
pub_type： 杂志文章,评审
doi：
更新日期：1989-09-01 00:00:00
abstract：:Recent decades have witnessed the emergence and spread of parasites resistant to standard drug therapies, particularly malaria. Chloroquine-resistant Plasmodium falciparum has now spread to most malarial areas, and resistance to other antimalarial drugs, including mefloquine and sulfadoxine-pyrimethamine, have become ...
journal_title：Infectious disease clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/s0891-5520(05)70400-1
更新日期：1997-12-01 00:00:00
abstract：:Infection with the human immunodeficiency virus type 1 (HIV-1) results in progressive loss of immune function marked by depletion of the CD4+ T-lymphocytes, leading to opportunistic infections and malignancies characteristic of AIDS. Although both host and viral determinants influence the rate of disease progression, ...
journal_title：Infectious disease clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/s0891-5520(05)70135-5
更新日期：2000-12-01 00:00:00
abstract：:Tegumentary leishmaniases are caused by approximately 15 species of protozoa of the genus Leishmania. They prevail in tropical and subtropical areas of the Old and New World but human mobility also makes them a medical problem in nonendemic areas. Clinical manifestations may comprise cutaneous and mucocutaneous forms ...
journal_title：Infectious disease clinics of North America
pub_type： 杂志文章
doi：10.1016/j.idc.2012.03.001
更新日期：2012-06-01 00:00:00
abstract：:Although antimicrobial stewardship has been shown to improve microbiologic susceptibility patterns, decrease drug toxicities, and lower overall drug costs in the inpatient setting, there are few studies assessing programs in the long-term care (LTC) setting. Implementing antimicrobial stewardship programs in LTC setti...
journal_title：Infectious disease clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.idc.2014.01.001
更新日期：2014-06-01 00:00:00
abstract：:Ebola virus disease (EVD) is a deadly zoonotic disease caused by the Ebola virus. There is no specific treatment approved for EVD. Supportive care and management of complications are mainstays of treatment. Effective outbreak control requires a multidisciplinary team effort applying case management, infection preventi...
journal_title：Infectious disease clinics of North America
pub_type： 历史文章,杂志文章,评审
doi：10.1016/j.idc.2019.08.005
更新日期：2019-12-01 00:00:00
abstract：:In the ICU, fever can be expected to accompany an extensive number of conditions of both infectious and noninfectious etiologies. It is crucial to identify the precise cause of fever, because certain conditions in either category may be life-threatening, whereas others require no treatment at all. It is important to r...
journal_title：Infectious disease clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/s0891-5520(05)70294-4
更新日期：1996-03-01 00:00:00
abstract：:Water serves as a major reservoir for the environmental mycobacteria. Many cases of cutaneous mycobacterial disease result from water exposure. The current theory of the pathogenesis of M. avium complex lung disease involves inhalation of organisms aerosolized from surface water. Disseminated M. avium disease in AIDS ...
journal_title：Infectious disease clinics of North America
pub_type： 杂志文章,评审
doi：
更新日期：1987-09-01 00:00:00
abstract：:This article reviews the microbiology, pathogenesis, epidemiology, clinical manifestations, diagnostic tests, and recent advances in the therapy of protozoan and helminthic infections of the central nervous system, with more emphasis given to protozoan than to helminthic infections. ...
journal_title：Infectious disease clinics of North America
pub_type： 杂志文章,评审
doi：
更新日期：1990-12-01 00:00:00
abstract：:Global eradication of smallpox, elimination of poliomyelitis in the Western Hemisphere, and a 90% decrease in Haemophilus influenzae meningitis in the Western Hemisphere mark some of the achievements of immunization programs around the world. Yet many serious problems continue to exist, particularly in the developing ...
journal_title：Infectious disease clinics of North America
pub_type： 历史文章,杂志文章
doi：
更新日期：1995-06-01 00:00:00
abstract：:At the heart of imminent healthcare reform are the future physicians of this decade. Medical educators will want to stimulate a desire within students to practice humanitarian, cost-effective, community-oriented primary care. Further studies to examine the effects of medical student experiences in international electi...
journal_title：Infectious disease clinics of North America
pub_type： 杂志文章
doi：
更新日期：1995-06-01 00:00:00
abstract：:Antiviral agents aimed at treating HSV-2 chronically infected individuals have proven to be effective in the prevention of symptomatic genital herpes and the reduction of viral shedding. These agents play a key role in current HIV prevention trials that will assess the role of suppression of HSV-2 infection on the ris...
journal_title：Infectious disease clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.idc.2005.04.005
更新日期：2005-06-01 00:00:00
abstract：:A small number of bacterial agents, including enterotoxigenic Escherichia coli (ETEC), enteropathogenic E. coli (EPEC), Shigella and Vibrio cholerae 01 and one virus, rotavirus, combine to cause a major proportion of the diarrheal illness of public health importance worldwide. Salmonella typhi is by far the major caus...
journal_title：Infectious disease clinics of North America
pub_type： 杂志文章,评审
doi：
更新日期：1990-03-01 00:00:00
abstract：:The penicillins continue to be important antibiotics for the treatment and prophylaxis of many infectious diseases. The emergence of resistant microorganism has led to the development of newer penicillin compounds that have extended spectrums of antimicrobial activity. Beta-lactamase production by many pathogenic bact...
journal_title：Infectious disease clinics of North America
pub_type： 杂志文章,评审
doi：
更新日期：1989-09-01 00:00:00
abstract：:The approach to neurologic diagnosis and management of HIV-infected and AIDS patients follows that used in general neurologic practice but takes into account the altered probabilities of differential diagnosis in this group of patients. Clinical and neurodiagnostic evaluations, when pursued with a background understan...
journal_title：Infectious disease clinics of North America
pub_type： 杂志文章,评审
doi：
更新日期：1988-06-01 00:00:00
abstract：:Occupational transmission of hepatitis B virus (HBV), hepatitis C virus, and HIV has been documented. The risk for occupationally transmitted infection varies for these three viruses. Despite effective pre- and postexposure prophylaxis for HBV and recent recommendations for postexposure chemoprophylaxis after an HIV e...
journal_title：Infectious disease clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/s0891-5520(05)70359-7
更新日期：1997-06-01 00:00:00
abstract：:In this article, gynecologic conditions of increased importance in the HIV-infected woman are discussed. Women living with HIV may have an increase in menstrual disorders, lower genital tract neoplasias, gynecologic surgery, and sexually transmitted infections. The literature relevant to choosing a method of contracep...
journal_title：Infectious disease clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.idc.2008.05.006
更新日期：2008-12-01 00:00:00
abstract：:Infectious complications remain a major source of morbidity and mortality for patients with end-stage renal disease on dialysis. The majority of these complications are related to dialysis access devices, and as such represent a potentially modifiable risk factor. This article reviews the important infectious complica...
journal_title：Infectious disease clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.idc.2011.09.005
更新日期：2012-03-01 00:00:00
abstract：:Vaccination usually means the immunization of persons or animals against foreign infectious organisms for disease prevention. However, it has now been demonstrated that immunization against certain self substances to which tolerance normally exists can elicit beneficial effects to humans and other animals without indu...
journal_title：Infectious disease clinics of North America
pub_type： 杂志文章
doi：
更新日期：1990-06-01 00:00:00
abstract：:The returning traveler with fever presents a diagnostic challenge for the health care provider. When evaluating such a patient, the highest priority should be given to diseases that are potentially fatal or may represent public health threats. A good history is paramount and needs to include destination, time and dura...
journal_title：Infectious disease clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.idc.2007.08.005
更新日期：2007-12-01 00:00:00
abstract：:Improvements in donor selection, testing of donors for markers of infection, and viral inactivation of plasma-derived products have helped reduce the risk of transfusion-associated infections, including hepatitis B (HBV), hepatitis C (HCV), and human immunodeficiency viruses (HIV). The potential for transmission of em...
journal_title：Infectious disease clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/s0891-5520(05)70419-0
更新日期：1998-03-01 00:00:00
abstract：:Amebiasis is a widespread parasitic disease caused by Entamoeba histolytica. This protozoan organism is the third leading parasitic cause of death in the developing world and is an important health risk to travelers in endemic areas. Amebiasis most commonly results in asymptomatic colonization of the gastrointestinal ...
journal_title：Infectious disease clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/s0891-5520(05)70121-5
更新日期：2000-09-01 00:00:00
abstract：:A wide range of soft-tissue infections can occur in diabetic patients, the consequences of which can be devastating. Early recognition and intervention, which may involve both surgical and medical approaches, can improve clinical outcomes. ...
journal_title：Infectious disease clinics of North America
pub_type： 杂志文章,评审
doi：
更新日期：1995-03-01 00:00:00
abstract：:Successful antimicrobial stewardship programs rely on engagement with hospital administrators. Antimicrobial stewards should understand the unique pressures and demands of hospital and health system administration and be familiar with key terminology and regulatory requirements. This article provides guidance on strat...
journal_title：Infectious disease clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.idc.2019.10.003
更新日期：2020-03-01 00:00:00
abstract：:This article familiarizes the clinician with the principles of bacterial susceptibility testing and reporting to facilitate communication with the clinical microbiology laboratory. The emergence of resistance in nearly all commonly isolated bacterial organisms has highlighted the need for ongoing dialogue between the ...
journal_title：Infectious disease clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.idc.2004.04.001
更新日期：2004-09-01 00:00:00
abstract：:Mold infections carry a substantial clinical and economic burden in solid organ transplant (SOT) recipients with a high overall mortality of near 30%. The most important pathogens include Aspergillus, the Zygomycetes, Fusarium, Scedosporium/Pseudallescheria, and the dematiaceous (dark) molds. Risk factors for the infe...
journal_title：Infectious disease clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.idc.2018.04.006
更新日期：2018-09-01 00:00:00
abstract：:Bronchiolitis is a lower respiratory tract illness caused by viral infection in children 2 years of age and younger, frequently associated with wheezing on physical examination. It is a common cause of hospitalization, particularly in patients with risk factors for more serious disease. The diagnosis can be made based...
journal_title：Infectious disease clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.idc.2017.10.002
更新日期：2018-03-01 00:00:00
abstract：:Although a small number of infections in total joint replacements are blood borne from distant sources, most infections appear to have been derived at operation. Strenuous attempts to reduce this risk by cleaning the air in the wound environment, coupled with prophylactic antibiotics, have reduced infection rates by a...
journal_title：Infectious disease clinics of North America
pub_type： 杂志文章,评审
doi：
更新日期：1990-09-01 00:00:00
abstract：:The central nervous system and systemic complications of bacterial meningitis cause significant morbidity and mortality. This article offers insight into the clinical features, pathogenesis, and management of these complications. In many instances, the improved outcome of intervention is based on clinical suspicion an...
journal_title：Infectious disease clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/s0891-5520(05)70099-4
更新日期：1999-09-01 00:00:00
