Abstract:
:The cerebellum is historically considered to be involved in motor control and motor learning. However, it is also a site of multimodal sensory and sensory-motor integration, implicated in auditory processing. The flocculus and paraflocculus are small lobes of the cerebellum, in humans located in the cerebellopontine angle. The last two decades, both structures have been a subject of interest in hearing loss and tinnitus research. The current review summarizes insights on the auditory function of the (para)flocculus and its contribution to hearing loss and tinnitus. This leads to the hypothesis of a feedback loop between the paraflocculus and the auditory cortex. Disruption of this loop may be instrumental in both maintaining tinnitus and reducing tinnitus. Although the research mostly has been performed in animals, the implications in humans are also discussed. If the (para)flocculus indeed comprises an auditory function and is part of a tinnitus-mechanism, this would potentially open up new treatment options that involve direct intervention at the (para)flocculus.
journal_name
Hear Resjournal_title
Hearing researchauthors
Mennink LM,van Dijk JMC,van Dijk Pdoi
10.1016/j.heares.2020.108081subject
Has Abstractpub_date
2020-12-01 00:00:00pages
108081eissn
0378-5955issn
1878-5891pii
S0378-5955(20)30352-Xjournal_volume
398pub_type
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