Abstract:
:Severe damage to the organ of Corti leads to degeneration of the spiral ganglion cells (SGCs) which form the auditory nerve. This degeneration starts at the level of synaptic connection of the peripheral processes (PPs) of SGCs with the cochlear hair cells. It is generally thought that from this point SGC degeneration progresses in a retrograde fashion: PPs degenerate first, followed by the SGC soma with a delay of several weeks to many months. Evidence for this course of events, both in animals and in humans, is not unambiguous, while this knowledge is important since the presence or absence of the different neural elements may greatly influence the response to electrical stimulation with a cochlear implant (CI). We therefore aimed to provide a comprehensive account of the course of SGC degeneration in the guinea pig cochlea after ototoxic treatment. Histological analysis of eighteen healthy and thirty-three deafened cochleas showed that the degeneration of SGCs and their peripheral processes was simultaneous rather than sequential. As the site of excitation for electrical stimulation with a CI may depend on the course of degeneration of the various neural elements, this finding is relevant both for understanding the electrophysiological mechanisms behind cochlear implantation and for recent efforts to induce PP resprouting for improved electrode-neural interface. Since excitation of the PPs is often thought to result in (secondary) longer-latency activity, we tested the hypothesis that having relatively many PPs produces a larger N2 peak in the electrically evoked compound action potential (eCAP); the present findings however do not support this theory. The course of the degeneration process may vary among species, and may depend on the cause of deafness, but the present findings at least indicate that gradual retrograde degeneration of the auditory nerve is not an elemental process following severe damage to the organ of Corti.
journal_name
Hear Resjournal_title
Hearing researchauthors
Ramekers D,Klis SFL,Versnel Hdoi
10.1016/j.heares.2020.107928subject
Has Abstractpub_date
2020-05-01 00:00:00pages
107928eissn
0378-5955issn
1878-5891pii
S0378-5955(19)30074-7journal_volume
390pub_type
杂志文章相关文献
HEARING RESEARCH文献大全abstract::At the synapse between olivocochlear efferent fibers and outer hair cells (OHCs) of the cochlea, a non-classical ionotropic cholinergic receptor allows Ca(2+) entry into the hair cell, thus activating a Ca(2+)-sensitive K(+) current which hyperpolarizes the cell's membrane. In the mammalian ear, this leads to a reduct...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/s0378-5955(99)00214-2
更新日期:2000-03-01 00:00:00
abstract::The ability of auditory-nerve (AN) fibers to encode modulation frequencies, as characterized by temporal modulation transfer functions (TMTFs), generally shows a low-pass shape with a cut-off frequency that increases with fiber characteristic frequency (CF). Because AN-fiber bandwidth increases with CF, this result ha...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2012.02.004
更新日期:2012-04-01 00:00:00
abstract::Nitric oxide (NO) is a messenger molecule that mediates several physiological functions and pathological processes. Sodium nitroprusside (SNP), a potent vasodilator, when given clinically as an anti-hypertension agent, exerts its function by releasing NO. It was reported recently that SNP causes a loss of auditory ner...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/s0378-5955(96)00076-7
更新日期:1996-09-15 00:00:00
abstract::A cochlear frequency-place map was developed for adult chickens by labeling cochlear ganglion neurons with biocytin and correlating the location of each labeled fiber along the basilar papilla with the characteristic frequency of the unit's tuning curve. Labeled fibers showed little or no branching within the sensory ...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(94)90160-0
更新日期:1994-12-01 00:00:00
abstract::Regrowth of peripheral spiral ganglion neuron (SGN) fibers is a primary objective in efforts to improve cochlear implant outcomes and to potentially reinnervate regenerated hair cells. Cyclic adenosine monophosphate (cAMP) regulates neurite growth and guidance via activation of protein kinase A (PKA) and Exchange Prot...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2011.11.010
更新日期:2012-01-01 00:00:00
abstract::Two-tone suppression was studied in the auditory nerve fibers of anesthetized cats, using low-frequency suppressors (50-2000 Hz). The response to the characteristic-frequency (CF) tone was suppressed in a phase-specific manner, attaining one or two minimums in 1 cycle of the suppressor (SUP) tone. The suppression phas...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(96)00034-2
更新日期:1996-07-01 00:00:00
abstract::Cochlear implant users with ipsilateral residual hearing combine acoustic and electric hearing in one ear, this is called electric-acoustic stimulation (EAS). In EAS users, masking can be shown for electric probes in the presence of acoustic maskers and vice versa. Masking effects in acoustic hearing are generally att...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2019.107873
更新日期:2020-02-01 00:00:00
abstract::In previous studies describing the effects of electrically stimulating the olivocochlear bundle, it seems possible that both medial and lateral (MOC and LOC) efferents may have been stimulated. To selectively stimulate MOC efferents, we used an electrode placed at the origin of the MOC efferents in the brainstem (MOC ...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(88)90023-8
更新日期:1988-05-01 00:00:00
abstract::There is evidence that pentobarbital, a commonly used anesthetic, can affect neuronal activity, but its effects on particular neurons of the dorsal cochlear nucleus (DCN) are not well known. Bursting (complex spiking) spontaneous activity has been observed in the DCN in brain slice preparations and in recordings from ...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/s0378-5955(00)00188-x
更新日期:2000-11-01 00:00:00
abstract::Human behavioral thresholds for trains of biphasic pulses applied to a single channel of Nucleus CI24 and LAURA cochlear implants were measured as a function of inter-phase gap (IPG). Experiment 1 used bipolar stimulation, a 100-pps pulse rate, and a 400-ms stimulus duration. In one condition, the two phases of each p...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2005.03.021
更新日期:2005-07-01 00:00:00
abstract::The field L complex is thought to be the highest auditory centre and the input in the song vocal nuclei. Different anatomical and functional subdivisions have been described in field L. Auditory neurons of field L are well activated by natural sounds and especially by species-specific sounds. A complex sound coding ap...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2005.01.008
更新日期:2005-09-01 00:00:00
abstract::Extracellular adenosine has been suggested as a modulator of cochlear function. To date the release of adenosine into the extracellular spaces of the cochlea has not been demonstrated. Therefore, experiments were designed to examine whether adenosine release into perilymph could be detected in response to depolarizati...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2005.03.009
更新日期:2005-07-01 00:00:00
abstract::Efferent neurones within the intraganglionic spiral bundle of the guinea pig cochlea were characterized in terms of their response properties, and their pattern of termination within the receptor organ revealed by intracellular labelling with horseradish peroxidase. All neurones subsequently identified as efferent neu...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(85)90059-0
更新日期:1985-01-01 00:00:00
abstract::A novel immunocytochemical method was used to determine whether the sound-damaged adult quail ear can repair its tectorial membrane (TM) and to compare the repair in quail to that in chicks. Birds were exposed to an octave band noise with a center frequency of 1.5 kHz at 116 dB SPL for 4 h. The chicks were grouped bas...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(95)00051-5
更新日期:1995-06-01 00:00:00
abstract::We investigated the effects of intracochlear electrical stimulation (ICES) on auditory pathways of neonatal rat deafened by daily amikacin injections. Expression of mRNAs encoding ionotropic glutamate receptor subunits such as alpha-amino-3-hydroxy-5-methyl-4-isoxazole (AMPA) and N-methyl-D-aspartate (NMDA), and gamma...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/s0378-5955(00)00167-2
更新日期:2000-12-01 00:00:00
abstract::When auditory nerve function is lost due to surgical removal of bilateral acoustic tumors in cases of neurofibromatosis type 2, a sense of hearing may be restored by means of an auditory brainstem implant (ABI), which electrically stimulates the cochlear nucleus. Electrically evoked auditory brainstem responses record...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/s0378-5955(99)00016-7
更新日期:1999-04-01 00:00:00
abstract::Inner hair cells (IHCs) were isolated from the 3rd and 4th turn of the guinea-pig cochlea using a new microsurgical technique. Microelectrode impalements in vitro with conventional microelectrodes yielded intracellular potentials of -14 +/- 7 mV (mean +/- SD, N = 43) at 24 degrees C. This suggested depletion of intrac...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(90)90185-r
更新日期:1990-04-01 00:00:00
abstract::The tympanic membrane is a key component of the human auditory apparatus. Good estimates of tympanic membrane mechanical properties are important to obtain realistic models of middle ear mechanics. Current literature values are almost all derived from direct mechanical tests on cut-out strips. For a biomedical specime...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2012.05.001
更新日期:2012-08-01 00:00:00
abstract::This study introduces and evaluates a method for measurement of the longitudinal spread of electrically evoked neural excitation in the cochlea, using the Neural Response Telemetry system (NRT) available with the Nucleus((R)) 24 cochlear implant system. The recently released version of the NRT software (version 3.0) e...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/s0378-5955(03)00096-0
更新日期:2003-05-01 00:00:00
abstract::Studies in several mammalian species have demonstrated that auditory cortical neurons respond strongly to single frequency-modulated (FM) sweeps, and that most responses are selective for sweep direction and/or rate. In the present study, we used extracellular recordings to examine how neurons in the auditory cortices...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/s0378-5955(01)00339-2
更新日期:2001-10-01 00:00:00
abstract::The electrically evoked compound action potential (CAP) of the auditory nerve exhibits two peaks, termed N0, at 350 microseconds latency, and N1, at 550 microseconds latency. At low stimulus intensities the CAP consists solely of the long latency N1 peak. As the stimulus strength is increased the higher threshold N0 a...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(84)90051-0
更新日期:1984-06-01 00:00:00
abstract::The distribution of S-100-like immunoreactivity in mouse and hamster auditory and vestibular end organs was determined by the use of immunohistochemistry. Within the organ of Corti, the cytoplasm of cells of Deiter and Hensen were strongly immunoreactive. Inner hair cells and the peripheral processes and cell bodies o...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(94)90176-7
更新日期:1994-04-01 00:00:00
abstract::The waveforms of the auditory evoked magnetic field in normal-hearing individuals and patients suffering from tinnitus are distinctly different. In tinnitus patients, the magnetic wave M200 (corresponding to the electric wave P200, or P2) is delayed and only poorly developed or even completely missing, while the ampli...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(89)90028-2
更新日期:1989-02-01 00:00:00
abstract::Left ear noise-induced hearing losses are dominant in the army. The common explanation is the asymmetrical effect of the shooting posture. However, firm evidence to support this possibility is still lacking. In the French army shooters, eye preference rather than hand preference for shooting determines the side of sho...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/s0378-5955(98)00104-x
更新日期:1998-08-01 00:00:00
abstract::The inner ear contains receptor cells that oscillate spontaneously, generating waves that propagate backward in the cochlea, ultimately causing sound to be radiated into the ear canal--the spontaneous otoacoustic emissions (SOAEs). Except in rare conditions, these internally generated signals appear to go unheard. The...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/s0378-5955(02)00388-x
更新日期:2002-09-01 00:00:00
abstract::Certain hair cells of fish exhibit strong immunoreactivity to an S-100 antibody. By their spatial locations in the utricle and saccule, these hair cells appear to possess a relatively short kinocilium and a roughly ovoid cell shape. In the utricle, these cells are predominantly located in the striola. In the saccule, ...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(90)90171-k
更新日期:1990-08-01 00:00:00
abstract::Spiral ganglion cell (SGC) degeneration following hair cell loss can be prevented by administration of exogenous neurotrophic factors. Many of these neurotrophic factors, in particular the neurotrophins brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3), have been described to be involved in the develo...
journal_title:Hearing research
pub_type: 杂志文章,评审
doi:10.1016/j.heares.2012.03.002
更新日期:2012-06-01 00:00:00
abstract::Several studies have reported an increased incidence of auditory dysfunction among HIV/AIDS patients. We used auditory HEI-OC1 cells in cell viability, flow cytometry and caspases 3/7-activation studies to investigate the potential ototoxicity of fourteen HIV antiretroviral agents: Abacavir, AZT, Delavirdine, Didenosi...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2014.01.005
更新日期:2014-04-01 00:00:00
abstract::Noise, hearing loss, and electronic signal distortion, which are common problems in military environments, can impair speech intelligibility and thereby jeopardize mission success. The current study investigated the impact that impaired communication has on operational performance in a command and control environment ...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2016.10.007
更新日期:2017-06-01 00:00:00
abstract::Averaged auditory evoked potentials (AEPs) to bilaterally presented 100 Hz click trains were recorded from multiple sites simultaneously within Heschl's gyrus (HG) and on the posterolateral surface of the superior temporal gyrus (STG) in epilepsy-surgery patients. Three auditory fields were identified based on AEP wav...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2007.11.012
更新日期:2008-04-01 00:00:00