Approaches for the study of epigenetic modifications in the inner ear and related tissues.

abstract：:Cochlear implant insertion should be as least traumatic as possible in order to reduce trauma to the cochlear sensory structures. The force applied to the cochlea during array insertion should be controlled to limit insertion-related damage. The relationship between insertion force and histological traumatism remains ...

journal_title：Hearing research

authors： De Seta D,Torres R,Russo FY,Ferrary E,Kazmitcheff G,Heymann D,Amiaud J,Sterkers O,Bernardeschi D,Nguyen Y

更新日期：2017-02-01 00:00:00

abstract：:Tympanosclerosis is a condition leading to a calcification process in the middle ear, and often develops after chronic inflammation of the middle ear. Since osteopontin (OPN) has been shown to participate in the pathological calcification, we here investigated whether OPN is involved in the process of calcification in...

journal_title：Hearing research

authors： Makiishi-Shimobayashi C,Tsujimura T,Sugihara A,Iwasaki T,Yamada N,Terada N,Sakagami M

更新日期：2001-03-01 00:00:00

abstract：:Normal-hearing listeners can perceptually segregate concurrent sound sources, but listeners with significant hearing loss or who wear a cochlear implant (CI) lag behind in this ability. Perceptual grouping mechanisms are essential to segregate concurrent sound sources and affect comodulation masking release (CMR). Thu...

journal_title：Hearing research

authors： Zirn S,Hempel JM,Schuster M,Hemmert W

更新日期：2013-02-01 00:00:00

abstract：UNLABELLED:This study sought to characterize the response of mammalian primary otolithic neurons to sound and vibration by measuring the resting discharge rates, thresholds for increases in firing rate and supra-threshold sensitivity functions of guinea pig single primary utricular and saccular afferents. Neurons with ...

journal_title：Hearing research

authors： Curthoys IS,Vulovic V,Burgess AM,Sokolic L,Goonetilleke SC

更新日期：2016-01-01 00:00:00

abstract：:Cochlear implant performance in difficult listening situations is limited by channel interactions. It is known that partial tripolar (PTP) stimulation reduces the spread of excitation (SOE). However, the greater the degree of current focusing, the greater the absolute current required to maintain a fixed loudness. As ...

journal_title：Hearing research

authors： Landsberger DM,Padilla M,Srinivasan AG

更新日期：2012-02-01 00:00:00

abstract：:Three budgerigars and three zebra finches were tested for their ability to detect sinusoidal stimuli in the presence of broadband noise. Masked thresholds for 1, 2, and 4 KHz pure tones were measured with a fixed frequency condition, in which only one test frequency was presented in a session, and with an uncertain fr...

journal_title：Hearing research

authors： Okanoya K,Dooling RJ

更新日期：1990-12-01 00:00:00

abstract：:In recent years, new designs of cochlear implant electrodes have been introduced in an attempt to improve efficiency and performance by locating stimulation sites closer to spiral ganglion neurons and deeper into the scala tympani. The goal of this study was to document insertion depth, intracochlear position and inse...

journal_title：Hearing research

authors： Wardrop P,Whinney D,Rebscher SJ,Roland JT Jr,Luxford W,Leake PA

更新日期：2005-05-01 00:00:00

abstract：:In cases of sudden, reversible hearing loss where perilymphatic fistulas are thought to be the cause, a multitude of causes have been postulated. These include perilymphatic pressure changes, Simmons' double-break theory, perilymphatic hemorrhage, pneumolabyrinth, and others. This study was proposed to explore the rol...

journal_title：Hearing research

authors： Foster PK,Luebke AE

更新日期：2002-05-01 00:00:00

abstract：:Auditory brainstem responses (ABR) from ten normal (3 males, 7 females) and ten environmentally sound deprived CBA/J mice (6 males, 4 females) were elicited by 30 dB HL click stimuli delivered via specially constructed, matched insert earphones. The mice were tested at 44-49 days of age under chloral hydrate sedation ...

journal_title：Hearing research

authors： Evans WJ,Webster DB,Cullen JK Jr

更新日期：1983-06-01 00:00:00

abstract：:In this paper, research on the temporal and spatial distribution of cholinergic-related molecules in the lower auditory brainstem, with an emphasis on nicotinic acetylcholine receptors (nAChRs), is reviewed. The possible functions of acetylcholine (ACh) in driving selective auditory neurons before the onset of hearing...

journal_title：Hearing research

authors： Morley BJ

更新日期：2005-08-01 00:00:00

abstract：:Syndromic hearing loss accounts for approximately 30% of all cases of hearing loss due to genetic causes. Mutation screening in known genes is important because it potentially sheds light on the genetic etiology of hearing loss and helps in genetic counseling of families. In this study, we describe a customized Ion Am...

journal_title：Hearing research

authors： Soares de Lima Y,Chiabai M,Shen J,Córdoba MS,Versiani BR,Benício ROA,Pogue R,Mingroni-Netto RC,Lezirovitz K,Pic-Taylor A,Mazzeu JF,Oliveira SF

更新日期：2018-12-01 00:00:00

abstract：:Older adults are often reported in the literature to have greater difficulty than younger adults understanding speech in noise [Helfer and Wilber (1988). J. Acoust. Soc. Am, 859-893]. The poorer performance of older adults has been attributed to a general deterioration of cognitive processing, deterioration of cochlea...

journal_title：Hearing research

authors： Gilbertson L,Lutfi RA

更新日期：2014-11-01 00:00:00

abstract：:A novel immunocytochemical method was used to determine whether the sound-damaged adult quail ear can repair its tectorial membrane (TM) and to compare the repair in quail to that in chicks. Birds were exposed to an octave band noise with a center frequency of 1.5 kHz at 116 dB SPL for 4 h. The chicks were grouped bas...

journal_title：Hearing research

authors： Adler HJ,Niemiec AJ,Moody DB,Raphael Y

更新日期：1995-06-01 00:00:00

abstract：:In our companion paper (Le Calvez et al., 1998), the levels of distortion product otoacoustic emissions (DPOAE) were collected in the ears of CD1 mice with progressive degeneration of cochlear outer hair cells (OHC). Their comparison to standard functional measurements such as auditory-evoked brainstem responses (ABR)...

journal_title：Hearing research

authors： Le Calvez S,Guilhaume A,Romand R,Aran JM,Avan P

更新日期：1998-06-01 00:00:00

abstract：:Tinnitus is most often initiated by modality specific otopathologic disturbances affecting peripheral and central auditory pathways. However, there is growing evidence indicating that the anatomical location generating tinnitus occurs at sites different from the initial pathology. Support for this notion is found in i...

journal_title：Hearing research

authors： Cacace AT

更新日期：2003-01-01 00:00:00

abstract：:We obtained just-noticeable differences (jnds) for the intensity of pure tones following a forward masker. The masker was a 100-ms burst of narrow-band noise centered at 1000 Hz presented at 90 dB SPL; the pure-tone signal was at 1000 Hz and was 25 ms in duration. The masker-signal delay was 100 ms. Under these condit...

journal_title：Hearing research

authors： Zeng FG,Turner CW,Relkin EM

更新日期：1991-10-01 00:00:00

abstract：:The effect of glutathione co-therapy on the expression of gentamicin ototoxicity was tested in pigmented guinea pigs. The first group of animals was injected with gentamicin (100 mg/kg body weight/day) for two weeks followed by 10 weeks of rest. A second group received glutathione by gastric gavage immediately prior t...

journal_title：Hearing research

authors： Garetz SL,Altschuler RA,Schacht J

更新日期：1994-06-15 00:00:00

abstract：:There is increasing evidence to suggest that free radical generation is central to a variety of pathological processes, including drug toxicity. Studies demonstrating the ability of gentamicin to facilitate the generation of radical species suggest that this process plays an important role in aminoglycoside-induced ot...

journal_title：Hearing research

authors： Conlon BJ,Smith DW

更新日期：1998-01-01 00:00:00

abstract：:Inhibition of sodium/potassium pumping by isolated goldfish hair cells led to a rapid gain of sodium and loss of potassium. Half-times for turnover were about 10 min, among the fastest of any cell type examined by electron-probe analysis. Pumping was inhibited by removal of extracellular potassium or by treatment with...

journal_title：Hearing research

authors： Mroz EA,Nissim KR,Lechene C

更新日期：1993-10-01 00:00:00

abstract：:In natural environments, temporally complex signals often occur in a background of noise. The neural mechanisms underlying the preservation of temporal sensitivity in background noise are poorly understood. In the present study, we examined the ability of inferior colliculus (IC) units with primary-like and sustained ...

journal_title：Hearing research

authors： Barsz K,Wilson WW,Walton JP

更新日期：2000-12-01 00:00:00

abstract：:Electrical stimulation of the cochlea is known to cause auditory sensations in humans and other animals. It also has been shown to produce emissions of sound from the inner ear. In the current study we investigate the relationship between electrically induced motion of the basilar membrane (BM) and the production of o...

journal_title：Hearing research

authors： Nuttall AL,Ren T

更新日期：1995-12-01 00:00:00

abstract：:Exposure of the auditory system to either continuous or interrupted nontraumatic noises, often collectively referred to as priming exposures, has been shown, in a number of experimental paradigms, to reduce the susceptibility of the auditory system to noise-induced hearing and sensory cell loss from a subsequent traum...

journal_title：Hearing research

authors： Hamernik RP,Ahroon WA

更新日期：1999-11-01 00:00:00

abstract：:The spontaneous fluctuations of the intracellular voltage and the position of the sensory hairbundle were measured concurrently using intracellular microelectrodes and an optical differential micro interferometer. Magnitude and frequency distribution of the hair bundles' spontaneous motion suggest that it consists mos...

journal_title：Hearing research

authors： Denk W,Webb WW

更新日期：1992-06-01 00:00:00

abstract：:The f2-f1 distortion product otoacoustic emission (DPOAE) can be observed to undergo gradual alterations in amplitude during continuous ipsilateral stimulation with primary tones. In the present experiments, we characterized the dependence of these amplitude alterations on several stimulus variables (intensity, durati...

journal_title：Hearing research

authors： Kujawa SG,Fallon M,Bobbin RP

更新日期：1995-05-01 00:00:00

abstract：:Frequency and impulse responses were determined for isolated guinea pig outer hair cells by electrically stimulating the cells between two wire electrodes with white noise. Cells were attached to the bottom of a small culture dish at one end while the other end was freely moving. Results have the character of a damped...

journal_title：Hearing research

authors： Wit HP,van Dijk P,Segenhout HM

更新日期：1996-09-01 00:00:00

abstract：:The radial width of three rows of cuticular plates of outer hair cells (width of the OHC triad), the distribution of inner hair cells along the organ of Corti, and postnatal maturation of the middle ear were examined in rats of the Srague-Dawley and Lewis strains aged 0-24 days and two months. The width of the OHC tri...

journal_title：Hearing research

authors： Burda H

更新日期：1985-03-01 00:00:00

abstract：:Extracellular adenosine has been suggested as a modulator of cochlear function. To date the release of adenosine into the extracellular spaces of the cochlea has not been demonstrated. Therefore, experiments were designed to examine whether adenosine release into perilymph could be detected in response to depolarizati...

journal_title：Hearing research

authors： Bobbin RP,Bledsoe SC Jr

更新日期：2005-07-01 00:00:00

abstract：:The present study measured interference-response areas (IRAs) for distortion-product otoacoustic emissions (DPOAEs) at 2f(1)-f(2), 3f(1)-2f(2), and 2f(2)-f(1). The IRAs were obtained in either awake or anesthetized rabbits, or in anesthetized guinea pigs and mice, by sweeping the frequencies and levels of an interfere...

journal_title：Hearing research

authors： Martin GK,Stagner BB,Jassir D,Telischi FF,Lonsbury-Martin BL

更新日期：1999-10-01 00:00:00

abstract：:The barn owl (Tyto alba) uses interaural level difference (ILD) as a cue for the localization of sound. The first site of binaural convergence in the pathway that processes ILD is the ventral lateral lemniscus pars posterior (VLVp). Neurons in VLVp receive excitatory input from the contralateral nucleus angularis, and...

journal_title：Hearing research

authors： Peddicord R

更新日期：1998-09-01 00:00:00

abstract：:Recently, ocular vestibular evoked myogenic potentials (oVEMPs) have been described and added to the neuro-otologic test battery as a new measure for the vestibulo-ocular reflex. oVEMPs represent extraocular muscle activity in response to otolith stimulation e.g. by air-conducted sound or bone-conducted vibration. In ...

journal_title：Hearing research

authors： Kantner C,Gürkov R

更新日期：2012-12-01 00:00:00