Rapid resting ion fluxes in goldfish hair cells are balanced by (Na+,K+)-ATPase.

Abstract:

:Inhibition of sodium/potassium pumping by isolated goldfish hair cells led to a rapid gain of sodium and loss of potassium. Half-times for turnover were about 10 min, among the fastest of any cell type examined by electron-probe analysis. Pumping was inhibited by removal of extracellular potassium or by treatment with 1 mM ouabain, as expected of a classical (Na+,K+)-ATPase. The initial rate of entry of sodium after inhibition, about 4 mM/min, provided an estimate of resting sodium-entry and sodium-pumping rates. After return to control medium, cells loaded with sodium by removal of extracellular potassium could recover their normal high-potassium/low-sodium status. The initial rate of recovery (an estimate of the cells' maximum sodium-pumping rate) was sufficient to lower cell sodium by 10 mM/min. This functional estimate of hair-cell (Na+,K+)-ATPase activity was of the same order of magnitude as the biochemical activity of (Na+,K+)-ATPase previously reported for sensory epithelia of other species. The balance between sodium entry and sodium pumping determines hair-cell ionic composition, and thus the resting potential and the driving forces for sodium-coupled transport processes. Imbalance due to excess sodium entry or loss of pump capacity could have significant consequences for hair-cell function and integrity.

journal_name

Hear Res

journal_title

Hearing research

authors

Mroz EA,Nissim KR,Lechene C

doi

10.1016/0378-5955(93)90049-7

subject

Has Abstract

pub_date

1993-10-01 00:00:00

pages

22-30

issue

1

eissn

0378-5955

issn

1878-5891

pii

0378-5955(93)90049-7

journal_volume

70

pub_type

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