Suppression and enhancement of distortion-product otoacoustic emissions by interference tones above f(2). I. Basic findings in rabbits.

Abstract:

:The present study measured interference-response areas (IRAs) for distortion-product otoacoustic emissions (DPOAEs) at 2f(1)-f(2), 3f(1)-2f(2), and 2f(2)-f(1). The IRAs were obtained in either awake or anesthetized rabbits, or in anesthetized guinea pigs and mice, by sweeping the frequencies and levels of an interference tone (IT) around a set of f(1) and f(2) primary tones, at several fixed frequencies and levels, while plotting the effects of the IT on DPOAE level. An unexpected outcome was the occurrence of regions of suppression and/or enhancement of DPOAE level when the IT was at a frequency slightly less than to more than an octave above f(2). The IRA of the 2f(1)-f(2) DPOAE typically displayed a high-frequency (HF) lobe of suppression, while the 2f(2)-f(1) emission often exhibited considerable amounts of enhancement. Moreover, for the 2f(2)-f(1) DPOAE, when enhancement was absent, its IRA usually tuned to a region above f(2). Whether or not suppression/enhancement was observed depended upon primary-tone level and frequency separation, as well as on the relative levels of the two primaries. Various physiological manipulations involving anesthesia, eighth-nerve section, diuretic administration, or pure-tone overstimulation showed that these phenomena were of cochlear origin, and were not dependent upon the acoustic reflex or cochlear-efferent activity. The aftereffects of applying diuretics or over-exposures revealed that suppression/enhancement required the presence of sensitive, low-level DPOAE-generator sources. Additionally, suppression/enhancement were general effects in that, in addition to rabbits, they were also observed in mice and guinea pigs. Further, corresponding plots of DPOAE phase often revealed areas of differing phase change in the vicinity of the primary tones as compared to regions above f(2). These findings, along with the effects of tonal exposures designed to fatigue regions above f(2), and instances in which DPOAE level was dependent upon the amount of suppression/enhancement, suggested that the interactions of two DPOAE-generator sources contributed, in some manner, to these phenomena.

journal_name

Hear Res

journal_title

Hearing research

authors

Martin GK,Stagner BB,Jassir D,Telischi FF,Lonsbury-Martin BL

doi

10.1016/s0378-5955(99)00119-7

keywords:

subject

Has Abstract

pub_date

1999-10-01 00:00:00

pages

105-23

issue

1-2

eissn

0378-5955

issn

1878-5891

pii

S0378-5955(99)00119-7

journal_volume

136

pub_type

杂志文章
  • Long-term observations on the reversibility of cochlear dysfunction after transient ischemia.

    abstract::To examine the reversibility of functional damage to the cochlea after transient ischemia, cochlear ischemia of 0-60 min was induced in 34 albino guinea pigs. Thresholds of auditory brainstem response (ABR) were then followed for 5 days after ischemia. Although the ABR threshold returned to almost the pre-ischemic val...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/s0378-5955(02)00299-x

    authors: Tsuji S,Tabuchi K,Hara A,Kusakari J

    更新日期:2002-04-01 00:00:00

  • Detection of acoustic temporal fine structure by cochlear implant listeners: behavioral results and computational modeling.

    abstract::A test of within-channel detection of acoustic temporal fine structure (aTFS) cues is presented. Eight cochlear implant listeners (CI) were asked to discriminate between two Schroeder-phase (SP) complexes using a two-alternative, forced-choice task. Because differences between the acoustic stimuli are primarily constr...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/j.heares.2013.01.004

    authors: Imennov NS,Won JH,Drennan WR,Jameyson E,Rubinstein JT

    更新日期:2013-04-01 00:00:00

  • Ototoxicity of sodium nitroprusside.

    abstract::Nitric oxide (NO) not only has normal physiological roles like vasodilation and neurotransmission in the living organism, it could also have possible neurodestructive effects under certain pathological conditions. The present study aimed to determine whether direct exposure of guinea pig cochlea to a NO donor like sod...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/s0378-5955(97)00159-7

    authors: Ruan RS,Leong SK,Yeoh KH

    更新日期:1997-12-01 00:00:00

  • Mineralocorticoid type I receptor in the rat cochlea: mRNA identification by polymerase chain reaction (PCR) and in situ hybridization.

    abstract::Expression of mineralocorticoid type I receptor (MR) gene in the rat cochlea was determined using molecular biological techniques. We synthesized complementary DNA (cDNA) from rat cochlear total RNA and then amplified MR cDNA fragments by polymerase chain reaction (PCR). The amplified cDNA fragments were subcloned int...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/0378-5955(94)90023-x

    authors: Furuta H,Mori N,Sato C,Hoshikawa H,Sakai S,Iwakura S,Doi K

    更新日期:1994-08-01 00:00:00

  • Aging alters the perception and physiological representation of frequency: evidence from human frequency-following response recordings.

    abstract::Older adults, even with clinically normal hearing sensitivity, have auditory perceptual deficits relative to their younger counterparts. This difficulty may in part, be related to a decline in the neural representation of frequency. The purpose of this study was to examine the effect of age on behavioral and physiolog...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/j.heares.2009.11.010

    authors: Clinard CG,Tremblay KL,Krishnan AR

    更新日期:2010-06-01 00:00:00

  • Modelling the effect of round window stiffness on residual hearing after cochlear implantation.

    abstract::Preservation of residual hearing after cochlear implantation is now considered an important goal of surgery. However, studies indicate an average post-operative hearing loss of around 20 dB at low frequencies. One factor which may contribute to post-operative hearing loss, but which has received little attention in th...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/j.heares.2016.08.006

    authors: Elliott SJ,Ni G,Verschuur CA

    更新日期:2016-11-01 00:00:00

  • Masculinization of the mammalian cochlea.

    abstract::Otoacoustic emissions (OAEs) differ between the sexes in humans, rhesus and marmoset monkeys, and sheep. OAEs also are different in a number of special populations of humans. Those basic findings are reviewed and discussed in the context of possible prenatal-androgen effects on the auditory system. A parsimonious expl...

    journal_title:Hearing research

    pub_type: 杂志文章,评审

    doi:10.1016/j.heares.2009.01.002

    authors: McFadden D

    更新日期:2009-06-01 00:00:00

  • The influence of postoperative tissue formation on sound transmission after stapes surgery.

    abstract::In the surgical treatment of otosclerosis, the coupling between the stapes prosthesis and the long process of the incus is critical. After surgery, connective tissue and mucosa may grow over the coupling area and thereby influence the sound transmission properties of the incus-prosthesis interface. It was the hypothes...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/j.heares.2009.08.012

    authors: Sim JH,Chatzimichalis M,Huber AM

    更新日期:2010-05-01 00:00:00

  • Hair-bundle stiffness dominates the elastic reactance to otolithic-membrane shear.

    abstract::Efficient transduction by acousticolateralis organs requires that a stimulus force principally deflect hair bundles, rather than flex other structural elements. Hair bundles might therefore be expected to provide a large fraction of the impedence to shear motions of otolithic membranes and other accessory structures. ...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/0378-5955(93)90128-n

    authors: Benser ME,Issa NP,Hudspeth AJ

    更新日期:1993-08-01 00:00:00

  • Physiology of cochlear efferent and afferent neurons: direct comparisons in the same animal.

    abstract::Exposure of the vestibulo-cochlear anastomosis in the cat allows single-unit recording of afferent fibers originating from inner hair cells and olivocochlear efferent fibers to the outer hair cells. Comparison of data obtained from individual animals show similarities in absolute threshold and dynamic range between th...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/0378-5955(88)90105-0

    authors: Liberman MC

    更新日期:1988-07-15 00:00:00

  • Utricular otoconia of some amphibians have calcitic morphology.

    abstract::This report concerns the morphological features of otoconia removed from the inner ear of four amphibian species. Results from scanning electron microscopic examination are compared based on the site of origin. These results show that utricular otoconia have a mineral structure that mimics calcite, rather than the wid...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/0378-5955(93)90246-w

    authors: Pote KG,Ross MD

    更新日期:1993-05-01 00:00:00

  • The isolated in vitro perfused spiral modiolar artery: pressure dependence of vasoconstriction.

    abstract::We developed a new technique, the isolated in vitro perfused spiral modiolar artery, which allowed the continuous measurement of the vascular diameter and control of the intravascular pressure. An isolated section of the spiral modiolar artery from the gerbil was perfused on one end with a set of concentric pipettes a...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/s0378-5955(97)00184-6

    authors: Wangemann P,Gruber DD

    更新日期:1998-01-01 00:00:00

  • Qualitative assessment of postnatal maturation of the organ of Corti in two rat strains.

    abstract::The radial width of three rows of cuticular plates of outer hair cells (width of the OHC triad), the distribution of inner hair cells along the organ of Corti, and postnatal maturation of the middle ear were examined in rats of the Srague-Dawley and Lewis strains aged 0-24 days and two months. The width of the OHC tri...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/0378-5955(85)90064-4

    authors: Burda H

    更新日期:1985-03-01 00:00:00

  • Age-related shifts in distortion product otoacoustic emissions peak-ratios and amplitude modulation spectra.

    abstract::Amplitude modulation (AM) is an important temporal cue for precise speech and complex sound recognition. However, functional decline of the auditory periphery as well as degradation of central auditory processing due to aging can reduce the salience and resolution of temporal cues. Age-related deficits in central temp...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/j.heares.2015.07.017

    authors: Lai J,Bartlett EL

    更新日期:2015-09-01 00:00:00

  • S-100 immunoreactivity identifies a subset of hair cells in the utricle and saccule of a fish.

    abstract::Certain hair cells of fish exhibit strong immunoreactivity to an S-100 antibody. By their spatial locations in the utricle and saccule, these hair cells appear to possess a relatively short kinocilium and a roughly ovoid cell shape. In the utricle, these cells are predominantly located in the striola. In the saccule, ...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/0378-5955(90)90171-k

    authors: Saidel WM,Presson JC,Chang JS

    更新日期:1990-08-01 00:00:00

  • A role for chloride in the hyperpolarizing effect of acetylcholine in isolated frog vestibular hair cells.

    abstract::Acetylcholine (ACh) is the dominant transmitter released from inner ear efferent neurons. In frog vestibular organs, these efferent neurons synapse exclusively with type II hair cells. Hair cells isolated from the frog saccule hyperpolarize following the application of 50 microM ACh, thereby demonstrating the presence...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/s0378-5955(00)00092-7

    authors: Holt JC,Pantoja AM,Athas GB,Guth PS

    更新日期:2000-08-01 00:00:00

  • Masking by harmonic complexes in birds: behavioral thresholds and cochlear responses.

    abstract::Thresholds for pure tones embedded in harmonic complexes were measured behaviorally and physiologically for three species of birds, and physiologically in gerbils. The harmonic maskers were generated using the Schroeder-phase algorithm, characterized by monotonically increasing or decreasing phase across frequency. Pr...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/s0378-5955(00)00249-5

    authors: Dooling RJ,Dent ML,Leek MR,Gleich O

    更新日期:2001-02-01 00:00:00

  • Frequency selectivity in macaque monkeys measured using a notched-noise method.

    abstract::The auditory system is thought to process complex sounds through overlapping bandpass filters. Frequency selectivity as estimated by auditory filters has been well quantified in humans and other mammalian species using behavioral and physiological methodologies, but little work has been done to examine frequency selec...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/j.heares.2017.11.012

    authors: Burton JA,Dylla ME,Ramachandran R

    更新日期:2018-01-01 00:00:00

  • A possible role for a paralemniscal auditory pathway in the coding of slow temporal information.

    abstract::Low-frequency temporal information present in speech is critical for normal perception, however the neural mechanism underlying the differentiation of slow rates in acoustic signals is not known. Data from the rat trigeminal system suggest that the paralemniscal pathway may be specifically tuned to code low-frequency ...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/j.heares.2010.10.009

    authors: Abrams DA,Nicol T,Zecker S,Kraus N

    更新日期:2011-02-01 00:00:00

  • Down-regulation of otospiralin mRNA in response to acoustic stress in guinea pig.

    abstract::Noise over-stimulation will induce or influence molecular pathways in the cochlea; one approach to the identification of the components of these pathways in the cochlea is to examine genes and proteins that change following different types and levels of stress. Quantitative reverse transcription polymerase chain react...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/j.heares.2004.07.011

    authors: Caravelli A,Pianese L,Saulino C,Di Leva F,Sequino L,Cocozza S,Marciano E,Franzé A

    更新日期:2004-12-01 00:00:00

  • Tonotopic mapping in auditory cortex of the chinchilla.

    abstract::Using single-unit electrophysiological methods we have mapped sound frequency (or cochleotopic) representation in the auditory cortex of the chinchilla. We describe the surgical approach to expose this area. We report on maps from six subjects and note a considerable variation in shape between individuals. In general,...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/0378-5955(96)00120-7

    authors: Harrison RV,Kakigi A,Hirakawa H,Harel N,Mount RJ

    更新日期:1996-10-01 00:00:00

  • Brain dynamics encode the spectrotemporal boundaries of auditory objects.

    abstract::Perception of objects in the scene around us is effortless and intuitive, yet entails profound computational challenges. Progress has been made in understanding some mechanisms by which the brain encodes the boundaries and surfaces of visual objects. However, in the auditory domain, these mechanisms are poorly underst...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/j.heares.2013.06.009

    authors: McMullan AR,Hambrook DA,Tata MS

    更新日期:2013-10-01 00:00:00

  • Columnar organization and reciprocity of commissural connections in cat primary auditory cortex (AI).

    abstract::The laminar distribution and reciprocity of commissural axon terminals and cells of origin in cat primary auditory cortex (AI) were studied after injections of tritiated proline combined with horseradish peroxidase in the middle ectosylvian gyrus. Terminal fields were found in every cortical layer in the contralateral...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/0378-5955(86)90110-3

    authors: Code RA,Winer JA

    更新日期:1986-01-01 00:00:00

  • Dynamic current steering with phantom electrode in cochlear implants.

    abstract::Phantom electrode (PE) stimulation can extend the lower limit of pitch perception with cochlear implants (CIs) by using simultaneous out-of-phase stimulation of the most apical primary electrode and the adjacent basal compensating electrode. The total electrical field may push the excitation pattern beyond the most ap...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/j.heares.2020.107949

    authors: Luo X,Garrett C

    更新日期:2020-05-01 00:00:00

  • Volume fraction and ultrastructure of age pigment in the saccular epithelium of old mice.

    abstract::Age pigment in the sensory and supporting cells was a prominent characteristic distinguishing old saccules from young. However, the pigment was not distributed uniformly throughout the sensory epithelium but displayed cell-specific patterns of accumulation. The highest cytoplasmic volume density was in the old support...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/0378-5955(89)90038-5

    authors: Hubel SB,Park JC

    更新日期:1989-01-01 00:00:00

  • A normative study of tympanic membrane motion in humans using a laser Doppler vibrometer (LDV).

    abstract::Laser Doppler vibrometry was used to measure the sound-induced tympanic membrane (TM) velocity, assessed near the umbo, in 56 normal hearing human subjects at nine sound frequencies. A second series of measurements was made in 47 subjects with sensorineural hearing loss (SNHL). Each set of measurements has features in...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/s0378-5955(03)00332-0

    authors: Whittemore KR Jr,Merchant SN,Poon BB,Rosowski JJ

    更新日期:2004-01-01 00:00:00

  • Automatic monitoring of mechano-electrical transduction in the guinea pig cochlea.

    abstract::We have estimated the transfer curve relating instantaneous sound pressure in the ear canal to instantaneous receptor current through the outer hair cells (OHCs) in the basal turn of the guinea pig cochlea using the cochlear microphonic (CM) elicited by continuous 200 Hz tones. The transfer curve is well approximated ...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/s0378-5955(98)00125-7

    authors: Patuzzi R,Moleirinho A

    更新日期:1998-11-01 00:00:00

  • The effect of BAPTA and 4AP in scala media on transduction and cochlear gain.

    abstract::We have injected by iontophoresis 4-amino-pyridine, a K+ channel blocker and BAPTA, (a Ca++ chelator), into scala media of the first three turns of the guinea pig cochlea. We measured the reduction in outer hair cell (OHC) receptor current, as indicated by cochlear microphonic measured in scala media evoked by a 207 H...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/j.heares.2005.05.016

    authors: Sellick PM,Robertson D,Patuzzi R

    更新日期:2006-01-01 00:00:00

  • Distribution of immunophilin FKBP-12 protein and mRNA within the mammalian cochlea and cochlear nucleus.

    abstract::Immunophilin FK binding protein-12 (FKBP-12), the soluble receptor for the immunosuppressant drug FK506, is involved in a number of neuronal activities including increased nerve regeneration in the peripheral nervous system and enhanced recovery in animal models of neurodegenerative diseases. In addition, FKBP-12 is t...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/s0378-5955(01)00319-7

    authors: Zajic G,Henley C,Louis JC,Nicolson M,Magal E

    更新日期:2001-09-01 00:00:00

  • Neural indices of phonemic discrimination and sentence-level speech intelligibility in quiet and noise: A P3 study.

    abstract::This study examined how speech babble noise differentially affected the auditory P3 responses and the associated neural oscillatory activities for consonant and vowel discrimination in relation to segmental- and sentence-level speech perception in noise. The data were collected from 16 normal-hearing participants in a...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/j.heares.2017.04.009

    authors: Koerner TK,Zhang Y,Nelson PB,Wang B,Zou H

    更新日期:2017-07-01 00:00:00