Suppression and enhancement of distortion-product otoacoustic emissions by interference tones above f(2). I. Basic findings in rabbits.


:The present study measured interference-response areas (IRAs) for distortion-product otoacoustic emissions (DPOAEs) at 2f(1)-f(2), 3f(1)-2f(2), and 2f(2)-f(1). The IRAs were obtained in either awake or anesthetized rabbits, or in anesthetized guinea pigs and mice, by sweeping the frequencies and levels of an interference tone (IT) around a set of f(1) and f(2) primary tones, at several fixed frequencies and levels, while plotting the effects of the IT on DPOAE level. An unexpected outcome was the occurrence of regions of suppression and/or enhancement of DPOAE level when the IT was at a frequency slightly less than to more than an octave above f(2). The IRA of the 2f(1)-f(2) DPOAE typically displayed a high-frequency (HF) lobe of suppression, while the 2f(2)-f(1) emission often exhibited considerable amounts of enhancement. Moreover, for the 2f(2)-f(1) DPOAE, when enhancement was absent, its IRA usually tuned to a region above f(2). Whether or not suppression/enhancement was observed depended upon primary-tone level and frequency separation, as well as on the relative levels of the two primaries. Various physiological manipulations involving anesthesia, eighth-nerve section, diuretic administration, or pure-tone overstimulation showed that these phenomena were of cochlear origin, and were not dependent upon the acoustic reflex or cochlear-efferent activity. The aftereffects of applying diuretics or over-exposures revealed that suppression/enhancement required the presence of sensitive, low-level DPOAE-generator sources. Additionally, suppression/enhancement were general effects in that, in addition to rabbits, they were also observed in mice and guinea pigs. Further, corresponding plots of DPOAE phase often revealed areas of differing phase change in the vicinity of the primary tones as compared to regions above f(2). These findings, along with the effects of tonal exposures designed to fatigue regions above f(2), and instances in which DPOAE level was dependent upon the amount of suppression/enhancement, suggested that the interactions of two DPOAE-generator sources contributed, in some manner, to these phenomena.


Hear Res


Hearing research


Martin GK,Stagner BB,Jassir D,Telischi FF,Lonsbury-Martin BL





Has Abstract


1999-10-01 00:00:00














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    journal_title:Hearing research

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    authors: Tsuji S,Tabuchi K,Hara A,Kusakari J

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  • Detection of acoustic temporal fine structure by cochlear implant listeners: behavioral results and computational modeling.

    abstract::A test of within-channel detection of acoustic temporal fine structure (aTFS) cues is presented. Eight cochlear implant listeners (CI) were asked to discriminate between two Schroeder-phase (SP) complexes using a two-alternative, forced-choice task. Because differences between the acoustic stimuli are primarily constr...

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    authors: Imennov NS,Won JH,Drennan WR,Jameyson E,Rubinstein JT

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  • Ototoxicity of sodium nitroprusside.

    abstract::Nitric oxide (NO) not only has normal physiological roles like vasodilation and neurotransmission in the living organism, it could also have possible neurodestructive effects under certain pathological conditions. The present study aimed to determine whether direct exposure of guinea pig cochlea to a NO donor like sod...

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    authors: Ruan RS,Leong SK,Yeoh KH

    更新日期:1997-12-01 00:00:00

  • Mineralocorticoid type I receptor in the rat cochlea: mRNA identification by polymerase chain reaction (PCR) and in situ hybridization.

    abstract::Expression of mineralocorticoid type I receptor (MR) gene in the rat cochlea was determined using molecular biological techniques. We synthesized complementary DNA (cDNA) from rat cochlear total RNA and then amplified MR cDNA fragments by polymerase chain reaction (PCR). The amplified cDNA fragments were subcloned int...

    journal_title:Hearing research

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    authors: Furuta H,Mori N,Sato C,Hoshikawa H,Sakai S,Iwakura S,Doi K

    更新日期:1994-08-01 00:00:00

  • Aging alters the perception and physiological representation of frequency: evidence from human frequency-following response recordings.

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    authors: Clinard CG,Tremblay KL,Krishnan AR

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  • Modelling the effect of round window stiffness on residual hearing after cochlear implantation.

    abstract::Preservation of residual hearing after cochlear implantation is now considered an important goal of surgery. However, studies indicate an average post-operative hearing loss of around 20 dB at low frequencies. One factor which may contribute to post-operative hearing loss, but which has received little attention in th...

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    authors: Elliott SJ,Ni G,Verschuur CA

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  • Masculinization of the mammalian cochlea.

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    journal_title:Hearing research

    pub_type: 杂志文章,评审


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  • The influence of postoperative tissue formation on sound transmission after stapes surgery.

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    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Benser ME,Issa NP,Hudspeth AJ

    更新日期:1993-08-01 00:00:00

  • Physiology of cochlear efferent and afferent neurons: direct comparisons in the same animal.

    abstract::Exposure of the vestibulo-cochlear anastomosis in the cat allows single-unit recording of afferent fibers originating from inner hair cells and olivocochlear efferent fibers to the outer hair cells. Comparison of data obtained from individual animals show similarities in absolute threshold and dynamic range between th...

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    pub_type: 杂志文章


    authors: Liberman MC

    更新日期:1988-07-15 00:00:00

  • Utricular otoconia of some amphibians have calcitic morphology.

    abstract::This report concerns the morphological features of otoconia removed from the inner ear of four amphibian species. Results from scanning electron microscopic examination are compared based on the site of origin. These results show that utricular otoconia have a mineral structure that mimics calcite, rather than the wid...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Pote KG,Ross MD

    更新日期:1993-05-01 00:00:00

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    authors: Wangemann P,Gruber DD

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    authors: Burda H

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    authors: Lai J,Bartlett EL

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  • S-100 immunoreactivity identifies a subset of hair cells in the utricle and saccule of a fish.

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    pub_type: 杂志文章


    authors: Saidel WM,Presson JC,Chang JS

    更新日期:1990-08-01 00:00:00

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  • Tonotopic mapping in auditory cortex of the chinchilla.

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    journal_title:Hearing research

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    journal_title:Hearing research

    pub_type: 杂志文章


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    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Patuzzi R,Moleirinho A

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    journal_title:Hearing research

    pub_type: 杂志文章


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    pub_type: 杂志文章


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    journal_title:Hearing research

    pub_type: 杂志文章


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    更新日期:2017-07-01 00:00:00