Abstract：
:Cochlear implant performance in difficult listening situations is limited by channel interactions. It is known that partial tripolar (PTP) stimulation reduces the spread of excitation (SOE). However, the greater the degree of current focusing, the greater the absolute current required to maintain a fixed loudness. As current increases, so does SOE. In experiment 1, the SOE for equally loud stimuli with different degrees of current focusing is measured via a forward-masking procedure. Results suggest that at a fixed loudness, some but not all patients have a reduced SOE with PTP stimulation. Therefore, it seems likely that a PTP speech processing strategy could improve spectral resolution for only those patients with a reduced SOE. In experiment 2, the ability to discriminate different levels of current focusing was measured. In experiment 3, patients subjectively scaled verbal descriptors of stimuli of various levels of current focusing. Both discrimination and scaling of verbal descriptors correlated well with SOE reduction, suggesting that either technique have the potential to be used clinically to quickly predict which patients would receive benefit from a current focusing strategy.
journal_name
Hear Resjournal_title
Hearing researchauthors
Landsberger DM,Padilla M,Srinivasan AGdoi
10.1016/j.heares.2011.12.009subject
Has Abstractpub_date
2012-02-01 00:00:00pages
16-24issue
1-2eissn
0378-5955issn
1878-5891pii
S0378-5955(11)00302-9journal_volume
284pub_type
杂志文章相关文献
HEARING RESEARCH文献大全abstract：:It is well known that quality of hearing decreases with increasing age due to changes in the peripheral or central auditory pathway. Along with the decrease in the number of neurons the neurotransmitter profile is also affected in the various parts of the auditory system. Particularly, changes in the inhibitory neuron...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2019.02.005
更新日期：2019-06-01 00:00:00
abstract：:Recent studies have shown that the vestibular and auditory systems of some species of birds have the capacity to generate sensory hair cells postnatally. We used a traditional technique, 3H-thymidine autoradiography, and a newer method, bromodeoxyuridine immunocytochemistry, to determine whether ongoing proliferation ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(92)90149-h
更新日期：1992-01-01 00:00:00
abstract：:DNA methylation and histone modifications such as methylation, acetylation, and phosphorylation, are two types of epigenetic modifications that alter gene expression. These additions to DNA regulatory elements or to the tails of histones can be inherited or can also occur de novo. Since epigenetic modifications can ha...
journal_title：Hearing research
pub_type： 杂志文章,评审
doi：10.1016/j.heares.2019.01.007
更新日期：2019-05-01 00:00:00
abstract：:A simplified network model of the organ of Corti is analyzed with the assumption of parametric excitation via resistance changes in the hair cells' apical membrane. Pertinent network variables (intracellular resting and receptor potentials, cellular input resistance, extracellular potentials) depend on the ratios of b...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(83)90120-x
更新日期：1983-10-01 00:00:00
abstract：:1. The sound pressure level required to produce a detectable gross action potential (N1) in the guinea pig was measured for a range of frequencies. The resulting electrocochleogram was compared with the click level require to produce a detectable N1. 2. Over most of the auditory range (1-30 kHz) the required click lev...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(81)90018-6
更新日期：1981-07-01 00:00:00
abstract：:The inner ear contains receptor cells that oscillate spontaneously, generating waves that propagate backward in the cochlea, ultimately causing sound to be radiated into the ear canal--the spontaneous otoacoustic emissions (SOAEs). Except in rare conditions, these internally generated signals appear to go unheard. The...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(02)00388-x
更新日期：2002-09-01 00:00:00
abstract：:This article presents a comparison of Liouville-Green (LG) calculations and exact solutions of 2- and 3-dimensional cochlea models. The agreement is in general quite good. For certain choices of the model parameters, however, the 2- and 3-dimensional LG solutions show appreciable errors in the region just beyond the l...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(82)90071-5
更新日期：1982-10-01 00:00:00
abstract：:A derived response method of acquiring frequency specific auditory evoked potentials that utilizes a pure tone in combination with a toneburst is applied to the measurement of hearing sensitivity in guinea pigs, chinchillas and pocket gophers. Two experiments which demonstrate that thresholds acquired via tone-derived...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(91)90097-s
更新日期：1991-09-01 00:00:00
abstract：:To examine the reversibility of functional damage to the cochlea after transient ischemia, cochlear ischemia of 0-60 min was induced in 34 albino guinea pigs. Thresholds of auditory brainstem response (ABR) were then followed for 5 days after ischemia. Although the ABR threshold returned to almost the pre-ischemic val...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(02)00299-x
更新日期：2002-04-01 00:00:00
abstract：:Bushy cells of the ventral cochlear nucleus produce a single, short latency action potential at the beginning of long depolarisations. In the present work an immunochemical survey was performed to detect the presence of K+ channel subunits which may contribute to the specific membrane properties of the bushy cells. Th...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2004.07.020
更新日期：2005-01-01 00:00:00
abstract：:Human behavioral thresholds for trains of biphasic pulses applied to a single channel of Nucleus CI24 and LAURA cochlear implants were measured as a function of inter-phase gap (IPG). Experiment 1 used bipolar stimulation, a 100-pps pulse rate, and a 400-ms stimulus duration. In one condition, the two phases of each p...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2005.03.021
更新日期：2005-07-01 00:00:00
abstract：:Within auditory pathways, the intrinsic electrical properties of neurons, and in particular their complement of potassium channels, play a key role in shaping the timing and pattern of action potentials produced by sound stimuli. The Kv9.1 gene encodes a potassium channel alpha subunit that is expressed in a variety o...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(00)00117-9
更新日期：2000-09-01 00:00:00
abstract：:The human fetus in utero is hypoxic relative to the neonate due to differences between placental and pulmonary oxygenation. Comparable degrees of hypoxia induced in young and adult animals caused an elevation in hearing threshold of a sensorineural nature. It was hypothesised therefore that the human fetus may also ha...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(94)90289-5
更新日期：1994-02-01 00:00:00
abstract：:The ear of the goldfish (Carassius auratus) contains three otolithic endorgans: the saccule, lagena, and utricle. The saccule has an auditory function in most teleost fishes for whom data are available, and there is evidence that the lagena is also an auditory endorgan in the goldfish. This study was conducted to comp...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(99)00207-5
更新日期：2000-03-01 00:00:00
abstract：:The purpose of this study was to compare cortical brain responses evoked by amplitude modulated acoustic beats of 3 and 6 Hz in tones of 250 and 1000 Hz with those evoked by their binaural beats counterparts in unmodulated tones to indicate whether the cortical processes involved differ. Event-related potentials (ERPs...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2010.01.013
更新日期：2010-04-01 00:00:00
abstract：:Sensorineural hearing loss is the most common sensory deficit worldwide, yet our understanding of the underlying pathophysiology is limited by the challenges of access to the inner ear in a safe and reliable manner. We present a novel microneedle device for trans-round window membrane liquid biopsy, which utilizes con...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2019.06.004
更新日期：2019-09-15 00:00:00
abstract：:This paper reports hourly and daily monitoring of the frequencies of spontaneous otoacoustic emissions. Regular circadian variations in frequency were found in two of three subjects. Consistent monthly variations, in step with the menstrual cycle, were seen in three of four women. The circadian cycle typically showed ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(92)90012-c
更新日期：1992-02-01 00:00:00
abstract：:Normotensive and spontaneously hypertensive rats (SHRs) were given arterial infusions of saline and pentoxifylline in doses of 1.5, 2.0, and 3.0 mg/kg/min. Blood pressure decreased in a dose related fashion with increasing doses of pentoxifylline. Cochlear blood flow, measured via laser Doppler flowmeter, increased wi...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(88)90059-7
更新日期：1988-11-01 00:00:00
abstract：:Dominant white spotting W/W(v) and W(v)/W(v) mice are well-known mutants that lack strial intermediate cells in their cochlea and manifest hereditary sensorineural hearing loss. We recently reported marked thickening of and IgG deposition on the basement membrane of strial capillaries in W/W(v) mutant mice, similar to...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2005.05.013
更新日期：2005-11-01 00:00:00
abstract：:Neural auditory thresholds in the guinea pig can be temporarily improved by up to 6 dB about 2 min after the cessation of an moderately intense low-frequency tone (Kirk and Patuzzi, 1997). We have measured changes in the f2-f1 distortion product otoacoustic emission (DPOAE) and low-frequency microphonic potential in s...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(97)00104-4
更新日期：1997-10-01 00:00:00
abstract：:Drugs of the salicylate family (aspirin-like drugs) are reversibly ototoxic. Electrophysiologic and ultrastructural evidence suggests an impairment of the sensory hair cells of the cochlea following salicylate treatment. In addition, since these drugs can cause vasoconstriction, the ototoxicity of salicylates may also...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(93)90108-d
更新日期：1993-09-01 00:00:00
abstract：:We have studied the noradrenergic and serotonergic changes induced by white noise stimulation at 70, 90 or 110 dB SPL for 45 min, in cochlear nuclei, inferior colliculus (IC), primary auditory cortex (PAC) and as a comparison in locus coeruleus (LC) and raphe dorsalis using HPLC. Both noradrenergic and serotonergic pa...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(98)00031-8
更新日期：1998-04-01 00:00:00
abstract：:Cochlear implant recipients show improved speech perception and music appreciation when residual acoustic hearing is combined with the cochlear implant. However, up to one third of patients lose their pre-operative residual hearing weeks to months after implantation, for reasons that are not well understood. This stud...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2015.12.012
更新日期：2016-03-01 00:00:00
abstract：:High doses of sodium salicylate (SS) have long been known to induce temporary hearing loss and tinnitus, effects attributed to cochlear dysfunction. However, our recent publications reviewed here show that SS can induce profound, permanent, and unexpected changes in the cochlea and central nervous system. Prolonged tr...
journal_title：Hearing research
pub_type： 杂志文章,评审
doi：10.1016/j.heares.2012.11.016
更新日期：2013-01-01 00:00:00
abstract：:Previous studies have shown that objective measures based on stimulation with low-rate pulse trains fail to predict the threshold levels of cochlear implant (CI) users for high-rate pulse trains, as used in clinical devices. Electrically evoked auditory steady-state responses (EASSRs) can be elicited by modulated high...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2016.03.006
更新日期：2016-05-01 00:00:00
abstract：:We determined velocity discrimination thresholds and Weber fractions for sounds revolving around the listener at very high velocities. Sounds used were a broadband white noise and two harmonic sounds with fundamental frequencies of 330 Hz and 1760 Hz. Experiment 1 used velocities ranging between 288°/s and 720°/s in a...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2014.07.014
更新日期：2014-10-01 00:00:00
abstract：:Although most birds encounter large pressure variations during flight, motion of the middle ear components as a result of changing ambient pressure are not well known or described. In the present study, motion of the columella footplate and tympanic membrane (extrastapedius) in domestic chickens (Gallus gallus domesti...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2018.05.012
更新日期：2018-08-01 00:00:00
abstract：:Despite advances in technology, the ability to perceive music remains limited for many cochlear implant users. This paper reviews the technological, biological, and acoustical constraints that make music an especially challenging stimulus for cochlear implant users, while highlighting recent research efforts to overco...
journal_title：Hearing research
pub_type： 杂志文章,评审
doi：10.1016/j.heares.2013.04.009
更新日期：2014-02-01 00:00:00
abstract：:Although gap junctions occur in auditory and vestibular systems, their function is unclear. Here we present evidence for gap junctional communication in transmitting mechanosensory signals in a sea anemone model system. Hair bundles on anemone tentacles are vibration-sensitive mechanoreceptors that regulate discharge ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(00)00047-2
更新日期：2000-06-01 00:00:00
abstract：:Auditory-nerve fibers demonstrate dynamic response properties in that they adapt to rapid changes in sound level, both at the onset and offset of a sound. These dynamic response properties affect temporal coding of stimulus modulations that are perceptually relevant for many sounds such as speech and music. Temporal d...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2010.07.009
更新日期：2010-10-01 00:00:00
