Origin of the guinea pig cochlear action potential produced by a click.

abstract：:The objective of the present study was to examine whether mepacrine, a commonly used phospholipase A2 inhibitor, decreases ischemic damage to the cochlea. Transient ischemia of the cochlea was induced in albino guinea pigs for 15, 30 or 60 min by pressing the labyrinthine artery at the porus acusticus internus. The an...

journal_title：Hearing research

authors： Tabuchi K,Ito Z,Tsuji S,Wada T,Takahashi K,Hara A,Kusakari J

更新日期：2000-06-01 00:00:00

abstract：:The effects of efferent activation on the otoacoustic emission were measured in anesthetized guinea pigs. The otoacoustic emission (2F(1)-F(2)) was evoked by the conventional method of presenting either two continuous tones or a sinusoidal current to the round window (RW) of the cochlea. The efferent effects on the ac...

journal_title：Hearing research

authors： Ota Y,Dolan DF

更新日期：2000-10-01 00:00:00

abstract：:Applying whole-head functional magnetic resonance imaging (fMRI) in 11 neurologically intact subjects, hemodynamic responses to mon- or binaurally presented auditory stimuli were measured. To expand on previous studies in this research area, we used tones and consonant-vowel (CV) syllables. In one group of subjects (n...

journal_title：Hearing research

authors： Jäncke L,Wüstenberg T,Schulze K,Heinze HJ

更新日期：2002-08-01 00:00:00

abstract：:A novel immunocytochemical method was used to determine whether the sound-damaged adult quail ear can repair its tectorial membrane (TM) and to compare the repair in quail to that in chicks. Birds were exposed to an octave band noise with a center frequency of 1.5 kHz at 116 dB SPL for 4 h. The chicks were grouped bas...

journal_title：Hearing research

authors： Adler HJ,Niemiec AJ,Moody DB,Raphael Y

更新日期：1995-06-01 00:00:00

abstract：:Cochlear function was monitored in adult gerbils using distortion product otoacoustic emissions (DPOAE) during intraperitoneal injection of furosemide. All stimulus parameters were varied independently over a wide range, the stimulus frequencies f1 and f2 from 1 to 16 kHz, and the stimulus levels L1 and L2 from 20 to ...

journal_title：Hearing research

authors： Mills DM,Rubel EW

更新日期：1994-06-15 00:00:00

abstract：:The voice is a rich source of information, which the human brain has evolved to decode and interpret. Empirical observations have shown that the human auditory system is especially sensitive to the human voice, and that activity within the voice-sensitive regions of the primary and secondary auditory cortex is modulat...

journal_title：Hearing research

authors： Pannese A,Grandjean D,Frühholz S

更新日期：2015-10-01 00:00:00

abstract：:The lipophilic dye, DiI, was placed into the macula lagena of paraformaldehyde-fixed embryonic chicks. Retrogradely labeled cells were found bilaterally in the pontine reticular formation (RF) between the dorsal facial nucleus and the abducens nerve root. This location is similar to that of the dorsomedial group of ef...

journal_title：Hearing research

authors： Code RA

更新日期：1995-01-01 00:00:00

abstract：:Songbirds spend much of their time learning, producing, and listening to complex vocal sequences we call songs. Songs are learned via cultural transmission, and singing, usually by males, has a strong impact on the behavioral state of the listeners, often promoting affiliation, pair bonding, or aggression. What is it ...

journal_title：Hearing research

authors： Rothenberg D,Roeske TC,Voss HU,Naguib M,Tchernichovski O

更新日期：2014-02-01 00:00:00

abstract：:The presence of dopamine (DA) within the cochlea has been previously reported, indicating that its turnover increases under noise stimulation. In the present report, piribedil, a dopaminergic D2 agonist, was used in order to provide evidence of the activity of D2 receptors in the turnover of DA under noise stimulation...

journal_title：Hearing research

authors： Gil-Loyzaga P,Vicente-Torres MA,Fernández-Mateos P,Arce A,Esquifino A

更新日期：1994-09-01 00:00:00

abstract：:Human subjects performed in several behavioral conditions requiring, or not requiring, selective attention to visual stimuli. Specifically, the attentional task was to recognize strings of digits that had been presented visually. A nonlinear version of the stimulus-frequency otoacoustic emission (SFOAE), called the nS...

journal_title：Hearing research

authors： Walsh KP,Pasanen EG,McFadden D

更新日期：2014-06-01 00:00:00

abstract：:At the synapse between olivocochlear efferent fibers and outer hair cells (OHCs) of the cochlea, a non-classical ionotropic cholinergic receptor allows Ca(2+) entry into the hair cell, thus activating a Ca(2+)-sensitive K(+) current which hyperpolarizes the cell's membrane. In the mammalian ear, this leads to a reduct...

journal_title：Hearing research

authors： Katz E,Verbitsky M,Rothlin CV,Vetter DE,Heinemann SF,Elgoyhen AB

更新日期：2000-03-01 00:00:00

abstract：:Distortion-product emissions at 2f1-f2 were measured in developing, pigmented rats to determine the characteristics of the functional onset and maturation of these emitted responses. Distortion-product testing was conducted on postnatal days 12, 14, 18, 21, 24, 28, and 51. The geometric-mean frequencies of the primari...

journal_title：Hearing research

authors： Henley CM 3rd,Owings MH,Stagner BB,Martin GK,Lonsbury-Martin BL

更新日期：1990-01-01 00:00:00

abstract：:Three budgerigars and three zebra finches were tested for their ability to detect sinusoidal stimuli in the presence of broadband noise. Masked thresholds for 1, 2, and 4 KHz pure tones were measured with a fixed frequency condition, in which only one test frequency was presented in a session, and with an uncertain fr...

journal_title：Hearing research

authors： Okanoya K,Dooling RJ

更新日期：1990-12-01 00:00:00

abstract：:Sudden sensorineural hearing loss (SSNHL) is generally defined as sensorineural hearing loss of 30 dB or greater over at least three contiguous audiometric frequencies and within a three-day period. This hearing loss is usually unilateral and can be associated with tinnitus and vertigo. The pathogenesis of unilateral ...

journal_title：Hearing research

authors： Xu H,Fan W,Zhao X,Li J,Zhang W,Lei P,Liu Y,Wang H,Cheng H,Shi H

更新日期：2016-05-01 00:00:00

abstract：:Two different radioligands were used to identify extracellular ATP binding sites specific to P2 purinoceptors in guinea-pig cochlear tissue. Deoxyadenosine 5'-(alpha-[35S]thio)triphosphate ([35S]dATP alpha S; 10 nM) provided a high activity probe for the P2y purinoceptor subtype on the basis of selective block by 2-me...

journal_title：Hearing research

authors： Mockett BG,Bo X,Housley GD,Thorne PR,Burnstock G

更新日期：1995-04-01 00:00:00

abstract：:Difference limens for the fundamental frequency (F0) of complex tones (DLCs) were measured for four normally hearing subjects and three subjects with cochlear hearing loss. The nominal F0 was 100, 200 or 400 Hz. The two tones to be compared contained either low resolved harmonics (RES), harmonics with intermediate res...

journal_title：Hearing research

authors： Moore BC,Moore GA

更新日期：2003-08-01 00:00:00

abstract：:Gamma-aminobutyric acid (GABA)-like immunoreactivity in the chick basilar papilla and lagenar macula was studied by using anti-serum against GABA coupled with glutaraldehyde to bovine serum albumin. GABA-like immunoreactivity was localized selectively in the cytoplasm of both tall and short hair cells in the basilar p...

journal_title：Hearing research

authors： Usami S,Igarashi M,Thompson GC

更新日期：1987-01-01 00:00:00

abstract：:Previous studies have shown that objective measures based on stimulation with low-rate pulse trains fail to predict the threshold levels of cochlear implant (CI) users for high-rate pulse trains, as used in clinical devices. Electrically evoked auditory steady-state responses (EASSRs) can be elicited by modulated high...

journal_title：Hearing research

authors： Gransier R,Deprez H,Hofmann M,Moonen M,van Wieringen A,Wouters J

更新日期：2016-05-01 00:00:00

abstract：:Guinea pigs were exposed to a 10 kHz pure tone and damage to the cochlea was investigated immediately after exposure, or after a recovery period ranging from 18-25 days. Structural damage was assessed using scanning electron microscopy and functional damage estimated using the N1 threshold audiogram. Exposure at 106 d...

journal_title：Hearing research

authors： Robertson D,Johnstone BM,McGill TJ

更新日期：1980-01-01 00:00:00

abstract：:Mitochondrial DNA (mtDNA) mutations/deletions are considered to be associated with the development of age-related hearing loss (AHL). We assessed the role of accumulation of mtDNA mutations in the development of AHL using Polg(D257A) knock-in mouse, which exhibited increased spontaneous mtDNA mutation rates during agi...

journal_title：Hearing research

authors： Yamasoba T,Someya S,Yamada C,Weindruch R,Prolla TA,Tanokura M

更新日期：2007-04-01 00:00:00

abstract：:The discharge properties of 735 single units located in the pars magnocellularis (M) of the medial division of the medial geniculate body (MGB) were studied in 23 nitrous oxide anesthetized cats in response to simple acoustic stimuli (clicks, noise and tone bursts). A systematic decrease of single unit characteristic ...

journal_title：Hearing research

authors： Rouiller EM,Rodrigues-Dagaeff C,Simm G,De Ribaupierre Y,Villa A,De Ribaupierre F

更新日期：1989-05-01 00:00:00

abstract：:In the cochlea, outer hair cells (OHCs) generate the active cochlear mechanics whereas the supporting cells, such as Deiters' cells and Hensen's cells, may play a role in both the active and passive cochlear mechanics. The presence of receptors for adenosine triphosphate (ATP) on OHCs, Deiters' cells and Hensen's cell...

journal_title：Hearing research

authors： Chen C,Skellett RA,Fallon M,Bobbin RP

更新日期：1998-04-01 00:00:00

abstract：:Cochlear outer hair cell (OHC) electromotility is associated with the cell's lateral wall. The lateral wall contains two distinct membranes: the plasma membrane (PM) and the subsurface cisternae (SSC). We explored biophysical characteristics of these lipid structures using membrane-specific fluorescent dyes. We have p...

journal_title：Hearing research

authors： Oghalai JS,Tran TD,Raphael RM,Nakagawa T,Brownell WE

更新日期：1999-09-01 00:00:00

abstract：:Human behavioral thresholds for trains of biphasic pulses applied to a single channel of Nucleus CI24 and LAURA cochlear implants were measured as a function of inter-phase gap (IPG). Experiment 1 used bipolar stimulation, a 100-pps pulse rate, and a 400-ms stimulus duration. In one condition, the two phases of each p...

journal_title：Hearing research

authors： Carlyon RP,van Wieringen A,Deeks JM,Long CJ,Lyzenga J,Wouters J

更新日期：2005-07-01 00:00:00

abstract：:The highly variable benefit of hearing devices is a serious challenge in auditory rehabilitation. Various factors contribute to this phenomenon such as the diversity in ear defects, the different extent of auditory nerve hypoplasia, the age of intervention, and cognitive abilities. Recent analyses indicate that, in ad...

journal_title：Hearing research

authors： Willaredt MA,Ebbers L,Nothwang HG

更新日期：2014-06-01 00:00:00

abstract：:During injection of artificial endolymph into scala media of the guinea pig, fluid pressure was simultaneously measured in endolymph and perilymph with micropipettes. Pressure differences in the order of 10 Pa could reproducibly be measured upon injection of 2-4 microl of artificial endolymph with a rate of 50 nl/s. I...

journal_title：Hearing research

authors： Wit HP,Warmerdam TJ,Albers FW

更新日期：2000-07-01 00:00:00

abstract：:We obtained just-noticeable differences (jnds) for the intensity of pure tones following a forward masker. The masker was a 100-ms burst of narrow-band noise centered at 1000 Hz presented at 90 dB SPL; the pure-tone signal was at 1000 Hz and was 25 ms in duration. The masker-signal delay was 100 ms. Under these condit...

journal_title：Hearing research

authors： Zeng FG,Turner CW,Relkin EM

更新日期：1991-10-01 00:00:00

abstract：:There is conflict in the literature over whether individual frequency components of a transient-evoked otoacoustic emission (TEOAE) are generated within relatively independent "channels" along the basilar membrane (BM), or whether each component may be generated by widespread areas of the BM. Two previous studies on T...

journal_title：Hearing research

authors： Killan EC,Kapadia S

更新日期：2006-02-01 00:00:00

abstract：:Most investigators place reflective beads on the basilar membrane to measure its vibration with optical methods. It is therefore important to find out if the beads faithfully follow the motion of the structures on which they are placed. Vibration of the beads on the basilar membrane and basilar membrane adjacent to th...

journal_title：Hearing research

authors： Khanna SM,Ulfendahl M,Steele CR

更新日期：1998-02-01 00:00:00

abstract：:Left-handed individuals show a 4 ms later Wave Pb in the 45-60 ms latency range of the auditory middle latency response (MLR) than right-handed individuals. Examination of auditory evoked potentials in fifteen right-handed and fifteen left-handed normal hearing adults showed that this difference was not evident in tim...

journal_title：Hearing research

authors： Hood LJ,Martin DA,Berlin CI

更新日期：1990-04-01 00:00:00