Abstract:
:Mitochondrial DNA (mtDNA) mutations/deletions are considered to be associated with the development of age-related hearing loss (AHL). We assessed the role of accumulation of mtDNA mutations in the development of AHL using Polg(D257A) knock-in mouse, which exhibited increased spontaneous mtDNA mutation rates during aging and showed accelerated aging primarily due to increased apoptosis. They exhibited moderate hearing loss and degeneration of the hair cells, spiral ganglion cells and stria vascularis by 9 month of age, while wild-type animals did not. We next examined if mitochondrial damage induced by systemic application of germanium dioxide caused progressive hearing loss and cochlear damage. Guinea pigs and mice given germanium dioxide exhibited degeneration of the muscles and kidney and developed hearing loss due to degeneration of cochlear tissues, including the stria vascularis. Calorie restriction, which causes a metabolic shift toward increased energy metabolism in some organs, has been shown to attenuate AHL and age-related cochlear degeneration and to lower quantity of mtDNA deletions in the cochlea of mammals. Together these findings indicate that decreased energy metabolism due to accumulation of mtDNA mutations/deletions and decline of respiratory chain function play an important role in the manifestation of AHL.
journal_name
Hear Resjournal_title
Hearing researchauthors
Yamasoba T,Someya S,Yamada C,Weindruch R,Prolla TA,Tanokura Mdoi
10.1016/j.heares.2006.06.004subject
Has Abstractpub_date
2007-04-01 00:00:00pages
185-93issue
1-2eissn
0378-5955issn
1878-5891pii
S0378-5955(06)00154-7journal_volume
226pub_type
杂志文章,评审相关文献
HEARING RESEARCH文献大全abstract::It is known that the threshold of an acoustically induced middle-ear-muscle (MEM) reflex can be lowered by the simultaneous presentation of a second tone (facilitator), which is presented to the ipsilateral or contralateral ear at a level below the acoustic reflex threshold (ART) of the facilitator itself (Sesterhenn ...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/s0378-5955(97)00039-7
更新日期:1997-06-01 00:00:00
abstract::Increase in spontaneous neural activity after noise-induced hearing loss has frequently been associated with the phenomenon of tinnitus. Eighteen juvenile and adult cats were exposed for 2 h to a 6 kHz tone with an intensity of 115 dB SPL at the cat's head. Seven non-exposed littermates and seven other normal hearing ...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/s0378-5955(03)00074-1
更新日期:2003-06-01 00:00:00
abstract::When using bone vibrator transducers for clinical measurements, the transfer of energy from the bone driver depends on the impedance match between the driver and the load (human mastoid or otherwise) to which the driver will be applied. Current clinical calibration methods are incapable of quantifying this impedance m...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2010.02.013
更新日期:2010-05-01 00:00:00
abstract::The effects of several hours of continuous electrical stimulation in the cats' cochlear nucleus with chronically implanted activated iridium microelectrodes was investigated from the changes in the evoked response near the inferior colliculus and also by histologic evaluation of the stimulated tissue. The stimulating ...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(92)90201-w
更新日期:1992-09-01 00:00:00
abstract::Salicylate is a well-known substance to produce reversible tinnitus in animals and humans as well. It has been shown that systemic application of salicylate changes the neuronal spontaneous activity in several parts of the auditory pathway. The effects observed in central auditory structures in vivo could be based upo...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2008.02.005
更新日期:2008-06-01 00:00:00
abstract::Single neuron responses to sinusoidal 20 Hz amplitude modulated tone bursts (612.5 ms stimulus-on time at the rate of once per 2.2 s) were studied in the auditory midbrain (torus semicircularis) of the immobilized grass frog (Rana temporaria temporaria). The characteristic frequency stimuli at 30 dB above the minimum ...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/s0378-5955(96)00128-1
更新日期:1996-11-01 00:00:00
abstract::The influence of noise exposure on the endothelial transport system in the cochlea was investigated using cationic polyethyleneimine (PEI), since systemically administered PEI passes through the capillary endothelial cell and attaches to basal lamina (BL) anionic sites in the cochlea. Under general anesthesia, all gui...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/s0378-5955(01)00397-5
更新日期:2002-02-01 00:00:00
abstract::It has previously been demonstrated that ototoxicity induced by systemic administration of cisplatin is reduced by concomitant systemic administration of alpha-melanocyte stimulating hormone (alpha-MSH). In this study we investigated the effects of cochlear, perilymphatic application of alpha-MSH during intraperitonea...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/S0378-5955(03)00396-4
更新日期:2004-03-01 00:00:00
abstract::The intercellular gap junction channels formed by connexins (CXs) are important for recycling potassium ions in the inner ear. CXs are encoded by a family of the CX gene, such as GJB2, and the mechanism leading to mutant connexin-associated diseases, including hearing loss, remains to be elucidated. In this study, usi...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2014.04.010
更新日期:2014-07-01 00:00:00
abstract::Although pulmonary infections caused by Pseudomonas aeruginosa can hardly be eradicated in patients with cystic fibrosis (CF, the most common genetic disease among Caucasians), these patients are mainly treated with intravenous and nebulized tobramycin. Long-term treatment with tobramycin, however, may induce ototoxic...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/s0378-5955(97)00191-3
更新日期:1998-01-01 00:00:00
abstract::The auditory brainstem response (ABR) is an acoustically evoked potential commonly used to determine hearing sensitivity in laboratory animals. Both isoflurane and ketamine/xylazine anesthesia are commonly used to immobilize animals during ABR procedures. Hearing threshold determination is often the primary interest. ...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2012.04.005
更新日期:2012-05-01 00:00:00
abstract::Guinea pigs were exposed to a 10 kHz pure tone and damage to the cochlea was investigated immediately after exposure, or after a recovery period ranging from 18-25 days. Structural damage was assessed using scanning electron microscopy and functional damage estimated using the N1 threshold audiogram. Exposure at 106 d...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(80)90015-5
更新日期:1980-01-01 00:00:00
abstract::Both outer hair cells (OHCs) and inner hair cells (IHCs) survive and mature in 3 days old rat organ of Corti explants cultured for 1 month in a minimal essential medium. In contrast, under the same culture conditions, only IHCs survive in explants from adult guinea pig organ of Corti while many of the OHCs are lost wi...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/s0378-5955(02)00451-3
更新日期:2002-08-01 00:00:00
abstract::The standard procedure to study temporal encoding of sound waveforms in the auditory system has been Fourier analysis of responses to periodic stimuli. We introduce a new metric--correlation index (CI)--which is based on a simple counting of spike coincidences. It can be used for responses to aperiodic stimuli and doe...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2006.03.010
更新日期:2006-06-01 00:00:00
abstract::The auditory system is thought to process complex sounds through overlapping bandpass filters. Frequency selectivity as estimated by auditory filters has been well quantified in humans and other mammalian species using behavioral and physiological methodologies, but little work has been done to examine frequency selec...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2017.11.012
更新日期:2018-01-01 00:00:00
abstract::During the simultaneous monaural presentation of two primary tones, distortion products can be measured acoustically in the ear canal (DPOAEs) and electrically as auditory evoked potentials (DPAEPs). The purpose of this investigation was to elucidate the sources of nonlinearity within the human auditory system respons...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2004.04.005
更新日期:2004-07-01 00:00:00
abstract::The peripheral auditory sense organ, the cochlea, receives innervation from lateral and medial olivocochlear neurons in the brainstem. These neurons are able to modulate cochlear neural output. Anatomical studies have shown that one of the neurotransmitters which is present in varicosities surrounding the olivocochlea...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2005.01.009
更新日期:2005-06-01 00:00:00
abstract::Cochlear implantation (CI), which directly stimulates the cochlear nerves, is the most effective and widely used medical intervention for patients with severe to profound sensorineural hearing loss. The etiology of the hearing loss is speculated to have a major influence of CI outcomes, particularly in cases resulting...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2017.02.017
更新日期:2017-05-01 00:00:00
abstract::The influence of an external tone on transitory evoked otoacoustic emissions (TEOAE) is investigated. Three different averaging techniques were used with the same acoustic stimulus paradigm. These techniques permitted the separation of those parts of the otoacoustic emission (OAE) that contribute to the transitory evo...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/s0378-5955(96)00160-8
更新日期:1997-01-01 00:00:00
abstract::The objective of the present study was to examine whether mepacrine, a commonly used phospholipase A2 inhibitor, decreases ischemic damage to the cochlea. Transient ischemia of the cochlea was induced in albino guinea pigs for 15, 30 or 60 min by pressing the labyrinthine artery at the porus acusticus internus. The an...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/s0378-5955(00)00038-1
更新日期:2000-06-01 00:00:00
abstract::Degeneration of spiral ganglion neurons (SGNs) in the cochlea following sensorineural hearing loss is preventable by the infusion of neurotrophins into the scala tympani. This study investigates the trophic effects and distribution of a single bolus infusion of neurotrophin-3 (NT3) into the scala tympani of the cochle...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2005.01.001
更新日期:2005-06-01 00:00:00
abstract::Exposure of the auditory system to either continuous or interrupted nontraumatic noises, often collectively referred to as priming exposures, has been shown, in a number of experimental paradigms, to reduce the susceptibility of the auditory system to noise-induced hearing and sensory cell loss from a subsequent traum...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/s0378-5955(99)00131-8
更新日期:1999-11-01 00:00:00
abstract::Two methods were used to extract frequency specific information from the gross d.c. cochlear potential, the summating potential (SP). The first approach was to derive SP tuning curves using a two-tone simultaneous masking procedure; the second to obtain SP iso-response functions. The influence of various parameter cha...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(84)90009-1
更新日期:1984-11-01 00:00:00
abstract::Expression of mineralocorticoid type I receptor (MR) gene in the rat cochlea was determined using molecular biological techniques. We synthesized complementary DNA (cDNA) from rat cochlear total RNA and then amplified MR cDNA fragments by polymerase chain reaction (PCR). The amplified cDNA fragments were subcloned int...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(94)90023-x
更新日期:1994-08-01 00:00:00
abstract::The distribution of neurotensin-containing cell bodies and fibers has been observed in the central and peripheral nervous system, including sensory ganglia, but no description has been found in the peripheral auditory system. Here, we investigated the presence of neurotensin immunoreactivity in the cochlea of the adul...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2005.02.011
更新日期:2005-07-01 00:00:00
abstract::We performed transient evoked otoacoustic emission (TEOAE) measurements on 29 ears of myasthenia gravis (MG) patients. The purpose of the study was to support the role of acetylcholine (ACh) in the efferent innervation of cochlear outer hair cells (OHCs). Another aim was to establish additional diagnostic tools for th...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/s0378-5955(98)00154-3
更新日期:1998-12-01 00:00:00
abstract::The compound action potential (CAP) and the auditory brainstem response (ABR; waves ii and iv) were recorded in young (4-8 month) and aged (33-37 month) gerbils using a paradigm similar to that used in some psychophysical studies of gap detection (a pair of identical low-pass noises separated by a silent gap). Respons...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/s0378-5955(96)90016-7
更新日期:1996-12-01 00:00:00
abstract::Although most birds encounter large pressure variations during flight, motion of the middle ear components as a result of changing ambient pressure are not well known or described. In the present study, motion of the columella footplate and tympanic membrane (extrastapedius) in domestic chickens (Gallus gallus domesti...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2018.05.012
更新日期:2018-08-01 00:00:00
abstract::Auditory evoked magnetic fields were measured using a stimulation sequence where repetitive identical tone bursts were randomly and infrequently replaced by shorter tones. The deviation in the stimulus duration evoked a specific response, the mismatch field, peaking about 130 ms after the end of the shorter stimulus. ...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(89)90174-3
更新日期:1989-08-01 00:00:00
abstract::Most investigators place reflective beads on the basilar membrane to measure its vibration with optical methods. It is therefore important to find out if the beads faithfully follow the motion of the structures on which they are placed. Vibration of the beads on the basilar membrane and basilar membrane adjacent to th...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/s0378-5955(97)00200-1
更新日期:1998-02-01 00:00:00