Abstract：
:The effects of several hours of continuous electrical stimulation in the cats' cochlear nucleus with chronically implanted activated iridium microelectrodes was investigated from the changes in the evoked response near the inferior colliculus and also by histologic evaluation of the stimulated tissue. The stimulating microelectrodes had geometric surface areas of 75-500 microns2. They were pulsed continuously for 4 h, at a pulse repetition rate of 200 Hz, using charge-balanced pulse pairs. The charge per phase was 1.8 or 3.6 nC/ph. The animals were sacrificed for histologic evaluation 2 h, or several days later. The only remarkable histologic change resulting from the 4 h of stimulation was some aggregation of lymphocytes at the site of stimulation. However, depression of the electrical excitability of neurons near the sites often persisted for several days after 4 h of stimulation at 3.6 nC/phase. The charge per phase of the stimulus pulse pair was correlated strongly with the depression of excitability, and there was a weaker correlation between the depression and the amplitude of the first phase of voltage transient induced across the electrode-tissue interface. The charge density, calculated from the geometric surface area of the stimulating electrodes, was poorly correlated with the severity of the depression. The findings suggest a means of detecting impending stimulation-induced neural damage while it is still reversible.
journal_name
Hear Resjournal_title
Hearing researchauthors
McCreery DB,Yuen TG,Agnew WF,Bullara LAdoi
10.1016/0378-5955(92)90201-wkeywords:
subject
Has Abstractpub_date
1992-09-01 00:00:00pages
42-56issue
1eissn
0378-5955issn
1878-5891pii
0378-5955(92)90201-Wjournal_volume
62pub_type
杂志文章相关文献
HEARING RESEARCH文献大全abstract：:Hearing sensitivity and the prevalence of spontaneous otoacoustic emissions show parallel ear and sex differences in humans. Here it is proposed that these lateral asymmetries and sex differences may all result from differences in the 'strength' of the efferent inhibition delivered to individual cochleas. Specifically...
journal_title：Hearing research
pub_type： 杂志文章,评审
doi：10.1016/0378-5955(93)90118-k
更新日期：1993-08-01 00:00:00
abstract：:Mutations of the otoferlin gene have been shown to underlie deafness disorders in humans and mice. Analyses of genetically engineered mice lacking otoferlin have demonstrated an essential role for this protein in vesicle exocytosis at the inner hair cell afferent synapse. Here, we report on the molecular and phenotypi...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2007.09.005
更新日期：2007-12-01 00:00:00
abstract：:Neural auditory thresholds in the guinea pig can be temporarily improved by up to 6 dB about 2 min after the cessation of an moderately intense low-frequency tone (Kirk and Patuzzi, 1997). We have measured changes in the f2-f1 distortion product otoacoustic emission (DPOAE) and low-frequency microphonic potential in s...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(97)00104-4
更新日期：1997-10-01 00:00:00
abstract：:Exposure of the vestibulo-cochlear anastomosis in the cat allows single-unit recording of afferent fibers originating from inner hair cells and olivocochlear efferent fibers to the outer hair cells. Comparison of data obtained from individual animals show similarities in absolute threshold and dynamic range between th...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(88)90105-0
更新日期：1988-07-15 00:00:00
abstract：:A number of studies have shown that the ear can be protected from sound over-exposure, either by activating the cochlear efferent system, or by sound 'conditioning' in which the role of the efferent system is less certain. To study more definitively the molecular basis of deliberately induced cochlear protection from ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(01)00265-9
更新日期：2001-06-01 00:00:00
abstract：:Both sound exposure and gentamicin treatment cause damage to sensory hair cells in the peripheral chick auditory organ, the basilar papilla. This induces a regeneration response which replaces hair cells and restores auditory function. Since functional recovery requires the re-establishment of connections between rege...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(97)00150-0
更新日期：1997-11-01 00:00:00
abstract：:Laser scanning confocal microscopy was used to determine the distribution of actin, spectrin and tubulin in whole mounts of the organ of Corti of guinea pig, monkey, rat and chinchilla. Actin, spectrin and tubulin were localized in all cell types in the auditory epithelium. No specialized cytoskeletal organization of ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(94)90098-1
更新日期：1994-06-01 00:00:00
abstract：:Behavioral studies on complex sound perception in goldfish were carried out in order to help determine what, if any, differences exist between the sense of hearing of fishes and other vertebrates. A stimulus generalization paradigm was used with classical conditioning in three experiments to determine: (1) the percept...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(95)00132-8
更新日期：1995-09-01 00:00:00
abstract：:Otoacoustic emissions (OAEs) differ between the sexes in humans, rhesus and marmoset monkeys, and sheep. OAEs also are different in a number of special populations of humans. Those basic findings are reviewed and discussed in the context of possible prenatal-androgen effects on the auditory system. A parsimonious expl...
journal_title：Hearing research
pub_type： 杂志文章,评审
doi：10.1016/j.heares.2009.01.002
更新日期：2009-06-01 00:00:00
abstract：:Noise-induced hearing loss (NIHL) and hair cell loss are known to show only a moderate correlation. One reason for this is that NIHL may reflect not only the sum of dead hair cells, but also the sum of impaired but still living hair cells. This report compares hair cell loss in different cochlear regions in rats with ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(02)00802-x
更新日期：2003-03-01 00:00:00
abstract：:Human subjects performed in several behavioral conditions requiring, or not requiring, selective attention to visual stimuli. Specifically, the attentional task was to recognize strings of digits that had been presented visually. A nonlinear version of the stimulus-frequency otoacoustic emission (SFOAE), called the nS...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2014.03.013
更新日期：2014-06-01 00:00:00
abstract：:The auditory brainstem response (ABR) is an acoustically evoked potential commonly used to determine hearing sensitivity in laboratory animals. Both isoflurane and ketamine/xylazine anesthesia are commonly used to immobilize animals during ABR procedures. Hearing threshold determination is often the primary interest. ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2012.04.005
更新日期：2012-05-01 00:00:00
abstract：:The middle ear is a sophisticated and complex structure with a variety of functions, yet a delicate organ prone to injuries due to various reasons. Both, understanding and reconstructing its functions has always been an important topic for researchers from medical and technical background. Currently, human temporal bo...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2015.12.025
更新日期：2016-10-01 00:00:00
abstract：:Auditory brainstem responses (ABR) from ten normal (3 males, 7 females) and ten environmentally sound deprived CBA/J mice (6 males, 4 females) were elicited by 30 dB HL click stimuli delivered via specially constructed, matched insert earphones. The mice were tested at 44-49 days of age under chloral hydrate sedation ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(83)90092-8
更新日期：1983-06-01 00:00:00
abstract：:Kanamycin (KM)-induced changes in expression of the gene for glutamate-aspartate transporter (GLAST) in the rat cochlea were analyzed by Northern blotting. With the administration of KM (600 mg/kg/day) once daily for 20 days, the expression of GLAST mRNA gradually increased and reached a peak on day 20. Although the e...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(99)00050-7
更新日期：1999-07-01 00:00:00
abstract：:Distortion product otoacoustic emission (DPOAE) iso-suppression tuning curves (STC) were generated in 15 normal-hearing adults and 16 healthy term-born neonates for three f2 frequencies. The 2f1-f2 DPOAE was elicited using f2/f1 = 1.2, LI = 1.2, LI = 65 and L2 = 50 dB SPL. A suppressor tone was presented at frequencie...
journal_title：Hearing research
pub_type： 临床试验,杂志文章
doi：10.1016/0378-5955(96)00056-1
更新日期：1996-09-01 00:00:00
abstract：:Sound frequency and binaural response properties were determined for single neurons in the rat's inferior colliculus. Nerve cell responses in the central nucleus of the inferior colliculus were narrowly tuned and had clearly defined characteristic frequencies (CF). The central nucleus was tonotopically organized with ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(91)90177-b
更新日期：1991-11-01 00:00:00
abstract：:In ears in which cochlear efferent pathways were cut and with testing done under anaesthetic conditions that preclude middle ear muscle activity (so as to examine the "intrinsic" effects of loud sound on the cochlea without any confounding effect of efferent pathways to the auditory periphery), atraumatic background w...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2005.12.006
更新日期：2006-03-01 00:00:00
abstract：:The human auditory brainstem is known to be exquisitely sensitive to fine-grained spectro-temporal differences between speech sound contrasts, and the ability of the brainstem to discriminate between these contrasts is important for speech perception. Recent work has described a novel method for translating brainstem ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2011.09.001
更新日期：2011-12-01 00:00:00
abstract：:We confirm the report of Mountain (Mountain, D.C. (1980): Science 210, 77-72) that stimulating the crossed olivocochlear bundle (COCB) can change the magnitude of the distortion product (f2-f1) in the ear-canal sound pressure. Our results are extended to include (2f1-f2) as well as (f2-f1) from anesthetized chinchilla...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(82)90052-1
更新日期：1982-02-01 00:00:00
abstract：:During normal development, cells divide, then differentiate to adopt their individual form and function in an organism. Under most circumstances, mature cells cannot transdifferentiate, changing their fate to adopt a different form and function. Because differentiated cells cannot usually divide, the repair of injurie...
journal_title：Hearing research
pub_type： 杂志文章,评审
doi：10.1016/j.heares.2006.08.015
更新日期：2007-05-01 00:00:00
abstract：:The effects of endogenous and exogenous Ca(2+) buffers on Ca(2+) current kinetics have been investigated by patch clamp in hair cells mechanically isolated from frog semicircular canals. This preparation displays at least three different Ca(2+) channel types: transient currents flow through a drug-resistant channel ("...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2004.05.009
更新日期：2004-09-01 00:00:00
abstract：:The inferior colliculus (IC) receives and integrates excitatory and inhibitory inputs from many bilateral lower auditory nuclei, intrinsic projections within IC, contralateral IC through the commissure of IC and from the auditory cortex (AC). These excitatory and inhibitory inputs from both ascending and descending au...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2019.01.024
更新日期：2019-06-01 00:00:00
abstract：:A model for cochlear mechanics is proposed to take account of its two systems, one passive and one active. The classical passive system stimulates the inner hair cells directly at levels above about 40 dB SL. At intensities below about 60 dB an active process, the 'cochlear amplifier' (CA), somehow provides additional...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(83)90136-3
更新日期：1983-01-01 00:00:00
abstract：:Stiffness of hair bundles on cochlear hair cells was measured in turns 2, 3 and 4 of isolated preparations of the guinea-pig organ of Corti maintained in tissue culture medium. Defined as the force required to produce a linear 1.0 micron deflection of the hair-bundle tip, stiffness is greater for deflection in the exc...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(84)90221-1
更新日期：1984-07-01 00:00:00
abstract：:To investigate the audio-vocal feedback responses of (F0) to hearing amplification in severe-to-profound prelingual hearing loss (SPHL) using power spectral analysis of F0 contour of sustained vowels. Sustained phonations of vowel/a/of seventeen participants with SPHL were acquired with and without hearing-aid amplifi...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2013.04.010
更新日期：2013-08-01 00:00:00
abstract：:The vestibular organs of young and very old C57BL/6NNia (B6) mice were compared by light and electron microscopy. Hair cell density decreased an average of 14% in the utricle, 19% in the saccule and posterior crista, 23% in the horizontal crista, and 24% in the anterior crista. Hair cell size remained the same through...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(87)90156-0
更新日期：1987-01-01 00:00:00
abstract：:Auditory evoked magnetic fields were measured using a stimulation sequence where repetitive identical tone bursts were randomly and infrequently replaced by shorter tones. The deviation in the stimulus duration evoked a specific response, the mismatch field, peaking about 130 ms after the end of the shorter stimulus. ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(89)90174-3
更新日期：1989-08-01 00:00:00
abstract：:Studies in several mammalian species have demonstrated that auditory cortical neurons respond strongly to single frequency-modulated (FM) sweeps, and that most responses are selective for sweep direction and/or rate. In the present study, we used extracellular recordings to examine how neurons in the auditory cortices...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(01)00339-2
更新日期：2001-10-01 00:00:00
abstract：:It is known that adrenocorticotrophic hormone (ACTH)-derived peptides, the so-called melanocortins, can reduce cisplatin-induced neurotoxicity. Recently, our group has found that cisplatin-induced ototoxicity can also be reduced or prevented by treatment with the synthetic melanocortin-like peptide, ORG 2766 (Hamers e...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(98)00194-4
更新日期：1999-02-01 00:00:00
