Abstract:
:The distribution of neurotensin-containing cell bodies and fibers has been observed in the central and peripheral nervous system, including sensory ganglia, but no description has been found in the peripheral auditory system. Here, we investigated the presence of neurotensin immunoreactivity in the cochlea of the adult Wistar rat. Strong neurotensin immunoreactivity was detected in the cytoplasm of the inner hair cells (IHC) and Deiters' cells of the organ of Corti. Outer hair cells (OHC) show weak immunoreaction. Neurotensin immunoreactivity was also found in the neurons and fibers of the spiral ganglia. Quantitative microdensitometric image analysis of the neurotensin immunoreactivity showed a strong immunoreaction in the hair cells of organ of Corti and a moderate to strong labeling in the spiral ganglion neurons. A series of double immunolabeling experiments demonstrated a strong neurotensin immunoreactivity in the parvalbumin immunoreactive IHC and also in the calbindin immunoreactive Deiters' cells. Weak neurotensin immunoreactivity was seen in the calbindin positive OHC. Neurofilament and parvalbumin immunoreactive neurons and fibers in the spiral ganglia showed neurotensin immunoreactivity. Calbindin immunoreactivity was not detected in the spiral ganglion neurons, which are labeled by neurotensin immunoreactivity. The presence of neurotensin in the cochlea may be related to its modulation of neurotransmission in the peripheral auditory pathway.
journal_name
Hear Resjournal_title
Hearing researchauthors
Gomide VC,de Francisco AC,Chadi Gdoi
10.1016/j.heares.2005.02.011keywords:
subject
Has Abstractpub_date
2005-07-01 00:00:00pages
1-6issue
1-2eissn
0378-5955issn
1878-5891pii
S0378-5955(05)00057-2journal_volume
205pub_type
杂志文章相关文献
HEARING RESEARCH文献大全abstract::Noise-induced hearing loss (NIHL) and hair cell loss are known to show only a moderate correlation. One reason for this is that NIHL may reflect not only the sum of dead hair cells, but also the sum of impaired but still living hair cells. This report compares hair cell loss in different cochlear regions in rats with ...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/s0378-5955(02)00802-x
更新日期:2003-03-01 00:00:00
abstract::Degeneration of spiral ganglion neurons (SGNs) in the cochlea following sensorineural hearing loss is preventable by the infusion of neurotrophins into the scala tympani. This study investigates the trophic effects and distribution of a single bolus infusion of neurotrophin-3 (NT3) into the scala tympani of the cochle...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2005.01.001
更新日期:2005-06-01 00:00:00
abstract::The present study examined synaptic potentials of neurons in inferior colliculus (IC) cortex slice and the roles of GABA and glutamate receptors in generating these potentials. Multipolar (82%) and elongated (18%) cells were observed with intracellular biocytin staining. Electrical stimulation of the IC commissure (Co...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/s0378-5955(99)00129-x
更新日期:1999-11-01 00:00:00
abstract::In a wide variety of mammals, the rim of the tympanic membrane (annulus fibrosus) has an array of contractile elements, either smooth muscle [Henson and Henson, J. Assoc. Res. Otolaryngol. 1 (2000) 25-32] or myofibroblasts [Kuijpers et al., Hear. Res. 128 (1999) 80-88]. These elements are anchored peripherally to the ...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/s0378-5955(01)00416-6
更新日期:2002-02-01 00:00:00
abstract::The auditory brainstem response (ABR) is an acoustically evoked potential commonly used to determine hearing sensitivity in laboratory animals. Both isoflurane and ketamine/xylazine anesthesia are commonly used to immobilize animals during ABR procedures. Hearing threshold determination is often the primary interest. ...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2012.04.005
更新日期:2012-05-01 00:00:00
abstract::The tension fibroblasts of the spiral ligament of the mammalian cochlea are thought to create radial tension on the basilar membrane. Their postnatal development was investigated in the gerbil (Meriones unguiculatus) with confocal fluorescence microscopy using phallotoxin as a specific marker for F-actin. In the adult...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/s0378-5955(97)00051-8
更新日期:1997-06-01 00:00:00
abstract::Distortion product otoacoustic emission (DPOAE) iso-suppression tuning curves (STC) were generated in 15 normal-hearing adults and 16 healthy term-born neonates for three f2 frequencies. The 2f1-f2 DPOAE was elicited using f2/f1 = 1.2, LI = 1.2, LI = 65 and L2 = 50 dB SPL. A suppressor tone was presented at frequencie...
journal_title:Hearing research
pub_type: 临床试验,杂志文章
doi:10.1016/0378-5955(96)00056-1
更新日期:1996-09-01 00:00:00
abstract::This chapter reviews evidence for functional connections of the somatosensory and auditory systems at the very lowest levels of the nervous system. Neural inputs from the dosal root and trigeminal ganglia, as well as their brain stem nuclei, cuneate, gracillis and trigeminal, terminate in the cochlear nuclei. Terminat...
journal_title:Hearing research
pub_type: 杂志文章,评审
doi:10.1016/j.heares.2011.05.001
更新日期:2011-11-01 00:00:00
abstract::Laser scanning confocal microscopy was used to determine the distribution of actin, spectrin and tubulin in whole mounts of the organ of Corti of guinea pig, monkey, rat and chinchilla. Actin, spectrin and tubulin were localized in all cell types in the auditory epithelium. No specialized cytoskeletal organization of ...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(94)90098-1
更新日期:1994-06-01 00:00:00
abstract::Potassium channels play a critical role in defining the electrophysiological properties accounting for the unique response patterns of auditory neurons. Serial analysis of gene expression (SAGE), microarrays, RT-PCR, and real-time RT-PCR were used to generate a broad profile of potassium channel expression in the rat ...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2007.01.024
更新日期:2007-06-01 00:00:00
abstract::The ultrastructure of the spiral ligament was compared in aged and young gerbils to assess the involvement of connective tissues in the lateral wall and particularly the fibrocytes in development of presbyacusis. Pathologic features in fibrocytes of senescent gerbils spanned a wide range reflecting different stages of...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/s0378-5955(02)00581-6
更新日期:2002-10-01 00:00:00
abstract::Estrogen signaling in auditory and vestibular sensory epithelia is a newly emerging focus propelled by the role of estrogen signaling in many other proliferative systems. Understanding the pathways with which estrogen interacts can provide a means to identify how estrogen may modulate proliferative signaling in inner ...
journal_title:Hearing research
pub_type: 杂志文章,评审
doi:10.1016/j.heares.2009.01.012
更新日期:2009-06-01 00:00:00
abstract::The directional dependence of sound pressure transformation of head and pinna has been measured in the phyllostomid bat Phyllostomus discolor for the frontal hemisphere using a maximum length sequence method. The azimuthal position of the axis of highest pinna gain came closer to the midsagital plane with increasing f...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/s0378-5955(03)00164-3
更新日期:2003-07-01 00:00:00
abstract::This report describes the effects of L-glutamate (Glu) introduced into the perilymph of scala tympani on the spontaneous and tone-evoked activity of guinea pig single primary auditory afferents. Concentrations below 2 mmol/l were in general ineffective, while a concentration of 5 mmol/l caused a marked decrease of the...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(90)90128-c
更新日期:1990-05-01 00:00:00
abstract::Certain hair cells of fish exhibit strong immunoreactivity to an S-100 antibody. By their spatial locations in the utricle and saccule, these hair cells appear to possess a relatively short kinocilium and a roughly ovoid cell shape. In the utricle, these cells are predominantly located in the striola. In the saccule, ...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(90)90171-k
更新日期:1990-08-01 00:00:00
abstract::The cochlear frequency map is believed to depend on the progressive decrease in partition stiffness from base to apex. Measurements on cochleae from human cadavers by von Békésy (1960) suggested that the elasticity of the partition increases by a factor of 100 from the stapes to the helicotrema. However, conventional ...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/s0378-5955(98)00133-6
更新日期:1998-10-01 00:00:00
abstract::The latency of the N1 component of tone burst evoked compound action potentials was examined in chinchilla following acute pure-tone trauma. At and below the trauma frequency (4 kHz) the N1 latency at threshold generally increased, while above the trauma frequency it decreased; tonotopically paralleling pitch shifts o...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(83)90047-3
更新日期:1983-07-01 00:00:00
abstract::Nitric oxide (NO) not only has normal physiological roles like vasodilation and neurotransmission in the living organism, it could also have possible neurodestructive effects under certain pathological conditions. The present study aimed to determine whether direct exposure of guinea pig cochlea to a NO donor like sod...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/s0378-5955(97)00159-7
更新日期:1997-12-01 00:00:00
abstract::Crossmodal plasticity takes place following sensory loss, such that areas that normally process the missing modality are reorganized to provide compensatory function in the remaining sensory systems. For example, congenitally deaf cats outperform normal hearing animals on localization of visual stimuli presented in th...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2016.06.003
更新日期:2017-01-01 00:00:00
abstract::Previous claims that auditory stream segregation occurs in cochlear implant listeners are based on limited evidence. In experiment 1, eight listeners heard tones presented in a 30-s repeating ABA-sequence, with frequencies matching the centre frequencies of the implant's 22 electrodes. Tone A always stimulated electro...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2006.11.010
更新日期:2007-03-01 00:00:00
abstract::The field L complex is thought to be the highest auditory centre and the input in the song vocal nuclei. Different anatomical and functional subdivisions have been described in field L. Auditory neurons of field L are well activated by natural sounds and especially by species-specific sounds. A complex sound coding ap...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2005.01.008
更新日期:2005-09-01 00:00:00
abstract::This paper reports hourly and daily monitoring of the frequencies of spontaneous otoacoustic emissions. Regular circadian variations in frequency were found in two of three subjects. Consistent monthly variations, in step with the menstrual cycle, were seen in three of four women. The circadian cycle typically showed ...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(92)90012-c
更新日期:1992-02-01 00:00:00
abstract::Auditory brainstem responses (ABR) from ten normal (3 males, 7 females) and ten environmentally sound deprived CBA/J mice (6 males, 4 females) were elicited by 30 dB HL click stimuli delivered via specially constructed, matched insert earphones. The mice were tested at 44-49 days of age under chloral hydrate sedation ...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(83)90092-8
更新日期:1983-06-01 00:00:00
abstract::An anatomically based model of cochlear neuron electrophysiology has been developed and used to interpret the physiological responses of the auditory neuron to electrical summation and refractory pulse-pair stimuli. For summation pulses, the summation time constant, tau(sum), indicates the ability of the membrane to h...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2006.02.011
更新日期:2006-05-01 00:00:00
abstract::We determined velocity discrimination thresholds and Weber fractions for sounds revolving around the listener at very high velocities. Sounds used were a broadband white noise and two harmonic sounds with fundamental frequencies of 330 Hz and 1760 Hz. Experiment 1 used velocities ranging between 288°/s and 720°/s in a...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2014.07.014
更新日期:2014-10-01 00:00:00
abstract::58 chicks or chick embryos were continuously exposed during 12 h on either embryonic day 18 or 20 or on post-hatching days 1, 10, 20 or 30 to 1.5 kHz pure tone at an intensity of 125 dB SPL. After a 20- or 30-day survival time, audiograms were recorded and then the basilar papillae were prepared for scanning electron ...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(85)90141-8
更新日期:1985-01-01 00:00:00
abstract::Left ear noise-induced hearing losses are dominant in the army. The common explanation is the asymmetrical effect of the shooting posture. However, firm evidence to support this possibility is still lacking. In the French army shooters, eye preference rather than hand preference for shooting determines the side of sho...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/s0378-5955(98)00104-x
更新日期:1998-08-01 00:00:00
abstract::Sustained vocalizations of vowels [a], [i], and syllable [mə] were collected in twenty normal-hearing individuals. On vocalizations, five conditions of different audio-vocal feedback were introduced separately to the speakers including no masking, wearing supra-aural headphones only, speech-noise masking, high-pass no...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2015.02.005
更新日期:2015-06-01 00:00:00
abstract::We have studied the noradrenergic and serotonergic changes induced by white noise stimulation at 70, 90 or 110 dB SPL for 45 min, in cochlear nuclei, inferior colliculus (IC), primary auditory cortex (PAC) and as a comparison in locus coeruleus (LC) and raphe dorsalis using HPLC. Both noradrenergic and serotonergic pa...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/s0378-5955(98)00031-8
更新日期:1998-04-01 00:00:00
abstract::Inner and outer hair cells were mechanically isolated from the guinea pig cochlea and subjected to stimuli known to induce shape changes in outer hair cells. Depolarization by 70 mM KCl which causes osmotic swelling of outer hair cells also swelled inner hair cells by approximately 8% of their volume. The application ...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(91)90202-k
更新日期:1991-03-01 00:00:00