Abstract：
:Estrogen signaling in auditory and vestibular sensory epithelia is a newly emerging focus propelled by the role of estrogen signaling in many other proliferative systems. Understanding the pathways with which estrogen interacts can provide a means to identify how estrogen may modulate proliferative signaling in inner ear sensory epithelia. Reviewed herein are two signaling families, EGF and TGFbeta. Both pathways are involved in regulating proliferation of supporting cells in mature vestibular sensory epithelia and have well characterized interactions with estrogen signaling in other systems. It is becoming increasingly clear that elucidating the complexity of signaling in regeneration will be necessary for development of therapeutics that can initiate regeneration and prevent progression to a pathogenic state.
journal_name
Hear Resjournal_title
Hearing researchauthors
McCullar JS,Oesterle ECdoi
10.1016/j.heares.2009.01.012subject
Has Abstractpub_date
2009-06-01 00:00:00pages
61-70issue
1-2eissn
0378-5955issn
1878-5891pii
S0378-5955(09)00023-9journal_volume
252pub_type
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