Specific sound-induced noradrenergic and serotonergic activation in central auditory structures.

abstract：:Transient-evoked otoacoustic emissions (TEOAEs) at high frequencies are a non-invasive physiological test of basilar membrane mechanics at the basal end, and have clinical potential to detect risk of hearing loss related to outer-hair-cell dysfunction. Using stimuli with constant incident pressure across frequency, TE...

journal_title：Hearing research

authors： Keefe DH,Feeney MP,Hunter LL,Fitzpatrick DF,Blankenship CM,Garinis AC,Putterman DB,Wróblewski M

更新日期：2019-01-01 00:00:00

abstract：:Efferent neurones within the intraganglionic spiral bundle of the guinea pig cochlea were characterized in terms of their response properties, and their pattern of termination within the receptor organ revealed by intracellular labelling with horseradish peroxidase. All neurones subsequently identified as efferent neu...

journal_title：Hearing research

authors： Robertson D,Gummer M

更新日期：1985-01-01 00:00:00

abstract：:Guinea pigs were exposed to a 10 kHz pure tone and damage to the cochlea was investigated immediately after exposure, or after a recovery period ranging from 18-25 days. Structural damage was assessed using scanning electron microscopy and functional damage estimated using the N1 threshold audiogram. Exposure at 106 d...

journal_title：Hearing research

authors： Robertson D,Johnstone BM,McGill TJ

更新日期：1980-01-01 00:00:00

abstract：:We report the results of behavioral studies in cats conducted first, to demonstrate the presence of a monaural mechanism for the enhancement of signal to noise; and then to examine the necessity or sufficiency of the acoustic striae for this mechanism. The results show that cats do indeed have a monaural mechanism for...

journal_title：Hearing research

authors： Masterton RB,Granger EM,Glendenning KK

更新日期：1994-03-01 00:00:00

abstract：:Doppler vibrometers are used by many research groups to monitor the motion of the tympanic membrane (TM) and of middle ear ossicles for in vivo and in vitro studies. Power densities in these applications reach 80 W/cm(2). To determine the safe limit of exposure, a cw dye laser at a wavelength of 633 nm was used to inv...

journal_title：Hearing research

authors： Foth H,Färber S,Gauer A,Wagner R

更新日期：2000-04-01 00:00:00

abstract：:The primary goal of this study was to characterize the variability in auditory-nerve temporal response patterns obtained with the electrically evoked compound action potential (ECAP) within and across a relatively large group of cochlear-implant recipients. ECAPs were recorded in response to each of 21 pulses in a pul...

journal_title：Hearing research

authors： Hughes ML,Castioni EE,Goehring JL,Baudhuin JL

更新日期：2012-03-01 00:00:00

abstract：:In the surgical treatment of otosclerosis, the coupling between the stapes prosthesis and the long process of the incus is critical. After surgery, connective tissue and mucosa may grow over the coupling area and thereby influence the sound transmission properties of the incus-prosthesis interface. It was the hypothes...

journal_title：Hearing research

authors： Sim JH,Chatzimichalis M,Huber AM

更新日期：2010-05-01 00:00:00

abstract：:The distribution of neurotensin-containing cell bodies and fibers has been observed in the central and peripheral nervous system, including sensory ganglia, but no description has been found in the peripheral auditory system. Here, we investigated the presence of neurotensin immunoreactivity in the cochlea of the adul...

journal_title：Hearing research

authors： Gomide VC,de Francisco AC,Chadi G

更新日期：2005-07-01 00:00:00

abstract：:Estrogen signaling in auditory and vestibular sensory epithelia is a newly emerging focus propelled by the role of estrogen signaling in many other proliferative systems. Understanding the pathways with which estrogen interacts can provide a means to identify how estrogen may modulate proliferative signaling in inner ...

journal_title：Hearing research

authors： McCullar JS,Oesterle EC

更新日期：2009-06-01 00:00:00

abstract：:Several studies have compared the frequency selectivity of waves I and V of the auditory brainstem response (ABR) in humans, however little is known about the frequency selectivity of the middle latency response (MLR). Simultaneous recordings of ABRs and MLRs to 60 dB peSPL 2000-Hz probe tones were obtained in the pre...

journal_title：Hearing research

authors： Mackersie C,Down KE,Stapells DR

更新日期：1993-02-01 00:00:00

abstract：:The effects of efferent activation on the otoacoustic emission were measured in anesthetized guinea pigs. The otoacoustic emission (2F(1)-F(2)) was evoked by the conventional method of presenting either two continuous tones or a sinusoidal current to the round window (RW) of the cochlea. The efferent effects on the ac...

journal_title：Hearing research

authors： Ota Y,Dolan DF

更新日期：2000-10-01 00:00:00

abstract：:Stiffness of hair bundles on cochlear hair cells was measured in turns 2, 3 and 4 of isolated preparations of the guinea-pig organ of Corti maintained in tissue culture medium. Defined as the force required to produce a linear 1.0 micron deflection of the hair-bundle tip, stiffness is greater for deflection in the exc...

journal_title：Hearing research

authors： Strelioff D,Flock A

更新日期：1984-07-01 00:00:00

abstract：:Owing to the advances in transgenic animal technology and the advent of the next-generation sequencing era, over 120 genes causing hereditary hearing loss have been identified by now. In parallel, the field of human gene therapy continues to make exciting and rapid progress, culminating in the recent approval of sever...

journal_title：Hearing research

authors： Fakhiri J,Landegger LD,Grimm D

更新日期：2020-10-15 00:00:00

abstract：:This paper discusses how ion transport proteins in the hair cells of the mammalian cochlea work to produce a sensitive but stable hearing organ. The transport proteins in the inner and outer hair cells are summarized (including their current voltage characteristics), and the roles of these proteins in determining intr...

journal_title：Hearing research

authors： Patuzzi R

更新日期：2011-10-01 00:00:00

abstract：:The effect of interaural time differences (ITDs) on stream segregation for successive tone bursts was investigated. Obligatory stream segregation was inferred from the threshold for detecting a rhythmic irregularity in an otherwise isochronous sequence of interleaved "A" and "B" tones (task 1). Subjective stream segre...

journal_title：Hearing research

authors： Füllgrabe C,Moore BC

更新日期：2012-09-01 00:00:00

abstract：:Chromogranin A (CgA) belongs to the family of chromogranin peptides which are contained in large dense-core vesicles. The novel CgA fragment catestatin (bovine CgA(344-364); RSMRLSFRARGYGFRGPGLQL) is a potent inhibitor of catecholamine release by acting as a nicotinic cholinergic antagonist. Catestatin is a recently c...

journal_title：Hearing research

authors： Bitsche M,Mahata SK,Marksteiner J,Schrott-Fischer A

更新日期：2003-10-01 00:00:00

abstract：:Damage to auditory nerve fibers that expresses with suprathreshold sounds but is hidden from the audiogram has been proposed to underlie deficits in temporal coding ability observed among individuals with otherwise normal hearing, and to be present in individuals experiencing chronic tinnitus with clinically normal au...

journal_title：Hearing research

authors： Paul BT,Bruce IC,Roberts LE

更新日期：2017-02-01 00:00:00

abstract：:Electrical stimulation of the cochlea is known to cause auditory sensations in humans and other animals. It also has been shown to produce emissions of sound from the inner ear. In the current study we investigate the relationship between electrically induced motion of the basilar membrane (BM) and the production of o...

journal_title：Hearing research

authors： Nuttall AL,Ren T

更新日期：1995-12-01 00:00:00

abstract：:No adequate theory for the signal-transmission properties of the peripheral auditory system exists for any vertebrate ear. Because the mammalian ear seems to pose conceptual and technical problems that complicate the development of an adequate theory, it is worthwhile to investigate simpler ears. The ear of the alliga...

journal_title：Hearing research

authors： Weiss TF,Peake WT,Rosowski JJ

更新日期：1985-01-01 00:00:00

abstract：:This study explored the effects on speech intelligibility of across-formant differences in fundamental frequency (ΔF0) and F0 contour. Sentence-length speech analogues were presented dichotically (left = F1+F3; right = F2), either alone or-because competition usually reveals grouping cues most clearly-accompanied in t...

journal_title：Hearing research

authors： Summers RJ,Bailey PJ,Roberts B

更新日期：2017-02-01 00:00:00

abstract：:Mammalian aquaporins constitute a family of so far 10 related water channel proteins which mediate osmotically driven water fluxes across the plasma membrane. Because regulation of the ionic composition and osmolality of inner ear fluids is of great functional significance, we investigated the expression patterns of a...

journal_title：Hearing research

authors： Beitz E,Kumagami H,Krippeit-Drews P,Ruppersberg JP,Schultz JE

更新日期：1999-06-01 00:00:00

abstract：:Caloric restriction (CR) slows aging in many species and protects some animals from age-related hearing loss (ARHL), but the effect on humans is not yet known. Because rhesus monkeys are long-lived primates that are phylogenically closer to humans than other research animals are, they provide a better model for studyi...

journal_title：Hearing research

authors： Fowler CG,Chiasson KB,Leslie TH,Thomas D,Beasley TM,Kemnitz JW,Weindruch R

更新日期：2010-03-01 00:00:00

abstract：:This article presents a comparison of Liouville-Green (LG) calculations and exact solutions of 2- and 3-dimensional cochlea models. The agreement is in general quite good. For certain choices of the model parameters, however, the 2- and 3-dimensional LG solutions show appreciable errors in the region just beyond the l...

journal_title：Hearing research

authors： de Boer E,Viergever MA

更新日期：1982-10-01 00:00:00

abstract：:Over the last 30 years a wide range of manipulations of auditory input and experience have been shown to result in plasticity in auditory cortical and subcortical structures. The time course of plasticity ranges from very rapid stimulus-specific adaptation to longer-term changes associated with, for example, partial h...

journal_title：Hearing research

authors： Irvine DRF

更新日期：2018-05-01 00:00:00

abstract：:Electrically evoked compound action potentials (ECAPs) have been used to examine temporal response patterns of the auditory nerve in cochlear implant (CI) recipients. ECAP responses to individual pulses in a pulse train vary across stimulation rates for individual CI users. For very slow rates, auditory neurons have a...

journal_title：Hearing research

authors： Hughes ML,Laurello SA

更新日期：2017-08-01 00:00:00

abstract：:There is accumulating evidence for a purinergic humoral system involved in the control of cochlear function. Evidence of specific P2 purinoceptors on cochlear tissues implies a role for extracellular adenosine triphosphate (ATP) in the cochlea. To further this hypothesis a study was undertaken to determine if there wa...

journal_title：Hearing research

authors： White PN,Thorne PR,Housley GD,Mockett B,Billett TE,Burnstock G

更新日期：1995-10-01 00:00:00

abstract：BACKGROUND:Noise-induced hearing loss (NIHL) is a multifactorial disease, and dysregulation of oxidative stress is universally acknowledged as one crucial pathogenic factor for this disease. Recently studies have found the LncRNA HOTAIR is involved in the alteration of oxidative stress level, cell proliferation, cell c...

journal_title：Hearing research

authors： Wang B,Ding E,Shen H,Wang J,Sun K,Chen S,Han L,Zhang H,Zhu B,Xu M

更新日期：2017-04-01 00:00:00

abstract：:This study concerns the connections of the inner and outer hair cells and the different types of ganglion cells of the mammalian cochlea with the central nervous system by making use of their putative neurotransmitters. D-[3H]Aspartate (D-ASP), a putative marker for glutamatergic neurons, was injected into the cochlea...

journal_title：Hearing research

authors： Jones DR,Morest DK,Oliver DL,Potashner SJ

更新日期：1984-09-01 00:00:00

abstract：:Nitric oxide (NO) not only has normal physiological roles like vasodilation and neurotransmission in the living organism, it could also have possible neurodestructive effects under certain pathological conditions. The present study aimed to determine whether direct exposure of guinea pig cochlea to a NO donor like sod...

journal_title：Hearing research

authors： Ruan RS,Leong SK,Yeoh KH

更新日期：1997-12-01 00:00:00

abstract：:A field potential could be recorded in the deep layers of the superior colliculus (SCd) in the guinea pig following presentation of pure tone bursts at frequencies between 1 and 22 kHz, bursts of white noise, and clicks presented in the free field. The potentials evoked by these stimuli at different intensities had tw...

journal_title：Hearing research

authors： Carlile S,Pettigrew AG

更新日期：1987-12-01 00:00:00