Abstract：
:Doppler vibrometers are used by many research groups to monitor the motion of the tympanic membrane (TM) and of middle ear ossicles for in vivo and in vitro studies. Power densities in these applications reach 80 W/cm(2). To determine the safe limit of exposure, a cw dye laser at a wavelength of 633 nm was used to investigate the threshold of thermal damage of TM of pigs under exposure times of 60 s. To determine the applied power density accurately, the spot size of the laser beam was monitored by an objective lens and a CCD camera. Twenty-six laser exposed samples of TM were stained by haematoxylin and eosin stain and the semi-thin sections were examined microscopically. In none of the sections was any laser induced damage observed with power densities below 7.1 kW/cm(2), whereas serious damage occurred showing coagulation, carbonisation and perforation in all cases with laser powers above 8.2 kW/cm(2). The threshold for damage and the conical shape of the damage zone is explained by photon propagation and absorption in the tissue especially by the increase of the scattering factor at higher tissue temperature. The thermal damage threshold of 8 kW/cm(2) is compared to the maximum permissible exposure given in laser safety standards for skin.
journal_name
Hear Resjournal_title
Hearing researchauthors
Foth H,Färber S,Gauer A,Wagner Rdoi
10.1016/s0378-5955(00)00013-7keywords:
subject
Has Abstractpub_date
2000-04-01 00:00:00pages
71-8issue
1-2eissn
0378-5955issn
1878-5891pii
S0378595500000137journal_volume
142pub_type
杂志文章相关文献
HEARING RESEARCH文献大全abstract：:The human fetus in utero is hypoxic relative to the neonate due to differences between placental and pulmonary oxygenation. Comparable degrees of hypoxia induced in young and adult animals caused an elevation in hearing threshold of a sensorineural nature. It was hypothesised therefore that the human fetus may also ha...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(94)90289-5
更新日期：1994-02-01 00:00:00
abstract：:Guinea pigs were exposed to a 10 kHz pure tone and damage to the cochlea was investigated immediately after exposure, or after a recovery period ranging from 18-25 days. Structural damage was assessed using scanning electron microscopy and functional damage estimated using the N1 threshold audiogram. Exposure at 106 d...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(80)90015-5
更新日期：1980-01-01 00:00:00
abstract：:In the cochlea, outer hair cells (OHCs) generate the active cochlear mechanics whereas the supporting cells, such as Deiters' cells and Hensen's cells, may play a role in both the active and passive cochlear mechanics. The presence of receptors for adenosine triphosphate (ATP) on OHCs, Deiters' cells and Hensen's cell...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(98)00019-7
更新日期：1998-04-01 00:00:00
abstract：:The auditory system can encode interaural delays in highpass-filtered complex sounds by phase locking to their slowly modulating envelopes. Spectrotemporal analysis of interaurally time-delayed highpass waveforms reveals the presence of a concomitant interaural level cue. The current study systematically investigated ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2011.01.008
更新日期：2011-07-01 00:00:00
abstract：:The distribution of S-100-like immunoreactivity in mouse and hamster auditory and vestibular end organs was determined by the use of immunohistochemistry. Within the organ of Corti, the cytoplasm of cells of Deiter and Hensen were strongly immunoreactive. Inner hair cells and the peripheral processes and cell bodies o...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(94)90176-7
更新日期：1994-04-01 00:00:00
abstract：:Tinnitus is most often initiated by modality specific otopathologic disturbances affecting peripheral and central auditory pathways. However, there is growing evidence indicating that the anatomical location generating tinnitus occurs at sites different from the initial pathology. Support for this notion is found in i...
journal_title：Hearing research
pub_type： 杂志文章,评审
doi：10.1016/s0378-5955(02)00717-7
更新日期：2003-01-01 00:00:00
abstract：:Synaptic bodies (SBs) associated with rings of synaptic vesicles and well-defined, pre- and post-synaptic membrane structures are indicators of maturity in most hair cell-afferent nerve junctions. The role of the SBs remains elusive despite several experiments showing that they may be involved in storage of neurotrans...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(93)90135-n
更新日期：1993-04-01 00:00:00
abstract：:Cochlear compression in normal-hearing listeners was estimated at octave frequencies from 250 to 4000 Hz using a forward-masking paradigm. Temporal masking curves (TMCs) for a 10-dB SL signal were obtained with two maskers -- one equal in frequency to the signal and another an octave below the signal. The ratio of the...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2004.10.006
更新日期：2005-03-01 00:00:00
abstract：:During normal development, cells divide, then differentiate to adopt their individual form and function in an organism. Under most circumstances, mature cells cannot transdifferentiate, changing their fate to adopt a different form and function. Because differentiated cells cannot usually divide, the repair of injurie...
journal_title：Hearing research
pub_type： 杂志文章,评审
doi：10.1016/j.heares.2006.08.015
更新日期：2007-05-01 00:00:00
abstract：:Carboplatin is currently being used as an anticancer drug against human cancers. However, high dose of carboplatin chemotherapy resulted in hearing loss in cancer patients. We have shown that carboplatin-induced hearing loss was related to dose-dependent oxidative injury to the cochlea in rat model. However, the time ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2004.01.011
更新日期：2004-05-01 00:00:00
abstract：:Mutations in GJB2 account for the majority of recessive forms of prelingual hearing loss. However, in most previous studies it was not possible to distinguish between congenital (present at birth) and non-congenital prelingual hearing loss. In the present study, the frequency of GJB2 alleles in 20 newborns with bilate...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2004.06.012
更新日期：2004-11-01 00:00:00
abstract：:Noise over-stimulation will induce or influence molecular pathways in the cochlea; one approach to the identification of the components of these pathways in the cochlea is to examine genes and proteins that change following different types and levels of stress. Quantitative reverse transcription polymerase chain react...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2004.07.011
更新日期：2004-12-01 00:00:00
abstract：:Immunocytochemical methods were used to examine cryosections of the embryonic and neonatal chicken cochlea in order to study the histological distribution of the Na+,K+-ATPase molecule during maturation. In complementary studies the Na+,K+-ATPase capacity of microdissected freeze-dried substructures of the cochlea was...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(87)90212-7
更新日期：1987-11-01 00:00:00
abstract：:Acetylcholine (ACh) is a neuromodulator that is likely to play a role in plasticity as well as other phenomena at many sites in the auditory system. The auditory cortex receives cholinergic innervation from the basal forebrain, whereas the cochlea receives cholinergic innervation from the superior olivary complex. Muc...
journal_title：Hearing research
pub_type： 杂志文章,评审
doi：10.1016/j.heares.2010.12.019
更新日期：2011-09-01 00:00:00
abstract：:The barn owl (Tyto alba) uses interaural level difference (ILD) as a cue for the localization of sound. The first site of binaural convergence in the pathway that processes ILD is the ventral lateral lemniscus pars posterior (VLVp). Neurons in VLVp receive excitatory input from the contralateral nucleus angularis, and...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(98)00102-6
更新日期：1998-09-01 00:00:00
abstract：:Dominant white spotting W/W(v) and W(v)/W(v) mice are well-known mutants that lack strial intermediate cells in their cochlea and manifest hereditary sensorineural hearing loss. We recently reported marked thickening of and IgG deposition on the basement membrane of strial capillaries in W/W(v) mutant mice, similar to...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2005.05.013
更新日期：2005-11-01 00:00:00
abstract：:Prior research [Caine et al., 1981] suggested that scopolamine, a central cholinergic antagonist, may increase gap thresholds in young human listeners. If confirmed, an effect of scopolamine on gap detection might help to explain why both aged humans and aged laboratory animals have less sensitive temporal acuity on g...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(00)00088-5
更新日期：2000-07-01 00:00:00
abstract：:Two different radioligands were used to identify extracellular ATP binding sites specific to P2 purinoceptors in guinea-pig cochlear tissue. Deoxyadenosine 5'-(alpha-[35S]thio)triphosphate ([35S]dATP alpha S; 10 nM) provided a high activity probe for the P2y purinoceptor subtype on the basis of selective block by 2-me...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(95)00024-x
更新日期：1995-04-01 00:00:00
abstract：:The discharge properties of 735 single units located in the pars magnocellularis (M) of the medial division of the medial geniculate body (MGB) were studied in 23 nitrous oxide anesthetized cats in response to simple acoustic stimuli (clicks, noise and tone bursts). A systematic decrease of single unit characteristic ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(89)90086-5
更新日期：1989-05-01 00:00:00
abstract：:DNA methylation and histone modifications such as methylation, acetylation, and phosphorylation, are two types of epigenetic modifications that alter gene expression. These additions to DNA regulatory elements or to the tails of histones can be inherited or can also occur de novo. Since epigenetic modifications can ha...
journal_title：Hearing research
pub_type： 杂志文章,评审
doi：10.1016/j.heares.2019.01.007
更新日期：2019-05-01 00:00:00
abstract：:Difference limens for the fundamental frequency (F0) of complex tones (DLCs) were measured for four normally hearing subjects and three subjects with cochlear hearing loss. The nominal F0 was 100, 200 or 400 Hz. The two tones to be compared contained either low resolved harmonics (RES), harmonics with intermediate res...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(03)00191-6
更新日期：2003-08-01 00:00:00
abstract：:In this series of behavioural experiments we investigated the effect of distraction on the maintenance of acoustic scene information in short-term memory. Stimuli are artificial acoustic 'scenes' composed of several (up to twelve) concurrent tone-pip streams ('sources'). A gap (1000 ms) is inserted partway through the...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2016.08.015
更新日期：2016-11-01 00:00:00
abstract：:Measurements of the responses to tones and clicks were made from single primary auditory fibres of the caiman. The distribution of the amplitude and phase of the fundamental component of the response rate modulation over the best frequencies of the fibres is comparable to that reported in the cat, despite the fact tha...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(86)90052-3
更新日期：1986-01-01 00:00:00
abstract：:The dorsal cochlear nucleus (DCN) has been shown to project to a region of the nucleus reticularis pontis caudalis (PnC) critical for the evocation of startle in rats, suggesting a possible modulatory influence of the DCN on startle. This study examined the involvement of the DCN in the acoustic startle reflex and var...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(98)00040-9
更新日期：1998-05-01 00:00:00
abstract：:Inbred strain variants of the Cdh23 gene have been shown to influence the onset and progression of age-related hearing loss (AHL) in mice. In linkage backcrosses, the recessive Cdh23 allele (ahl) of the C57BL/6J strain, when homozygous, confers increased susceptibility to AHL, while the dominant allele (Ahl+) of the C...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2011.11.007
更新日期：2012-01-01 00:00:00
abstract：:When auditory nerve function is lost due to surgical removal of bilateral acoustic tumors in cases of neurofibromatosis type 2, a sense of hearing may be restored by means of an auditory brainstem implant (ABI), which electrically stimulates the cochlear nucleus. Electrically evoked auditory brainstem responses record...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(99)00016-7
更新日期：1999-04-01 00:00:00
abstract：:Immunolabeling of heregulin, a growth factor that enhances cell proliferation in damaged utricles, and one of its binding receptors, ErbB-2, has been briefly described in the P3 rat cochlea and utricle [Zheng et al. (1999) J. Neurocytol. 28, 901-912]. However, little is known about the distribution of heregulin and it...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(02)00339-8
更新日期：2002-07-01 00:00:00
abstract：:The tympanic membrane is a key component of the human auditory apparatus. Good estimates of tympanic membrane mechanical properties are important to obtain realistic models of middle ear mechanics. Current literature values are almost all derived from direct mechanical tests on cut-out strips. For a biomedical specime...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2012.05.001
更新日期：2012-08-01 00:00:00
abstract：:Carbohydrate distribution in the fresh utricular macula of the guinea pig was analysed using lectins such as Concanavalin A (ConA), Dolichos biflorus agglutinin (DBA), peanut agglutinin (PNA), soybean agglutinin (SBA), Ulex europeus agglutinin (UEA-1) and wheat germ agglutinin (WGA) by means of confocal laser scanning...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(95)00075-f
更新日期：1995-07-01 00:00:00
abstract：:Differences between inner and outer hair cells in the cellular content of precipitable calcium were detected using a potassium pyroantimonate precipitation method and the electron spectroscopic imaging (ESI-) technique. The cytoplasm of the inner hair cells was scattered with a high number of calcium precipitates in a...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(94)90213-5
更新日期：1994-01-01 00:00:00
