Abstract：
:Differences between inner and outer hair cells in the cellular content of precipitable calcium were detected using a potassium pyroantimonate precipitation method and the electron spectroscopic imaging (ESI-) technique. The cytoplasm of the inner hair cells was scattered with a high number of calcium precipitates in all analysed animals, but only a few reaction products could be identified in the cytoplasm of the outer hair cells in all analyzed specimens. Even the well developed system of the subsurface fenestrated cisternae in the outer hair cells was nearly empty of calcium precipitates. A relatively high amount of reaction products could be identified in the nuclei of both types of nerve endings of the receptor cells. Significant differences regarding the content of precipitable calcium were found in the different types of nerve endings, which come into contact with the basal parts of both receptor cells. The observed differences in the content of precipitable calcium between the two types of hair cells are discussed with respect to their probable different roles in signal transduction processes.
journal_name
Hear Resjournal_title
Hearing researchauthors
Maurer J,Heinrich UR,Mann Wdoi
10.1016/0378-5955(94)90213-5subject
Has Abstractpub_date
1994-01-01 00:00:00pages
135-42issue
1-2eissn
0378-5955issn
1878-5891pii
0378-5955(94)90213-5journal_volume
72pub_type
杂志文章相关文献
HEARING RESEARCH文献大全abstract：:Transient-evoked otoacoustic emissions (TEOAEs) at high frequencies are a non-invasive physiological test of basilar membrane mechanics at the basal end, and have clinical potential to detect risk of hearing loss related to outer-hair-cell dysfunction. Using stimuli with constant incident pressure across frequency, TE...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2018.09.010
更新日期：2019-01-01 00:00:00
abstract：:Kanamycin ototoxicity, combined with behavioral audiometry to evaluate threshold shifts, was used to destroy outer hair cells (OHCs) in the basal cochlea of the chincilla while leaving the inner hair cell (IHC) population largely intact. After survival times of four weeks to one year, transmission electron microscopy ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(80)90027-1
更新日期：1980-12-01 00:00:00
abstract：:The time of onset of hyperactivity (increased spontaneous firing rates) was investigated by single neuron recording in the inferior colliculus (IC) of guinea pigs subjected to unilateral acoustic trauma (exposure to a loud 10 kHz tone). Hyperactivity was present by 12 h post acoustic trauma whereas data obtained withi...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2012.12.008
更新日期：2013-04-01 00:00:00
abstract：:The distribution of S-100-like immunoreactivity in mouse and hamster auditory and vestibular end organs was determined by the use of immunohistochemistry. Within the organ of Corti, the cytoplasm of cells of Deiter and Hensen were strongly immunoreactive. Inner hair cells and the peripheral processes and cell bodies o...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(94)90176-7
更新日期：1994-04-01 00:00:00
abstract：:An investigation of the effects of the level and bandwidth of the masking noise and of the effect of test-tone duration on binaural masking-level differences (BMLDs) has been carried out using the standard Békésy audiometric techniques. The BMLDs increase in magnitude with increasing masker level, reach a shallow maxi...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(84)90015-7
更新日期：1984-05-01 00:00:00
abstract：:The goal of the current study was to characterize the normative features of wideband acoustic immittance in children for describing the functional maturation of the middle ear in 5 to 12-year-old children. Absorbance and group delay were measured in adults and three groups of children, 5-6, 7-9 and 10-12-year-olds, in...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2016.10.029
更新日期：2017-02-01 00:00:00
abstract：:Actin mRNA was characterised in hair-cell enriched fractions of the chick basilar papilla, by means of the reverse-transcription polymerase chain reaction technique. Primers were directed against the 3' untranslated portions of the actin mRNAs. Evidence for beta-cytoplasmic and gamma-cytoplasmic actin mRNA was found; ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(93)90038-3
更新日期：1993-12-01 00:00:00
abstract：:A model was developed to simulate acoustically the effects of excitation spread in cochlear implants (CI). Based on neurophysiologic data, the proposed model simulates the electrical-current decay rate associated with broad and narrow types of excitation, such as those produced by monopolar and bipolar electrode confi...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2008.04.012
更新日期：2008-07-01 00:00:00
abstract：:Psychophysical measures of the electrically stimulated human auditory system were obtained for different types of symmetric and asymmetric charge-balanced waveforms. Absolute detection thresholds of biphasic, pseudomonophasic, and 'alternating monophasic' current waveforms delivered by a bipolar intra-cochlear electro...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2004.08.006
更新日期：2005-02-01 00:00:00
abstract：:The intercellular gap junction channels formed by connexins (CXs) are important for recycling potassium ions in the inner ear. CXs are encoded by a family of the CX gene, such as GJB2, and the mechanism leading to mutant connexin-associated diseases, including hearing loss, remains to be elucidated. In this study, usi...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2014.04.010
更新日期：2014-07-01 00:00:00
abstract：:Otoacoustic emissions (OAEs) differ between the sexes in humans, rhesus and marmoset monkeys, and sheep. OAEs also are different in a number of special populations of humans. Those basic findings are reviewed and discussed in the context of possible prenatal-androgen effects on the auditory system. A parsimonious expl...
journal_title：Hearing research
pub_type： 杂志文章,评审
doi：10.1016/j.heares.2009.01.002
更新日期：2009-06-01 00:00:00
abstract：:There is accumulating evidence for a purinergic humoral system involved in the control of cochlear function. Evidence of specific P2 purinoceptors on cochlear tissues implies a role for extracellular adenosine triphosphate (ATP) in the cochlea. To further this hypothesis a study was undertaken to determine if there wa...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(95)00151-1
更新日期：1995-10-01 00:00:00
abstract：:The cytosolic pH (pHi) of transitional cells from the ampulla of the gerbil was measured micro-fluorometrically with the pH-sensitive dye 2',7'-bicarboxyethyl-5(6)-carboxyfluorescein (BCECF) to assess the possible contribution of a Na+/H+ exchanger to the regulation of pHi. All experiments were conducted in virtually ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(93)90098-l
更新日期：1993-09-01 00:00:00
abstract：:Alterations in the distribution and activity of Na,K-ATPase have been implicated in declining cell function with age. However, the location, size and anatomical complexity of the cochlea have limited study of this essential enzyme. Here we describe a micro-colorimetric assay which measures Na,K-ATPase activity in subr...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(94)00188-v
更新日期：1995-03-01 00:00:00
abstract：:A series of organic acid transport inhibitors significantly reduced the endocochlear potential (EP) decline produced by furosemide in the chinchilla. Probenecid, sodium salicylate and penicillin G were much more effective than novobiocin, meclofenamate or diatrizoate. Inhibitors of organic base transport, choline and ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(87)90037-2
更新日期：1987-01-01 00:00:00
abstract：:In common inbred mouse strains, hearing loss is a highly prevalent quantitative trait, which is mainly controlled by the Cdh23(753A) variant and alleles at numerous other strain-specific loci. Here, we investigated the genetic basis of hearing loss in non-inbred strains. Mice of Swiss Webster, CF-1, NIH Swiss, ICR, an...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2005.11.006
更新日期：2006-02-01 00:00:00
abstract：:Cochlear Implant (CI) sound coding strategies based on simultaneous stimulation lead to an increased loudness percept when compared to sequential stimulation using the same current levels. This is due to loudness summation as a result of channel interactions. Studying the loudness perception evoked by dual-channels co...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2020.108091
更新日期：2020-12-01 00:00:00
abstract：:This study concerns the connections of the inner and outer hair cells and the different types of ganglion cells of the mammalian cochlea with the central nervous system by making use of their putative neurotransmitters. D-[3H]Aspartate (D-ASP), a putative marker for glutamatergic neurons, was injected into the cochlea...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(84)90029-7
更新日期：1984-09-01 00:00:00
abstract：:Previous investigations have shown that components of a tone burst-evoked otoacoustic emission (TBOAE) evoked by a 1 kHz tone burst (TB1) can be suppressed by the simultaneous presence of a 2 kHz tone burst (TB2) or a pair of tone bursts at 2 and 3 kHz (TB2 and TB3 respectively). No previous study has measured this "s...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2015.04.013
更新日期：2015-09-01 00:00:00
abstract：:The auditory filter may be considered as a weighting function representing frequency selectivity at a particular centre frequency. Its shape can be derived using the power-spectrum model of masking which assumes: (1) in detecting a signal in a masker the observer uses the single auditory filter giving the highest sign...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(87)90050-5
更新日期：1987-01-01 00:00:00
abstract：:A transmission electron microscopy (TEM) study and synaptophysin immunoreactivity analysis of neurons in the human spiral ganglion was performed with particular emphasis on the demonstration of synapses. The study was based on surgical biopsy material obtained during transcochlear meningioma surgery. Vesiculated nerve...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(99)00179-3
更新日期：2000-03-01 00:00:00
abstract：:In this study, which aims to investigate for the first time auditoty sensitivity in congenital central hypothyroidism (CH), we concluded that: (1) permanent sensorineural hearing loss may be observed not only in congenital primary disorders of thyroid function, as reported hitherto; (2) it may also be found in patient...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(02)00515-4
更新日期：2002-10-01 00:00:00
abstract：:It has previously been demonstrated that ototoxicity induced by systemic administration of cisplatin is reduced by concomitant systemic administration of alpha-melanocyte stimulating hormone (alpha-MSH). In this study we investigated the effects of cochlear, perilymphatic application of alpha-MSH during intraperitonea...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/S0378-5955(03)00396-4
更新日期：2004-03-01 00:00:00
abstract：:Rodents have proven to be a useful model system to screen genes, ototoxic compounds and sound exposure protocols that may play a role in hearing loss. High-throughput screening depends upon a rapid and reliable functional assay for hearing loss. This study describes the use of a frequency modulated (FM) chirp stimulus...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2008.09.001
更新日期：2008-11-01 00:00:00
abstract：:Regrowth of peripheral spiral ganglion neuron (SGN) fibers is a primary objective in efforts to improve cochlear implant outcomes and to potentially reinnervate regenerated hair cells. Cyclic adenosine monophosphate (cAMP) regulates neurite growth and guidance via activation of protein kinase A (PKA) and Exchange Prot...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2011.11.010
更新日期：2012-01-01 00:00:00
abstract：:The f2-f1 distortion product otoacoustic emission (DPOAE) can be observed to undergo gradual alterations in amplitude during continuous ipsilateral stimulation with primary tones. In the present experiments, we characterized the dependence of these amplitude alterations on several stimulus variables (intensity, durati...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(95)00041-2
更新日期：1995-05-01 00:00:00
abstract：BACKGROUND:Pitch perception of complex tones relies on place or temporal fine structure-based mechanisms from resolved harmonics and the temporal envelope of unresolved harmonics. Combining this information is essential for speech-in-noise performance, as it allows segregation of a target speaker from background noise....
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2018.06.016
更新日期：2018-09-01 00:00:00
abstract：:The spontaneous fluctuations of the intracellular voltage and the position of the sensory hairbundle were measured concurrently using intracellular microelectrodes and an optical differential micro interferometer. Magnitude and frequency distribution of the hair bundles' spontaneous motion suggest that it consists mos...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(92)90062-r
更新日期：1992-06-01 00:00:00
abstract：:The ototoxic effects of salicylates, reversible hearing loss and tinnitus, are well documented. However, the pharmacological mechanisms underlying these changes in cochlear function are not well understood. The studies reported here were an investigation of the site and mechanism of salicylate ototoxicity through an e...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(90)90144-e
更新日期：1990-06-01 00:00:00
abstract：:Input-specific remodeling is observed both in the primary auditory cortex (AI) and the ventral division of the medial geniculate body of the thalamus (MGBv) through motivation such as learning. Here, we show the role of AI in the MGBv remodeling induced by the electrical stimulation (ES) of the central division of the...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2015.06.016
更新日期：2015-10-01 00:00:00
