Abstract：
:Input-specific remodeling is observed both in the primary auditory cortex (AI) and the ventral division of the medial geniculate body of the thalamus (MGBv) through motivation such as learning. Here, we show the role of AI in the MGBv remodeling induced by the electrical stimulation (ES) of the central division of the inferior colliculus (ICc). For the MGBv neurons with frequency tunings different from those of electrically stimulated ICc neurons, their frequency tunings shifted towards the tunings of the ICc neurons. AI neurons also showed this input-specific remodeling after ES of the ICc (ESICc). Interestingly, the input-specific remodeling of MGBv was eliminated when the AI was inactivated using cortical application of muscimol. For the MGBv neurons tuned to the same frequency as the stimulated ICc neurons, their tunings were kept but their responses were facilitated after the ESICc. In contrast to the input-specific tuning shifts, this facilitation was rarely impacted by the AI inactivation. Thus, we conclude that AI directs the input-specific remodeling of MGBv induced by ESICc. It is suggested that the tuning shift in the MGBv primarily takes place in the AI and is relayed to the MGBv through the corticofugal system while the MGBv mainly highlights the frequency information emphasized in ICc.
journal_name
Hear Resjournal_title
Hearing researchauthors
Nelson SL,Kong L,Liu X,Yan Jdoi
10.1016/j.heares.2015.06.016subject
Has Abstractpub_date
2015-10-01 00:00:00pages
1-7eissn
0378-5955issn
1878-5891pii
S0378-5955(15)00139-2journal_volume
328pub_type
杂志文章相关文献
HEARING RESEARCH文献大全abstract：:Tinnitus is highly prevalent in the general population. Tinnitus sufferers often report having difficulties focusing on a task at hand and ignoring the tinnitus percept. Behavioral studies have shown evidence for impairments in attention, interference inhibition, and various other executive functions in tinnitus. Howe...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2015.03.006
更新日期：2015-08-01 00:00:00
abstract：:Long-term experience enhances neural representation of temporal attributes of pitch in the brainstem and auditory cortex in favorable listening conditions. Herein we examine whether cortical pitch mechanisms shaped by language experience are more resilient to degradation in background noise, and exhibit greater binaur...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2017.09.006
更新日期：2017-11-01 00:00:00
abstract：:Mitochondrial DNA (mtDNA) mutations/deletions are considered to be associated with the development of age-related hearing loss (AHL). We assessed the role of accumulation of mtDNA mutations in the development of AHL using Polg(D257A) knock-in mouse, which exhibited increased spontaneous mtDNA mutation rates during agi...
journal_title：Hearing research
pub_type： 杂志文章,评审
doi：10.1016/j.heares.2006.06.004
更新日期：2007-04-01 00:00:00
abstract：BACKGROUND:Noise-induced hearing loss (NIHL) is a multifactorial disease, and dysregulation of oxidative stress is universally acknowledged as one crucial pathogenic factor for this disease. Recently studies have found the LncRNA HOTAIR is involved in the alteration of oxidative stress level, cell proliferation, cell c...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2017.02.007
更新日期：2017-04-01 00:00:00
abstract：:Georg von Békésy was one of the first comparative auditory researchers. He not only studied basilar membrane (BM) movements in a range of mammals of widely different sizes, he also worked on the chicken basilar papilla and the frog middle ear. We show that, in mammals, at least, his data do not differ from those that ...
journal_title：Hearing research
pub_type： 历史文章,杂志文章,评审
doi：10.1016/j.heares.2012.04.013
更新日期：2012-11-01 00:00:00
abstract：:A simple model for the acoustic enhancement of electrically evoked otoacoustic emissions (EEOEs) is presented in this paper. The model is based on the assumption that the enhancement is a result of the local interaction between the electrical current spreading in the scala media and the basilar membrane (BM) response ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(95)00175-1
更新日期：1995-11-01 00:00:00
abstract：:In the developing inner ear, a naturally occurring programmed cell death of cochleovestibular ganglion (CVG) neurons as well as peripheral and central target-derived trophic effects on survival of embryonic CVG neurons are known. To further analyze these target derived trophic interactions, spiral ganglion explants ob...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(92)90127-9
更新日期：1992-03-01 00:00:00
abstract：:Change in PO2 in endolymph, endocochlear potentials and cochlear microphonics have been tested in normoxia, hyperoxia and anoxia on 24 guinea pigs. The polarographic method and construction of oxygen-sensitive microelectrodes is described in detail. The normal level of PO2 in endolymph vaires between 20 and 30 mm Hg. ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(78)90003-5
更新日期：1978-10-01 00:00:00
abstract：:Ototoxicity is a dose-limiting side effect of chemotherapeutic treatment with cisplatin. In a series of experiments on neonatal rat cochlear organotypic cultures, the extent of damage induced by a broad range of cisplatin treatment concentrations was examined. Paradoxically, it was found that hair cell loss was greate...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2011.08.002
更新日期：2011-12-01 00:00:00
abstract：:In different animal models, auditory nerve fibers display variation in spontaneous activity and response threshold. Functional and structural differences among inner hair cell ribbon synapses are believed to contribute to this variation. The relative volumes of synaptic proteins at individual synapses might be one suc...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2020.107933
更新日期：2020-05-01 00:00:00
abstract：:Auditory evoked magnetic fields were measured using a stimulation sequence where repetitive identical tone bursts were randomly and infrequently replaced by shorter tones. The deviation in the stimulus duration evoked a specific response, the mismatch field, peaking about 130 ms after the end of the shorter stimulus. ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(89)90174-3
更新日期：1989-08-01 00:00:00
abstract：:Temporal modulation transfer functions (TMTF) were obtained from four European starlings (Sturnus vulgaris) using a psychophysical Go/NoGo procedure combined with the method of constant stimuli. The TMTF for a continuous, broad-band noise of 55 dB SPL had a low-pass characteristic with a cut-off frequency of 123 Hz. F...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(91)90182-9
更新日期：1991-03-01 00:00:00
abstract：:This study examined the effect of monaural middle ear destruction on postnatal development of auditory response properties of inferior collicular (IC) neurons of the laboratory mouse, Mus musculus. Monaural middle ear destruction was performed on juvenile and adult mice and the auditory response properties of neurons ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(01)00304-5
更新日期：2001-09-01 00:00:00
abstract：:The human fetus in utero is hypoxic relative to the neonate due to differences between placental and pulmonary oxygenation. Comparable degrees of hypoxia induced in young and adult animals caused an elevation in hearing threshold of a sensorineural nature. It was hypothesised therefore that the human fetus may also ha...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(94)90289-5
更新日期：1994-02-01 00:00:00
abstract：:Previous studies indicate the presence of adenosine receptors in the cochlear tissues obtained from different animals. This study was initiated to determine the subtypes of adenosine receptor (AR) present in the chinchilla cochlea and to assess their function. Radioligand binding studies demonstrate the presence of bo...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(96)00204-3
更新日期：1997-03-01 00:00:00
abstract：:Sensorineural hearing loss, which is often caused by degeneration of hair cells in the auditory epithelium, is permanent because lost hair cells are not replaced. Several conceptual approaches can be used to place new hair cells in the auditory epithelium. One possibility is to enhance proliferation of non-sensory cel...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2007.06.005
更新日期：2007-10-01 00:00:00
abstract：:The origins of extrinsic projections to the guinea pig dorsal and ventral cochlear nuclei were identified by examining the retrograde transport of horseradish peroxidase conjugated to wheatgerm agglutinin following its injection into each of these divisions. Major projections originated in periolivary regions of the s...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(91)90205-n
更新日期：1991-03-01 00:00:00
abstract：:The Federal Food and Drug Administration, or FDA is generally considered a powerful gatekeeper, able to deliver or withhold life-saving cures and create or destroy economic windfalls. As the decades go by, and technologies, diseases, public health demands, and politics evolve, we can identify patterns of change, actio...
journal_title：Hearing research
pub_type： 杂志文章,评审
doi：10.1016/j.heares.2016.11.006
更新日期：2017-06-01 00:00:00
abstract：:Single neuron responses to sinusoidal 20 Hz amplitude modulated tone bursts (612.5 ms stimulus-on time at the rate of once per 2.2 s) were studied in the auditory midbrain (torus semicircularis) of the immobilized grass frog (Rana temporaria temporaria). The characteristic frequency stimuli at 30 dB above the minimum ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(96)00128-1
更新日期：1996-11-01 00:00:00
abstract：:Perception of objects in the scene around us is effortless and intuitive, yet entails profound computational challenges. Progress has been made in understanding some mechanisms by which the brain encodes the boundaries and surfaces of visual objects. However, in the auditory domain, these mechanisms are poorly underst...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2013.06.009
更新日期：2013-10-01 00:00:00
abstract：:In natural environments, temporally complex signals often occur in a background of noise. The neural mechanisms underlying the preservation of temporal sensitivity in background noise are poorly understood. In the present study, we examined the ability of inferior colliculus (IC) units with primary-like and sustained ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(00)00186-6
更新日期：2000-12-01 00:00:00
abstract：:It is known that adrenocorticotrophic hormone (ACTH)-derived peptides, the so-called melanocortins, can reduce cisplatin-induced neurotoxicity. Recently, our group has found that cisplatin-induced ototoxicity can also be reduced or prevented by treatment with the synthetic melanocortin-like peptide, ORG 2766 (Hamers e...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(98)00194-4
更新日期：1999-02-01 00:00:00
abstract：:The effects of efferent activation on the otoacoustic emission were measured in anesthetized guinea pigs. The otoacoustic emission (2F(1)-F(2)) was evoked by the conventional method of presenting either two continuous tones or a sinusoidal current to the round window (RW) of the cochlea. The efferent effects on the ac...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(00)00150-7
更新日期：2000-10-01 00:00:00
abstract：:Noise, hearing loss, and electronic signal distortion, which are common problems in military environments, can impair speech intelligibility and thereby jeopardize mission success. The current study investigated the impact that impaired communication has on operational performance in a command and control environment ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2016.10.007
更新日期：2017-06-01 00:00:00
abstract：:The central nucleus of the inferior colliculus (CNIC) contains different types of neurons and is a source of ascending projection to the medial geniculate body (MGB), commissural projection to the contralateral IC, direct descending projection to the cochlea nucleus (CN) and indirect projection to the CN via the super...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2006.04.004
更新日期：2006-08-01 00:00:00
abstract：:The olivocochlear bundle was sectioned at the floor of the fourth ventricle in a series of cats. From three to thirty weeks post-operatively, recordings were made from single auditory-nerve fibers. Tuning curves, spontaneous discharge rates, and rate-level functions for tones at the characteristic frequency were measu...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(90)90105-x
更新日期：1990-11-01 00:00:00
abstract：:Cave fish have rarely been investigated with regard to their inner ear morphology, hearing abilities, and acoustic communication. Based on a previous study that revealed morphological differences in the saccular otolith between a cave and two surface populations of Poecilia mexicana, we checked for additional differen...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2010.04.001
更新日期：2010-08-01 00:00:00
abstract：:The dose-response ototoxic effects of cisplatin were studied in guinea pigs. Loss of Preyer reflex and suppression of the N1 amplitude occurred in cisplatin-treated animals and was described as dose-related. Drug-induced hair cell damage, as observed with scanning electron microscopy, occurred sporadically throughout ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(87)90104-3
更新日期：1987-01-01 00:00:00
abstract：:This study examined the neural basis of auditory selective attention using functional magnetic resonance imaging. The main hypothesis stated that attending to a particular sound frequency would significantly enhance the neural response within those tonotopic regions of the auditory cortex sensitive to that frequency. ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2009.08.007
更新日期：2009-11-01 00:00:00
abstract：:The inner ear contains receptor cells that oscillate spontaneously, generating waves that propagate backward in the cochlea, ultimately causing sound to be radiated into the ear canal--the spontaneous otoacoustic emissions (SOAEs). Except in rare conditions, these internally generated signals appear to go unheard. The...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(02)00388-x
更新日期：2002-09-01 00:00:00
