Abstract：
:The dose-response ototoxic effects of cisplatin were studied in guinea pigs. Loss of Preyer reflex and suppression of the N1 amplitude occurred in cisplatin-treated animals and was described as dose-related. Drug-induced hair cell damage, as observed with scanning electron microscopy, occurred sporadically throughout the turns of the cochlea and the incidence increased with dose. Na,K-ATPase activity in the lateral wall tissues was not significantly different between treatment groups. The results reported here indicate that cisplatin ototoxicity was dose-dependent, but was not directly related to Na,K-ATPase activity in the lateral wall.
journal_name
Hear Resjournal_title
Hearing researchauthors
Barron SE,Daigneault EAdoi
10.1016/0378-5955(87)90104-3subject
Has Abstractpub_date
1987-01-01 00:00:00pages
131-7issue
2eissn
0378-5955issn
1878-5891pii
0378-5955(87)90104-3journal_volume
26pub_type
杂志文章相关文献
HEARING RESEARCH文献大全abstract：:Polyclonal antibodies were raised in chickens to the glycosylated forms of the high (H), medium (M) and low (L) molecular mass (MM) mouse tectorins. In the mouse cochlea, all three antibodies stained the tectorial membrane. Antibodies raised to HMM tectorin also stained the hair bundles of both inner and outer hair ce...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(96)00174-8
更新日期：1997-01-01 00:00:00
abstract：BACKGROUND:Recently, in vitro and in vivo models have identified that microRNAs (miRNAs), which are extensively expressed in the inner ear, play important roles in inner ear development and function. However, the function of miRNA in vertebrate tissue is not well understood. RESULTS:The current study used an in vitro ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2012.02.005
更新日期：2012-04-01 00:00:00
abstract：:The responses to two identical, consecutive pure tone stimuli with varying inter-stimulus intervals (delta ts) were measured for 89 neurons in the cochlear nucleus of the anaesthetised guinea pig. We observed two main effects; either a decrease (suppression) or an increase (facilitation) in response to the second tone...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2005.12.005
更新日期：2006-02-01 00:00:00
abstract：:During the simultaneous monaural presentation of two primary tones, distortion products can be measured acoustically in the ear canal (DPOAEs) and electrically as auditory evoked potentials (DPAEPs). The purpose of this investigation was to elucidate the sources of nonlinearity within the human auditory system respons...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2004.04.005
更新日期：2004-07-01 00:00:00
abstract：:Damage to auditory nerve fibers that expresses with suprathreshold sounds but is hidden from the audiogram has been proposed to underlie deficits in temporal coding ability observed among individuals with otherwise normal hearing, and to be present in individuals experiencing chronic tinnitus with clinically normal au...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2016.11.010
更新日期：2017-02-01 00:00:00
abstract：:Three budgerigars and three zebra finches were tested for their ability to detect sinusoidal stimuli in the presence of broadband noise. Masked thresholds for 1, 2, and 4 KHz pure tones were measured with a fixed frequency condition, in which only one test frequency was presented in a session, and with an uncertain fr...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(90)90043-o
更新日期：1990-12-01 00:00:00
abstract：:Membranous vestibular labyrinths from the oyster toadfish, Opsanus tau, were fixed, dissected from the animal, stained, and embedded in rectangular blocks of clear histological resin. Photomicrographs of complete embedded labyrinths were taken from six orthogonal directions and used to construct three-dimensional (3D)...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(98)00108-7
更新日期：1998-10-01 00:00:00
abstract：:Electrically evoked auditory brainstem response (EABR) recordings were made from 38 humans implanted with one of three cochlear prostheses, and from 25 cats. Recognizable auditory potentials were identified in 27 of the profoundly deaf implanted subjects. In both cats and humans EABR waveform morphology and magnitude ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(86)90033-x
更新日期：1986-01-01 00:00:00
abstract：:Eye color may be an indicator of inner ear melanin content and has been associated with hearing loss. There is controversy as to whether eye color has an effect on acquired causes of sensorineural hearing loss. This review was conducted to analyze the literature evaluating the relationship between eye color and causes...
journal_title：Hearing research
pub_type： 杂志文章,评审
doi：10.1016/j.heares.2014.12.002
更新日期：2015-02-01 00:00:00
abstract：UNLABELLED:This study sought to characterize the response of mammalian primary otolithic neurons to sound and vibration by measuring the resting discharge rates, thresholds for increases in firing rate and supra-threshold sensitivity functions of guinea pig single primary utricular and saccular afferents. Neurons with ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2015.10.019
更新日期：2016-01-01 00:00:00
abstract：:We report the results of behavioral studies in cats conducted first, to demonstrate the presence of a monaural mechanism for the enhancement of signal to noise; and then to examine the necessity or sufficiency of the acoustic striae for this mechanism. The results show that cats do indeed have a monaural mechanism for...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(94)90237-2
更新日期：1994-03-01 00:00:00
abstract：:Binaural temporal resolution was measured using the discrimination of brief interaural time delays (ITDs). In experiment 1, three listeners performed a 2I-2AFC, ITD-discrimination procedure. ITD changes of 8 to 1024micros were applied to brief probe noises. These probes, with durations of 16 to 362ms, were placed symm...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2008.12.001
更新日期：2009-02-01 00:00:00
abstract：:Salicylate is a well-known substance to produce reversible tinnitus in animals and humans as well. It has been shown that systemic application of salicylate changes the neuronal spontaneous activity in several parts of the auditory pathway. The effects observed in central auditory structures in vivo could be based upo...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2008.02.005
更新日期：2008-06-01 00:00:00
abstract：:This study examined how speech babble noise differentially affected the auditory P3 responses and the associated neural oscillatory activities for consonant and vowel discrimination in relation to segmental- and sentence-level speech perception in noise. The data were collected from 16 normal-hearing participants in a...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2017.04.009
更新日期：2017-07-01 00:00:00
abstract：:Males and females differ in their subcortical evoked responses to sound. For many evoked response measures, the sex difference is driven by a faster developmental decline of auditory processing in males. Using the frequency-following response (FFR), an evoked potential that reflects predominately midbrain processing o...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2020.108075
更新日期：2020-12-01 00:00:00
abstract：:Hypoxia/ischemia is a major pathogenetic factor in the development of hearing loss. An important transcription factor involved in the signaling and adaptation to hypoxia/ischemia is the hypoxia-inducible factor-1 (HIF-1). To study HIF-1 expression we used an in vitro hypoxia model of explant and dissociated cultures o...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(03)00222-3
更新日期：2003-09-01 00:00:00
abstract：:Voltage-dependent K+ channels in the basolateral membrane of hair cells in guinea-pig cochlea might contribute to the non-linear current-voltage relationships in these hair cells and, thereby, to generation of the extracellular summating potential (SP). To evaluate the role of K+ channels in the generation of the SP t...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(95)00095-l
更新日期：1995-08-01 00:00:00
abstract：:Many hearing-impaired listeners struggle to localize sounds due to poor availability of binaural cues. Listeners with a cochlear implant and a contralateral hearing aid - so-called bimodal listeners - are amongst the worst performers, as both interaural time and level differences are poorly transmitted. We present a n...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2018.03.007
更新日期：2018-06-01 00:00:00
abstract：:The marsupials, the large group of mammals which develop during fetal life in an externalized pouch, have been given little attention by auditory neurobiologists. In this review the structure of the auditory systems of the handful of marsupials which have been studied is described, the course of auditory development m...
journal_title：Hearing research
pub_type： 杂志文章,评审
doi：10.1016/0378-5955(94)00182-p
更新日期：1995-02-01 00:00:00
abstract：:Using transgenic fluorescent reporter mice in combination with an established tissue clearing method, we detail heretofore optically opaque regions of the spiral lamina and spiral limbus where the auditory peripheral nervous system is located and provide insight into changes in cochlear vascular density with ageing. W...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2018.11.012
更新日期：2019-01-01 00:00:00
abstract：:Auditory brainstem responses (ABRs) were evoked in developing wallabies by click and tone burst stimuli delivered by bone conduction and air conduction, at progressive stages of post-natal (pouch) life. ABRs were recorded through the onset of auditory responses (95-110 days), the opening of the external ear canal (125...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(97)00211-6
更新日期：1998-03-01 00:00:00
abstract：:Delayed acoustic waves have been measured in the sealed ear canal in response to click and tone-burst stimuli. The response shows compressive nonlinearity, evidence for 'active' processing, and frequency tuning. At low sound levels group and phase delays correspond, and represent about 15 waves delay for the mid-frequ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(80)90060-x
更新日期：1980-06-01 00:00:00
abstract：:Biomarkers in easy-to-access body fluid compartments, such as blood, are commonly used to assess health of various organ systems in clinical medicine. At present, no such biomarkers are available to inform on the health of the inner ear. Previously, we proposed the outer-hair-cell-specific protein prestin, as a possib...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2018.11.013
更新日期：2019-01-01 00:00:00
abstract：:The peripheral auditory sense organ, the cochlea, receives innervation from lateral and medial olivocochlear neurons in the brainstem. These neurons are able to modulate cochlear neural output. Anatomical studies have shown that one of the neurotransmitters which is present in varicosities surrounding the olivocochlea...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2005.01.009
更新日期：2005-06-01 00:00:00
abstract：:We confirm the report of Mountain (Mountain, D.C. (1980): Science 210, 77-72) that stimulating the crossed olivocochlear bundle (COCB) can change the magnitude of the distortion product (f2-f1) in the ear-canal sound pressure. Our results are extended to include (2f1-f2) as well as (f2-f1) from anesthetized chinchilla...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(82)90052-1
更新日期：1982-02-01 00:00:00
abstract：:In mammals, the cochlear sensory epithelium becomes quiescent early during development. After the first postnatal week, there is no cell replacement or proliferation, and severe damage leads to permanent deafness. Supporting cells' trans-differentiation has been suggested as a way to regenerate cochlear hair cells aft...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2018.12.002
更新日期：2019-03-01 00:00:00
abstract：:Efferent neurones within the intraganglionic spiral bundle of the guinea pig cochlea were characterized in terms of their response properties, and their pattern of termination within the receptor organ revealed by intracellular labelling with horseradish peroxidase. All neurones subsequently identified as efferent neu...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(85)90059-0
更新日期：1985-01-01 00:00:00
abstract：:Inner hair cells (IHCs) were isolated from the 3rd and 4th turn of the guinea-pig cochlea using a new microsurgical technique. Microelectrode impalements in vitro with conventional microelectrodes yielded intracellular potentials of -14 +/- 7 mV (mean +/- SD, N = 43) at 24 degrees C. This suggested depletion of intrac...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(90)90185-r
更新日期：1990-04-01 00:00:00
abstract：:We studied hair cell regeneration in the crista ampullaris of the lizard Podarcis sicula both in untreated animals and at early and late time intervals following a single high dose of gentamicin. The study was carried out using the S-phase marker 5-bromo-2'-deoxyuridine. Our ultrastructural and immunofluorescence stud...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(03)00040-6
更新日期：2003-04-01 00:00:00
abstract：:A technique was devised in order to study the fast electromechanical length changes of outer hair cells at low stimulus levels. Solitary outer hair cells were drawn into a glass microchamber. Length changes were evoked by the application of transcellular potentials and were detected with a photodiode. The method is no...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(91)90019-6
更新日期：1991-04-01 00:00:00
