Evidence for hair cell regeneration in the crista ampullaris of the lizard Podarcis sicula.

Abstract:

:We studied hair cell regeneration in the crista ampullaris of the lizard Podarcis sicula both in untreated animals and at early and late time intervals following a single high dose of gentamicin. The study was carried out using the S-phase marker 5-bromo-2'-deoxyuridine. Our ultrastructural and immunofluorescence studies showed that both apoptosis and hair cell regeneration happen in the lizard crista ampullaris in untreated animals, and that regenerative processes are greatly accelerated after treatment with the aminoglycoside antibiotic gentamicin. Our observations indicate that hair cell regeneration is strongly implicated in the repair of damaged sensory epithelium, and that new hair cells appear likely to arise from supporting cells.

journal_name

Hear Res

journal_title

Hearing research

authors

Avallone B,Porritiello M,Esposito D,Mutone R,Balsamo G,Marmo F

doi

10.1016/s0378-5955(03)00040-6

keywords:

subject

Has Abstract

pub_date

2003-04-01 00:00:00

pages

79-88

issue

1-2

eissn

0378-5955

issn

1878-5891

pii

S0378595503000406

journal_volume

178

pub_type

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