Effects of forskolin and 1,9-dideoxy-forskolin on cochlear potentials.

abstract：:The purpose of this study was to investigate the protective effects of U74389F (Upjohn Co. Kalamazoo, MI), a 21-aminosteroid/lipid peroxidation inhibitor, and a member of the lazaroid drug class, on temporary threshold shifts in animals exposed to prolonged noise stimulation. Animals treated with U74389F and exposed t...

journal_title：Hearing research

authors： Quirk WS,Shivapuja BG,Schwimmer CL,Seidman MD

更新日期：1994-04-01 00:00:00

abstract：:The cochlear nucleus (CN) is the first sound processing center in the central auditory system that receives the almost unprocessed auditory information from the auditory periphery. The functional organization of the CN has been studied to a great extent in many mammals, including the cat, rat and bat. Yet, despite the...

journal_title：Hearing research

authors： Luo F,Wang Q,Farid N,Liu X,Yan J

更新日期：2009-11-01 00:00:00

abstract：:Stiffness of hair bundles on cochlear hair cells was measured in turns 2, 3 and 4 of isolated preparations of the guinea-pig organ of Corti maintained in tissue culture medium. Defined as the force required to produce a linear 1.0 micron deflection of the hair-bundle tip, stiffness is greater for deflection in the exc...

journal_title：Hearing research

authors： Strelioff D,Flock A

更新日期：1984-07-01 00:00:00

abstract：:Inner hair cells (IHCs) were isolated from the 3rd and 4th turn of the guinea-pig cochlea using a new microsurgical technique. Microelectrode impalements in vitro with conventional microelectrodes yielded intracellular potentials of -14 +/- 7 mV (mean +/- SD, N = 43) at 24 degrees C. This suggested depletion of intrac...

journal_title：Hearing research

authors： Gitter AH,Zenner HP

更新日期：1990-04-01 00:00:00

abstract：:This paper reports hourly and daily monitoring of the frequencies of spontaneous otoacoustic emissions. Regular circadian variations in frequency were found in two of three subjects. Consistent monthly variations, in step with the menstrual cycle, were seen in three of four women. The circadian cycle typically showed ...

journal_title：Hearing research

authors： Bell A

更新日期：1992-02-01 00:00:00

abstract：:Gene therapy using virus vectors to treat hereditary diseases has made remarkable progress in the past decade. There are FDA-approved products for ex-vivo gene therapy for diseases such as immunodeficiencies (e.g., SCID), and in vivo gene therapy for a rare blindness and neuro-muscular disease. Gene therapy for heredi...

journal_title：Hearing research

authors： Maguire CA,Corey DP

更新日期：2020-09-01 00:00:00

abstract：:The marsupials, the large group of mammals which develop during fetal life in an externalized pouch, have been given little attention by auditory neurobiologists. In this review the structure of the auditory systems of the handful of marsupials which have been studied is described, the course of auditory development m...

journal_title：Hearing research

authors： Aitkin L

更新日期：1995-02-01 00:00:00

abstract：:In this series of behavioural experiments we investigated the effect of distraction on the maintenance of acoustic scene information in short-term memory. Stimuli are artificial acoustic 'scenes' composed of several (up to twelve) concurrent tone-pip streams ('sources'). A gap (1000 ms) is inserted partway through the...

journal_title：Hearing research

authors： Petsas T,Harrison J,Kashino M,Furukawa S,Chait M

更新日期：2016-11-01 00:00:00

abstract：:The rather shallow growth of click-evoked otoacoustic emissions (CEOAE) with click intensity, namely <1 dB/dB, distinguishes genuine CEOAEs from stimulus artifacts, thereby providing the rationale for the popular 'derived nonlinear recording' method. However, other CEOAE nonlinearities regarding phase or envelope depe...

journal_title：Hearing research

authors： Carvalho S,Büki B,Bonfils P,Avan P

更新日期：2003-01-01 00:00:00

abstract：:Inhibition of sodium/potassium pumping by isolated goldfish hair cells led to a rapid gain of sodium and loss of potassium. Half-times for turnover were about 10 min, among the fastest of any cell type examined by electron-probe analysis. Pumping was inhibited by removal of extracellular potassium or by treatment with...

journal_title：Hearing research

authors： Mroz EA,Nissim KR,Lechene C

更新日期：1993-10-01 00:00:00

abstract：:Left-handed individuals show a 4 ms later Wave Pb in the 45-60 ms latency range of the auditory middle latency response (MLR) than right-handed individuals. Examination of auditory evoked potentials in fifteen right-handed and fifteen left-handed normal hearing adults showed that this difference was not evident in tim...

journal_title：Hearing research

authors： Hood LJ,Martin DA,Berlin CI

更新日期：1990-04-01 00:00:00

abstract：:One can construct narrow bands of noise that contain delays of either the envelope, the phase, or the carrier separately or in combination. Delayed and undelayed noises will have identical spectra if, and only if, both the envelope and the phase undergo delays of the same magnitude. To study lateralization of these si...

journal_title：Hearing research

authors： Amenta CA 3rd,Trahiotis C,Bernstein LR,Nuetzel JM

更新日期：1987-01-01 00:00:00

abstract：:Noninvasive auditory brainstem responses (ABRs) are commonly used to assess cochlear pathology in both clinical and research environments. In the current study, we evaluated the relationship between ABR characteristics and more direct measures of cochlear function. We recorded ABRs and auditory nerve (AN) single-unit ...

journal_title：Hearing research

authors： Henry KS,Kale S,Scheidt RE,Heinz MG

更新日期：2011-10-01 00:00:00

abstract：:This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...

journal_title：Hearing research

authors： Brownell WE

更新日期：2009-10-07 00:00:00

abstract：:Nitric oxide (NO) not only has normal physiological roles like vasodilation and neurotransmission in the living organism, it could also have possible neurodestructive effects under certain pathological conditions. The present study aimed to determine whether direct exposure of guinea pig cochlea to a NO donor like sod...

journal_title：Hearing research

authors： Ruan RS,Leong SK,Yeoh KH

更新日期：1997-12-01 00:00:00

abstract：:The density of cochlear inner hair cells in Wistar rats is greatest on a short section of the basilar membrane about a fifth of its length from the base. This place corresponds to the frequency region of 30--40 kHz which is supposed to be the region of best hearing. ...

journal_title：Hearing research

authors： Burda H,Voldrick L

更新日期：1980-07-01 00:00:00

abstract：:Binaural hearing confers many beneficial functions but our understanding of its underlying neural substrates is limited. This study examines the bilateral synaptic assemblies and binaural computation (or integration) in the central nucleus of the inferior colliculus (ICc) of the auditory midbrain, a key convergent cen...

journal_title：Hearing research

authors： He N,Kong L,Lin T,Wang S,Liu X,Qi J,Yan J

更新日期：2017-11-01 00:00:00

abstract：:The possible presence of different types of delayed rectifier K+ current (I(K)) was studied in vestibular hair cells of frog semicircular canals. Experiments were performed in thin slice preparations of the whole crista ampullaris and recordings were made using the whole-cell patch-clamp technique. We found that an ap...

journal_title：Hearing research

authors： Marcotti W,Russo G,Prigioni I

更新日期：1999-09-01 00:00:00

abstract：:Periodicity coding was studied in primary auditory cortex of the ketamine anesthetized cat by simultaneously recording with two electrodes from up to 6 neural units in response to one second long click trains presented once per 3 s. Trains with click rates of 1, 2, 4, 8, 16 and 32/s were used and the responses of the ...

journal_title：Hearing research

authors： Eggermont JJ

更新日期：1991-11-01 00:00:00

abstract：:One role of the inferior colliculus (IC) in bats is to create neuronal delay-tuning, which is used for the estimation of target distance in the echolocating bat's auditory system. In this study, we describe response properties of IC delay-tuned neurons of the mustached bat (Pteronotus parnellii) and compare it with th...

journal_title：Hearing research

authors： Macías S,Mora EC,Hechavarría JC,Kössl M

更新日期：2012-04-01 00:00:00

abstract：:This study addressed the hypotheses that the growth of the level of distortion product otoacoustic emissions (LDP) with primary-tone level reflects the behavior of a third-order nonlinear polynomial system, and that two sources exist for these distortion products. The results indicated that the 2f1-f2 otoacoustic emis...

journal_title：Hearing research

authors： Popelka GR,Osterhammel PA,Nielsen LH,Rasmussen AN

更新日期：1993-12-01 00:00:00

abstract：:Transient-evoked otoacoustic emissions (TEOAEs) at high frequencies are a non-invasive physiological test of basilar membrane mechanics at the basal end, and have clinical potential to detect risk of hearing loss related to outer-hair-cell dysfunction. Using stimuli with constant incident pressure across frequency, TE...

journal_title：Hearing research

authors： Keefe DH,Feeney MP,Hunter LL,Fitzpatrick DF,Blankenship CM,Garinis AC,Putterman DB,Wróblewski M

更新日期：2019-01-01 00:00:00

abstract：:Listening to speech in noise can be effortful but when motivated people seem to be more persevering. Previous research showed effects of monetary reward on autonomic responses like cardiovascular reactivity and pupil dilation while participants processed auditory information. The current study examined the effects of ...

journal_title：Hearing research

authors： Koelewijn T,Zekveld AA,Lunner T,Kramer SE

更新日期：2018-09-01 00:00:00

abstract：:The vibration characteristics (amplitude and phase as a function of frequency) of the tympanic membrane in the grass frog were measured using a laser-doppler velocity meter. It was tested to what extent the frog's acoustic system behaves as a pressure gradient receiver. This might clarify how the frog localizes sound....

journal_title：Hearing research

authors： Vlaming MS,Aertsen AM,Epping WJ

更新日期：1984-05-01 00:00:00

abstract：:Cochlear implant users with ipsilateral residual hearing combine acoustic and electric hearing in one ear, this is called electric-acoustic stimulation (EAS). In EAS users, masking can be shown for electric probes in the presence of acoustic maskers and vice versa. Masking effects in acoustic hearing are generally att...

journal_title：Hearing research

authors： Imsiecke M,Büchner A,Lenarz T,Nogueira W

更新日期：2020-02-01 00:00:00

abstract：:In the pigeon no influence of high doses (135 mg/kg) of furosemide on endocochlear potential and sound evoked activity in single auditory nerve fibres was found. This finding contrasts strongly to results in mammals. ...

journal_title：Hearing research

authors： Schermuly L,Vossieck T,Klinke R

更新日期：1990-12-01 00:00:00

abstract：:It has been demonstrated that INS can be utilized to stimulate spiral ganglion cells in the cochlea. Although neural stimulation can be achieved without direct contact of the radiation source and the tissue, the presence of fluids or bone between the target structure and the radiation source may lead to absorption or ...

journal_title：Hearing research

authors： Moreno LE,Rajguru SM,Matic AI,Yerram N,Robinson AM,Hwang M,Stock S,Richter CP

更新日期：2011-12-01 00:00:00

abstract：:The hair cells of the vertebrate inner ear posses active mechanical processes to amplify their inputs. The stereocilia bundle of various vertebrate animals can produce active movements. Though standard stereocilia-based mechanisms to promote amplification persist in mammals, an additional radically different mechanism...

journal_title：Hearing research

authors： Elgoyhen AB,Franchini LF

更新日期：2011-03-01 00:00:00

abstract：:Auditory-nerve fibers demonstrate dynamic response properties in that they adapt to rapid changes in sound level, both at the onset and offset of a sound. These dynamic response properties affect temporal coding of stimulus modulations that are perceptually relevant for many sounds such as speech and music. Temporal d...

journal_title：Hearing research

authors： Scheidt RE,Kale S,Heinz MG

更新日期：2010-10-01 00:00:00

abstract：:Most investigators place reflective beads on the basilar membrane to measure its vibration with optical methods. It is therefore important to find out if the beads faithfully follow the motion of the structures on which they are placed. Vibration of the beads on the basilar membrane and basilar membrane adjacent to th...

journal_title：Hearing research

authors： Khanna SM,Ulfendahl M,Steele CR

更新日期：1998-02-01 00:00:00