Abstract：
:Auditory-nerve fibers demonstrate dynamic response properties in that they adapt to rapid changes in sound level, both at the onset and offset of a sound. These dynamic response properties affect temporal coding of stimulus modulations that are perceptually relevant for many sounds such as speech and music. Temporal dynamics have been well characterized in auditory-nerve fibers from normal-hearing animals, but little is known about the effects of sensorineural hearing loss on these dynamics. This study examined the effects of noise-induced hearing loss on the temporal dynamics in auditory-nerve fiber responses from anesthetized chinchillas. Post-stimulus-time histograms were computed from responses to 50-ms tones presented at characteristic frequency and 30 dB above fiber threshold. Several response metrics related to temporal dynamics were computed from post-stimulus-time histograms and were compared between normal-hearing and noise-exposed animals. Results indicate that noise-exposed auditory-nerve fibers show significantly reduced response latency, increased onset response and percent adaptation, faster adaptation after onset, and slower recovery after offset. The decrease in response latency only occurred in noise-exposed fibers with significantly reduced frequency selectivity. These changes in temporal dynamics have important implications for temporal envelope coding in hearing-impaired ears, as well as for the design of dynamic compression algorithms for hearing aids.
journal_name
Hear Resjournal_title
Hearing researchauthors
Scheidt RE,Kale S,Heinz MGdoi
10.1016/j.heares.2010.07.009subject
Has Abstractpub_date
2010-10-01 00:00:00pages
23-33issue
1-2eissn
0378-5955issn
1878-5891pii
S0378-5955(10)00353-9journal_volume
269pub_type
杂志文章相关文献
HEARING RESEARCH文献大全abstract：:Tinnitus is a perception of sound that can occur in the absence of an external stimulus. A brief review of electroencephalography (EEG) and magnetoencephalography (MEG) literature demonstrates that there is no clear relationship between tinnitus presence and frequency band power in whole scalp or source oscillatory ac...
journal_title：Hearing research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.heares.2015.11.003
更新日期：2016-01-01 00:00:00
abstract：:The inferior colliculus (IC) is one nucleus of the central auditory system which displays age-related changes. Inputs to the IC use primarily the amino acid neurotransmitters glutamate and gamma-aminobutryic acid (GABA). Neurochemical and anatomical studies of the Fischer 344 (F344) rat IC have shown decreases in GABA...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(96)00113-x
更新日期：1996-10-01 00:00:00
abstract：:Structural relationships between intermediate cells and capillaries in the stria vascularis of gerbils were examined by confocal laser microscopy and electron microscopy. Immunostaining for an inward rectifier K(+) channel (Kir4.1), which was localized to intermediate cells, was used to determine the three-dimensional...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(01)00252-0
更新日期：2001-05-01 00:00:00
abstract：:Acetylcholine (ACh) appears to be the major neurotransmitter liberated from olivocochlear efferents terminating on outer hair cells (OHC). Recently, cholinergic receptor epitopes were visualized at the basal pole of the OHCs. To evaluate the ACh receptor type at OHC we performed binding studies with [125I]-labelled al...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(91)90219-y
更新日期：1991-05-01 00:00:00
abstract：:Application of dexamethasone to the round window has been shown to ameliorate high frequency hearing loss resulting from the trauma of cochlear implantation in experimental animals, but elucidation of the factors influencing protection of the high frequencies has been confounded by the local trauma from electrode arra...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2010.03.006
更新日期：2010-06-14 00:00:00
abstract：:Emerging evidence suggests that cochlear synaptopathy is a common feature of sensorineural hearing loss, but it is not known to what extent electrophysiological metrics targeting synaptopathy in animals can be applied to people, such as those with impaired audiograms. This study investigates the applicability of subco...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2019.07.001
更新日期：2019-09-01 00:00:00
abstract：:The intercellular gap junction channels formed by connexins (CXs) are important for recycling potassium ions in the inner ear. CXs are encoded by a family of the CX gene, such as GJB2, and the mechanism leading to mutant connexin-associated diseases, including hearing loss, remains to be elucidated. In this study, usi...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2014.04.010
更新日期：2014-07-01 00:00:00
abstract：:We recorded auditory evoked magnetic fields from 8 patients with unilateral, idiopathic, sudden, sensorineural hearing loss and from 8 healthy controls, using a 122-channel whole-scalp neuromagnetometer. The stimuli were 50-ms l-kHz tone bursts, delivered to the healthy ear at interstimulus intervals (ISIs) of 1, 2, 4...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(95)00086-j
更新日期：1995-07-01 00:00:00
abstract：:There is conflict in the literature over whether individual frequency components of a transient-evoked otoacoustic emission (TEOAE) are generated within relatively independent "channels" along the basilar membrane (BM), or whether each component may be generated by widespread areas of the BM. Two previous studies on T...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2005.10.010
更新日期：2006-02-01 00:00:00
abstract：:The directional dependence of sound pressure transformation of head and pinna has been measured in the phyllostomid bat Phyllostomus discolor for the frontal hemisphere using a maximum length sequence method. The azimuthal position of the axis of highest pinna gain came closer to the midsagital plane with increasing f...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(03)00164-3
更新日期：2003-07-01 00:00:00
abstract：:The induction of the heat shock protein, HSP72, was studied in the cochlea of guinea pigs and rats subjected to a hyperthermic stress. Analyses were done by immunoblotting and immunocytochemistry at 6 and 12 h after heat shock, using a commercially available monoclonal antibody (Amersham), and by in situ hybridization...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(92)90116-5
更新日期：1992-05-01 00:00:00
abstract：:Glutamate, gamma aminobutyric acid (GABA) and glycine receptors have different properties depending on the specific subunit combination utilized. The subunit composition of amino acid receptors may help to shape the responses of neurons and can provide a diversity of response properties in different neuronal types and...
journal_title：Hearing research
pub_type： 杂志文章,评审
doi：10.1016/s0378-5955(00)00127-1
更新日期：2000-09-01 00:00:00
abstract：:Acetylcholine (ACh) is the dominant transmitter released from inner ear efferent neurons. In frog vestibular organs, these efferent neurons synapse exclusively with type II hair cells. Hair cells isolated from the frog saccule hyperpolarize following the application of 50 microM ACh, thereby demonstrating the presence...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(00)00092-7
更新日期：2000-08-01 00:00:00
abstract：:C57BL/6 inbred mice are frequently used as models in auditory research, mostly the C57BL/6J and C57BL/6N substrains. Genetic variation and phenotypic disparities between these two substrains have been extensively investigated, but conflicting information exists about differences in their auditory and vestibular phenot...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2014.10.005
更新日期：2014-12-01 00:00:00
abstract：:Auditory-nerve excitation by two response factors that can be in antiphase has been hypothesized by Kiang (1990) on the basis of non-linear interference in responses to tones (Kiang et al., 1969). The general conditions for antiphasic responses and the relevance of the hypothesis for other auditory stimuli are unknown...
journal_title：Hearing research
pub_type： 杂志文章,评审
doi：10.1016/0378-5955(95)00154-7
更新日期：1995-10-01 00:00:00
abstract：:Cochlear compression in normal-hearing listeners was estimated at octave frequencies from 250 to 4000 Hz using a forward-masking paradigm. Temporal masking curves (TMCs) for a 10-dB SL signal were obtained with two maskers -- one equal in frequency to the signal and another an octave below the signal. The ratio of the...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2004.10.006
更新日期：2005-03-01 00:00:00
abstract：:The human fetus in utero is hypoxic relative to the neonate due to differences between placental and pulmonary oxygenation. Comparable degrees of hypoxia induced in young and adult animals caused an elevation in hearing threshold of a sensorineural nature. It was hypothesised therefore that the human fetus may also ha...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(94)90289-5
更新日期：1994-02-01 00:00:00
abstract：:Using single-unit electrophysiological methods we have mapped sound frequency (or cochleotopic) representation in the auditory cortex of the chinchilla. We describe the surgical approach to expose this area. We report on maps from six subjects and note a considerable variation in shape between individuals. In general,...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(96)00120-7
更新日期：1996-10-01 00:00:00
abstract：:The organisation and response properties of the rat auditory cortex were investigated with single and multi-unit electrophysiological recording. Two tonotopically organised 'core' fields, i.e. the primary (A1) and anterior (AAF) auditory fields, as well as three non-tonotopically organised 'belt' fields, i.e. the post...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(03)00182-5
更新日期：2003-07-01 00:00:00
abstract：:The analysis of the auditory scene begins from the moment we hear sounds, making it possible for the infant to distinguish the mother's voice from other sounds in the environment. The purpose of the study was to determine, in two experiments, whether the frequency separation threshold, at which the perception of a mix...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2006.12.013
更新日期：2007-03-01 00:00:00
abstract：:Differences between inner and outer hair cells in the cellular content of precipitable calcium were detected using a potassium pyroantimonate precipitation method and the electron spectroscopic imaging (ESI-) technique. The cytoplasm of the inner hair cells was scattered with a high number of calcium precipitates in a...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(94)90213-5
更新日期：1994-01-01 00:00:00
abstract：:Endocochlear potentials (EPs) were investigated in healthy guinea pigs and in those exposed to white noise of 125 dB SPL for 20-80 min. EPs were measured during and after temporary anoxia (3.5 min, denoted as reversible anoxia) and then during continuous anoxia to evaluate noise-induced changes in EP properties. Succi...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(90)90076-2
更新日期：1990-03-01 00:00:00
abstract：:Laser scanning confocal microscopy was used to determine the distribution of actin, spectrin and tubulin in whole mounts of the organ of Corti of guinea pig, monkey, rat and chinchilla. Actin, spectrin and tubulin were localized in all cell types in the auditory epithelium. No specialized cytoskeletal organization of ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(94)90098-1
更新日期：1994-06-01 00:00:00
abstract：:The understanding of speech in noise relies (at least partially) on spectrotemporal modulation sensitivity. This sensitivity can be measured by spectral ripple tests, which can be administered at different presentation levels. However, it is not known how presentation level affects spectrotemporal modulation threshold...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2018.10.017
更新日期：2019-01-01 00:00:00
abstract：:It has previously been demonstrated that ototoxicity induced by systemic administration of cisplatin is reduced by concomitant systemic administration of alpha-melanocyte stimulating hormone (alpha-MSH). In this study we investigated the effects of cochlear, perilymphatic application of alpha-MSH during intraperitonea...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/S0378-5955(03)00396-4
更新日期：2004-03-01 00:00:00
abstract：:The tension fibroblasts of the spiral ligament of the mammalian cochlea are thought to create radial tension on the basilar membrane. Their postnatal development was investigated in the gerbil (Meriones unguiculatus) with confocal fluorescence microscopy using phallotoxin as a specific marker for F-actin. In the adult...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(97)00051-8
更新日期：1997-06-01 00:00:00
abstract：:The compound action potential (CAP) and the auditory brainstem response (ABR; waves ii and iv) were recorded in young (4-8 month) and aged (33-37 month) gerbils using a paradigm similar to that used in some psychophysical studies of gap detection (a pair of identical low-pass noises separated by a silent gap). Respons...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(96)90016-7
更新日期：1996-12-01 00:00:00
abstract：:The central nucleus of the inferior colliculus (CNIC) contains different types of neurons and is a source of ascending projection to the medial geniculate body (MGB), commissural projection to the contralateral IC, direct descending projection to the cochlea nucleus (CN) and indirect projection to the CN via the super...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2006.04.004
更新日期：2006-08-01 00:00:00
abstract：:The distribution of neurotensin-containing cell bodies and fibers has been observed in the central and peripheral nervous system, including sensory ganglia, but no description has been found in the peripheral auditory system. Here, we investigated the presence of neurotensin immunoreactivity in the cochlea of the adul...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2005.02.011
更新日期：2005-07-01 00:00:00
abstract：:Experiments on the flow-sensitive lateral line system of fishes have provided important insights into the function and sensory transduction of vertebrate hair cells. A common experimental approach has been to pharmacologically block lateral line hair cells and measure how behavior changes. Cobalt chloride (CoCl2) bloc...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2017.04.001
更新日期：2017-07-01 00:00:00
