Abstract：
:C57BL/6 inbred mice are frequently used as models in auditory research, mostly the C57BL/6J and C57BL/6N substrains. Genetic variation and phenotypic disparities between these two substrains have been extensively investigated, but conflicting information exists about differences in their auditory and vestibular phenotypes. Literature-based comparisons are rendered difficult or impossible because most auditory publications do not designate the substrain used. We therefore evaluated commercial C57BL/6N and C57BL/6J mice for their baseline auditory brainstem response (ABR) thresholds at 3 months of age as well as their susceptibility to noise exposure and aminoglycoside antibiotics. Both substrains have similar thresholds at 4 and 12 kHz, but C57BL/6N show significantly higher baseline thresholds at 24 and 32 kHz. Because of these elevated thresholds, the N substrain is unsuitable as a model for drug ototoxicity, which primarily affects high frequencies. Exposure to 2-20 kHz broadband noise for 2 h at 110 dB produced significantly higher threshold shifts in the J substrain. These results suggest caution in the selection of C57BL/6 substrains for auditory research and indicate the need to specify substrains, age and the breeding source in all publications.
journal_name
Hear Resjournal_title
Hearing researchauthors
Kendall A,Schacht Jdoi
10.1016/j.heares.2014.10.005subject
Has Abstractpub_date
2014-12-01 00:00:00pages
18-22eissn
0378-5955issn
1878-5891pii
S0378-5955(14)00169-5journal_volume
318pub_type
杂志文章相关文献
HEARING RESEARCH文献大全abstract：:Electrical stimulation of the cochlea is known to cause auditory sensations in humans and other animals. It also has been shown to produce emissions of sound from the inner ear. In the current study we investigate the relationship between electrically induced motion of the basilar membrane (BM) and the production of o...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(95)00216-2
更新日期：1995-12-01 00:00:00
abstract：:The IgG1 mouse monoclonal antibody (MAb) KHRI-3, binds to an antigen of 65-68 kDa expressed on inner ear supporting cells in guinea pigs. We previously showed [Nair et al. (1995) Monoclonal antibody induced hearing loss. Hear. Res. 83, 101-113] that mice carrying the KHRI-3 hybridoma develop high frequency hearing los...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(97)00024-5
更新日期：1997-05-01 00:00:00
abstract：:Recent studies have shown that the vestibular and auditory systems of some species of birds have the capacity to generate sensory hair cells postnatally. We used a traditional technique, 3H-thymidine autoradiography, and a newer method, bromodeoxyuridine immunocytochemistry, to determine whether ongoing proliferation ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(92)90149-h
更新日期：1992-01-01 00:00:00
abstract：:In cases of sudden, reversible hearing loss where perilymphatic fistulas are thought to be the cause, a multitude of causes have been postulated. These include perilymphatic pressure changes, Simmons' double-break theory, perilymphatic hemorrhage, pneumolabyrinth, and others. This study was proposed to explore the rol...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(02)00389-1
更新日期：2002-05-01 00:00:00
abstract：:Sudden sensorineural hearing loss (SSNHL) is generally defined as sensorineural hearing loss of 30 dB or greater over at least three contiguous audiometric frequencies and within a three-day period. This hearing loss is usually unilateral and can be associated with tinnitus and vertigo. The pathogenesis of unilateral ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2016.02.016
更新日期：2016-05-01 00:00:00
abstract：:Action potentials recorded extracellularly from neurons within the caudal cochlear nuclei of developing cats exhibited distinctive temporal characteristics (i.e., rhythmic responses) in response to long-duration acoustic stimuli including both tone and noise bursts. Unlike the homogeneous response characteristics of a...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(88)90065-2
更新日期：1988-11-01 00:00:00
abstract：:The dynamic properties of single olivocochlear efferent neurones in the guinea pig cochlea were examined using sinusoidally amplitude modulated (AM) pure tones. The neural discharge, when displayed as a cyclic histogram, clearly followed the rapid fluctuations in the continuous input sound. Modulation transfer functio...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(88)90136-0
更新日期：1988-10-01 00:00:00
abstract：:Interaural time and intensity differences (ITD and IID) are important cues in binaural hearing and allow for sound localization, improving speech understanding in noise and reverberation, and integrating sound sources in the auditory scene. Whereas previous research showed that the upper-frequency limit for ITD detect...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2018.09.001
更新日期：2018-12-01 00:00:00
abstract：:This report describes the effects of L-glutamate (Glu) introduced into the perilymph of scala tympani on the spontaneous and tone-evoked activity of guinea pig single primary auditory afferents. Concentrations below 2 mmol/l were in general ineffective, while a concentration of 5 mmol/l caused a marked decrease of the...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(90)90128-c
更新日期：1990-05-01 00:00:00
abstract：:Cochlear implantation (CI), which directly stimulates the cochlear nerves, is the most effective and widely used medical intervention for patients with severe to profound sensorineural hearing loss. The etiology of the hearing loss is speculated to have a major influence of CI outcomes, particularly in cases resulting...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2017.02.017
更新日期：2017-05-01 00:00:00
abstract：:The density of cochlear inner hair cells in Wistar rats is greatest on a short section of the basilar membrane about a fifth of its length from the base. This place corresponds to the frequency region of 30--40 kHz which is supposed to be the region of best hearing. ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(80)90010-6
更新日期：1980-07-01 00:00:00
abstract：:We review event-related slow firing changes in the auditory cortex and related brain structures. Two types of changes can be distinguished, namely increases and decreases of firing, lasting in the order of seconds. Triggering events can be auditory stimuli, reinforcers, and behavioral responses. Slow firing changes te...
journal_title：Hearing research
pub_type： 杂志文章,评审
doi：10.1016/j.heares.2010.05.003
更新日期：2011-01-01 00:00:00
abstract：:Recent physiological and pharmacological studies have implicated involvement of the Na/H exchanger (NHE) in regulating inner ear ion homeostasis, but the cellular distribution of this membrane transporter remains unknown. Here reverse transcription and the polymerase chain reaction (RT-PCR) were employed to screen adu...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(98)00089-6
更新日期：1998-09-01 00:00:00
abstract：:Tinnitus is most often initiated by modality specific otopathologic disturbances affecting peripheral and central auditory pathways. However, there is growing evidence indicating that the anatomical location generating tinnitus occurs at sites different from the initial pathology. Support for this notion is found in i...
journal_title：Hearing research
pub_type： 杂志文章,评审
doi：10.1016/s0378-5955(02)00717-7
更新日期：2003-01-01 00:00:00
abstract：:In order to determine the place-frequency map of the rat cochlea, iontophoretic HRP-injections were made into the cochlear nucleus at electrophysiologically characterized positions. Distribution of retrograde HRP transport in cochlear spiral ganglion cells was analysed by means of a three dimensional reconstruction of...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(91)90041-7
更新日期：1991-02-01 00:00:00
abstract：:Hearing aid (HA) users can differ markedly in their benefit from directional processing (or beamforming) algorithms. The current study therefore investigated candidacy for different bilateral directional processing schemes. Groups of elderly listeners with symmetric (N = 20) or asymmetric (N = 19) hearing thresholds f...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2017.07.014
更新日期：2017-09-01 00:00:00
abstract：:Several lines of evidence implicate a neurotransmitter/modulator role for ATP in the cochlea. Most of the work supporting such a notion has been accomplished using in vitro preparations of sensory hair cells or other cochlear tissues. Little is known regarding the functional consequences of ATP receptor activation in ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(94)90091-4
更新日期：1994-06-01 00:00:00
abstract：:The dorsal cochlear nucleus (DCN) has been shown to project to a region of the nucleus reticularis pontis caudalis (PnC) critical for the evocation of startle in rats, suggesting a possible modulatory influence of the DCN on startle. This study examined the involvement of the DCN in the acoustic startle reflex and var...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(98)00040-9
更新日期：1998-05-01 00:00:00
abstract：:This paper discusses how ion transport proteins in the hair cells of the mammalian cochlea work to produce a sensitive but stable hearing organ. The transport proteins in the inner and outer hair cells are summarized (including their current voltage characteristics), and the roles of these proteins in determining intr...
journal_title：Hearing research
pub_type： 杂志文章,评审
doi：10.1016/j.heares.2011.04.006
更新日期：2011-10-01 00:00:00
abstract：:The induction of the heat shock protein, HSP72, was studied in the cochlea of guinea pigs and rats subjected to a hyperthermic stress. Analyses were done by immunoblotting and immunocytochemistry at 6 and 12 h after heat shock, using a commercially available monoclonal antibody (Amersham), and by in situ hybridization...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(92)90116-5
更新日期：1992-05-01 00:00:00
abstract：:A technique was devised in order to study the fast electromechanical length changes of outer hair cells at low stimulus levels. Solitary outer hair cells were drawn into a glass microchamber. Length changes were evoked by the application of transcellular potentials and were detected with a photodiode. The method is no...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(91)90019-6
更新日期：1991-04-01 00:00:00
abstract：:Platelet-derived growth factor receptor (PDGFR) signaling has been demonstrated to play a pivotal role in early embryonic development. Although the expression of PDGF in the inner ear has been studied by RT-PCR, how PDGFR is involved there remains largely unclear. In the current study, we used the antagonistic anti-PD...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2008.08.011
更新日期：2008-11-01 00:00:00
abstract：:We have investigated the morphometric changes in the cochlear nucleus of patients who had undergone cochlear implantation following profound deafness. The brain stems of 11 adult patients who had undergone implantation and four non-implanted control cases with varying degrees of hearing loss were studied. The volumes ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(02)00694-9
更新日期：2002-12-01 00:00:00
abstract：:We developed a new technique, the isolated in vitro perfused spiral modiolar artery, which allowed the continuous measurement of the vascular diameter and control of the intravascular pressure. An isolated section of the spiral modiolar artery from the gerbil was perfused on one end with a set of concentric pipettes a...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(97)00184-6
更新日期：1998-01-01 00:00:00
abstract：:Insight into cochlear mechanics can be obtained from semi-analytical and asymptotic solution methods of which the Liouville -Green (LG) method - in another context known as the WKB method - is the most important one. This paper describes the dispersion properties of fluid waves in general terms and develops the LG for...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(84)90101-1
更新日期：1984-02-01 00:00:00
abstract：:Immunohistochemical data indicate that OCP1 co-localizes exactly with OCP2 in the epithelial gap junction region of the guinea pig organ of Corti (OC). Despite the abundance of OCP1 in the OC, gaining access to its coding sequence -- and, in particular, the 5' end of the coding sequence -- proved unexpectedly challeng...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(01)00285-4
更新日期：2001-07-01 00:00:00
abstract：:The effects of several hours of continuous electrical stimulation in the cats' cochlear nucleus with chronically implanted activated iridium microelectrodes was investigated from the changes in the evoked response near the inferior colliculus and also by histologic evaluation of the stimulated tissue. The stimulating ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(92)90201-w
更新日期：1992-09-01 00:00:00
abstract：:We studied the 2IFC detectability of a 500 Hz tone masked by computer-generated maskers under the N0SII interaural condition, and under two masker conditions. In the first masker condition the maskers in the two intervals of a trial were independent of each other, and in the second masker condition the maskers were id...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(83)90074-6
更新日期：1983-08-01 00:00:00
abstract：:The ototoxic effects of salicylates, reversible hearing loss and tinnitus, are well documented. However, the pharmacological mechanisms underlying these changes in cochlear function are not well understood. The studies reported here were an investigation of the site and mechanism of salicylate ototoxicity through an e...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(90)90144-e
更新日期：1990-06-01 00:00:00
abstract：:This study examined the effect of monaural middle ear destruction on postnatal development of auditory response properties of inferior collicular (IC) neurons of the laboratory mouse, Mus musculus. Monaural middle ear destruction was performed on juvenile and adult mice and the auditory response properties of neurons ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(01)00304-5
更新日期：2001-09-01 00:00:00
