Ion flow in cochlear hair cells and the regulation of hearing sensitivity.

abstract：:Despite the common use of guinea pigs in investigations of the neural mechanisms of binaural and spatial hearing, their behavioral capabilities in spatial hearing tasks have surprisingly not been thoroughly investigated. To begin to fill this void, we tested the spatial hearing of adult male guinea pigs in several exp...

journal_title：Hearing research

authors： Greene NT,Anbuhl KL,Ferber AT,DeGuzman M,Allen PD,Tollin DJ

更新日期：2018-08-01 00:00:00

abstract：:Preservation of residual hearing after cochlear implantation is now considered an important goal of surgery. However, studies indicate an average post-operative hearing loss of around 20 dB at low frequencies. One factor which may contribute to post-operative hearing loss, but which has received little attention in th...

journal_title：Hearing research

authors： Elliott SJ,Ni G,Verschuur CA

更新日期：2016-11-01 00:00:00

abstract：:Sodium salicylate (SS) can penetrate the blood-brain barrier to target neurons in the central auditory system. Understanding how SS alters functional behaviors of different types of central auditory neurons will provide insights into the neural mechanisms of SS-induced tinnitus. Here, we report the differential effect...

journal_title：Hearing research

authors： Su YY,Luo B,Wang HT,Chen L

更新日期：2009-07-01 00:00:00

abstract：:The discharge properties of 735 single units located in the pars magnocellularis (M) of the medial division of the medial geniculate body (MGB) were studied in 23 nitrous oxide anesthetized cats in response to simple acoustic stimuli (clicks, noise and tone bursts). A systematic decrease of single unit characteristic ...

journal_title：Hearing research

authors： Rouiller EM,Rodrigues-Dagaeff C,Simm G,De Ribaupierre Y,Villa A,De Ribaupierre F

更新日期：1989-05-01 00:00:00

abstract：:The current distribution of bipolar electrodes implanted into the scala tympani of the cat cochlea was investigated using a two-electrode masking technique. Two electrode masking is a non-invasive technique which requires two electrically independent electrodes and relies upon the forward masking of the electrically e...

journal_title：Hearing research

authors： O'Leary SJ,Black RC,Clark GM

更新日期：1985-06-01 00:00:00

abstract：:Delayed acoustic waves have been measured in the sealed ear canal in response to click and tone-burst stimuli. The response shows compressive nonlinearity, evidence for 'active' processing, and frequency tuning. At low sound levels group and phase delays correspond, and represent about 15 waves delay for the mid-frequ...

journal_title：Hearing research

authors： Wilson JP

更新日期：1980-06-01 00:00:00

abstract：:Echolocation offers a promising approach to improve the quality of life of people with blindness although little is known about the factors influencing object localisation using a 'searching' strategy. In this paper, we describe a series of experiments using sighted and blind human listeners and a 'virtual auditory sp...

journal_title：Hearing research

authors： Rowan D,Papadopoulos T,Edwards D,Holmes H,Hollingdale A,Evans L,Allen R

更新日期：2013-06-01 00:00:00

abstract：:Thresholds for pure tones embedded in harmonic complexes were measured behaviorally and physiologically for three species of birds, and physiologically in gerbils. The harmonic maskers were generated using the Schroeder-phase algorithm, characterized by monotonically increasing or decreasing phase across frequency. Pr...

journal_title：Hearing research

authors： Dooling RJ,Dent ML,Leek MR,Gleich O

更新日期：2001-02-01 00:00:00

abstract：:There is convincing evidence that cochlear microphonics (CM) arise primarily from outer hair cells and have a frequency distribution that is much broader than that measured in inner hair cells by Russel and Sellick [6,7]. The broad tuning results from the fact that CM generated at each location decays exponentially al...

journal_title：Hearing research

authors： Kletsky EJ,Zwislocki JJ

更新日期：1980-06-01 00:00:00

abstract：:Psychophysical measures of the electrically stimulated human auditory system were obtained for different types of symmetric and asymmetric charge-balanced waveforms. Absolute detection thresholds of biphasic, pseudomonophasic, and 'alternating monophasic' current waveforms delivered by a bipolar intra-cochlear electro...

journal_title：Hearing research

authors： van Wieringen A,Carlyon RP,Laneau J,Wouters J

更新日期：2005-02-01 00:00:00

abstract：:This study introduces and evaluates a method for measurement of the longitudinal spread of electrically evoked neural excitation in the cochlea, using the Neural Response Telemetry system (NRT) available with the Nucleus((R)) 24 cochlear implant system. The recently released version of the NRT software (version 3.0) e...

journal_title：Hearing research

authors： Cohen LT,Richardson LM,Saunders E,Cowan RS

更新日期：2003-05-01 00:00:00

abstract：:Acoustic signals are extensively used for guiding various behaviors in frogs such as vocalization and phonotaxis. While numerous studies have investigated the anatomy and physiology of the auditory system, our knowledge of intrinsic properties and connectivity of individual auditory neurons remains poor. Moreover, the...

journal_title：Hearing research

authors： Luksch H,Walkowiak W

更新日期：1998-08-01 00:00:00

abstract：:Cisplatin-induced ototoxicity results in significant, permanent hearing loss in pediatric and adult cancer survivors. Elucidating the mechanisms underlying cisplatin-induced hearing loss as well as the development of therapies to reduce and/or reverse cisplatin ototoxicity have been impeded by suboptimal animal models...

journal_title：Hearing research

authors： Fernandez K,Wafa T,Fitzgerald TS,Cunningham LL

更新日期：2019-04-01 00:00:00

abstract：:In order to clarify the otoconia formation and turnover, tetracycline, an antibiotic that precipitates at calcifying fronts and serves as a fluorescent marker, was injected into eggs at different stages of chick embryonic development, as well as into postnatal chicken and into adult animals. The changes in the intensi...

journal_title：Hearing research

authors： Balsamo G,Avallone B,Del Genio F,Trapani S,Marmo F

更新日期：2000-10-01 00:00:00

abstract：:We confirm the report of Mountain (Mountain, D.C. (1980): Science 210, 77-72) that stimulating the crossed olivocochlear bundle (COCB) can change the magnitude of the distortion product (f2-f1) in the ear-canal sound pressure. Our results are extended to include (2f1-f2) as well as (f2-f1) from anesthetized chinchilla...

journal_title：Hearing research

authors： Siegel JH,Kim DO

更新日期：1982-02-01 00:00:00

abstract：:This study examined the neural basis of auditory selective attention using functional magnetic resonance imaging. The main hypothesis stated that attending to a particular sound frequency would significantly enhance the neural response within those tonotopic regions of the auditory cortex sensitive to that frequency. ...

journal_title：Hearing research

authors： Paltoglou AE,Sumner CJ,Hall DA

更新日期：2009-11-01 00:00:00

abstract：:Difference limens for the fundamental frequency (F0) of complex tones (DLCs) were measured for four normally hearing subjects and three subjects with cochlear hearing loss. The nominal F0 was 100, 200 or 400 Hz. The two tones to be compared contained either low resolved harmonics (RES), harmonics with intermediate res...

journal_title：Hearing research

authors： Moore BC,Moore GA

更新日期：2003-08-01 00:00:00

abstract：:We used whole cell voltage clamp recordings from neurones in rat auditory brainstem slices to study the Ca(2+) channel types involved in triggering synaptic glutamate and glycine release in the medial superior olivary nucleus. Glutamate release from the anterior ventral cochlear (aVCN) bushy neurone synapse did not in...

journal_title：Hearing research

authors： Barnes-Davies M,Owens S,Forsythe ID

更新日期：2001-12-01 00:00:00

abstract：:The mastoid air cell system has traditionally been considered to have a passive role in gas exchange and pressure regulation of the middle ear possibly with some acoustic function. However, more evidence has focused on the mucosa of the mastoid, which may play a more active role in regulation of middle ear pressure. I...

journal_title：Hearing research

authors： Cros O,Borga M,Pauwels E,Dirckx JJ,Gaihede M

更新日期：2013-07-01 00:00:00

abstract：:The Frequency-Following Response (FFR) is a neurophonic auditory evoked potential that reflects the efficient encoding of speech sounds and is disrupted in a range of speech and language disorders. This raises the possibility to use it as a potential biomarker for literacy impairment. However, reference values for com...

journal_title：Hearing research

authors： Ribas-Prats T,Almeida L,Costa-Faidella J,Plana M,Corral MJ,Gómez-Roig MD,Escera C

更新日期：2019-01-01 00:00:00

abstract：:To create experimental lesions localized to the low frequency region of the organ of Corti, a cryoprobe was applied to the apical area of 37 cochleas from 26 adult chinchillas. Twenty cochleas were exposed to single applications of a cryoprobe for 2.5, 3.0 and 3.5 min; 17 cochleas were exposed to two applications of 1...

journal_title：Hearing research

authors： Brown JN,Nuttall AL

更新日期：1987-01-01 00:00:00

abstract：:The ultrastructure of the spiral ligament was compared in aged and young gerbils to assess the involvement of connective tissues in the lateral wall and particularly the fibrocytes in development of presbyacusis. Pathologic features in fibrocytes of senescent gerbils spanned a wide range reflecting different stages of...

journal_title：Hearing research

authors： Spicer SS,Schulte BA

更新日期：2002-10-01 00:00:00

abstract：:The inferior colliculus occupies a central position in ascending and descending auditory pathways. A substantial proportion of its neurons are GABAergic, and these neurons contribute to intracollicular circuits as well as to extrinsic projections to numerous targets. A variety of types of evidence - morphology, physio...

journal_title：Hearing research

authors： Schofield BR,Beebe NL

更新日期：2019-05-01 00:00:00

abstract：:The human fetus in utero is hypoxic relative to the neonate due to differences between placental and pulmonary oxygenation. Comparable degrees of hypoxia induced in young and adult animals caused an elevation in hearing threshold of a sensorineural nature. It was hypothesised therefore that the human fetus may also ha...

journal_title：Hearing research

authors： Sohmer H,Goitein K,Freeman S

更新日期：1994-02-01 00:00:00

abstract：:We report the results of behavioral studies in cats conducted first, to demonstrate the presence of a monaural mechanism for the enhancement of signal to noise; and then to examine the necessity or sufficiency of the acoustic striae for this mechanism. The results show that cats do indeed have a monaural mechanism for...

journal_title：Hearing research

authors： Masterton RB,Granger EM,Glendenning KK

更新日期：1994-03-01 00:00:00

abstract：:During noise-induced temporary threshold shift cytoplasmic vacuoles increase in the synaptic region of auditory hair cells. This structural change in the presynaptic region suggests that afferent synapses between hair cells and auditory nerve fibers fail during the period of threshold elevation, and that synaptic fati...

journal_title：Hearing research

authors： Mulroy MJ,Fromm RF,Curtis S

更新日期：1990-11-01 00:00:00

abstract：:Although the neural mechanisms underlying pitch perception are not yet fully understood, there is general agreement that place and temporal representations of pitch are both used by the auditory system. This paper describes a neural network model of pitch perception that integrates both codes of pitch and explores the...

journal_title：Hearing research

authors： Erfanian Saeedi N,Blamey PJ,Burkitt AN,Grayden DB

更新日期：2017-02-01 00:00:00

abstract：:Blind cave fish employ superficial neuromasts to detect currents [Baker, C.F. and J.C. Montgomery, J. Comp. Physiol. A 184 (1999) 519-527]. Briefly exposing fish to calcium-free water significantly reduces the ability of the fish to perform rheotaxis (i.e., to orient properly in currents). Spontaneous recovery to cont...

journal_title：Hearing research

authors： Berg A,Watson GM

更新日期：2002-12-01 00:00:00

abstract：:The basilar papilla length increases systematically with body mass for 41 species from more than 10 avian orders and this relation does not differ between phylogenetic groups. Audiograms of 25 non-strigiform and 12 owl species, normalized relative to best frequency and best threshold, were used to compare audiogram sh...

journal_title：Hearing research

authors： Gleich O,Langemann U

更新日期：2011-03-01 00:00:00

abstract：:In mammals, the cochlear sensory epithelium becomes quiescent early during development. After the first postnatal week, there is no cell replacement or proliferation, and severe damage leads to permanent deafness. Supporting cells' trans-differentiation has been suggested as a way to regenerate cochlear hair cells aft...

journal_title：Hearing research

authors： Silva SA,Maass JC

更新日期：2019-03-01 00:00:00