Abstract：
:Several lines of evidence implicate a neurotransmitter/modulator role for ATP in the cochlea. Most of the work supporting such a notion has been accomplished using in vitro preparations of sensory hair cells or other cochlear tissues. Little is known regarding the functional consequences of ATP receptor activation in vivo. In the present experiments, we tested ATP and related agonist analogs for their effects on sound-evoked responses of the cochlea (cochlear microphonic, CM; summating potential, SP; distortion product otoacoustic emissions, DPOAE) and auditory nerve (compound action potential, CAP) in vivo and on outer hair cell (OHC) currents and cell length in vitro. In vivo, local application of these compounds was associated with concentration- and intensity-dependent response alterations. The slowly-hydrolyzable P2y agonist, ATP-gamma-S, was clearly of greatest in vivo potency: At low to moderate stimulus intensities, micromolar concentrations of this drug reduced all responses, in particular CAP and DPOAEs, which fell to the level of the noise floor. At high intensities, response suppression was smaller and SP was increased. In vivo effects of ATP, ATP-alpha-S and 2-Me-S-ATP were qualitatively similar to, but smaller in magnitude and requiring higher concentrations than those observed for ATP-gamma-S. Adenosine was without significant effect on responses of the cochlea and auditory nerve. In vitro, effects of ATP-gamma-S and ATP were similar: both induced inward currents in OHCs held at -60 mV without producing observable (> 0.3 micron) changes in OHC length. Results suggest that endogenous ATP influences cochlear function through receptors at several sites in the cochlea. Results suggest further that these response alterations are mediated, at least in part, by receptors of the P2y subtype.
journal_name
Hear Resjournal_title
Hearing researchauthors
Kujawa SG,Erostegui C,Fallon M,Crist J,Bobbin RPdoi
10.1016/0378-5955(94)90091-4subject
Has Abstractpub_date
1994-06-01 00:00:00pages
87-100issue
1-2eissn
0378-5955issn
1878-5891pii
0378-5955(94)90091-4journal_volume
76pub_type
杂志文章相关文献
HEARING RESEARCH文献大全abstract：:Using morphological criteria, death pathways in outer hair cells (OHCs) were determined in chinchilla organs of Corti that had been exposed to a high- or moderate-level octave band of noise (OBN) centered at either 0.5 or 4-kHz. The specimens were part of our large collection of plastic-embedded flat preparations of c...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2006.10.004
更新日期：2007-01-01 00:00:00
abstract：:Superposition of point processes has often been suggested as an abstract model for the generation of neural discharge patterns due to its simplicity (input spike trains are simply merged and then retransmitted by the model neuron). The properties of the superposition of two renewal processes are examined in relation t...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(86)90015-8
更新日期：1986-01-01 00:00:00
abstract：:The avian auditory papilla provides an interesting object on which to study efferent influences, because whereas a significant population of hair cells in birds is not afferently innervated, all hair cells are efferently innervated (Fischer, 1992, 1994a, b). Previous studies in mammals using contralateral sound to sti...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(99)00126-4
更新日期：1999-12-01 00:00:00
abstract：:Noise exposure and the subsequent hearing loss are well documented aspects of military life. Numerous studies have indicated high rates of noise-induced hearing injury (NIHI) in active-duty service men and women, and recent statistics from the U.S. Department of Veterans Affairs indicate a population of veterans with ...
journal_title：Hearing research
pub_type： 杂志文章,评审
doi：10.1016/j.heares.2016.11.008
更新日期：2017-06-01 00:00:00
abstract：:The structure of the tectorial membrane of the chick was evaluated by scanning electron microscopy (SEM), using standard techniques, and, for the first time, by studying unfixed tectorial membranes with video-enhanced light microscopy techniques (AVEC-DIC). The SEM pictures show a widely varying morphology, ranging fr...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(89)90039-7
更新日期：1989-01-01 00:00:00
abstract：:C57BL/6 inbred mice are frequently used as models in auditory research, mostly the C57BL/6J and C57BL/6N substrains. Genetic variation and phenotypic disparities between these two substrains have been extensively investigated, but conflicting information exists about differences in their auditory and vestibular phenot...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2014.10.005
更新日期：2014-12-01 00:00:00
abstract：:Electrical stimulation of the cochlea is known to cause auditory sensations in humans and other animals. It also has been shown to produce emissions of sound from the inner ear. In the current study we investigate the relationship between electrically induced motion of the basilar membrane (BM) and the production of o...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(95)00216-2
更新日期：1995-12-01 00:00:00
abstract：:The nature of age-related improvements in auditory sensitivity was explored by comparing behavioral and auditory brainstem response (ABR) thresholds in 3- and 6-month-old infants and in adults. Thresholds were estimated for tone pips at 1, 4, and 8 kHz, presented at a rate of 13.3/s. The time course of development of ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(93)90071-8
更新日期：1993-06-01 00:00:00
abstract：:Glass microelectrodes were introduced into the stria vascularis (SV) to measure the DC potential profile of the SV in vivo from its apical as well as basal side. The K+ concentration gradient in the lateral cochlear wall was measured by means of double barrel K+-selective microelectrodes. A positive potential 10.4 +/-...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(87)90077-3
更新日期：1987-01-01 00:00:00
abstract：BACKGROUND:Epidemiological studies have shown that women have better high-frequency thresholds than men in virtually all age groups, and that age-related hearing decline starts after 30 in men but not until after the age of 50 in women. This coincides with the menopausal transition in most women, thus leading us to hyp...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2009.09.009
更新日期：2010-01-01 00:00:00
abstract：:The presence of dopamine (DA) within the cochlea has been previously reported, indicating that its turnover increases under noise stimulation. In the present report, piribedil, a dopaminergic D2 agonist, was used in order to provide evidence of the activity of D2 receptors in the turnover of DA under noise stimulation...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(94)90138-4
更新日期：1994-09-01 00:00:00
abstract：:Both sound exposure and gentamicin treatment cause damage to sensory hair cells in the peripheral chick auditory organ, the basilar papilla. This induces a regeneration response which replaces hair cells and restores auditory function. Since functional recovery requires the re-establishment of connections between rege...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(97)00150-0
更新日期：1997-11-01 00:00:00
abstract：:Eye color may be an indicator of inner ear melanin content and has been associated with hearing loss. There is controversy as to whether eye color has an effect on acquired causes of sensorineural hearing loss. This review was conducted to analyze the literature evaluating the relationship between eye color and causes...
journal_title：Hearing research
pub_type： 杂志文章,评审
doi：10.1016/j.heares.2014.12.002
更新日期：2015-02-01 00:00:00
abstract：:There are multiple etiologies and phenotypes of age-related hearing loss or presbyacusis. In this review we summarize findings from animal and human studies of presbyacusis, including those that provide the theoretical framework for distinct metabolic, sensory, and neural presbyacusis phenotypes. A key finding in quie...
journal_title：Hearing research
pub_type： 杂志文章,评审
doi：10.1016/j.heares.2020.108109
更新日期：2020-10-31 00:00:00
abstract：:This study used immunocytochemical markers for various classes of glial cells to investigate the relationship between glial elements and microcysts in the gerbil auditory system at the light and electron microscopic level. Monoclonal antibodies S-100, GFAP and Rip were used on tissue from 3- and 12-month old animals a...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(93)90226-q
更新日期：1993-05-01 00:00:00
abstract：:Mitochondrial DNA (mtDNA) mutations/deletions are considered to be associated with the development of age-related hearing loss (AHL). We assessed the role of accumulation of mtDNA mutations in the development of AHL using Polg(D257A) knock-in mouse, which exhibited increased spontaneous mtDNA mutation rates during agi...
journal_title：Hearing research
pub_type： 杂志文章,评审
doi：10.1016/j.heares.2006.06.004
更新日期：2007-04-01 00:00:00
abstract：:The number, size and distribution of myelinated nerve fibers were analyzed in the osseous spiral lamina (OSL) of young and old gerbils raised in a quiet environment. Because decreased endocochlear potentials (EPs) play a significant role in age-related hearing loss in the gerbil, we correlated morphometric and topogra...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(01)00340-9
更新日期：2001-11-01 00:00:00
abstract：:This study was performed to elucidate the contribution of the stapedial artery (SA)--which has been considered to be independent of the vertebrobasilar system--to blood flow in the ear by observing ear blood flow in Sprague-Dawley rats. A laser-Doppler (LD) probe was positioned on the bony wall of the cochlear basal t...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(03)00310-1
更新日期：2003-12-01 00:00:00
abstract：:Thresholds to sinusoidal and biphasic pulsatile electrical stimuli were measured in two patients with electrodes positioned on the cochlear nucleus. The threshold functions differ from those observed in patients with scala tympani electrodes, primarily at low sinusoidal frequencies and long pulse widths. This differen...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(89)90110-x
更新日期：1989-06-15 00:00:00
abstract：:Cochlear microphonics (CM) were recorded with differential electrodes from several locations in the guinea pig cochlea. Input-output curves and amplitude-frequency curves were plotted before and after short exposures to intense noise. In addition to amplitude losses, important changes in the intensity functions result...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(84)90067-4
更新日期：1984-04-01 00:00:00
abstract：:Hypoxia/ischemia is a major pathogenetic factor in the development of hearing loss. An important transcription factor involved in the signaling and adaptation to hypoxia/ischemia is the hypoxia-inducible factor-1 (HIF-1). To study HIF-1 expression we used an in vitro hypoxia model of explant and dissociated cultures o...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(03)00222-3
更新日期：2003-09-01 00:00:00
abstract：:Guinea pigs were exposed to a 10 kHz pure tone and damage to the cochlea was investigated immediately after exposure, or after a recovery period ranging from 18-25 days. Structural damage was assessed using scanning electron microscopy and functional damage estimated using the N1 threshold audiogram. Exposure at 106 d...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(80)90015-5
更新日期：1980-01-01 00:00:00
abstract：:The influence of noise exposure on the endothelial transport system in the cochlea was investigated using cationic polyethyleneimine (PEI), since systemically administered PEI passes through the capillary endothelial cell and attaches to basal lamina (BL) anionic sites in the cochlea. Under general anesthesia, all gui...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(01)00397-5
更新日期：2002-02-01 00:00:00
abstract：:The present study aimed to investigate whether gap-prepulse inhibition (GPI) deficit in patients with tinnitus occurred in the N1-P2 complex of the cortical auditory evoked potential. Auditory late responses to the intense sound of the GPI paradigm were obtained from 16 patients with tinnitus and 18 age- and hearing l...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2017.03.003
更新日期：2017-05-01 00:00:00
abstract：:The human auditory brainstem is known to be exquisitely sensitive to fine-grained spectro-temporal differences between speech sound contrasts, and the ability of the brainstem to discriminate between these contrasts is important for speech perception. Recent work has described a novel method for translating brainstem ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2011.09.001
更新日期：2011-12-01 00:00:00
abstract：:The mastoid air cell system has traditionally been considered to have a passive role in gas exchange and pressure regulation of the middle ear possibly with some acoustic function. However, more evidence has focused on the mucosa of the mastoid, which may play a more active role in regulation of middle ear pressure. I...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2013.03.002
更新日期：2013-07-01 00:00:00
abstract：:Exposure of the vestibulo-cochlear anastomosis in the cat allows single-unit recording of afferent fibers originating from inner hair cells and olivocochlear efferent fibers to the outer hair cells. Comparison of data obtained from individual animals show similarities in absolute threshold and dynamic range between th...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(88)90105-0
更新日期：1988-07-15 00:00:00
abstract：:Distortion-product emissions at 2f1-f2 were measured in developing, pigmented rats to determine the characteristics of the functional onset and maturation of these emitted responses. Distortion-product testing was conducted on postnatal days 12, 14, 18, 21, 24, 28, and 51. The geometric-mean frequencies of the primari...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(90)90223-c
更新日期：1990-01-01 00:00:00
abstract：:The concept of perceptual inferences taking place over multiple timescales simultaneously raises questions about how the brain can balance the demands of remaining sensitive to local rarity while utilising more global longer-term predictability to modulate cortical responses. In the present study auditory evoked poten...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2020.107975
更新日期：2021-01-01 00:00:00
abstract：:This study examined the neural basis of auditory selective attention using functional magnetic resonance imaging. The main hypothesis stated that attending to a particular sound frequency would significantly enhance the neural response within those tonotopic regions of the auditory cortex sensitive to that frequency. ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2009.08.007
更新日期：2009-11-01 00:00:00
