Abstract：
:Distortion-product emissions at 2f1-f2 were measured in developing, pigmented rats to determine the characteristics of the functional onset and maturation of these emitted responses. Distortion-product testing was conducted on postnatal days 12, 14, 18, 21, 24, 28, and 51. The geometric-mean frequencies of the primaries were tested at one-half octave intervals, between 4 and 11.3 kHz. No emissions were detected on postnatal day 12; however, by day 14, emissions were measured at geometric-mean frequencies between 5.7 and 11.3 kHz, but not at 4 kHz. By the 18th postnatal day, all animals had measurable emissions at 4, 5, 7, 8, and 11.3 kHz. Both the functional onset and maturation of high- to midfrequency emissions developed before those elicited by lower-frequency primaries. Response/growth or input/output functions for the higher frequencies exhibited 'adult-like' properties that included an increase in maximum amplitude and 'saturation' at high levels of stimulation by the third to fourth postnatal week. Maturation of the lower-frequency responses progressed at a slower rate. These results differ somewhat from those reported previously for the neonatal albino rat. However, the present findings were based upon a wider frequency range of primary tones, lower levels of acoustic stimulation, and a measuring system with a significantly lower noise floor. These results are consistent with documented periods of the anatomical maturation of the rat outer hair-cell system and establish a functional 'baseline' for future studies utilizing agents that damage the developing cochlea.
journal_name
Hear Resjournal_title
Hearing researchauthors
Henley CM 3rd,Owings MH,Stagner BB,Martin GK,Lonsbury-Martin BLdoi
10.1016/0378-5955(90)90223-csubject
Has Abstractpub_date
1990-01-01 00:00:00pages
141-8issue
2-3eissn
0378-5955issn
1878-5891pii
0378-5955(90)90223-Cjournal_volume
43pub_type
杂志文章相关文献
HEARING RESEARCH文献大全abstract：:This study examined the effect of monaural middle ear destruction on postnatal development of auditory response properties of inferior collicular (IC) neurons of the laboratory mouse, Mus musculus. Monaural middle ear destruction was performed on juvenile and adult mice and the auditory response properties of neurons ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(01)00304-5
更新日期：2001-09-01 00:00:00
abstract：:The purpose of this study was to investigate horizontal plane localization and interaural time difference (ITD) thresholds for 14 adult cochlear implant recipients with hearing preservation in the implanted ear. Localization to broadband noise was assessed in an anechoic chamber with a 33-loudspeaker array extending f...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2014.02.007
更新日期：2014-06-01 00:00:00
abstract：:We used whole cell voltage clamp recordings from neurones in rat auditory brainstem slices to study the Ca(2+) channel types involved in triggering synaptic glutamate and glycine release in the medial superior olivary nucleus. Glutamate release from the anterior ventral cochlear (aVCN) bushy neurone synapse did not in...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(01)00378-1
更新日期：2001-12-01 00:00:00
abstract：:The suppression tuning properties of the oto-acoustic distortion product emission, 2f1-f2 have been measured in the ear canal of gerbil and man. The results show the acoustic response to be suppressible in a similar, frequency-dependent manner in both species. Frequencies near to those of the stimulating tones are mos...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(84)90092-3
更新日期：1984-01-01 00:00:00
abstract：:In order to study the effects of efferent activity, olivocochlear efferents were stimulated with an electrode in the fourth ventricle at the decussation of the crossed olivocochlear bundle (midline-OCB stimulation) or with an electrode at the brainstem origin of medial efferents (MOC stimulation). Tuning curves, or si...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(88)90075-5
更新日期：1988-12-01 00:00:00
abstract：:Measurements of the responses to tones and clicks were made from single primary auditory fibres of the caiman. The distribution of the amplitude and phase of the fundamental component of the response rate modulation over the best frequencies of the fibres is comparable to that reported in the cat, despite the fact tha...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(86)90052-3
更新日期：1986-01-01 00:00:00
abstract：:Cochlear Implant (CI) sound coding strategies based on simultaneous stimulation lead to an increased loudness percept when compared to sequential stimulation using the same current levels. This is due to loudness summation as a result of channel interactions. Studying the loudness perception evoked by dual-channels co...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2020.108091
更新日期：2020-12-01 00:00:00
abstract：:Membranous vestibular labyrinths from the oyster toadfish, Opsanus tau, were fixed, dissected from the animal, stained, and embedded in rectangular blocks of clear histological resin. Photomicrographs of complete embedded labyrinths were taken from six orthogonal directions and used to construct three-dimensional (3D)...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(98)00108-7
更新日期：1998-10-01 00:00:00
abstract：:We show that trkB and trkC mRNAs, encoding the high-affinity receptor tyrosine kinases for brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3), respectively, as well as low-affinity nerve growth factor receptor (p75LNGFR) mRNA are expressed in the cochleovestibular ganglion (CVG) before and during inner...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(94)90064-7
更新日期：1994-05-01 00:00:00
abstract：:Expression of mineralocorticoid type I receptor (MR) gene in the rat cochlea was determined using molecular biological techniques. We synthesized complementary DNA (cDNA) from rat cochlear total RNA and then amplified MR cDNA fragments by polymerase chain reaction (PCR). The amplified cDNA fragments were subcloned int...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(94)90023-x
更新日期：1994-08-01 00:00:00
abstract：:In Menière's disease, the increase of extracellular potassium concentration in the perilymph is thought to play a key role in determining the progressive loss of cochlear hair cells. In this paper, we describe a serum-free culture preparation of hair cells from 5 day-old rat and report the release by the cochlea, in r...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(90)90168-o
更新日期：1990-08-01 00:00:00
abstract：:Progress in amino acid sequencing of two low-molecular weight acidic proteins of unknown function which are present at high concentrations in the organ of Corti is reported. These two proteins, provisionally termed OCP1 and OCP2, were originally demonstrated by two-dimensional polyacrylamide gel electrophoresis; their...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(93)90005-l
更新日期：1993-01-01 00:00:00
abstract：:Thresholds for responses to tone bursts in the primary auditory field of pentobarbital-anesthetized rat are significantly lower for local field potentials (5.60 dB+/-1.76 S.E.M.) than for multiple unit discharges (17.80 dB+/-3.17), recorded simultaneously from the same microelectrode. The characteristic frequencies (C...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(02)00333-7
更新日期：2002-05-01 00:00:00
abstract：:The density of cochlear inner hair cells in Wistar rats is greatest on a short section of the basilar membrane about a fifth of its length from the base. This place corresponds to the frequency region of 30--40 kHz which is supposed to be the region of best hearing. ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(80)90010-6
更新日期：1980-07-01 00:00:00
abstract：:The time of onset of hyperactivity (increased spontaneous firing rates) was investigated by single neuron recording in the inferior colliculus (IC) of guinea pigs subjected to unilateral acoustic trauma (exposure to a loud 10 kHz tone). Hyperactivity was present by 12 h post acoustic trauma whereas data obtained withi...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2012.12.008
更新日期：2013-04-01 00:00:00
abstract：:The spontaneous fluctuations of the intracellular voltage and the position of the sensory hairbundle were measured concurrently using intracellular microelectrodes and an optical differential micro interferometer. Magnitude and frequency distribution of the hair bundles' spontaneous motion suggest that it consists mos...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(92)90062-r
更新日期：1992-06-01 00:00:00
abstract：:The human fetal auditory system is functional around the 25th week of gestational age when the thalamocortical connections are established. Fetal magnetoencephalography (fMEG) provides evidence for fetal auditory brain responses to pure tones and syllables. Fifty-five pregnant women between 31 and 40 weeks of gestatio...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2018.03.005
更新日期：2018-06-01 00:00:00
abstract：:The US Navy, through an Office of Naval Research (ONR) lead effort on Noise Induced Hearing Loss (NIHL), is investigating methods and techniques to mitigate hearing loss for the crews and warfighters. Hearing protection is a viable and increasingly popular method of reducing hearing exposure for many ship crew members...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2017.01.004
更新日期：2017-06-01 00:00:00
abstract：:Mutations in GJB2 account for the majority of recessive forms of prelingual hearing loss. However, in most previous studies it was not possible to distinguish between congenital (present at birth) and non-congenital prelingual hearing loss. In the present study, the frequency of GJB2 alleles in 20 newborns with bilate...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2004.06.012
更新日期：2004-11-01 00:00:00
abstract：:Platelet-derived growth factor receptor (PDGFR) signaling has been demonstrated to play a pivotal role in early embryonic development. Although the expression of PDGF in the inner ear has been studied by RT-PCR, how PDGFR is involved there remains largely unclear. In the current study, we used the antagonistic anti-PD...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2008.08.011
更新日期：2008-11-01 00:00:00
abstract：:Recently, many lines of evidence have supported the possibilities that vasopressin (VP) is closely linked to the formation of endolymphatic hydrops in Meniere's disease. In the present study, it was examined whether or not the chronic administration of VP might induce endolymphatic hydrops. For this purpose, histologi...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(99)00180-x
更新日期：2000-02-01 00:00:00
abstract：:Behavioral studies on complex sound perception in goldfish were carried out in order to help determine what, if any, differences exist between the sense of hearing of fishes and other vertebrates. A stimulus generalization paradigm was used with classical conditioning in three experiments to determine: (1) the percept...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(95)00132-8
更新日期：1995-09-01 00:00:00
abstract：:Size and bilateral asymmetry (i.e. size difference between the left and the right hand side) of inner ear otoliths of larval mouthbreeding cichlid fish were determined during the ontogenetic development of larvae from hatching to the free swimming stage. Animals of two batches were raised in aquarium hatch baskets. Th...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(98)00067-7
更新日期：1998-07-01 00:00:00
abstract：:58 chicks or chick embryos were continuously exposed during 12 h on either embryonic day 18 or 20 or on post-hatching days 1, 10, 20 or 30 to 1.5 kHz pure tone at an intensity of 125 dB SPL. After a 20- or 30-day survival time, audiograms were recorded and then the basilar papillae were prepared for scanning electron ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(85)90141-8
更新日期：1985-01-01 00:00:00
abstract：:To examine the reversibility of functional damage to the cochlea after transient ischemia, cochlear ischemia of 0-60 min was induced in 34 albino guinea pigs. Thresholds of auditory brainstem response (ABR) were then followed for 5 days after ischemia. Although the ABR threshold returned to almost the pre-ischemic val...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(02)00299-x
更新日期：2002-04-01 00:00:00
abstract：:Voice emotion is a fundamental component of human social interaction and social development. Unfortunately, cochlear implant users are often forced to interface with highly degraded prosodic cues as a result of device constraints in extraction, processing, and transmission. As such, individuals with cochlear implants ...
journal_title：Hearing research
pub_type： 杂志文章,评审
doi：10.1016/j.heares.2017.01.006
更新日期：2017-09-01 00:00:00
abstract：:The presence of dopamine (DA) within the cochlea has been previously reported, indicating that its turnover increases under noise stimulation. In the present report, piribedil, a dopaminergic D2 agonist, was used in order to provide evidence of the activity of D2 receptors in the turnover of DA under noise stimulation...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(94)90138-4
更新日期：1994-09-01 00:00:00
abstract：:Actin mRNA was characterised in hair-cell enriched fractions of the chick basilar papilla, by means of the reverse-transcription polymerase chain reaction technique. Primers were directed against the 3' untranslated portions of the actin mRNAs. Evidence for beta-cytoplasmic and gamma-cytoplasmic actin mRNA was found; ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(93)90038-3
更新日期：1993-12-01 00:00:00
abstract：:The incidence and severity of audiogenic seizures in kanamycin (KM)-treated rat pups, from a Wistar strain which is inherently seizure-resistant, was analyzed as a function of (a) postnatal age at the time of KM injection (i.p.) and (b) KM dosage. The vigor of the pinna reflex response on postnatal day (PND) 28 was co...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(88)90142-6
更新日期：1988-01-01 00:00:00
abstract：:Listening to speech in noise can be effortful but when motivated people seem to be more persevering. Previous research showed effects of monetary reward on autonomic responses like cardiovascular reactivity and pupil dilation while participants processed auditory information. The current study examined the effects of ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2018.07.011
更新日期：2018-09-01 00:00:00
