Abstract:
:We used whole cell voltage clamp recordings from neurones in rat auditory brainstem slices to study the Ca(2+) channel types involved in triggering synaptic glutamate and glycine release in the medial superior olivary nucleus. Glutamate release from the anterior ventral cochlear (aVCN) bushy neurone synapse did not involve L-type Ca(2+) channels (alpha(1C-D); Ca(V)1.2-1.3), but was mediated with similar efficacies by both N-type (alpha(1B); Ca(V)2.2) and the P/Q-type Ca(2+) channels (alpha(1A); Ca(V)2.1). Glycine release from the medial nucleus of the trapezoid body (MNTB) synapse was mediated predominantly by P/Q-type Ca(2+) channels, but with a significant contribution from N-type Ca(2+) channels. Combined application of the P/Q- and N-type Ca(2+) channel toxins, omega-agatoxin IVA and omega-conotoxin GVIA, left a very small remnant of both the inhibitory and excitatory postsynaptic currents, probably reflecting a minimal contribution of R-type Ca(2+) channels (alpha(1E); Ca(V)2.3) to transmitter release. In contrast with aVCN bushy neurones, MNTB somata lacked both T- (alpha(1G-I); Ca(V)3.1-3.3) and L-type channels, but expressed a higher proportion of P/Q-type Ca(2+) channels.
journal_name
Hear Resjournal_title
Hearing researchauthors
Barnes-Davies M,Owens S,Forsythe IDdoi
10.1016/s0378-5955(01)00378-1keywords:
subject
Has Abstractpub_date
2001-12-01 00:00:00pages
134-45issue
1-2eissn
0378-5955issn
1878-5891pii
S0378595501003781journal_volume
162pub_type
杂志文章相关文献
HEARING RESEARCH文献大全abstract::Mice of the C57BL/6J (B6) inbred strain exhibit genetic progressive sensorineural hearing loss and have been widely used as a model of adult-onset hearing loss and presbycusis. Males and females exhibit similar degrees of hearing loss until about 3 months of age, after which, the loss accelerates in females. This pape...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2008.12.002
更新日期:2009-06-01 00:00:00
abstract::Noise exposure and the subsequent hearing loss are well documented aspects of military life. Numerous studies have indicated high rates of noise-induced hearing injury (NIHI) in active-duty service men and women, and recent statistics from the U.S. Department of Veterans Affairs indicate a population of veterans with ...
journal_title:Hearing research
pub_type: 杂志文章,评审
doi:10.1016/j.heares.2016.11.008
更新日期:2017-06-01 00:00:00
abstract::We report the results of behavioral studies in cats conducted first, to demonstrate the presence of a monaural mechanism for the enhancement of signal to noise; and then to examine the necessity or sufficiency of the acoustic striae for this mechanism. The results show that cats do indeed have a monaural mechanism for...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(94)90237-2
更新日期:1994-03-01 00:00:00
abstract::The human auditory system is comprised of specialized but interacting anatomic and functional pathways encoding object, spatial, and temporal information. We review how learning-induced plasticity manifests along these pathways and to what extent there are common mechanisms subserving such plasticity. A first series o...
journal_title:Hearing research
pub_type: 杂志文章,评审
doi:10.1016/j.heares.2010.03.086
更新日期:2011-01-01 00:00:00
abstract::58 chicks or chick embryos were continuously exposed during 12 h on either embryonic day 18 or 20 or on post-hatching days 1, 10, 20 or 30 to 1.5 kHz pure tone at an intensity of 125 dB SPL. After a 20- or 30-day survival time, audiograms were recorded and then the basilar papillae were prepared for scanning electron ...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(85)90141-8
更新日期:1985-01-01 00:00:00
abstract::Selected mechanical features of the design of the homodyne interferometer are described. This interferometer was utilized for basilar membrane vibration measurements. The massive construction necessary to minimize mechanical vibration and noise is described. In order to measure basilar membrane vibrations, it was nece...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(86)90173-5
更新日期:1986-01-01 00:00:00
abstract::Prior research [Caine et al., 1981] suggested that scopolamine, a central cholinergic antagonist, may increase gap thresholds in young human listeners. If confirmed, an effect of scopolamine on gap detection might help to explain why both aged humans and aged laboratory animals have less sensitive temporal acuity on g...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/s0378-5955(00)00088-5
更新日期:2000-07-01 00:00:00
abstract::Spontaneous synaptic activity in afferent fibers innervating hair cells of the lateral line organ was monitored with micropipettes at visually identified locations near the peripheral terminations of the fibers. Spontaneous action potentials as well as spontaneous excitatory post-synaptic potentials (EPSPs) were obser...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(90)90023-i
更新日期:1990-02-01 00:00:00
abstract::We show that trkB and trkC mRNAs, encoding the high-affinity receptor tyrosine kinases for brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3), respectively, as well as low-affinity nerve growth factor receptor (p75LNGFR) mRNA are expressed in the cochleovestibular ganglion (CVG) before and during inner...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(94)90064-7
更新日期:1994-05-01 00:00:00
abstract::The presence of dopamine (DA) within the cochlea has been previously reported, indicating that its turnover increases under noise stimulation. In the present report, piribedil, a dopaminergic D2 agonist, was used in order to provide evidence of the activity of D2 receptors in the turnover of DA under noise stimulation...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(94)90138-4
更新日期:1994-09-01 00:00:00
abstract::Chromogranin A (CgA) belongs to the family of chromogranin peptides which are contained in large dense-core vesicles. The novel CgA fragment catestatin (bovine CgA(344-364); RSMRLSFRARGYGFRGPGLQL) is a potent inhibitor of catecholamine release by acting as a nicotinic cholinergic antagonist. Catestatin is a recently c...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/s0378-5955(03)00223-5
更新日期:2003-10-01 00:00:00
abstract:OBJECTIVES:Investigation of bone conduction sound propagation by osseous and non-osseous pathways and their interactions based upon the stimulation site and coupling method of the actuator from a bone conduction hearing aid (BCHA). METHODS:Experiments were conducted on five Thiel embalmed whole head cadaver specimens....
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2019.03.005
更新日期:2019-07-01 00:00:00
abstract::The olivocochlear bundle was sectioned at the floor of the fourth ventricle in a series of cats. From three to thirty weeks post-operatively, recordings were made from single auditory-nerve fibers. Tuning curves, spontaneous discharge rates, and rate-level functions for tones at the characteristic frequency were measu...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(90)90105-x
更新日期:1990-11-01 00:00:00
abstract::Spike potentials were recorded from single, afferent fibres in the pigeon auditory nerve. Pure-tone stimuli were presented in quiet and in combination with wide band noise. Presented alone, tones produced tuned response areas; noise generally drove spike rate to well above the spontaneous rate measured in quiet. When ...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(89)90081-6
更新日期:1989-05-01 00:00:00
abstract::To rehabilitate profoundly deaf patients who are not suitable for cochlear implants, central auditory prostheses have been implanted. To compare two possible electrode configurations - penetrating and surface ones - electrical stimulation of the cochlear nucleus with both types of arrays was tested on guinea pigs and ...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/s0378-5955(97)00170-6
更新日期:1997-12-01 00:00:00
abstract::The waveforms of the auditory evoked magnetic field in normal-hearing individuals and patients suffering from tinnitus are distinctly different. In tinnitus patients, the magnetic wave M200 (corresponding to the electric wave P200, or P2) is delayed and only poorly developed or even completely missing, while the ampli...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(89)90028-2
更新日期:1989-02-01 00:00:00
abstract::The suppression tuning properties of the oto-acoustic distortion product emission, 2f1-f2 have been measured in the ear canal of gerbil and man. The results show the acoustic response to be suppressible in a similar, frequency-dependent manner in both species. Frequencies near to those of the stimulating tones are mos...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(84)90092-3
更新日期:1984-01-01 00:00:00
abstract::A growing body of evidence implies that the dorsal cochlear nucleus (DCN) plays an important role in tinnitus. To test the hypothesis that the rostral output of the DCN is necessary for the experience of chronic tinnitus, the dorsal DCN and the dorsal acoustic stria of rats with psychophysical evidence of tinnitus was...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2004.12.013
更新日期:2005-08-01 00:00:00
abstract::Sound frequency and binaural response properties were determined for single neurons in the rat's inferior colliculus. Nerve cell responses in the central nucleus of the inferior colliculus were narrowly tuned and had clearly defined characteristic frequencies (CF). The central nucleus was tonotopically organized with ...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(91)90177-b
更新日期:1991-11-01 00:00:00
abstract::Immunolabeling of heregulin, a growth factor that enhances cell proliferation in damaged utricles, and one of its binding receptors, ErbB-2, has been briefly described in the P3 rat cochlea and utricle [Zheng et al. (1999) J. Neurocytol. 28, 901-912]. However, little is known about the distribution of heregulin and it...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/s0378-5955(02)00339-8
更新日期:2002-07-01 00:00:00
abstract::Hair cells of the lateral line system in fish may differ in their susceptibility to damage by aminoglycoside antibiotics. Gentamicin has been reported to damage hair cells within canal neuromasts, but not those within superficial neuromasts. This finding, based on SEM imaging, indicates a distinction in the physiology...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2010.01.001
更新日期:2010-03-01 00:00:00
abstract::Cochlear Implant (CI) sound coding strategies based on simultaneous stimulation lead to an increased loudness percept when compared to sequential stimulation using the same current levels. This is due to loudness summation as a result of channel interactions. Studying the loudness perception evoked by dual-channels co...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2020.108091
更新日期:2020-12-01 00:00:00
abstract::There are multiple etiologies and phenotypes of age-related hearing loss or presbyacusis. In this review we summarize findings from animal and human studies of presbyacusis, including those that provide the theoretical framework for distinct metabolic, sensory, and neural presbyacusis phenotypes. A key finding in quie...
journal_title:Hearing research
pub_type: 杂志文章,评审
doi:10.1016/j.heares.2020.108109
更新日期:2020-10-31 00:00:00
abstract::A single-channel hydromechanical model of the human cochlea with nonlinear feedback on the membrane is introduced. The piezoelectric transducers for displacement measurement and force exertion on the membrane are constructed of PVF2 in the bimorph bending type. The passive response shows high-frequency slopes of about...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(93)90140-v
更新日期:1993-04-01 00:00:00
abstract::Although gap junctions occur in auditory and vestibular systems, their function is unclear. Here we present evidence for gap junctional communication in transmitting mechanosensory signals in a sea anemone model system. Hair bundles on anemone tentacles are vibration-sensitive mechanoreceptors that regulate discharge ...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/s0378-5955(00)00047-2
更新日期:2000-06-01 00:00:00
abstract:INTRODUCTION:Distortion product otoacoustic emissions (DPOAEs) are known to represent the contractile amplifier function of cochlear outer hair cells. It is known that low or absent DPOAEs are associated with hearing loss on audiograms. However, low DPOAEs can also be found associated with normal audiograms. It is unkn...
journal_title:Hearing research
pub_type: 临床试验,杂志文章
doi:10.1016/j.heares.2009.02.008
更新日期:2009-05-01 00:00:00
abstract::The present study presents an atlas of the effects of 10 kHz tone exposures of different levels and durations on cochlear hair cells and their stereocilia in the Syrian golden hamster. Animals were sound exposed while under anesthesia. The exposure conditions were varied over an intensity range of 90-129 dB SPL; at th...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(92)90022-f
更新日期:1992-07-01 00:00:00
abstract::The directionality of the cat's pinna was studied by using the amplitude of the cochlear microphonic (CM) as a quantitative indicator of tympanic sound pressure level (SPL). It was found that tympanic SPL varied with the location of a free field stimulator in anechoic space. For high (tonal) frequencies, there was a c...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(82)90031-4
更新日期:1982-09-01 00:00:00
abstract::It is widely appreciated that the key predictor of the pitch of a sound is its periodicity. Neural structures which support pitch perception must therefore be able to reflect the repetition rate of a sound, but this alone is not sufficient. Since pitch is a psychoacoustic property, a putative cortical code for pitch m...
journal_title:Hearing research
pub_type: 杂志文章,评审
doi:10.1016/j.heares.2010.04.015
更新日期:2011-01-01 00:00:00
abstract::Left-handed individuals show a 4 ms later Wave Pb in the 45-60 ms latency range of the auditory middle latency response (MLR) than right-handed individuals. Examination of auditory evoked potentials in fifteen right-handed and fifteen left-handed normal hearing adults showed that this difference was not evident in tim...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(90)90187-t
更新日期:1990-04-01 00:00:00