Calcium channels triggering transmitter release in the rat medial superior olive.

Abstract:

:We used whole cell voltage clamp recordings from neurones in rat auditory brainstem slices to study the Ca(2+) channel types involved in triggering synaptic glutamate and glycine release in the medial superior olivary nucleus. Glutamate release from the anterior ventral cochlear (aVCN) bushy neurone synapse did not involve L-type Ca(2+) channels (alpha(1C-D); Ca(V)1.2-1.3), but was mediated with similar efficacies by both N-type (alpha(1B); Ca(V)2.2) and the P/Q-type Ca(2+) channels (alpha(1A); Ca(V)2.1). Glycine release from the medial nucleus of the trapezoid body (MNTB) synapse was mediated predominantly by P/Q-type Ca(2+) channels, but with a significant contribution from N-type Ca(2+) channels. Combined application of the P/Q- and N-type Ca(2+) channel toxins, omega-agatoxin IVA and omega-conotoxin GVIA, left a very small remnant of both the inhibitory and excitatory postsynaptic currents, probably reflecting a minimal contribution of R-type Ca(2+) channels (alpha(1E); Ca(V)2.3) to transmitter release. In contrast with aVCN bushy neurones, MNTB somata lacked both T- (alpha(1G-I); Ca(V)3.1-3.3) and L-type channels, but expressed a higher proportion of P/Q-type Ca(2+) channels.

journal_name

Hear Res

journal_title

Hearing research

authors

Barnes-Davies M,Owens S,Forsythe ID

doi

10.1016/s0378-5955(01)00378-1

keywords:

subject

Has Abstract

pub_date

2001-12-01 00:00:00

pages

134-45

issue

1-2

eissn

0378-5955

issn

1878-5891

pii

S0378595501003781

journal_volume

162

pub_type

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