Abstract:
:We show that trkB and trkC mRNAs, encoding the high-affinity receptor tyrosine kinases for brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3), respectively, as well as low-affinity nerve growth factor receptor (p75LNGFR) mRNA are expressed in the cochleovestibular ganglion (CVG) before and during innervation of the target fields. Correspondingly, from preinnervation stages onward, BDNF and NT-3, but neither nerve growth factor (NGF) nor neurotrophin-4 (NT-4) mRNAs are expressed in the sensory epithelium of the otic vesicle, the peripheral target field of CVG neurons. No neurotrophin transcripts were detected by in situ hybridization in the medullary central targets. In explant cultures, neuritogenesis from both the cochlear and vestibular part of the CVG was promoted by BDNF, while NT-3 evoked neurites mainly from the cochlear neurons. Also NT-4 stimulated neurite outgrowth from the CVG in vitro. In dissociated neuron-enriched cultures, NT-3 and BDNF promoted survival of overlapping subsets of CVG neurons and, correspondingly, results from in situ hybridization showed that both trkC and trkB mRNAs were expressed in most neurons of this ganglion. The negligible effect of NGF seen in the bioassays agrees well with the expression of only a few trkA transcripts, encoding the high-affinity receptor for NGF, in the CVG. Based on the spatiotemporal expression patterns and biological effects in vitro, peripherally-synthesized BDNF and NT-3 regulate the survival of CVG neurons as well as the establishment of neuron-target cell contacts in the early-developing inner ear. In addition, the expression of trkB mRNA, more specifically its truncated form, and trkC as well as p75LNGFR mRNAs in distinct non-neuronal structures indicates novel roles for these molecules during development.
journal_name
Hear Resjournal_title
Hearing researchauthors
Pirvola U,Arumäe U,Moshnyakov M,Palgi J,Saarma M,Ylikoski Jdoi
10.1016/0378-5955(94)90064-7subject
Has Abstractpub_date
1994-05-01 00:00:00pages
131-44issue
1-2eissn
0378-5955issn
1878-5891pii
0378-5955(94)90064-7journal_volume
75pub_type
杂志文章相关文献
HEARING RESEARCH文献大全abstract::Nitric oxide (NO) is a messenger molecule that mediates several physiological functions and pathological processes. Sodium nitroprusside (SNP), a potent vasodilator, when given clinically as an anti-hypertension agent, exerts its function by releasing NO. It was reported recently that SNP causes a loss of auditory ner...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/s0378-5955(96)00076-7
更新日期:1996-09-15 00:00:00
abstract::An analysis of the central projections of the ventral nucleus of the trapezoid body (VNTB) in the rat, a region of the superior olivary complex known for its neuronal heterogeneity, was made using two anterograde axonal tracers, [3H]leucine and biotinylated dextran amine (BDA). A mixture of these tracers was injected ...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(95)00198-0
更新日期:1996-04-01 00:00:00
abstract::Mortality is a major complication in animal models of cisplatin-induced hearing loss due to the systemic toxicity of the drug. Here we report on a novel two-cycle treatment in rats, each cycle consisting of four days of cisplatin injections (1 mg/kg, i.p., twice daily) separated by 10 days of rest. This regimen, simil...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2004.07.016
更新日期:2004-12-01 00:00:00
abstract::Uncoupling proteins (UCPs) are a proton transporter family located in the mitochondrial inner membrane. The molecular expression and activity of UCPs in brown adipose tissue and skeletal muscle are regulated by factors as diverse as chronic overeating and cold exposure, suggesting roles in energy expenditure and heat ...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2004.02.002
更新日期:2004-10-01 00:00:00
abstract::We review event-related slow firing changes in the auditory cortex and related brain structures. Two types of changes can be distinguished, namely increases and decreases of firing, lasting in the order of seconds. Triggering events can be auditory stimuli, reinforcers, and behavioral responses. Slow firing changes te...
journal_title:Hearing research
pub_type: 杂志文章,评审
doi:10.1016/j.heares.2010.05.003
更新日期:2011-01-01 00:00:00
abstract::Several electrophysiological and psychophysical studies have shown that the spatial excitation pattern produced by bipolar stimulation of a cochlear implant (CI) can have a dual-peak shape. The perceptual effects of this dual-peak shape were investigated using noise-vocoded CI simulations in which synthesis filters we...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2014.11.001
更新日期:2015-01-01 00:00:00
abstract::The spontaneous fluctuations of the intracellular voltage and the position of the sensory hairbundle were measured concurrently using intracellular microelectrodes and an optical differential micro interferometer. Magnitude and frequency distribution of the hair bundles' spontaneous motion suggest that it consists mos...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(92)90062-r
更新日期:1992-06-01 00:00:00
abstract::High doses of aminoglycoside antibiotics cause massive damage to the avian basilar papilla. The resulting functional loss could conceivably arise from the reduction in the DC endocochlear potential (EP) due to impairment of the tegmentum vasculosum (TV) or to shunting of current through the damaged sensory epithelium....
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(95)00119-5
更新日期:1995-09-01 00:00:00
abstract::Certain hair cells of fish exhibit strong immunoreactivity to an S-100 antibody. By their spatial locations in the utricle and saccule, these hair cells appear to possess a relatively short kinocilium and a roughly ovoid cell shape. In the utricle, these cells are predominantly located in the striola. In the saccule, ...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(90)90171-k
更新日期:1990-08-01 00:00:00
abstract::This review is concerned with the operation of circuits in the central auditory system, how they transform response features and what functional significance may be attributed to those transformations. We focus on the role that GABAergic inhibition plays in processing interaural intensity disparities (IIDs), the princ...
journal_title:Hearing research
pub_type: 杂志文章,评审
doi:10.1016/s0378-5955(02)00362-3
更新日期:2002-06-01 00:00:00
abstract::The glycoconjugates in the cochlea of the guinea pig were studied by staining samples by the silver methenamine method as well as after periodic acid-Schiff (PAS) staining. Results obtained by the two methods were similar but not identical. The silver methenamine method was much better in terms of resolution. However,...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(93)90234-r
更新日期:1993-05-01 00:00:00
abstract::It has been demonstrated that INS can be utilized to stimulate spiral ganglion cells in the cochlea. Although neural stimulation can be achieved without direct contact of the radiation source and the tissue, the presence of fluids or bone between the target structure and the radiation source may lead to absorption or ...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2011.06.006
更新日期:2011-12-01 00:00:00
abstract::The central nucleus of the inferior colliculus (CNIC) contains different types of neurons and is a source of ascending projection to the medial geniculate body (MGB), commissural projection to the contralateral IC, direct descending projection to the cochlea nucleus (CN) and indirect projection to the CN via the super...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2006.04.004
更新日期:2006-08-01 00:00:00
abstract::One of the key components of fully-implantable hearing devices is the implantable microphone. A crucial parameter when characterizing implantable microphones is the acoustic sensitivity, as it is one of the input parameters for the fitting algorithm and influences the achievable gain. The aim of our study was to inves...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2020.108018
更新日期:2020-09-15 00:00:00
abstract::The scalp distributions of middle latency auditory evoked potentials (MAEPs) elicited by tone bursts of 250 and 4000 Hz were compared in two experiments. Na (19.9 ms), Pa (29.8 ms), and Pb (51.4 ms) components elicited by tones of either frequency had fronto-central distributions, whereas the Nb component (38.4 ms) wa...
journal_title:Hearing research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0378-5955(95)00035-3
更新日期:1995-05-01 00:00:00
abstract::Following hair cell elimination in severely traumatized cochleae, differentiated supporting cells are often replaced by a simple epithelium with cuboidal or flat appearance. Atoh1 (previously Math1) is a basic helix-loop-helix transcription factor critical to hair cell differentiation during mammalian embryogenesis. F...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2008.02.007
更新日期:2008-06-01 00:00:00
abstract::The properties of the ACh (acetylcholine) response in guinea pig outer hair cells (OHCs) are not well understood. It has been shown that the response to ACh involves the activation of a Ca2+ dependent K+ selective conductance (referred to as Ksub where sub stands for suberyldicholine). In the present study, we examine...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/s0378-5955(96)00142-6
更新日期:1996-11-01 00:00:00
abstract::Amplitude modulation (AM) is an important temporal cue for precise speech and complex sound recognition. However, functional decline of the auditory periphery as well as degradation of central auditory processing due to aging can reduce the salience and resolution of temporal cues. Age-related deficits in central temp...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2015.07.017
更新日期:2015-09-01 00:00:00
abstract::The distribution of actin, alpha-actinin, fimbrin, tropomyosin and tubulin in the apical region of inner and outer hair cells was studied by immunofluorescent localization of antibodies to these proteins. The macromolecular distribution of actin and alpha-actinin was studied using post-embedding immunoelectron microsc...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(85)90029-2
更新日期:1985-01-01 00:00:00
abstract::The waveforms of the auditory evoked magnetic field in normal-hearing individuals and patients suffering from tinnitus are distinctly different. In tinnitus patients, the magnetic wave M200 (corresponding to the electric wave P200, or P2) is delayed and only poorly developed or even completely missing, while the ampli...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(89)90028-2
更新日期:1989-02-01 00:00:00
abstract::The distribution of neurotensin-containing cell bodies and fibers has been observed in the central and peripheral nervous system, including sensory ganglia, but no description has been found in the peripheral auditory system. Here, we investigated the presence of neurotensin immunoreactivity in the cochlea of the adul...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2005.02.011
更新日期:2005-07-01 00:00:00
abstract::Difference limens for the fundamental frequency (F0) of complex tones (DLCs) were measured for four normally hearing subjects and three subjects with cochlear hearing loss. The nominal F0 was 100, 200 or 400 Hz. The two tones to be compared contained either low resolved harmonics (RES), harmonics with intermediate res...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/s0378-5955(03)00191-6
更新日期:2003-08-01 00:00:00
abstract::In this series of behavioural experiments we investigated the effect of distraction on the maintenance of acoustic scene information in short-term memory. Stimuli are artificial acoustic 'scenes' composed of several (up to twelve) concurrent tone-pip streams ('sources'). A gap (1000 ms) is inserted partway through the...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2016.08.015
更新日期:2016-11-01 00:00:00
abstract::Inner and outer hair cells were mechanically isolated from the guinea pig cochlea and subjected to stimuli known to induce shape changes in outer hair cells. Depolarization by 70 mM KCl which causes osmotic swelling of outer hair cells also swelled inner hair cells by approximately 8% of their volume. The application ...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/0378-5955(91)90202-k
更新日期:1991-03-01 00:00:00
abstract::The Federal Food and Drug Administration, or FDA is generally considered a powerful gatekeeper, able to deliver or withhold life-saving cures and create or destroy economic windfalls. As the decades go by, and technologies, diseases, public health demands, and politics evolve, we can identify patterns of change, actio...
journal_title:Hearing research
pub_type: 杂志文章,评审
doi:10.1016/j.heares.2016.11.006
更新日期:2017-06-01 00:00:00
abstract::Peripheral auditory adaptation has been studied extensively in animal models, and multiple exponential components have been identified. This study explores the feasibility of estimating these component processes for human listeners with a peripheral model of adaptation. The processes were estimated from off-frequency ...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/s0378-5955(01)00428-2
更新日期:2002-02-01 00:00:00
abstract::Exposure of the auditory system to either continuous or interrupted nontraumatic noises, often collectively referred to as priming exposures, has been shown, in a number of experimental paradigms, to reduce the susceptibility of the auditory system to noise-induced hearing and sensory cell loss from a subsequent traum...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/s0378-5955(99)00131-8
更新日期:1999-11-01 00:00:00
abstract::Salicylate is a well-known substance to produce reversible tinnitus in animals and humans as well. It has been shown that systemic application of salicylate changes the neuronal spontaneous activity in several parts of the auditory pathway. The effects observed in central auditory structures in vivo could be based upo...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2008.02.005
更新日期:2008-06-01 00:00:00
abstract::Progress in drug delivery to the ear has been achieved over the last few years. This review illustrates the main mechanisms of controlled drug release and the resulting geometry- and size-dependent release kinetics. The potency, physicochemical properties, and stability of the drug molecules are key parameters for des...
journal_title:Hearing research
pub_type: 杂志文章,评审
doi:10.1016/j.heares.2018.03.006
更新日期:2018-10-01 00:00:00
abstract::Transient-evoked otoacoustic emissions (TEOAEs) at high frequencies are a non-invasive physiological test of basilar membrane mechanics at the basal end, and have clinical potential to detect risk of hearing loss related to outer-hair-cell dysfunction. Using stimuli with constant incident pressure across frequency, TE...
journal_title:Hearing research
pub_type: 杂志文章
doi:10.1016/j.heares.2018.09.010
更新日期:2019-01-01 00:00:00