Effects of kanamycin ototoxicity and hair cell regeneration on the DC endocochlear potential in adult chickens.


:High doses of aminoglycoside antibiotics cause massive damage to the avian basilar papilla. The resulting functional loss could conceivably arise from the reduction in the DC endocochlear potential (EP) due to impairment of the tegmentum vasculosum (TV) or to shunting of current through the damaged sensory epithelium. To test this hypothesis, the EP was measured in adult chickens after destroying hair cells in the basal half of the cochlea with a high dose (400 mg/kg per day for 10 days) of kanamycin (KM). KM treatment caused an increase in the steady-state EP from +18.1 to +23.3 mV and a decrease in the magnitude of the negative EP from -42.0 to -19.2 mV. The EP showed almost no change between 1 and 2 days and 1 week post-KM treatment. After 4 weeks of recovery, most hair cells had regenerated; however, the steady-state EP was still elevated by 13% and the negative EP was depressed by 37%. These results suggest that functional loss as shown by the large reduction in cochlear microphonic (CM) and the elevated thresholds of compound action potential (CAP) following KM treatment is not due to a reduction in the EP but may arise from functional deficits in the hair cells and/or the auditory nerve.


Hear Res


Hearing research


Chen L,Trautwein PG,Miller K,Salvi RJ




Has Abstract


1995-09-01 00:00:00














  • CM tuning can be compatible with sharply tuned receptor potentials.

    abstract::There is convincing evidence that cochlear microphonics (CM) arise primarily from outer hair cells and have a frequency distribution that is much broader than that measured in inner hair cells by Russel and Sellick [6,7]. The broad tuning results from the fact that CM generated at each location decays exponentially al...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Kletsky EJ,Zwislocki JJ

    更新日期:1980-06-01 00:00:00

  • Simulation of ILD sensitive neurons in the inferior colliculus of the barn owl.

    abstract::The barn owl (Tyto alba) uses interaural level difference (ILD) as a cue for the localization of sound. The first site of binaural convergence in the pathway that processes ILD is the ventral lateral lemniscus pars posterior (VLVp). Neurons in VLVp receive excitatory input from the contralateral nucleus angularis, and...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Peddicord R

    更新日期:1998-09-01 00:00:00

  • Quantitative analysis of the innervation of the chicken basilar papilla.

    abstract::Unlike the organ of Corti in mammals, the avian basilar papilla has no distinct populations of hair cells. Instead, there is a continuous change between the extreme forms (tall hair cells = THC, and short hair cells = SHC). The hair-cell innervation pattern is complicated, there being no simple gradient between THC (m...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Fischer FP

    更新日期:1992-08-01 00:00:00

  • A mechanism of adaptation to hypergravity in the statocyst of Aplysia californica.

    abstract::The gravity-sensing organ of Aplysia californica consists of bilaterally paired statocysts containing statoconia, which are granules composed of calcium carbonate crystals in an organic matrix. In early embryonic development, Aplysia contain a single granule called a statolith, and as the animal matures, statoconia pr...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Pedrozo HA,Schwartz Z,Luther M,Dean DD,Boyan BD,Wiederhold ML

    更新日期:1996-12-01 00:00:00

  • Detection of auditory sinusoids of fixed and uncertain frequency by budgerigars (Melopsittacus undulatus) and zebra finches (Poephila guttata).

    abstract::Three budgerigars and three zebra finches were tested for their ability to detect sinusoidal stimuli in the presence of broadband noise. Masked thresholds for 1, 2, and 4 KHz pure tones were measured with a fixed frequency condition, in which only one test frequency was presented in a session, and with an uncertain fr...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Okanoya K,Dooling RJ

    更新日期:1990-12-01 00:00:00

  • Measurement of frequency selectivity of single neurons in the central auditory pathway.

    abstract::A large sample of threshold tuning curves of single units from various levels of the auditory pathway was used in order to examine the relationship between best frequency and a measure of sharpness of tuning. This measure is simply the tuning curve bandwidth at 20 dB above threshold on a square-root scale of frequency...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Calford MB,Webster WR,Semple MM

    更新日期:1983-09-01 00:00:00

  • Three-dimensional tonotopic organization of the C57 mouse cochlear nucleus.

    abstract::The cochlear nucleus (CN) is the first sound processing center in the central auditory system that receives the almost unprocessed auditory information from the auditory periphery. The functional organization of the CN has been studied to a great extent in many mammals, including the cat, rat and bat. Yet, despite the...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Luo F,Wang Q,Farid N,Liu X,Yan J

    更新日期:2009-11-01 00:00:00

  • Contribution of various frequency bands to ABR in dolphins.

    abstract::Auditory brainstem responses (ABR) to clicks and noise bursts of various frequency bands and intensities were recorded in two bottlenosed dolphins, Tursiops truncatus. The purpose was to assess contributions of various parts of the cochlear partition to ABR and travelling wave velocity in the cochlea. At band-pass fil...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Popov VV,Supin AY

    更新日期:2001-01-01 00:00:00

  • The effects of efferent activation on the acoustically and electrically evoked otoacoustic emission.

    abstract::The effects of efferent activation on the otoacoustic emission were measured in anesthetized guinea pigs. The otoacoustic emission (2F(1)-F(2)) was evoked by the conventional method of presenting either two continuous tones or a sinusoidal current to the round window (RW) of the cochlea. The efferent effects on the ac...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Ota Y,Dolan DF

    更新日期:2000-10-01 00:00:00

  • Auditory brainstem responses in neonatally sound deprived CBA/J mice.

    abstract::Auditory brainstem responses (ABR) from ten normal (3 males, 7 females) and ten environmentally sound deprived CBA/J mice (6 males, 4 females) were elicited by 30 dB HL click stimuli delivered via specially constructed, matched insert earphones. The mice were tested at 44-49 days of age under chloral hydrate sedation ...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Evans WJ,Webster DB,Cullen JK Jr

    更新日期:1983-06-01 00:00:00

  • Physiological and morphological characterization of efferent neurones in the guinea pig cochlea.

    abstract::Efferent neurones within the intraganglionic spiral bundle of the guinea pig cochlea were characterized in terms of their response properties, and their pattern of termination within the receptor organ revealed by intracellular labelling with horseradish peroxidase. All neurones subsequently identified as efferent neu...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Robertson D,Gummer M

    更新日期:1985-01-01 00:00:00

  • Characteristics and clinical applications of ocular vestibular evoked myogenic potentials.

    abstract::Recently, ocular vestibular evoked myogenic potentials (oVEMPs) have been described and added to the neuro-otologic test battery as a new measure for the vestibulo-ocular reflex. oVEMPs represent extraocular muscle activity in response to otolith stimulation e.g. by air-conducted sound or bone-conducted vibration. In ...

    journal_title:Hearing research

    pub_type: 杂志文章,评审


    authors: Kantner C,Gürkov R

    更新日期:2012-12-01 00:00:00

  • Prestin and the cholinergic receptor of hair cells: positively-selected proteins in mammals.

    abstract::The hair cells of the vertebrate inner ear posses active mechanical processes to amplify their inputs. The stereocilia bundle of various vertebrate animals can produce active movements. Though standard stereocilia-based mechanisms to promote amplification persist in mammals, an additional radically different mechanism...

    journal_title:Hearing research

    pub_type: 杂志文章,评审


    authors: Elgoyhen AB,Franchini LF

    更新日期:2011-03-01 00:00:00

  • Potassium channel gene expression in the rat cochlear nucleus.

    abstract::Potassium channels play a critical role in defining the electrophysiological properties accounting for the unique response patterns of auditory neurons. Serial analysis of gene expression (SAGE), microarrays, RT-PCR, and real-time RT-PCR were used to generate a broad profile of potassium channel expression in the rat ...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Friedland DR,Eernisse R,Popper P

    更新日期:2007-06-01 00:00:00

  • Forward and reverse transfer functions of the middle ear based on pressure and velocity DPOAEs with implications for differential hearing diagnosis.

    abstract::Recently it was shown that distortion product otoacoustic emissions (DPOAEs) can be measured as vibration of the human tympanic membrane in vivo, and proposed to use these vibration DPOAEs to support a differential diagnosis of middle-ear and cochlear pathologies. Here, we investigate how the reverse transfer function...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Dalhoff E,Turcanu D,Gummer AW

    更新日期:2011-10-01 00:00:00

  • Anemone repair proteins as a potential therapeutic agent for vertebrate hair cells: facilitated recovery of the lateral line of blind cave fish.

    abstract::Blind cave fish use the lateral line sensory system to detect nearby objects. The fish responds to sudden perturbations in the water column by initiating startle responses in which they swim more rapidly. Normal startle responses disappear after trauma caused by a single 15 s immersion in calcium free water, but retur...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Repass JJ,Watson GM

    更新日期:2001-04-01 00:00:00

  • Time-varying alterations in the f2-f1 DPOAE response to continuous primary stimulation. I: Response characterization and contribution of the olivocochlear efferents.

    abstract::The f2-f1 distortion product otoacoustic emission (DPOAE) can be observed to undergo gradual alterations in amplitude during continuous ipsilateral stimulation with primary tones. In the present experiments, we characterized the dependence of these amplitude alterations on several stimulus variables (intensity, durati...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Kujawa SG,Fallon M,Bobbin RP

    更新日期:1995-05-01 00:00:00

  • Formation of associations in auditory cortex by slow changes of tonic firing.

    abstract::We review event-related slow firing changes in the auditory cortex and related brain structures. Two types of changes can be distinguished, namely increases and decreases of firing, lasting in the order of seconds. Triggering events can be auditory stimuli, reinforcers, and behavioral responses. Slow firing changes te...

    journal_title:Hearing research

    pub_type: 杂志文章,评审


    authors: Brosch M,Selezneva E,Scheich H

    更新日期:2011-01-01 00:00:00

  • Stimulation with chronically implanted microelectrodes in the cochlear nucleus of the cat: histologic and physiologic effects.

    abstract::The effects of several hours of continuous electrical stimulation in the cats' cochlear nucleus with chronically implanted activated iridium microelectrodes was investigated from the changes in the evoked response near the inferior colliculus and also by histologic evaluation of the stimulated tissue. The stimulating ...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: McCreery DB,Yuen TG,Agnew WF,Bullara LA

    更新日期:1992-09-01 00:00:00

  • Development of activity patterns in auditory nerve fibres of pigeons.

    abstract::Little is known about inner ear development in pigeons. This paper addresses the question of maturation in activity patterns of pigeon auditory nerve fibres, Pigeons that were 1, 2 and 4 weeks and 1, 2, 3 and 4 years old were investigated. Adult-like activity patterns are found 4 weeks post-hatching. Spontaneous activ...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Richter CP,Sauer G,Hoidis S,Klinke R

    更新日期:1996-05-01 00:00:00

  • Death pathways in noise-damaged outer hair cells.

    abstract::Using morphological criteria, death pathways in outer hair cells (OHCs) were determined in chinchilla organs of Corti that had been exposed to a high- or moderate-level octave band of noise (OBN) centered at either 0.5 or 4-kHz. The specimens were part of our large collection of plastic-embedded flat preparations of c...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Bohne BA,Harding GW,Lee SC

    更新日期:2007-01-01 00:00:00

  • Expression pattern of aquaporin water channels in the inner ear of the rat. The molecular basis for a water regulation system in the endolymphatic sac.

    abstract::Mammalian aquaporins constitute a family of so far 10 related water channel proteins which mediate osmotically driven water fluxes across the plasma membrane. Because regulation of the ionic composition and osmolality of inner ear fluids is of great functional significance, we investigated the expression patterns of a...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Beitz E,Kumagami H,Krippeit-Drews P,Ruppersberg JP,Schultz JE

    更新日期:1999-06-01 00:00:00

  • Endocochlear potential in focal lesions of the guinea pig cochlea.

    abstract::To estimate the correlation between the cochlear lateral wall and endocochlear potential (EP), the EP was measured at different time intervals up to 3 weeks at cochlear focal lesions made in the guinea pig. Lesions were produced by a photochemical reaction between systemically administered Rose Bengal and green light ...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Wu R,Hoshino T,Nagura M

    更新日期:1999-02-01 00:00:00

  • Salicylate-induced cochlear impairments, cortical hyperactivity and re-tuning, and tinnitus.

    abstract::High doses of sodium salicylate (SS) have long been known to induce temporary hearing loss and tinnitus, effects attributed to cochlear dysfunction. However, our recent publications reviewed here show that SS can induce profound, permanent, and unexpected changes in the cochlea and central nervous system. Prolonged tr...

    journal_title:Hearing research

    pub_type: 杂志文章,评审


    authors: Chen GD,Stolzberg D,Lobarinas E,Sun W,Ding D,Salvi R

    更新日期:2013-01-01 00:00:00

  • Association of TagSNP in lncRNA HOTAIR with susceptibility to noise-induced hearing loss in a Chinese population.

    abstract:BACKGROUND:Noise-induced hearing loss (NIHL) is a multifactorial disease, and dysregulation of oxidative stress is universally acknowledged as one crucial pathogenic factor for this disease. Recently studies have found the LncRNA HOTAIR is involved in the alteration of oxidative stress level, cell proliferation, cell c...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Wang B,Ding E,Shen H,Wang J,Sun K,Chen S,Han L,Zhang H,Zhu B,Xu M

    更新日期:2017-04-01 00:00:00

  • Na,K-ATPase activity decreases in the cochlear lateral wall of quiet-aged gerbils.

    abstract::Alterations in the distribution and activity of Na,K-ATPase have been implicated in declining cell function with age. However, the location, size and anatomical complexity of the cochlea have limited study of this essential enzyme. Here we describe a micro-colorimetric assay which measures Na,K-ATPase activity in subr...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Gratton MA,Smyth BJ,Schulte BA,Vincent DA Jr

    更新日期:1995-03-01 00:00:00

  • Hyperpolarization-activated current (Ih) in primary auditory neurons.

    abstract::A hyperpolarization-activated current (termed I[h]) is believed to provide a pacemaker depolarization in sinoatrial node cells and in some central and peripheral neurons. In the present study, we examined if such an inward cation current exists in primary auditory neurons using the whole-cell patch-clamp technique. A ...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Chen C

    更新日期:1997-08-01 00:00:00

  • A model for perilymphatic fistula induced hearing loss in the guinea pig cochlea.

    abstract::In cases of sudden, reversible hearing loss where perilymphatic fistulas are thought to be the cause, a multitude of causes have been postulated. These include perilymphatic pressure changes, Simmons' double-break theory, perilymphatic hemorrhage, pneumolabyrinth, and others. This study was proposed to explore the rol...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Foster PK,Luebke AE

    更新日期:2002-05-01 00:00:00

  • Auditory nerve of the normal and jaundiced rat. II. Frequency selectivity and two-tone rate suppression.

    abstract::This study is the continuation of the functional probing of the auditory periphery in the normal and jaundiced rat. Threshold tuning curves from normal rat auditory nerve fibers were comparable to those reported in other mammals. Life-long unconjugated hyperbilirubinemia does not appear to have a widespread, demonstra...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: el Barbary A

    更新日期:1991-07-01 00:00:00

  • Simultaneous suppression of tone burst-evoked otoacoustic emissions: Two and three-tone burst combinations.

    abstract::Previous investigations have shown that components of a tone burst-evoked otoacoustic emission (TBOAE) evoked by a 1 kHz tone burst (TB1) can be suppressed by the simultaneous presence of a 2 kHz tone burst (TB2) or a pair of tone bursts at 2 and 3 kHz (TB2 and TB3 respectively). No previous study has measured this "s...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Killan EC,Lutman ME,Thyer NJ

    更新日期:2015-09-01 00:00:00