Effects of kanamycin ototoxicity and hair cell regeneration on the DC endocochlear potential in adult chickens.


:High doses of aminoglycoside antibiotics cause massive damage to the avian basilar papilla. The resulting functional loss could conceivably arise from the reduction in the DC endocochlear potential (EP) due to impairment of the tegmentum vasculosum (TV) or to shunting of current through the damaged sensory epithelium. To test this hypothesis, the EP was measured in adult chickens after destroying hair cells in the basal half of the cochlea with a high dose (400 mg/kg per day for 10 days) of kanamycin (KM). KM treatment caused an increase in the steady-state EP from +18.1 to +23.3 mV and a decrease in the magnitude of the negative EP from -42.0 to -19.2 mV. The EP showed almost no change between 1 and 2 days and 1 week post-KM treatment. After 4 weeks of recovery, most hair cells had regenerated; however, the steady-state EP was still elevated by 13% and the negative EP was depressed by 37%. These results suggest that functional loss as shown by the large reduction in cochlear microphonic (CM) and the elevated thresholds of compound action potential (CAP) following KM treatment is not due to a reduction in the EP but may arise from functional deficits in the hair cells and/or the auditory nerve.


Hear Res


Hearing research


Chen L,Trautwein PG,Miller K,Salvi RJ




Has Abstract


1995-09-01 00:00:00














  • Changes in middle-ear input admittance during postnatal auditory development in chicks.

    abstract::Admittance at the tympanic membrane was measured in one ear of 73 chicks in 8 age groups between 1 and 150 days post-hatch. Admittance at 7 frequencies (0.66-1.8 kHz) was calculated from measurements of the magnitude and phase angle of sound pressure in front of the tympanic membrane. The results show that admittance ...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Saunders JC,Relkin EM,Rosowski JJ,Bahl C

    更新日期:1986-01-01 00:00:00

  • Differential effects of iontophoretic in vivo application of the GABA(A)-antagonists bicuculline and gabazine in sensory cortex.

    abstract::We have compared the effects of microiontophoretic application of the GABA(A)-receptor antagonists bicuculline (BIC) and gabazine (SR95531) on responses to pure tones and to sinusoidally amplitude-modulated (AM) tones in cells recorded extracellularly from primary auditory cortex (AI) of Mongolian gerbils. Besides sim...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Kurt S,Crook JM,Ohl FW,Scheich H,Schulze H

    更新日期:2006-02-01 00:00:00

  • Computational models of hair cell bundle mechanics: III. 3-D utricular bundles.

    abstract::Six utricular hair bundles from a red-eared turtle are modeled using 3-D finite element analysis. The mechanical model includes shear deformable stereocilia, realignment of all forces during force load increments, and tip and lateral link inter-stereocilia connections. Results show that there are two distinct bundle t...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Silber J,Cotton J,Nam JH,Peterson EH,Grant W

    更新日期:2004-11-01 00:00:00

  • Masculinization of the mammalian cochlea.

    abstract::Otoacoustic emissions (OAEs) differ between the sexes in humans, rhesus and marmoset monkeys, and sheep. OAEs also are different in a number of special populations of humans. Those basic findings are reviewed and discussed in the context of possible prenatal-androgen effects on the auditory system. A parsimonious expl...

    journal_title:Hearing research

    pub_type: 杂志文章,评审


    authors: McFadden D

    更新日期:2009-06-01 00:00:00

  • Slow variations of the amplitude and frequency of spontaneous otoacoustic emissions.

    abstract::Systematic, slow variations of the amplitude and frequency of spontaneous otoacoustic emissions in human ears, occurring over the first 20-30 min of recording, are described. Experimental observations suggest that these variations may arise from a centrally mediated, bilateral influence on the mechanics of the ear. ...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Whitehead ML

    更新日期:1991-06-01 00:00:00

  • Voltage-gated and background K+ channel subunits expressed by the bushy cells of the rat cochlear nucleus.

    abstract::Bushy cells of the ventral cochlear nucleus produce a single, short latency action potential at the beginning of long depolarisations. In the present work an immunochemical survey was performed to detect the presence of K+ channel subunits which may contribute to the specific membrane properties of the bushy cells. Th...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Pál B,Pór A,Pocsai K,Szücs G,Rusznák Z

    更新日期:2005-01-01 00:00:00

  • Intracellular Ca2+ buffers can dramatically affect Ca2+ conductances in hair cells.

    abstract::The effects of endogenous and exogenous Ca(2+) buffers on Ca(2+) current kinetics have been investigated by patch clamp in hair cells mechanically isolated from frog semicircular canals. This preparation displays at least three different Ca(2+) channel types: transient currents flow through a drug-resistant channel ("...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Martini M,Rispoli G,Farinelli F,Fesce R,Rossi ML

    更新日期:2004-09-01 00:00:00

  • The menopause triggers hearing decline in healthy women.

    abstract:BACKGROUND:Epidemiological studies have shown that women have better high-frequency thresholds than men in virtually all age groups, and that age-related hearing decline starts after 30 in men but not until after the age of 50 in women. This coincides with the menopausal transition in most women, thus leading us to hyp...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Hederstierna C,Hultcrantz M,Collins A,Rosenhall U

    更新日期:2010-01-01 00:00:00

  • Suppression in auditory-nerve fibers of cats using low-side suppressors. I. Temporal aspects.

    abstract::Two-tone suppression was studied in the auditory nerve fibers of anesthetized cats, using low-frequency suppressors (50-2000 Hz). The response to the characteristic-frequency (CF) tone was suppressed in a phase-specific manner, attaining one or two minimums in 1 cycle of the suppressor (SUP) tone. The suppression phas...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Cai Y,Geisler CD

    更新日期:1996-07-01 00:00:00

  • Qualitative assessment of postnatal maturation of the organ of Corti in two rat strains.

    abstract::The radial width of three rows of cuticular plates of outer hair cells (width of the OHC triad), the distribution of inner hair cells along the organ of Corti, and postnatal maturation of the middle ear were examined in rats of the Srague-Dawley and Lewis strains aged 0-24 days and two months. The width of the OHC tri...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Burda H

    更新日期:1985-03-01 00:00:00

  • Course of hearing loss and occurrence of tinnitus.

    abstract::Chronic tinnitus is often accompanied by a hearing impairment, but it is still unknown whether hearing loss can actually cause tinnitus. The association between the pitch of the tinnitus sensation and the audiogram edge in patients with high-frequency hearing loss suggests a functional relation, but a large fraction o...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: König O,Schaette R,Kempter R,Gross M

    更新日期:2006-11-01 00:00:00

  • Descending projections to the inferior colliculus from the posterior thalamus and the auditory cortex in rat, cat, and monkey.

    abstract::Projections from the posterior thalamus and medial geniculate body were labeled retrogradely with wheat germ agglutinin conjugated to horseradish peroxidase injected into the rat, cat, and squirrel monkey inferior colliculus. Neurons were found ipsilaterally in the (1) medial division of the medial geniculate body, (2...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Winer JA,Chernock ML,Larue DT,Cheung SW

    更新日期:2002-06-01 00:00:00

  • Physiology of cochlear efferent and afferent neurons: direct comparisons in the same animal.

    abstract::Exposure of the vestibulo-cochlear anastomosis in the cat allows single-unit recording of afferent fibers originating from inner hair cells and olivocochlear efferent fibers to the outer hair cells. Comparison of data obtained from individual animals show similarities in absolute threshold and dynamic range between th...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Liberman MC

    更新日期:1988-07-15 00:00:00

  • Endocochlear potential in focal lesions of the guinea pig cochlea.

    abstract::To estimate the correlation between the cochlear lateral wall and endocochlear potential (EP), the EP was measured at different time intervals up to 3 weeks at cochlear focal lesions made in the guinea pig. Lesions were produced by a photochemical reaction between systemically administered Rose Bengal and green light ...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Wu R,Hoshino T,Nagura M

    更新日期:1999-02-01 00:00:00

  • The dorsal cochlear nucleus contributes to a high intensity component of the acoustic startle reflex in rats.

    abstract::The dorsal cochlear nucleus (DCN) has been shown to project to a region of the nucleus reticularis pontis caudalis (PnC) critical for the evocation of startle in rats, suggesting a possible modulatory influence of the DCN on startle. This study examined the involvement of the DCN in the acoustic startle reflex and var...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Meloni EG,Davis M

    更新日期:1998-05-01 00:00:00

  • Calcium channels triggering transmitter release in the rat medial superior olive.

    abstract::We used whole cell voltage clamp recordings from neurones in rat auditory brainstem slices to study the Ca(2+) channel types involved in triggering synaptic glutamate and glycine release in the medial superior olivary nucleus. Glutamate release from the anterior ventral cochlear (aVCN) bushy neurone synapse did not in...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Barnes-Davies M,Owens S,Forsythe ID

    更新日期:2001-12-01 00:00:00

  • Effects of electrical stimulation of efferent olivocochlear neurons on cat auditory-nerve fibers. III. Tuning curves and thresholds at CF.

    abstract::In order to study the effects of efferent activity, olivocochlear efferents were stimulated with an electrode in the fourth ventricle at the decussation of the crossed olivocochlear bundle (midline-OCB stimulation) or with an electrode at the brainstem origin of medial efferents (MOC stimulation). Tuning curves, or si...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Guinan JJ Jr,Gifford ML

    更新日期:1988-12-01 00:00:00

  • Synaptophysin immunohistochemistry in the human cochlea.

    abstract::Light microscopy and immunohistochemical analyses of a freshly prepared human cochlea, removed at meningioma skull base surgery, were performed with particular emphasis on synaptophysin (SY) reactivity. Synaptophysin, a 38-kDa glycoprotein, is one of the most abundant integral membrane proteins of small presynaptic ve...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Khalifa SA,Friberg U,Illing RB,Rask-Andersen H

    更新日期:2003-11-01 00:00:00

  • Interaction of otoacoustic emissions with additional tones: suppression or synchronization?

    abstract::The influence of an external tone on transitory evoked otoacoustic emissions (TEOAE) is investigated. Three different averaging techniques were used with the same acoustic stimulus paradigm. These techniques permitted the separation of those parts of the otoacoustic emission (OAE) that contribute to the transitory evo...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Neumann J,Uppenkamp S,Kollmeier B

    更新日期:1997-01-01 00:00:00

  • Background noise differentially effects temporal coding by tonic units in the mouse inferior colliculus.

    abstract::In natural environments, temporally complex signals often occur in a background of noise. The neural mechanisms underlying the preservation of temporal sensitivity in background noise are poorly understood. In the present study, we examined the ability of inferior colliculus (IC) units with primary-like and sustained ...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Barsz K,Wilson WW,Walton JP

    更新日期:2000-12-01 00:00:00

  • Origins of thalamic and cortical projections to the posterior auditory field in congenitally deaf cats.

    abstract::Crossmodal plasticity takes place following sensory loss, such that areas that normally process the missing modality are reorganized to provide compensatory function in the remaining sensory systems. For example, congenitally deaf cats outperform normal hearing animals on localization of visual stimuli presented in th...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Butler BE,Chabot N,Kral A,Lomber SG

    更新日期:2017-01-01 00:00:00

  • Time-varying alterations in the f2-f1 DPOAE response to continuous primary stimulation. I: Response characterization and contribution of the olivocochlear efferents.

    abstract::The f2-f1 distortion product otoacoustic emission (DPOAE) can be observed to undergo gradual alterations in amplitude during continuous ipsilateral stimulation with primary tones. In the present experiments, we characterized the dependence of these amplitude alterations on several stimulus variables (intensity, durati...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Kujawa SG,Fallon M,Bobbin RP

    更新日期:1995-05-01 00:00:00

  • Diversity of bilateral synaptic assemblies for binaural computation in midbrain single neurons.

    abstract::Binaural hearing confers many beneficial functions but our understanding of its underlying neural substrates is limited. This study examines the bilateral synaptic assemblies and binaural computation (or integration) in the central nucleus of the inferior colliculus (ICc) of the auditory midbrain, a key convergent cen...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: He N,Kong L,Lin T,Wang S,Liu X,Qi J,Yan J

    更新日期:2017-11-01 00:00:00

  • Cortical encoding of pitch: recent results and open questions.

    abstract::It is widely appreciated that the key predictor of the pitch of a sound is its periodicity. Neural structures which support pitch perception must therefore be able to reflect the repetition rate of a sound, but this alone is not sufficient. Since pitch is a psychoacoustic property, a putative cortical code for pitch m...

    journal_title:Hearing research

    pub_type: 杂志文章,评审


    authors: Walker KM,Bizley JK,King AJ,Schnupp JW

    更新日期:2011-01-01 00:00:00

  • Maturation of kinocilia in amphibian hair cells: growth and shortening related to kinociliary bulb formation.

    abstract::New hair cells are added to the amphibian sacculus throughout life, primarily at its outer edge. The stereociliary bundles near that edge are heterogeneous, but eventually develop the more homogeneous morphology of the overwhelming majority of mature cells near the center of the epithelium. During their development th...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Kelley MW,Ochiai CK,Corwin JT

    更新日期:1992-04-01 00:00:00

  • Formation of associations in auditory cortex by slow changes of tonic firing.

    abstract::We review event-related slow firing changes in the auditory cortex and related brain structures. Two types of changes can be distinguished, namely increases and decreases of firing, lasting in the order of seconds. Triggering events can be auditory stimuli, reinforcers, and behavioral responses. Slow firing changes te...

    journal_title:Hearing research

    pub_type: 杂志文章,评审


    authors: Brosch M,Selezneva E,Scheich H

    更新日期:2011-01-01 00:00:00

  • Involvement of platelet-derived growth factor receptor-beta in maintenance of mesenchyme and sensory epithelium of the neonatal mouse inner ear.

    abstract::Platelet-derived growth factor receptor (PDGFR) signaling has been demonstrated to play a pivotal role in early embryonic development. Although the expression of PDGF in the inner ear has been studied by RT-PCR, how PDGFR is involved there remains largely unclear. In the current study, we used the antagonistic anti-PD...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Hayashi H,Kunisada T,Takakura N,Aoki M,Mizuta K,Ito Y

    更新日期:2008-11-01 00:00:00

  • Piribedil affects dopamine turnover in cochleas stimulated by white noise.

    abstract::The presence of dopamine (DA) within the cochlea has been previously reported, indicating that its turnover increases under noise stimulation. In the present report, piribedil, a dopaminergic D2 agonist, was used in order to provide evidence of the activity of D2 receptors in the turnover of DA under noise stimulation...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Gil-Loyzaga P,Vicente-Torres MA,Fernández-Mateos P,Arce A,Esquifino A

    更新日期:1994-09-01 00:00:00

  • Measurements of the stiffness map challenge a basic tenet of cochlear theories.

    abstract::The cochlear frequency map is believed to depend on the progressive decrease in partition stiffness from base to apex. Measurements on cochleae from human cadavers by von Békésy (1960) suggested that the elasticity of the partition increases by a factor of 100 from the stapes to the helicotrema. However, conventional ...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Naidu RC,Mountain DC

    更新日期:1998-10-01 00:00:00

  • The sensitive period and optimum dosage for induction of audiogenic seizure susceptibility by kanamycin in the Wistar rat.

    abstract::The incidence and severity of audiogenic seizures in kanamycin (KM)-treated rat pups, from a Wistar strain which is inherently seizure-resistant, was analyzed as a function of (a) postnatal age at the time of KM injection (i.p.) and (b) KM dosage. The vigor of the pinna reflex response on postnatal day (PND) 28 was co...

    journal_title:Hearing research

    pub_type: 杂志文章


    authors: Pierson MG,Swann JW

    更新日期:1988-01-01 00:00:00