Abstract：
:It has been demonstrated that INS can be utilized to stimulate spiral ganglion cells in the cochlea. Although neural stimulation can be achieved without direct contact of the radiation source and the tissue, the presence of fluids or bone between the target structure and the radiation source may lead to absorption or scattering of the radiation, which may limit the efficacy of INS. The present study demonstrates the neural structures in the radiation beam path that can be stimulated. Histological reconstructions and microCT of guinea pig cochleae stimulated with an infrared laser suggest that the orientation of the beam from the optical fiber determined the site of stimulation in the cochlea. Best frequencies of the INS-evoked neural responses obtained from the central nucleus of the inferior colliculus matched the histological sites in the spiral ganglion.
journal_name
Hear Resjournal_title
Hearing researchauthors
Moreno LE,Rajguru SM,Matic AI,Yerram N,Robinson AM,Hwang M,Stock S,Richter CPdoi
10.1016/j.heares.2011.06.006subject
Has Abstractpub_date
2011-12-01 00:00:00pages
289-302issue
1-2eissn
0378-5955issn
1878-5891pii
S0378-5955(11)00166-3journal_volume
282pub_type
杂志文章相关文献
HEARING RESEARCH文献大全abstract：:Stiffness of hair bundles on cochlear hair cells was measured in turns 2, 3 and 4 of isolated preparations of the guinea-pig organ of Corti maintained in tissue culture medium. Defined as the force required to produce a linear 1.0 micron deflection of the hair-bundle tip, stiffness is greater for deflection in the exc...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(84)90221-1
更新日期：1984-07-01 00:00:00
abstract：:Activation of heat shock factors (Hsfs) is one of the potential mechanisms for regulating the transcription of the heat shock proteins (Hsps) and certain other stress-responsive genes. Reverse transcription polymerase chain reaction (RT-PCR), Western blot and immunocytochemistry were used to examine the expression and...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(02)00607-x
更新日期：2002-11-01 00:00:00
abstract：:Inner hair cells (IHCs) were isolated from the 3rd and 4th turn of the guinea-pig cochlea using a new microsurgical technique. Microelectrode impalements in vitro with conventional microelectrodes yielded intracellular potentials of -14 +/- 7 mV (mean +/- SD, N = 43) at 24 degrees C. This suggested depletion of intrac...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(90)90185-r
更新日期：1990-04-01 00:00:00
abstract：:During noise-induced temporary threshold shift cytoplasmic vacuoles increase in the synaptic region of auditory hair cells. This structural change in the presynaptic region suggests that afferent synapses between hair cells and auditory nerve fibers fail during the period of threshold elevation, and that synaptic fati...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(90)90096-8
更新日期：1990-11-01 00:00:00
abstract：:The auditory filter may be considered as a weighting function representing frequency selectivity at a particular centre frequency. Its shape can be derived using the power-spectrum model of masking which assumes: (1) in detecting a signal in a masker the observer uses the single auditory filter giving the highest sign...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(87)90050-5
更新日期：1987-01-01 00:00:00
abstract：:Several studies have compared the frequency selectivity of waves I and V of the auditory brainstem response (ABR) in humans, however little is known about the frequency selectivity of the middle latency response (MLR). Simultaneous recordings of ABRs and MLRs to 60 dB peSPL 2000-Hz probe tones were obtained in the pre...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(93)90201-b
更新日期：1993-02-01 00:00:00
abstract：:In mammals, the cochlear sensory epithelium becomes quiescent early during development. After the first postnatal week, there is no cell replacement or proliferation, and severe damage leads to permanent deafness. Supporting cells' trans-differentiation has been suggested as a way to regenerate cochlear hair cells aft...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2018.12.002
更新日期：2019-03-01 00:00:00
abstract：:Measurements were made of inner hair cell receptor potentials and basilar membrane motion in the 17-21 kHz region of the guinea pig cochlea. The latter were made using the Mossbauer technique. Isoamplitude curves at 0.9 mV d.c. receptor potential were compared with isovelocity curves at 0.04 mm/s and the corresponding...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(83)90019-9
更新日期：1983-04-01 00:00:00
abstract：:This study was aimed at defining the relationship between noise-related hearing impairment in industrial workers exposed to continuous noise. For this malondialdehyde and glutathione peroxidase were analyzed as free radical form and antioxidant form. A total of 60 patients working in the units of a hydroelectric power...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(01)00365-3
更新日期：2001-12-01 00:00:00
abstract：:The marsupials, the large group of mammals which develop during fetal life in an externalized pouch, have been given little attention by auditory neurobiologists. In this review the structure of the auditory systems of the handful of marsupials which have been studied is described, the course of auditory development m...
journal_title：Hearing research
pub_type： 杂志文章,评审
doi：10.1016/0378-5955(94)00182-p
更新日期：1995-02-01 00:00:00
abstract：:The laminar distribution and reciprocity of commissural axon terminals and cells of origin in cat primary auditory cortex (AI) were studied after injections of tritiated proline combined with horseradish peroxidase in the middle ectosylvian gyrus. Terminal fields were found in every cortical layer in the contralateral...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(86)90110-3
更新日期：1986-01-01 00:00:00
abstract：:Experiments on the flow-sensitive lateral line system of fishes have provided important insights into the function and sensory transduction of vertebrate hair cells. A common experimental approach has been to pharmacologically block lateral line hair cells and measure how behavior changes. Cobalt chloride (CoCl2) bloc...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2017.04.001
更新日期：2017-07-01 00:00:00
abstract：:With the aim of characterizing the loss of high frequency hearing sensitivity in children, hearing thresholds and otoacoustic emissions were measured in a group of 126 normal hearing children and adolescents aged from 6 to 25 years. The subjects were divided into four 5-year age groups. Hearing thresholds over a range...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2005.11.003
更新日期：2006-02-01 00:00:00
abstract：:We studied the 2IFC detectability of a 500 Hz tone masked by computer-generated maskers under the N0SII interaural condition, and under two masker conditions. In the first masker condition the maskers in the two intervals of a trial were independent of each other, and in the second masker condition the maskers were id...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(83)90074-6
更新日期：1983-08-01 00:00:00
abstract：:In this paper, research on the temporal and spatial distribution of cholinergic-related molecules in the lower auditory brainstem, with an emphasis on nicotinic acetylcholine receptors (nAChRs), is reviewed. The possible functions of acetylcholine (ACh) in driving selective auditory neurons before the onset of hearing...
journal_title：Hearing research
pub_type： 杂志文章,评审
doi：10.1016/j.heares.2005.02.012
更新日期：2005-08-01 00:00:00
abstract：:It is widely appreciated that the key predictor of the pitch of a sound is its periodicity. Neural structures which support pitch perception must therefore be able to reflect the repetition rate of a sound, but this alone is not sufficient. Since pitch is a psychoacoustic property, a putative cortical code for pitch m...
journal_title：Hearing research
pub_type： 杂志文章,评审
doi：10.1016/j.heares.2010.04.015
更新日期：2011-01-01 00:00:00
abstract：:Heat shock protein-27 (Hsp27) is known to function as both a stress-inducible molecular chaperone and regulator of actin polymerization. For many cells in the cochlea, actin is part of the cytoskeleton and plays an important role in the maintenance of cochlear function. To understand the molecular processes by which t...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(01)00379-3
更新日期：2002-01-01 00:00:00
abstract：:Noise-induced hearing loss (NIHL) and hair cell loss are known to show only a moderate correlation. One reason for this is that NIHL may reflect not only the sum of dead hair cells, but also the sum of impaired but still living hair cells. This report compares hair cell loss in different cochlear regions in rats with ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(02)00802-x
更新日期：2003-03-01 00:00:00
abstract：:Proteomic analysis of cadaveric formalin-fixed, celloidin-embedded (FFCE) temporal bone tissue has the potential to provide new insights into inner ear disorders. We have developed a liquid chromatography-mass spectrometry (LC-MS) method for tissue sections embedded with celloidin. Q-TOF (Quadrupole-time of flight mas...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2010.08.003
更新日期：2010-12-01 00:00:00
abstract：:DNA methylation and histone modifications such as methylation, acetylation, and phosphorylation, are two types of epigenetic modifications that alter gene expression. These additions to DNA regulatory elements or to the tails of histones can be inherited or can also occur de novo. Since epigenetic modifications can ha...
journal_title：Hearing research
pub_type： 杂志文章,评审
doi：10.1016/j.heares.2019.01.007
更新日期：2019-05-01 00:00:00
abstract：:A model for cochlear mechanics is proposed to take account of its two systems, one passive and one active. The classical passive system stimulates the inner hair cells directly at levels above about 40 dB SL. At intensities below about 60 dB an active process, the 'cochlear amplifier' (CA), somehow provides additional...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(83)90136-3
更新日期：1983-01-01 00:00:00
abstract：:Sodium salicylate (SS) can penetrate the blood-brain barrier to target neurons in the central auditory system. Understanding how SS alters functional behaviors of different types of central auditory neurons will provide insights into the neural mechanisms of SS-induced tinnitus. Here, we report the differential effect...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2009.03.007
更新日期：2009-07-01 00:00:00
abstract：:Carboplatin is currently being used as an anticancer drug against human cancers. However, high dose of carboplatin chemotherapy resulted in hearing loss in cancer patients. We have shown that carboplatin-induced hearing loss was related to dose-dependent oxidative injury to the cochlea in rat model. However, the time ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2004.01.011
更新日期：2004-05-01 00:00:00
abstract：:Auditory-nerve excitation by two response factors that can be in antiphase has been hypothesized by Kiang (1990) on the basis of non-linear interference in responses to tones (Kiang et al., 1969). The general conditions for antiphasic responses and the relevance of the hypothesis for other auditory stimuli are unknown...
journal_title：Hearing research
pub_type： 杂志文章,评审
doi：10.1016/0378-5955(95)00154-7
更新日期：1995-10-01 00:00:00
abstract：:Averaged auditory evoked potentials (AEPs) to bilaterally presented 100 Hz click trains were recorded from multiple sites simultaneously within Heschl's gyrus (HG) and on the posterolateral surface of the superior temporal gyrus (STG) in epilepsy-surgery patients. Three auditory fields were identified based on AEP wav...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2007.11.012
更新日期：2008-04-01 00:00:00
abstract：:The auditory brainstem response (ABR) is an acoustically evoked potential commonly used to determine hearing sensitivity in laboratory animals. Both isoflurane and ketamine/xylazine anesthesia are commonly used to immobilize animals during ABR procedures. Hearing threshold determination is often the primary interest. ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2012.04.005
更新日期：2012-05-01 00:00:00
abstract：:Spontaneous local field potential (LFP) spindle frequencies in cat primary auditory cortex (AI) were estimated from the LFP-trigger autocorrelogram before and after application of sodium salicylate and quinine sulfate. A significant decrease (from 8.7 Hz to 7.6 Hz) was observed. The best modulation frequencies for 251...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(97)00137-8
更新日期：1997-11-01 00:00:00
abstract：:In the pigeon no influence of high doses (135 mg/kg) of furosemide on endocochlear potential and sound evoked activity in single auditory nerve fibres was found. This finding contrasts strongly to results in mammals. ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(90)90053-r
更新日期：1990-12-01 00:00:00
abstract：:Endocochlear potentials (EPs) were investigated in healthy guinea pigs and in those exposed to white noise of 125 dB SPL for 20-80 min. EPs were measured during and after temporary anoxia (3.5 min, denoted as reversible anoxia) and then during continuous anoxia to evaluate noise-induced changes in EP properties. Succi...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(90)90076-2
更新日期：1990-03-01 00:00:00
abstract：:The effects of hyperosmolar substances on the ultrastructure of the endolymphatic sac were studied in mice. Fifteen minutes after intravenous injection of urea or glycerol, subcellular changes in the endolymphatic sac were observed. These consisted of the occurrence of abundant cytoplasmic granules with a floccular or...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(88)90045-7
更新日期：1988-09-01 00:00:00
