Abstract：
:Mortality is a major complication in animal models of cisplatin-induced hearing loss due to the systemic toxicity of the drug. Here we report on a novel two-cycle treatment in rats, each cycle consisting of four days of cisplatin injections (1 mg/kg, i.p., twice daily) separated by 10 days of rest. This regimen, similar to clinical courses of cancer chemotherapy, produced significant hearing loss without mortality. Auditory brain stem evoked responses were unchanged after the first cycle but were elevated by 40-50 dB at 16 and 20 kHz after the second. Loss of outer hair cells occurred after the second cycle, predominantly in the base of the cochlea. Total cochlear antioxidants declined progressively during drug treatment and were reduced to 60% of control values after the second cisplatin cycle. Co-administration of salicylate (100 mg/kg, s.c., twice daily) during both cycles or during the second cycle restored antioxidant levels and reduced cisplatin-induced threshold shifts. This model of cisplatin ototoxicity without mortality eliminates potentially confounding factors that may determine the survival of a special cohort of animals. The results also support the notion that reactive oxygen species are involved in cisplatin ototoxicity and show the potential usefulness of antioxidant treatment.
journal_name
Hear Resjournal_title
Hearing researchauthors
Minami SB,Sha SH,Schacht Jdoi
10.1016/j.heares.2004.07.016keywords:
subject
Has Abstractpub_date
2004-12-01 00:00:00pages
137-43issue
1-2eissn
0378-5955issn
1878-5891pii
S0378-5955(04)00244-8journal_volume
198pub_type
杂志文章相关文献
HEARING RESEARCH文献大全abstract：:Cochlear implantation (CI), which directly stimulates the cochlear nerves, is the most effective and widely used medical intervention for patients with severe to profound sensorineural hearing loss. The etiology of the hearing loss is speculated to have a major influence of CI outcomes, particularly in cases resulting...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2017.02.017
更新日期：2017-05-01 00:00:00
abstract：:Phantom electrode (PE) stimulation can extend the lower limit of pitch perception with cochlear implants (CIs) by using simultaneous out-of-phase stimulation of the most apical primary electrode and the adjacent basal compensating electrode. The total electrical field may push the excitation pattern beyond the most ap...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2020.107949
更新日期：2020-05-01 00:00:00
abstract：:Although the tectorial membrane has a key role in the function of the organ of Corti, its structural relationship within the cochlear partition is still not fully characterised. Being an acellular structure, the tectorial membrane is not readily stained with dyes and is thus difficult to visualise. We present here det...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(00)00208-2
更新日期：2001-01-01 00:00:00
abstract：:Recordings were made from 185 neurons in the primary auditory cortex of cats in the age range of 15 to 297 days. A comparison was made between the tuning for click repetition-rate and for amplitude modulation-frequency of a noise burst on the basis of temporal Modulation Transfer Functions (tMTF). 90 of the 185 units ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(93)90212-j
更新日期：1993-02-01 00:00:00
abstract：:The ubiquity of social vocalizations among animals provides the opportunity to identify conserved mechanisms of auditory processing that subserve communication. Identifying auditory coding properties that are shared across vocal communicators will provide insight into how human auditory processing leads to speech perc...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2013.05.005
更新日期：2013-11-01 00:00:00
abstract：:Binaural hearing confers many beneficial functions but our understanding of its underlying neural substrates is limited. This study examines the bilateral synaptic assemblies and binaural computation (or integration) in the central nucleus of the inferior colliculus (ICc) of the auditory midbrain, a key convergent cen...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2017.09.007
更新日期：2017-11-01 00:00:00
abstract：:In developing neural prostheses, particular success has been realized with cochlear implants. These devices bypass damaged hair cells in the auditory system and electrically stimulate the auditory nerve directly. In contemporary cochlear implants, however, the injected electric current spreads widely along the scala t...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2008.01.011
更新日期：2008-08-01 00:00:00
abstract：:The ear of the goldfish (Carassius auratus) contains three otolithic endorgans: the saccule, lagena, and utricle. The saccule has an auditory function in most teleost fishes for whom data are available, and there is evidence that the lagena is also an auditory endorgan in the goldfish. This study was conducted to comp...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(99)00207-5
更新日期：2000-03-01 00:00:00
abstract：:Low-frequency temporal information present in speech is critical for normal perception, however the neural mechanism underlying the differentiation of slow rates in acoustic signals is not known. Data from the rat trigeminal system suggest that the paralemniscal pathway may be specifically tuned to code low-frequency ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2010.10.009
更新日期：2011-02-01 00:00:00
abstract：:Cave fish have rarely been investigated with regard to their inner ear morphology, hearing abilities, and acoustic communication. Based on a previous study that revealed morphological differences in the saccular otolith between a cave and two surface populations of Poecilia mexicana, we checked for additional differen...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2010.04.001
更新日期：2010-08-01 00:00:00
abstract：:The cochlear microphonic (CM) is produced by a change in standing currents during the motion of the cochlear partition. The motion of the partition and associated hair cell transduction processes are nonlinear and are reflected in the variation of the instantaneous frequency (IF) of the CM. Although the CM is dominate...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(02)00642-1
更新日期：2002-12-01 00:00:00
abstract：:The present study presents an atlas of the effects of 10 kHz tone exposures of different levels and durations on cochlear hair cells and their stereocilia in the Syrian golden hamster. Animals were sound exposed while under anesthesia. The exposure conditions were varied over an intensity range of 90-129 dB SPL; at th...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(92)90022-f
更新日期：1992-07-01 00:00:00
abstract：:Exposure of the auditory system to either continuous or interrupted nontraumatic noises, often collectively referred to as priming exposures, has been shown, in a number of experimental paradigms, to reduce the susceptibility of the auditory system to noise-induced hearing and sensory cell loss from a subsequent traum...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(99)00131-8
更新日期：1999-11-01 00:00:00
abstract：:High dose of salicylate, the active ingredient in aspirin, has long been known to induce transient hearing loss, tinnitus and hyperacusis making it a powerful experimental tool. These salicylate-induced perceptual disturbances are associated with a massive reduction in the neural output of the cochlea. Paradoxically, ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2016.10.021
更新日期：2017-04-01 00:00:00
abstract：:Inner and outer hair cells were mechanically isolated from the guinea pig cochlea and subjected to stimuli known to induce shape changes in outer hair cells. Depolarization by 70 mM KCl which causes osmotic swelling of outer hair cells also swelled inner hair cells by approximately 8% of their volume. The application ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(91)90202-k
更新日期：1991-03-01 00:00:00
abstract：:Rodents have proven to be a useful model system to screen genes, ototoxic compounds and sound exposure protocols that may play a role in hearing loss. High-throughput screening depends upon a rapid and reliable functional assay for hearing loss. This study describes the use of a frequency modulated (FM) chirp stimulus...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2008.09.001
更新日期：2008-11-01 00:00:00
abstract：:Active transcutaneous bone conduction devices, where the transducer is implanted, are used for rehabilitation of hearing impaired patients by directly stimulating the skull bone. The transducer and the way it is attached to the bone play a central role in the design of such devices. The actual effect of varying the co...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2018.01.007
更新日期：2018-04-01 00:00:00
abstract：:Intracellular recordings were made from both inner and outer hair cells (IHC, OHC) in the basal coil of the guinea pig cochlea before, during and after the animal was exposed to loud, pure tones. Following multiple loud tones both types of sensory cells demonstrate a culmulative decrease in their voltage responses to ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(88)90040-8
更新日期：1988-09-01 00:00:00
abstract：:One of the factors which can affect the amount of temporary threshold shift (TTS) due to acoustic overstimulation is known to be the general metabolic state of the exposed subject. The present study was conducted to elucidate how preexisting intense emotional stress in awake guinea pigs could influence the TTS induced...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(92)90013-d
更新日期：1992-02-01 00:00:00
abstract：:Age-related cochlear synaptopathy (CS) has been shown to occur in rodents with minimal noise exposure, and has been hypothesized to play a crucial role in age-related hearing declines in humans. Because CS affects mainly low-spontaneous rate auditory nerve fibers, differential electrophysiological measures such as the...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2020.108068
更新日期：2020-10-01 00:00:00
abstract：:The acoustic input-admittance at the alligator lizard's tympanic membrane varies with stimulus level; the magnitude of the variation can be as much as a factor of three. At 1.6 kHz, the frequency of maximum admittance magnitude, the admittance varies when the stimulus level exceeds 65 dB SPL. At frequencies above or b...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(84)90110-2
更新日期：1984-12-01 00:00:00
abstract：:The ultrastructure of the sensory epithelia in the auditory regions of the ear, the sacculus and lagena, were investigated in the blue gourami, Trichogaster trichopterus, using transmission and scanning electron microscopy. The sensory epithelium consists of sensory hair cells surrounded by supporting cells, both of w...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(81)90049-6
更新日期：1981-11-01 00:00:00
abstract：:Mice of the C57BL/6J (B6) inbred strain exhibit genetic progressive sensorineural hearing loss and have been widely used as a model of adult-onset hearing loss and presbycusis. Males and females exhibit similar degrees of hearing loss until about 3 months of age, after which, the loss accelerates in females. This pape...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2008.12.002
更新日期：2009-06-01 00:00:00
abstract：:In a wide variety of mammals, the rim of the tympanic membrane (annulus fibrosus) has an array of contractile elements, either smooth muscle [Henson and Henson, J. Assoc. Res. Otolaryngol. 1 (2000) 25-32] or myofibroblasts [Kuijpers et al., Hear. Res. 128 (1999) 80-88]. These elements are anchored peripherally to the ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(01)00416-6
更新日期：2002-02-01 00:00:00
abstract：:The superior olivary complex (SOC) is a cluster of nuclei situated in the caudal brainstem tegmentum that forms an essential component of the auditory pathway. The SOC includes two principal nuclei, the medial and lateral superior olives (MSO and LSO respectively), that have clear roles in sound source localization. S...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2008.04.010
更新日期：2008-07-01 00:00:00
abstract：BACKGROUND:Pitch perception of complex tones relies on place or temporal fine structure-based mechanisms from resolved harmonics and the temporal envelope of unresolved harmonics. Combining this information is essential for speech-in-noise performance, as it allows segregation of a target speaker from background noise....
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2018.06.016
更新日期：2018-09-01 00:00:00
abstract：:Several studies have demonstrated that treatment with intracochlear chronic electrical stimulation (CES) protects spiral ganglion cells (SGCs) from degeneration in deafened animals. Other studies could not confirm this effect of CES. The present study examined whether CES in a mode as presented in cochlear implant use...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2010.06.015
更新日期：2010-10-01 00:00:00
abstract：:We show that trkB and trkC mRNAs, encoding the high-affinity receptor tyrosine kinases for brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3), respectively, as well as low-affinity nerve growth factor receptor (p75LNGFR) mRNA are expressed in the cochleovestibular ganglion (CVG) before and during inner...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(94)90064-7
更新日期：1994-05-01 00:00:00
abstract：:Caloric restriction (CR) slows aging in many species and protects some animals from age-related hearing loss (ARHL), but the effect on humans is not yet known. Because rhesus monkeys are long-lived primates that are phylogenically closer to humans than other research animals are, they provide a better model for studyi...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2010.01.006
更新日期：2010-03-01 00:00:00
abstract：:The tension fibroblasts of the spiral ligament of the mammalian cochlea are thought to create radial tension on the basilar membrane. Their postnatal development was investigated in the gerbil (Meriones unguiculatus) with confocal fluorescence microscopy using phallotoxin as a specific marker for F-actin. In the adult...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(97)00051-8
更新日期：1997-06-01 00:00:00
