Abstract：
:Mice of the C57BL/6J (B6) inbred strain exhibit genetic progressive sensorineural hearing loss and have been widely used as a model of adult-onset hearing loss and presbycusis. Males and females exhibit similar degrees of hearing loss until about 3 months of age, after which, the loss accelerates in females. This paper reviews research on how the B6 auditory system is affected by sex, gonadectomy (i.e., a reduction of gonadal hormone levels), and nightly exposure to moderately intense augmented acoustic environments (AAEs) - a low-frequency noise band (LAAE) or high-frequency band (HAAE). Several findings indicate a negative effect of ovarian hormones on the female B6 auditory system. Whereas the sex difference in high-frequency hearing loss was not significantly affected by gondadectomies, the female disadvantage in ABR thresholds at lower frequencies was erased by ovariectomy. Moreover, exposure to the LAAE or HAAE caused losses of hair cells that were more severe in intact females than in ovariectomized females or in males. Finally, intact females had more severe loss of neurons in the low-frequency region of the anterior ventral cochlear nucleus (AVCN) than other groups. In contrast, the presence of androgens had beneficial effects. Loss of hair cells and AVCN neurons after AAE exposure were more severe in orchidectomized males than in intact males. Ideas, hypotheses, and potential mechanisms concerning the findings are discussed.
journal_name
Hear Resjournal_title
Hearing researchauthors
Willott JFdoi
10.1016/j.heares.2008.12.002subject
Has Abstractpub_date
2009-06-01 00:00:00pages
89-99issue
1-2eissn
0378-5955issn
1878-5891pii
S0378-5955(08)00258-Xjournal_volume
252pub_type
杂志文章相关文献
HEARING RESEARCH文献大全abstract：:Exposure of the auditory system to either continuous or interrupted nontraumatic noises, often collectively referred to as priming exposures, has been shown, in a number of experimental paradigms, to reduce the susceptibility of the auditory system to noise-induced hearing and sensory cell loss from a subsequent traum...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(99)00131-8
更新日期：1999-11-01 00:00:00
abstract：:Biomarkers in easy-to-access body fluid compartments, such as blood, are commonly used to assess health of various organ systems in clinical medicine. At present, no such biomarkers are available to inform on the health of the inner ear. Previously, we proposed the outer-hair-cell-specific protein prestin, as a possib...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2018.11.013
更新日期：2019-01-01 00:00:00
abstract：:The analysis of the auditory scene begins from the moment we hear sounds, making it possible for the infant to distinguish the mother's voice from other sounds in the environment. The purpose of the study was to determine, in two experiments, whether the frequency separation threshold, at which the perception of a mix...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2006.12.013
更新日期：2007-03-01 00:00:00
abstract：:Several studies have been performed in which both the time-dependent and steady state output of cells in the dorsal nucleus of the lateral lemniscus (DNLL) have been measured in response to binaural sound stimulation. In this paper, a mathematical and computational model for the steady state output of DNLL cells is fo...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(99)00096-9
更新日期：1999-10-01 00:00:00
abstract：:Georg von Békésy designed the instruments needed for his research. He also created physical models of the cochlea allowing him to manipulate the parameters (such as volume elasticity) that could be involved in controlling traveling waves. This review is about the specific devices that he used to study the motion of th...
journal_title：Hearing research
pub_type： 历史文章,杂志文章,评审
doi：10.1016/j.heares.2012.08.009
更新日期：2012-11-01 00:00:00
abstract：:The inferior colliculus occupies a central position in ascending and descending auditory pathways. A substantial proportion of its neurons are GABAergic, and these neurons contribute to intracollicular circuits as well as to extrinsic projections to numerous targets. A variety of types of evidence - morphology, physio...
journal_title：Hearing research
pub_type： 杂志文章,评审
doi：10.1016/j.heares.2018.10.001
更新日期：2019-05-01 00:00:00
abstract：:Genetically manipulated mice have gained a prominent role in in vivo research on development and function of the auditory system. A prerequisite for the interpretation of normal and abnormal structural and functional features of the inner ear is the exact knowledge of the cochlear place-frequency map. Using a stereota...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2004.08.011
更新日期：2005-04-01 00:00:00
abstract：:The responses to two identical, consecutive pure tone stimuli with varying inter-stimulus intervals (delta ts) were measured for 89 neurons in the cochlear nucleus of the anaesthetised guinea pig. We observed two main effects; either a decrease (suppression) or an increase (facilitation) in response to the second tone...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2005.12.005
更新日期：2006-02-01 00:00:00
abstract：:Collin and Lavandier [J. Acoust. Soc. Am. 134, 1146-1159 (2013)] proposed a binaural model predicting speech intelligibility against envelope-modulated noises, evaluated in 24 acoustic conditions, involving similar masker types. The aim of the present study was to test the model robustness modeling 80 additional condi...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2020.107937
更新日期：2020-05-01 00:00:00
abstract：:One of the key components of fully-implantable hearing devices is the implantable microphone. A crucial parameter when characterizing implantable microphones is the acoustic sensitivity, as it is one of the input parameters for the fitting algorithm and influences the achievable gain. The aim of our study was to inves...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2020.108018
更新日期：2020-09-15 00:00:00
abstract：:We review event-related slow firing changes in the auditory cortex and related brain structures. Two types of changes can be distinguished, namely increases and decreases of firing, lasting in the order of seconds. Triggering events can be auditory stimuli, reinforcers, and behavioral responses. Slow firing changes te...
journal_title：Hearing research
pub_type： 杂志文章,评审
doi：10.1016/j.heares.2010.05.003
更新日期：2011-01-01 00:00:00
abstract：:In common inbred mouse strains, hearing loss is a highly prevalent quantitative trait, which is mainly controlled by the Cdh23(753A) variant and alleles at numerous other strain-specific loci. Here, we investigated the genetic basis of hearing loss in non-inbred strains. Mice of Swiss Webster, CF-1, NIH Swiss, ICR, an...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2005.11.006
更新日期：2006-02-01 00:00:00
abstract：:In the surgical treatment of otosclerosis, the coupling between the stapes prosthesis and the long process of the incus is critical. After surgery, connective tissue and mucosa may grow over the coupling area and thereby influence the sound transmission properties of the incus-prosthesis interface. It was the hypothes...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2009.08.012
更新日期：2010-05-01 00:00:00
abstract：:Interactions between the statoacoustic ganglion and sensory vestibular epithelia have been investigated using different methods of organ and tissue cultures taken from mouse embryos on gestation day 13. Ultrastructural and biochemical observations of the degree of maturation of vestibular sensory cells and ganglion ne...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(87)90152-3
更新日期：1987-01-01 00:00:00
abstract：:Cochlear outer hair cell (OHC) electromotility is associated with the cell's lateral wall. The lateral wall contains two distinct membranes: the plasma membrane (PM) and the subsurface cisternae (SSC). We explored biophysical characteristics of these lipid structures using membrane-specific fluorescent dyes. We have p...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(99)00077-5
更新日期：1999-09-01 00:00:00
abstract：:Certain characteristics of the extracellular cochlear microphonic (CM) recorded by intracochlear electrodes change in a bimodal manner as a function of prior acoustic exposure, intensity of stimulation, or stimulus frequency. In the present study, it is shown that biasing the basilar membrane position toward scala tym...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(80)90036-2
更新日期：1980-03-01 00:00:00
abstract：:Carboplatin is currently being used as an anticancer drug against human cancers. However, high dose of carboplatin chemotherapy resulted in hearing loss in cancer patients. We have shown that carboplatin-induced hearing loss was related to dose-dependent oxidative injury to the cochlea in rat model. However, the time ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2004.01.011
更新日期：2004-05-01 00:00:00
abstract：:Hearing aids are a relatively non-invasive means of reducing the negative effects of hearing loss on an individual who does not require a cochlear implant. Music amplified through hearing aids has some interesting characteristics but high fidelity is not typically one of them. This poses a serious problem for the inve...
journal_title：Hearing research
pub_type： 杂志文章,评审
doi：10.1016/j.heares.2013.07.003
更新日期：2014-02-01 00:00:00
abstract：:Mutations in GJB2 account for the majority of recessive forms of prelingual hearing loss. However, in most previous studies it was not possible to distinguish between congenital (present at birth) and non-congenital prelingual hearing loss. In the present study, the frequency of GJB2 alleles in 20 newborns with bilate...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2004.06.012
更新日期：2004-11-01 00:00:00
abstract：:To rehabilitate profoundly deaf patients who are not suitable for cochlear implants, central auditory prostheses have been implanted. To compare two possible electrode configurations - penetrating and surface ones - electrical stimulation of the cochlear nucleus with both types of arrays was tested on guinea pigs and ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(97)00170-6
更新日期：1997-12-01 00:00:00
abstract：:The current distribution of bipolar electrodes implanted into the scala tympani of the cat cochlea was investigated using a two-electrode masking technique. Two electrode masking is a non-invasive technique which requires two electrically independent electrodes and relies upon the forward masking of the electrically e...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(85)90044-9
更新日期：1985-06-01 00:00:00
abstract：:Interaural time and intensity differences (ITD and IID) are important cues in binaural hearing and allow for sound localization, improving speech understanding in noise and reverberation, and integrating sound sources in the auditory scene. Whereas previous research showed that the upper-frequency limit for ITD detect...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2018.09.001
更新日期：2018-12-01 00:00:00
abstract：:The influence of an external tone on transitory evoked otoacoustic emissions (TEOAE) is investigated. Three different averaging techniques were used with the same acoustic stimulus paradigm. These techniques permitted the separation of those parts of the otoacoustic emission (OAE) that contribute to the transitory evo...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(96)00160-8
更新日期：1997-01-01 00:00:00
abstract：:Two-tone stimuli have traditionally been used to reveal regions of inhibition in auditory spectral receptive fields, particularly for neurons with low spontaneous rates. These techniques reveal how different frequencies excite or suppress the response to an excitatory frequency of a cell, but have often been assessed ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2005.07.005
更新日期：2005-12-01 00:00:00
abstract：OBJECTIVE:To objectively measure speech intelligibility of individual subjects from the EEG, based on cortical tracking of different representations of speech: low-level acoustical, higher-level discrete, or a combination. To compare each model's prediction of the speech reception threshold (SRT) for each individual wi...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2019.05.006
更新日期：2019-09-01 00:00:00
abstract：:Temperature sensitive auditory neuropathy is a very rare and puzzling disorder. In the present study, we reported three unrelated 2 to 6 year-old children who were diagnosed as auditory neuropathy patients who complained of severe hearing loss when they had fever. Their hearing thresholds varied from the morning to th...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2016.01.008
更新日期：2016-05-01 00:00:00
abstract：:The goal of the present paper is to relate the coding of amplitude modulation (AM) in the auditory pathway to the behavioral detection performance. To address this issue, the detectability of AM was estimated by modelling a single neuron located in the central nucleus of the inferior colliculus (IC). The computational...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(95)00169-9
更新日期：1995-10-01 00:00:00
abstract：:Transtympanic administration of gentamicin is a widely accepted and effective approach for treating patients with intractable vertigo. Previous studies have demonstrated the uptake, distribution and effects of gentamicin in peripheral vestibular and cochlear structures after transtympanic injection. However, little is...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2011.10.003
更新日期：2012-01-01 00:00:00
abstract：:A series of organic acid transport inhibitors significantly reduced the endocochlear potential (EP) decline produced by furosemide in the chinchilla. Probenecid, sodium salicylate and penicillin G were much more effective than novobiocin, meclofenamate or diatrizoate. Inhibitors of organic base transport, choline and ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(87)90037-2
更新日期：1987-01-01 00:00:00
abstract：:Following hair cell elimination in severely traumatized cochleae, differentiated supporting cells are often replaced by a simple epithelium with cuboidal or flat appearance. Atoh1 (previously Math1) is a basic helix-loop-helix transcription factor critical to hair cell differentiation during mammalian embryogenesis. F...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2008.02.007
更新日期：2008-06-01 00:00:00
