Effect of modulation of basilar membrane position on the cochlear microphonic.

Abstract:

:Certain characteristics of the extracellular cochlear microphonic (CM) recorded by intracochlear electrodes change in a bimodal manner as a function of prior acoustic exposure, intensity of stimulation, or stimulus frequency. In the present study, it is shown that biasing the basilar membrane position toward scala tympani serves to enhance the CM amplitude when the cochlea is unfatigued, when low-intensity stimuli are used, or when frequencies below the best frequency of a differential electrode pair are used. Conversely, after acoustic fatigue, or during high-intensity or high-frequency stimulation, the microphonic potential is enhanced by a movement of the basilar membrane toward the scala vestibuli. The two populations of hair cells, whose responses are enhanced and diminished on opposing positions of the basilar membrane, are probably outer and inner hair cells.

journal_name

Hear Res

journal_title

Hearing research

authors

Pierson M,Møller A

doi

10.1016/0378-5955(80)90036-2

subject

Has Abstract

pub_date

1980-03-01 00:00:00

pages

151-62

issue

2

eissn

0378-5955

issn

1878-5891

pii

0378-5955(80)90036-2

journal_volume

2

pub_type

杂志文章
  • Technological, biological, and acoustical constraints to music perception in cochlear implant users.

    abstract::Despite advances in technology, the ability to perceive music remains limited for many cochlear implant users. This paper reviews the technological, biological, and acoustical constraints that make music an especially challenging stimulus for cochlear implant users, while highlighting recent research efforts to overco...

    journal_title:Hearing research

    pub_type: 杂志文章,评审

    doi:10.1016/j.heares.2013.04.009

    authors: Limb CJ,Roy AT

    更新日期:2014-02-01 00:00:00

  • Death pathways in noise-damaged outer hair cells.

    abstract::Using morphological criteria, death pathways in outer hair cells (OHCs) were determined in chinchilla organs of Corti that had been exposed to a high- or moderate-level octave band of noise (OBN) centered at either 0.5 or 4-kHz. The specimens were part of our large collection of plastic-embedded flat preparations of c...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/j.heares.2006.10.004

    authors: Bohne BA,Harding GW,Lee SC

    更新日期:2007-01-01 00:00:00

  • Detection of acoustic temporal fine structure by cochlear implant listeners: behavioral results and computational modeling.

    abstract::A test of within-channel detection of acoustic temporal fine structure (aTFS) cues is presented. Eight cochlear implant listeners (CI) were asked to discriminate between two Schroeder-phase (SP) complexes using a two-alternative, forced-choice task. Because differences between the acoustic stimuli are primarily constr...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/j.heares.2013.01.004

    authors: Imennov NS,Won JH,Drennan WR,Jameyson E,Rubinstein JT

    更新日期:2013-04-01 00:00:00

  • Spatial organization of the reciprocal connections between the cat dorsal and anteroventral cochlear nuclei.

    abstract::We are studying the interconnections between the anteroventral cochlear nucleus (AVCN) and the dorsal cochlear nucleus (DCN). Biotinylated dextran was injected into the DCN, where the best frequency of responses was also recorded. Ventrotubercular neurons in AVCN were labeled, along with cochlear nerve fibers and the ...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/s0378-5955(98)00224-x

    authors: Ostapoff EM,Morest DK,Parham K

    更新日期:1999-04-01 00:00:00

  • Modulation transfer function of efferent neurones in the guinea pig cochlea.

    abstract::The dynamic properties of single olivocochlear efferent neurones in the guinea pig cochlea were examined using sinusoidally amplitude modulated (AM) pure tones. The neural discharge, when displayed as a cyclic histogram, clearly followed the rapid fluctuations in the continuous input sound. Modulation transfer functio...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/0378-5955(88)90136-0

    authors: Gummer M,Yates GK,Johnstone BM

    更新日期:1988-10-01 00:00:00

  • A speculation about the parallel ear asymmetries and sex differences in hearing sensitivity and otoacoustic emissions.

    abstract::Hearing sensitivity and the prevalence of spontaneous otoacoustic emissions show parallel ear and sex differences in humans. Here it is proposed that these lateral asymmetries and sex differences may all result from differences in the 'strength' of the efferent inhibition delivered to individual cochleas. Specifically...

    journal_title:Hearing research

    pub_type: 杂志文章,评审

    doi:10.1016/0378-5955(93)90118-k

    authors: McFadden D

    更新日期:1993-08-01 00:00:00

  • Transdifferentiation and its applicability for inner ear therapy.

    abstract::During normal development, cells divide, then differentiate to adopt their individual form and function in an organism. Under most circumstances, mature cells cannot transdifferentiate, changing their fate to adopt a different form and function. Because differentiated cells cannot usually divide, the repair of injurie...

    journal_title:Hearing research

    pub_type: 杂志文章,评审

    doi:10.1016/j.heares.2006.08.015

    authors: Batts SA,Raphael Y

    更新日期:2007-05-01 00:00:00

  • The effect of dorsal cochlear nucleus ablation on tinnitus in rats.

    abstract::A growing body of evidence implies that the dorsal cochlear nucleus (DCN) plays an important role in tinnitus. To test the hypothesis that the rostral output of the DCN is necessary for the experience of chronic tinnitus, the dorsal DCN and the dorsal acoustic stria of rats with psychophysical evidence of tinnitus was...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/j.heares.2004.12.013

    authors: Brozoski TJ,Bauer CA

    更新日期:2005-08-01 00:00:00

  • Auditory evoked potentials in aged gerbils: responses elicited by noises separated by a silent gap.

    abstract::The compound action potential (CAP) and the auditory brainstem response (ABR; waves ii and iv) were recorded in young (4-8 month) and aged (33-37 month) gerbils using a paradigm similar to that used in some psychophysical studies of gap detection (a pair of identical low-pass noises separated by a silent gap). Respons...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/s0378-5955(96)90016-7

    authors: Boettcher FA,Mills JH,Swerdloff JL,Holley BL

    更新日期:1996-12-01 00:00:00

  • Rapid recovery of sensory function in blind cave fish treated with anemone repair proteins.

    abstract::Blind cave fish employ superficial neuromasts to detect currents [Baker, C.F. and J.C. Montgomery, J. Comp. Physiol. A 184 (1999) 519-527]. Briefly exposing fish to calcium-free water significantly reduces the ability of the fish to perform rheotaxis (i.e., to orient properly in currents). Spontaneous recovery to cont...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/s0378-5955(02)00705-0

    authors: Berg A,Watson GM

    更新日期:2002-12-01 00:00:00

  • A nicotinic acetylcholine receptor-like alpha-bungarotoxin-binding site on outer hair cells.

    abstract::Acetylcholine (ACh) appears to be the major neurotransmitter liberated from olivocochlear efferents terminating on outer hair cells (OHC). Recently, cholinergic receptor epitopes were visualized at the basal pole of the OHCs. To evaluate the ACh receptor type at OHC we performed binding studies with [125I]-labelled al...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/0378-5955(91)90219-y

    authors: Plinkert PK,Zenner HP,Heilbronn E

    更新日期:1991-05-01 00:00:00

  • Manipulating cell cycle regulation in the mature cochlea.

    abstract::Sensorineural hearing loss, which is often caused by degeneration of hair cells in the auditory epithelium, is permanent because lost hair cells are not replaced. Several conceptual approaches can be used to place new hair cells in the auditory epithelium. One possibility is to enhance proliferation of non-sensory cel...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/j.heares.2007.06.005

    authors: Minoda R,Izumikawa M,Kawamoto K,Zhang H,Raphael Y

    更新日期:2007-10-01 00:00:00

  • The paracrine effect of mesenchymal human stem cells restored hearing in β-tubulin induced autoimmune sensorineural hearing loss.

    abstract::The aim of this study was to examine the activities of hASCs (Human Adipose tissue Derived Stem Cells) on experimental autoimmune hearing loss (EAHL) and how human stem cells regenerated mouse cochlea cells. We have restored hearing in 19 years old white female with autoimmune hearing loss with autologous adipose tiss...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/j.heares.2015.07.021

    authors: Yoo TJ,Du X,Zhou B

    更新日期:2015-12-01 00:00:00

  • Potential role of angiotensin II in noise-induced increases in inner ear blood flow.

    abstract::Guinea pigs were exposed to 120 dB white noise for 30 min and evidenced a four-fold elevation in plasma concentration of the potent vasoconstricting hormone angiotensin II (AII). Anesthetized animals received intra-arterial injections of AII at doses that approximated the endogenous levels measured following noise exp...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/0378-5955(85)90128-5

    authors: Wright JW,Dengerink HA,Miller JM,Goodwin PC

    更新日期:1985-01-01 00:00:00

  • Some physical and psychological effects produced by selective delays of the envelope of narrow bands of noise.

    abstract::One can construct narrow bands of noise that contain delays of either the envelope, the phase, or the carrier separately or in combination. Delayed and undelayed noises will have identical spectra if, and only if, both the envelope and the phase undergo delays of the same magnitude. To study lateralization of these si...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/0378-5955(87)90163-8

    authors: Amenta CA 3rd,Trahiotis C,Bernstein LR,Nuetzel JM

    更新日期:1987-01-01 00:00:00

  • Characterisation of multiple physiological fields within the anatomical core of rat auditory cortex.

    abstract::The organisation and response properties of the rat auditory cortex were investigated with single and multi-unit electrophysiological recording. Two tonotopically organised 'core' fields, i.e. the primary (A1) and anterior (AAF) auditory fields, as well as three non-tonotopically organised 'belt' fields, i.e. the post...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/s0378-5955(03)00182-5

    authors: Rutkowski RG,Miasnikov AA,Weinberger NM

    更新日期:2003-07-01 00:00:00

  • Loss of hair cells and threshold sensitivity during prolonged noise exposure in normotensive albino rats.

    abstract::The relation between hearing loss and loss of hair cells after prolonged exposure to a simulated industrial noise environment was determined in normotensive albino rats. Hearing loss was assessed behaviorally by a conditioned suppression technique and electrophysiologically by auditory brainstem response to pulses of ...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/0378-5955(87)90129-8

    authors: Borg E

    更新日期:1987-01-01 00:00:00

  • Viral vectors for gene delivery to the inner ear.

    abstract::Gene therapy using virus vectors to treat hereditary diseases has made remarkable progress in the past decade. There are FDA-approved products for ex-vivo gene therapy for diseases such as immunodeficiencies (e.g., SCID), and in vivo gene therapy for a rare blindness and neuro-muscular disease. Gene therapy for heredi...

    journal_title:Hearing research

    pub_type: 杂志文章,评审

    doi:10.1016/j.heares.2020.107927

    authors: Maguire CA,Corey DP

    更新日期:2020-09-01 00:00:00

  • Detection of sinusoidal amplitude modulation in logarithmic frequency sweeps across wide regions of the spectrum.

    abstract::Many natural sounds such as speech contain concurrent amplitude and frequency modulation (AM and FM), with the FM components often in the form of directional frequency sweeps or glides. Most studies of modulation coding, however, have employed one modulation type in stationary carriers, and in cases where mixed-modula...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/j.heares.2010.02.002

    authors: Hsieh IH,Saberi K

    更新日期:2010-04-01 00:00:00

  • Course and distribution of efferent fibers in the cochlea of the mouse.

    abstract::The course, distribution and termination of single efferent fibers to the cochlea has been described in only a few animals and relatively few fibers have been studied with knowledge of their ipsilateral or contralateral origin. In order to examine the efferent fibers in the mouse, the anterograde tracer Phaseolus vulg...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/0378-5955(91)90096-r

    authors: Wilson JL,Henson MM,Henson OW Jr

    更新日期:1991-09-01 00:00:00

  • The relative role of beats and combination tones in determining the shapes of masking patterns: II. Hearing-impaired listeners.

    abstract::Masking patterns were measured for hearing-impaired subjects with varying degrees of hearing loss. In one set of conditions, three subjects were tested using narrowband noise ('noise') and sinusoidal ('tone') maskers and narrowband noise signals. The maskers had centre frequencies of 0.25, 0.5, 1.0 and 4.0 kHz and lev...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/s0378-5955(02)00291-5

    authors: Alcántara JI,Moore BC

    更新日期:2002-03-01 00:00:00

  • Suppression and enhancement of distortion-product otoacoustic emissions by interference tones above f(2). I. Basic findings in rabbits.

    abstract::The present study measured interference-response areas (IRAs) for distortion-product otoacoustic emissions (DPOAEs) at 2f(1)-f(2), 3f(1)-2f(2), and 2f(2)-f(1). The IRAs were obtained in either awake or anesthetized rabbits, or in anesthetized guinea pigs and mice, by sweeping the frequencies and levels of an interfere...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/s0378-5955(99)00119-7

    authors: Martin GK,Stagner BB,Jassir D,Telischi FF,Lonsbury-Martin BL

    更新日期:1999-10-01 00:00:00

  • Immunohistochemical localization of S-100 protein in auditory and vestibular end organs of the mouse and hamster.

    abstract::The distribution of S-100-like immunoreactivity in mouse and hamster auditory and vestibular end organs was determined by the use of immunohistochemistry. Within the organ of Corti, the cytoplasm of cells of Deiter and Hensen were strongly immunoreactive. Inner hair cells and the peripheral processes and cell bodies o...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/0378-5955(94)90176-7

    authors: Foster JD,Drescher MJ,Hatfield JS,Drescher DG

    更新日期:1994-04-01 00:00:00

  • Structural effects of short term and chronic extracochlear electrical stimulation on the guinea pig spiral organ.

    abstract::To assess the effects of extracochlear electrical stimulation on cochlear structure, guinea pigs were implanted and stimulated with single middle ear electrodes either at round window or promontory sites, and their cochleae examined by transmission electron microscopy. Implanted but unstimulated, or unimplanted contro...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/0378-5955(87)90214-0

    authors: Dodson HC,Walliker JR,Bannister LH,Douek EE,Fourcin AJ

    更新日期:1987-11-01 00:00:00

  • The cochlear place-frequency map of the adult and developing Mongolian gerbil.

    abstract::Gerbils are frequently used in auditory research; however, only limited information on the exact frequency representation in the cochlea is available. Therefore the place-frequency map of the gerbil was determined by iontophoretic application of horseradish peroxidase in physiologically characterized single auditory n...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/0378-5955(95)00230-8

    authors: Müller M

    更新日期:1996-05-01 00:00:00

  • Correlation index: a new metric to quantify temporal coding.

    abstract::The standard procedure to study temporal encoding of sound waveforms in the auditory system has been Fourier analysis of responses to periodic stimuli. We introduce a new metric--correlation index (CI)--which is based on a simple counting of spike coincidences. It can be used for responses to aperiodic stimuli and doe...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/j.heares.2006.03.010

    authors: Joris PX,Louage DH,Cardoen L,van der Heijden M

    更新日期:2006-06-01 00:00:00

  • An optimized, clinically relevant mouse model of cisplatin-induced ototoxicity.

    abstract::Cisplatin-induced ototoxicity results in significant, permanent hearing loss in pediatric and adult cancer survivors. Elucidating the mechanisms underlying cisplatin-induced hearing loss as well as the development of therapies to reduce and/or reverse cisplatin ototoxicity have been impeded by suboptimal animal models...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/j.heares.2019.02.006

    authors: Fernandez K,Wafa T,Fitzgerald TS,Cunningham LL

    更新日期:2019-04-01 00:00:00

  • WITHDRAWN: A critical need in hearing.

    abstract::This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/j.heares.2009.12.012

    authors: Hudspeth AJ,Martin P

    更新日期:2010-01-30 00:00:00

  • Internal and external noise in binaural detection.

    abstract::We studied the 2IFC detectability of a 500 Hz tone masked by computer-generated maskers under the N0SII interaural condition, and under two masker conditions. In the first masker condition the maskers in the two intervals of a trial were independent of each other, and in the second masker condition the maskers were id...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/0378-5955(83)90074-6

    authors: Siegel RA,Colburn HS

    更新日期:1983-08-01 00:00:00

  • Dynamic current steering with phantom electrode in cochlear implants.

    abstract::Phantom electrode (PE) stimulation can extend the lower limit of pitch perception with cochlear implants (CIs) by using simultaneous out-of-phase stimulation of the most apical primary electrode and the adjacent basal compensating electrode. The total electrical field may push the excitation pattern beyond the most ap...

    journal_title:Hearing research

    pub_type: 杂志文章

    doi:10.1016/j.heares.2020.107949

    authors: Luo X,Garrett C

    更新日期:2020-05-01 00:00:00