Abstract：
:A series of organic acid transport inhibitors significantly reduced the endocochlear potential (EP) decline produced by furosemide in the chinchilla. Probenecid, sodium salicylate and penicillin G were much more effective than novobiocin, meclofenamate or diatrizoate. Inhibitors of organic base transport, choline and N-methyl nicotinamide, had no effect on the furosemide-induced drop of the EP. These findings suggest that at least part of furosemide ototoxicity may be mediated by organic acid transport.
journal_name
Hear Resjournal_title
Hearing researchauthors
Rybak LP,Whitworth Cdoi
10.1016/0378-5955(87)90037-2subject
Has Abstractpub_date
1987-01-01 00:00:00pages
89-93issue
1eissn
0378-5955issn
1878-5891pii
0378-5955(87)90037-2journal_volume
26pub_type
杂志文章相关文献
HEARING RESEARCH文献大全abstract：:Systematic, slow variations of the amplitude and frequency of spontaneous otoacoustic emissions in human ears, occurring over the first 20-30 min of recording, are described. Experimental observations suggest that these variations may arise from a centrally mediated, bilateral influence on the mechanics of the ear. ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(91)90060-m
更新日期：1991-06-01 00:00:00
abstract：:Normal-hearing listeners can perceptually segregate concurrent sound sources, but listeners with significant hearing loss or who wear a cochlear implant (CI) lag behind in this ability. Perceptual grouping mechanisms are essential to segregate concurrent sound sources and affect comodulation masking release (CMR). Thu...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2012.11.023
更新日期：2013-02-01 00:00:00
abstract：:Exposure to harsh environment induces stress reactions that increase probability of survival. Stress influences the endocrine, nervous and immune systems and affects the functioning of a variety of organs. Numerous researchers demonstrated that a 24-h exposure to an acoustic rodent repellent provokes stress reaction i...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2009.10.006
更新日期：2010-01-01 00:00:00
abstract：:This paper reviews the contributions of von Békésy to psychoacoustics, comparing his findings and interpretations to those that have emerged since his work. The areas covered include the perception of pitch for pure tones and complex tones, the effect of frequency on the apparent location of pure tones, estimation of ...
journal_title：Hearing research
pub_type： 历史文章,杂志文章,评审
doi：10.1016/j.heares.2012.04.009
更新日期：2012-11-01 00:00:00
abstract：:DNA methylation and histone modifications such as methylation, acetylation, and phosphorylation, are two types of epigenetic modifications that alter gene expression. These additions to DNA regulatory elements or to the tails of histones can be inherited or can also occur de novo. Since epigenetic modifications can ha...
journal_title：Hearing research
pub_type： 杂志文章,评审
doi：10.1016/j.heares.2019.01.007
更新日期：2019-05-01 00:00:00
abstract：:Most previous reports of ototoxicity following exposure to several volatile organic solvents have restricted testing to the low- and mid-frequencies (2-20 kHz) of the hearing range in the rat (0.25-80 kHz). We report here that inhalation exposure to styrene, mixed xylene, toluene, and 1,1,2-trichloroethylene resulted ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(94)90005-1
更新日期：1994-10-01 00:00:00
abstract：:We obtained just-noticeable differences (jnds) for the intensity of pure tones following a forward masker. The masker was a 100-ms burst of narrow-band noise centered at 1000 Hz presented at 90 dB SPL; the pure-tone signal was at 1000 Hz and was 25 ms in duration. The masker-signal delay was 100 ms. Under these condit...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(91)90107-k
更新日期：1991-10-01 00:00:00
abstract：:The course, distribution and termination of single efferent fibers to the cochlea has been described in only a few animals and relatively few fibers have been studied with knowledge of their ipsilateral or contralateral origin. In order to examine the efferent fibers in the mouse, the anterograde tracer Phaseolus vulg...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(91)90096-r
更新日期：1991-09-01 00:00:00
abstract：:Gross electrical responses to tone bursts were measured in the guinea pig with electrodes located in scala tympani (ST) and scala vestibuli (SV) of the cochlea, on the central portion of the VIIIth nerve fibres in the internal auditory meatus, and on the surface of the cochlear nuclear complex (CN). Intracochlear perf...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(02)00716-5
更新日期：2003-02-01 00:00:00
abstract：:In developing neural prostheses, particular success has been realized with cochlear implants. These devices bypass damaged hair cells in the auditory system and electrically stimulate the auditory nerve directly. In contemporary cochlear implants, however, the injected electric current spreads widely along the scala t...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2008.01.011
更新日期：2008-08-01 00:00:00
abstract：:The aim of this study was to examine the activities of hASCs (Human Adipose tissue Derived Stem Cells) on experimental autoimmune hearing loss (EAHL) and how human stem cells regenerated mouse cochlea cells. We have restored hearing in 19 years old white female with autoimmune hearing loss with autologous adipose tiss...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2015.07.021
更新日期：2015-12-01 00:00:00
abstract：:The time of onset of hyperactivity (increased spontaneous firing rates) was investigated by single neuron recording in the inferior colliculus (IC) of guinea pigs subjected to unilateral acoustic trauma (exposure to a loud 10 kHz tone). Hyperactivity was present by 12 h post acoustic trauma whereas data obtained withi...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2012.12.008
更新日期：2013-04-01 00:00:00
abstract：:The phase angle, alpha, between a tonal signal and a tonal masker was varied from 0 degrees to 135 degrees in simultaneous masking, forward masking, and pulsation-threshold paradigms. In all conditions the frequency of the signal and masker was 500 Hz. For forward masking both diotic (MOSO) and dichotic (MOS pi) liste...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(82)90039-9
更新日期：1982-08-01 00:00:00
abstract：:We have investigated the morphometric changes in the cochlear nucleus of patients who had undergone cochlear implantation following profound deafness. The brain stems of 11 adult patients who had undergone implantation and four non-implanted control cases with varying degrees of hearing loss were studied. The volumes ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(02)00694-9
更新日期：2002-12-01 00:00:00
abstract：:Sensorineural hearing loss, which is often caused by degeneration of hair cells in the auditory epithelium, is permanent because lost hair cells are not replaced. Several conceptual approaches can be used to place new hair cells in the auditory epithelium. One possibility is to enhance proliferation of non-sensory cel...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2007.06.005
更新日期：2007-10-01 00:00:00
abstract：:Inner and outer hair cells were mechanically isolated from the guinea pig cochlea and subjected to stimuli known to induce shape changes in outer hair cells. Depolarization by 70 mM KCl which causes osmotic swelling of outer hair cells also swelled inner hair cells by approximately 8% of their volume. The application ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(91)90202-k
更新日期：1991-03-01 00:00:00
abstract：:For the purpose of creating a finite element model of the middle ear, the ossicles can be modelled as rigid bodies or as linear elastic materials. The general elasticity parameters used are usually measured on larger bones like the femur. In order to obtain a highly realistic model, the actual elastic modulus (Young's...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2009.10.001
更新日期：2010-05-01 00:00:00
abstract：:A simplified network model of the organ of Corti is analyzed with the assumption of parametric excitation via resistance changes in the hair cells' apical membrane. Pertinent network variables (intracellular resting and receptor potentials, cellular input resistance, extracellular potentials) depend on the ratios of b...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(83)90120-x
更新日期：1983-10-01 00:00:00
abstract：:Auditory prostheses use implanted electrode arrays that permit stimulation at many sites along the tonotopic axis of auditory neurons. Psychophysical studies demonstrate that measures of implant function, such as detection and discrimination thresholds, vary considerably across these sites, that the across-site patter...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2007.11.007
更新日期：2008-08-01 00:00:00
abstract：:In order to investigate the localization and the type(s) of excitatory amino acid receptors in the frog vestibular system, the exogenous amino acid agonists Quisqualic acid, Kainic acid and N-methyl-D-aspartic acid were tested on the sensory organ of semicircular canals. Intracellular recordings of the resting dischar...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(90)90006-b
更新日期：1990-07-01 00:00:00
abstract：:Auditory-nerve fibers demonstrate dynamic response properties in that they adapt to rapid changes in sound level, both at the onset and offset of a sound. These dynamic response properties affect temporal coding of stimulus modulations that are perceptually relevant for many sounds such as speech and music. Temporal d...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2010.07.009
更新日期：2010-10-01 00:00:00
abstract：:Structural relationships between intermediate cells and capillaries in the stria vascularis of gerbils were examined by confocal laser microscopy and electron microscopy. Immunostaining for an inward rectifier K(+) channel (Kir4.1), which was localized to intermediate cells, was used to determine the three-dimensional...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(01)00252-0
更新日期：2001-05-01 00:00:00
abstract：:The influence of noise exposure on the endothelial transport system in the cochlea was investigated using cationic polyethyleneimine (PEI), since systemically administered PEI passes through the capillary endothelial cell and attaches to basal lamina (BL) anionic sites in the cochlea. Under general anesthesia, all gui...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(01)00397-5
更新日期：2002-02-01 00:00:00
abstract：:This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2009.09.016
更新日期：2009-10-07 00:00:00
abstract：:The present study aimed to investigate whether gap-prepulse inhibition (GPI) deficit in patients with tinnitus occurred in the N1-P2 complex of the cortical auditory evoked potential. Auditory late responses to the intense sound of the GPI paradigm were obtained from 16 patients with tinnitus and 18 age- and hearing l...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2017.03.003
更新日期：2017-05-01 00:00:00
abstract：:This study was aimed at defining the relationship between noise-related hearing impairment in industrial workers exposed to continuous noise. For this malondialdehyde and glutathione peroxidase were analyzed as free radical form and antioxidant form. A total of 60 patients working in the units of a hydroelectric power...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(01)00365-3
更新日期：2001-12-01 00:00:00
abstract：:The nature of age-related improvements in auditory sensitivity was explored by comparing behavioral and auditory brainstem response (ABR) thresholds in 3- and 6-month-old infants and in adults. Thresholds were estimated for tone pips at 1, 4, and 8 kHz, presented at a rate of 13.3/s. The time course of development of ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(93)90071-8
更新日期：1993-06-01 00:00:00
abstract：:One role of the inferior colliculus (IC) in bats is to create neuronal delay-tuning, which is used for the estimation of target distance in the echolocating bat's auditory system. In this study, we describe response properties of IC delay-tuned neurons of the mustached bat (Pteronotus parnellii) and compare it with th...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2012.02.013
更新日期：2012-04-01 00:00:00
abstract：:In these experiments the development of summating potential (SP) responses in gerbils from neonates to adults was followed. Special recording techniques were used to eliminate maturational effects associated with the middle ear so that developmental changes in cochlear physiology were isolated for study. Results indic...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(85)90011-5
更新日期：1985-05-01 00:00:00
abstract：:Glutamate, gamma aminobutyric acid (GABA) and glycine receptors have different properties depending on the specific subunit combination utilized. The subunit composition of amino acid receptors may help to shape the responses of neurons and can provide a diversity of response properties in different neuronal types and...
journal_title：Hearing research
pub_type： 杂志文章,评审
doi：10.1016/s0378-5955(00)00127-1
更新日期：2000-09-01 00:00:00
