Abstract：
:Auditory prostheses use implanted electrode arrays that permit stimulation at many sites along the tonotopic axis of auditory neurons. Psychophysical studies demonstrate that measures of implant function, such as detection and discrimination thresholds, vary considerably across these sites, that the across-site patterns of these measures differ across subjects, and that the likely mechanisms underlying this variability differ across measures. Psychophysical and speech recognition studies suggest that not all stimulation sites contribute equally to perception with the prosthesis and that some sites might have negative effects on perception. Studies that reduce the number of active stimulation sites indicate that most cochlear implant users can effectively utilize a maximum of only about seven sites in their processors. These findings support a strategy for improving implant performance by selecting only the best stimulation sites for the processor map. Another approach is to revise stimulation parameters for ineffective sites in an effort to improve acuity at those sites. In this paper, we discuss data supporting these approaches and some potential pitfalls.
journal_name
Hear Resjournal_title
Hearing researchauthors
Pfingst BE,Burkholder-Juhasz RA,Zwolan TA,Xu Ldoi
10.1016/j.heares.2007.11.007subject
Has Abstractpub_date
2008-08-01 00:00:00pages
172-83issue
1-2eissn
0378-5955issn
1878-5891pii
S0378-5955(07)00266-3journal_volume
242pub_type
杂志文章相关文献
HEARING RESEARCH文献大全abstract：:The concept of perceptual inferences taking place over multiple timescales simultaneously raises questions about how the brain can balance the demands of remaining sensitive to local rarity while utilising more global longer-term predictability to modulate cortical responses. In the present study auditory evoked poten...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2020.107975
更新日期：2021-01-01 00:00:00
abstract：:Sudden sensorineural hearing loss (SSNHL) is generally defined as sensorineural hearing loss of 30 dB or greater over at least three contiguous audiometric frequencies and within a three-day period. This hearing loss is usually unilateral and can be associated with tinnitus and vertigo. The pathogenesis of unilateral ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2016.02.016
更新日期：2016-05-01 00:00:00
abstract：:There is accumulating evidence for a purinergic humoral system involved in the control of cochlear function. Evidence of specific P2 purinoceptors on cochlear tissues implies a role for extracellular adenosine triphosphate (ATP) in the cochlea. To further this hypothesis a study was undertaken to determine if there wa...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(95)00151-1
更新日期：1995-10-01 00:00:00
abstract：:Spike potentials were recorded from single, afferent fibres in the pigeon auditory nerve. Pure-tone stimuli were presented in quiet and in combination with wide band noise. Presented alone, tones produced tuned response areas; noise generally drove spike rate to well above the spontaneous rate measured in quiet. When ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(89)90081-6
更新日期：1989-05-01 00:00:00
abstract：:In these experiments the development of summating potential (SP) responses in gerbils from neonates to adults was followed. Special recording techniques were used to eliminate maturational effects associated with the middle ear so that developmental changes in cochlear physiology were isolated for study. Results indic...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(85)90011-5
更新日期：1985-05-01 00:00:00
abstract：:We have studied the noradrenergic and serotonergic changes induced by white noise stimulation at 70, 90 or 110 dB SPL for 45 min, in cochlear nuclei, inferior colliculus (IC), primary auditory cortex (PAC) and as a comparison in locus coeruleus (LC) and raphe dorsalis using HPLC. Both noradrenergic and serotonergic pa...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(98)00031-8
更新日期：1998-04-01 00:00:00
abstract：:We obtained just-noticeable differences (jnds) for the intensity of pure tones following a forward masker. The masker was a 100-ms burst of narrow-band noise centered at 1000 Hz presented at 90 dB SPL; the pure-tone signal was at 1000 Hz and was 25 ms in duration. The masker-signal delay was 100 ms. Under these condit...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(91)90107-k
更新日期：1991-10-01 00:00:00
abstract：:Gene therapy using virus vectors to treat hereditary diseases has made remarkable progress in the past decade. There are FDA-approved products for ex-vivo gene therapy for diseases such as immunodeficiencies (e.g., SCID), and in vivo gene therapy for a rare blindness and neuro-muscular disease. Gene therapy for heredi...
journal_title：Hearing research
pub_type： 杂志文章,评审
doi：10.1016/j.heares.2020.107927
更新日期：2020-09-01 00:00:00
abstract：:Size and bilateral asymmetry (i.e. size difference between the left and the right hand side) of inner ear otoliths of larval mouthbreeding cichlid fish were determined during the ontogenetic development of larvae from hatching to the free swimming stage. Animals of two batches were raised in aquarium hatch baskets. Th...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(98)00067-7
更新日期：1998-07-01 00:00:00
abstract：:Peripheral auditory adaptation has been studied extensively in animal models, and multiple exponential components have been identified. This study explores the feasibility of estimating these component processes for human listeners with a peripheral model of adaptation. The processes were estimated from off-frequency ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(01)00428-2
更新日期：2002-02-01 00:00:00
abstract：:This report concerns the morphological features of otoconia removed from the inner ear of four amphibian species. Results from scanning electron microscopic examination are compared based on the site of origin. These results show that utricular otoconia have a mineral structure that mimics calcite, rather than the wid...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(93)90246-w
更新日期：1993-05-01 00:00:00
abstract：:Georg von Békésy designed the instruments needed for his research. He also created physical models of the cochlea allowing him to manipulate the parameters (such as volume elasticity) that could be involved in controlling traveling waves. This review is about the specific devices that he used to study the motion of th...
journal_title：Hearing research
pub_type： 历史文章,杂志文章,评审
doi：10.1016/j.heares.2012.08.009
更新日期：2012-11-01 00:00:00
abstract：:Neural auditory thresholds in the guinea pig can be temporarily improved by up to 6 dB about 2 min after the cessation of an moderately intense low-frequency tone (Kirk and Patuzzi, 1997). We have measured changes in the f2-f1 distortion product otoacoustic emission (DPOAE) and low-frequency microphonic potential in s...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(97)00104-4
更新日期：1997-10-01 00:00:00
abstract：:The radial width of three rows of cuticular plates of outer hair cells (width of the OHC triad), the distribution of inner hair cells along the organ of Corti, and postnatal maturation of the middle ear were examined in rats of the Srague-Dawley and Lewis strains aged 0-24 days and two months. The width of the OHC tri...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(85)90064-4
更新日期：1985-03-01 00:00:00
abstract：:When using bone vibrator transducers for clinical measurements, the transfer of energy from the bone driver depends on the impedance match between the driver and the load (human mastoid or otherwise) to which the driver will be applied. Current clinical calibration methods are incapable of quantifying this impedance m...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2010.02.013
更新日期：2010-05-01 00:00:00
abstract：:Mitochondrial DNA (mtDNA) mutations/deletions are considered to be associated with the development of age-related hearing loss (AHL). We assessed the role of accumulation of mtDNA mutations in the development of AHL using Polg(D257A) knock-in mouse, which exhibited increased spontaneous mtDNA mutation rates during agi...
journal_title：Hearing research
pub_type： 杂志文章,评审
doi：10.1016/j.heares.2006.06.004
更新日期：2007-04-01 00:00:00
abstract：:Laser scanning confocal microscopy was used to determine the distribution of actin, spectrin and tubulin in whole mounts of the organ of Corti of guinea pig, monkey, rat and chinchilla. Actin, spectrin and tubulin were localized in all cell types in the auditory epithelium. No specialized cytoskeletal organization of ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(94)90098-1
更新日期：1994-06-01 00:00:00
abstract：:Admittance at the tympanic membrane was measured in one ear of 73 chicks in 8 age groups between 1 and 150 days post-hatch. Admittance at 7 frequencies (0.66-1.8 kHz) was calculated from measurements of the magnitude and phase angle of sound pressure in front of the tympanic membrane. The results show that admittance ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(86)90021-3
更新日期：1986-01-01 00:00:00
abstract：:This study examined the effect of monaural middle ear destruction on postnatal development of auditory response properties of inferior collicular (IC) neurons of the laboratory mouse, Mus musculus. Monaural middle ear destruction was performed on juvenile and adult mice and the auditory response properties of neurons ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/s0378-5955(01)00304-5
更新日期：2001-09-01 00:00:00
abstract：:Several studies have reported an increased incidence of auditory dysfunction among HIV/AIDS patients. We used auditory HEI-OC1 cells in cell viability, flow cytometry and caspases 3/7-activation studies to investigate the potential ototoxicity of fourteen HIV antiretroviral agents: Abacavir, AZT, Delavirdine, Didenosi...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2014.01.005
更新日期：2014-04-01 00:00:00
abstract：:We confirm the report of Mountain (Mountain, D.C. (1980): Science 210, 77-72) that stimulating the crossed olivocochlear bundle (COCB) can change the magnitude of the distortion product (f2-f1) in the ear-canal sound pressure. Our results are extended to include (2f1-f2) as well as (f2-f1) from anesthetized chinchilla...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(82)90052-1
更新日期：1982-02-01 00:00:00
abstract：:During the simultaneous monaural presentation of two primary tones, distortion products can be measured acoustically in the ear canal (DPOAEs) and electrically as auditory evoked potentials (DPAEPs). The purpose of this investigation was to elucidate the sources of nonlinearity within the human auditory system respons...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2004.04.005
更新日期：2004-07-01 00:00:00
abstract：:We determined velocity discrimination thresholds and Weber fractions for sounds revolving around the listener at very high velocities. Sounds used were a broadband white noise and two harmonic sounds with fundamental frequencies of 330 Hz and 1760 Hz. Experiment 1 used velocities ranging between 288°/s and 720°/s in a...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2014.07.014
更新日期：2014-10-01 00:00:00
abstract：:Compound action potentials (AP) were recorded under various stimulus conditions in 31 guinea pigs. Stimulus attenuation, decrease of inter-stimulus interval, increase of the level of a continuous wide-band noise maker, and lowering the animal's temperature all resulted in a drop of the AP amplitude and an increase in ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(81)90034-4
更新日期：1981-03-01 00:00:00
abstract：:The responses of single units in the ventral cochlear nucleus of acute anesthetized guinea pigs were studied with continuous sinusoidal electrical stimuli presented through a multi-electrode implant in the scala tympani. Implants had two or four electrodes along the axis of the scala with 1 mm separations. Best freque...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(83)90108-9
更新日期：1983-11-01 00:00:00
abstract：:Cochlear implant performance in difficult listening situations is limited by channel interactions. It is known that partial tripolar (PTP) stimulation reduces the spread of excitation (SOE). However, the greater the degree of current focusing, the greater the absolute current required to maintain a fixed loudness. As ...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2011.12.009
更新日期：2012-02-01 00:00:00
abstract：:Cochlear implant (CI) users typically have excellent speech recognition in quiet but struggle with understanding speech in noise. It is thought that broad current spread from stimulating electrodes causes adjacent electrodes to activate overlapping populations of neurons which results in interactions across adjacent c...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2013.02.004
更新日期：2013-05-01 00:00:00
abstract：:Inbred strain variants of the Cdh23 gene have been shown to influence the onset and progression of age-related hearing loss (AHL) in mice. In linkage backcrosses, the recessive Cdh23 allele (ahl) of the C57BL/6J strain, when homozygous, confers increased susceptibility to AHL, while the dominant allele (Ahl+) of the C...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2011.11.007
更新日期：2012-01-01 00:00:00
abstract：:With the aim of characterizing the loss of high frequency hearing sensitivity in children, hearing thresholds and otoacoustic emissions were measured in a group of 126 normal hearing children and adolescents aged from 6 to 25 years. The subjects were divided into four 5-year age groups. Hearing thresholds over a range...
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/j.heares.2005.11.003
更新日期：2006-02-01 00:00:00
abstract：:The vibration characteristics (amplitude and phase as a function of frequency) of the tympanic membrane in the grass frog were measured using a laser-doppler velocity meter. It was tested to what extent the frog's acoustic system behaves as a pressure gradient receiver. This might clarify how the frog localizes sound....
journal_title：Hearing research
pub_type： 杂志文章
doi：10.1016/0378-5955(84)90018-2
更新日期：1984-05-01 00:00:00
